JP2008514248A - 可撓性で多孔性の構造をもつ抗菌性埋入物 - Google Patents
可撓性で多孔性の構造をもつ抗菌性埋入物 Download PDFInfo
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- JP2008514248A JP2008514248A JP2007532832A JP2007532832A JP2008514248A JP 2008514248 A JP2008514248 A JP 2008514248A JP 2007532832 A JP2007532832 A JP 2007532832A JP 2007532832 A JP2007532832 A JP 2007532832A JP 2008514248 A JP2008514248 A JP 2008514248A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/624—Nanocapsules
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
【解決手段】 本発明は、生体適合性合成材料からなる可撓性で多孔性の構造をもち、少なくとも1種の抗菌剤の粒子を含有する抗菌性埋入物に関する。
【選択図】 なし
Description
粒状ポリウレタン1200gとクロロホルム13500g(9リットル)を撹拌槽に入れ、約270rpmで72時間撹拌して、完全に溶解させる。
銀含量0.1%の吹付け溶液→銀含量1.2%の人口血管
銀含量0.5%の吹付け溶液→銀含量6.1%の人口血管
銀含量1.0%の吹付け溶液→銀含量12.3%の人口血管
PU製人工血管の気孔率および細孔径
気孔率 50%(自由体積)
細孔径 細孔の95%が0.1〜100μmの間の細孔径をもつ。大部分(細孔の50%より多く)が1〜10μmの間の径をもつ。最も共有されている細孔径は1μmである。
方法: 試験対象人工血管を水で満たし、増大していく圧に曝露する。外面に水が認められると、直ちに圧を記録し、試験を中止する。この圧が透水圧である。PU製人口血管の透水圧は、250〜320mmHgである。
1)試験方法
検体を、試験対象菌株の細胞とともにインキュベートし、娘細胞の周囲への増殖を、光学濃度によって確認する。
スタフィロコッカス・エピデルミディス9142(〜106CFU/ml)
2)操作法
人工血管を、大きさ7x4mmの試験片に切断し、試験片当りn=8の回数で調査を行なった。
銀配合ポリウレタン製人工血管
最初のPU/クロロホルム溶液を基準にした添加ナノ銀の含量は、0.1%、0.5%および1.0%(PU基準の重量百分率で1.2%、6.1%、12.3%)であった。
Claims (19)
- 生体適合性合成材料からなる可撓性で多孔性のウェブ構造をもつ抗菌性埋入物であって、少なくとも1種の抗菌剤の粒子を含有する埋入物。
- 中空器官、とりわけ人工血管として設計されていることを特徴とする請求項1に記載の埋入物。
- 平面状埋入物、とりわけパッチとして設計されていることを特徴とする請求項1に記載の埋入物。
- 多孔性構造が微孔性構造であり、とりわけ圧力差が1.2kPaのときの空気透過率が5〜500ml/cm2/分、好ましくは10〜200ml/cm2/分のものであることを特徴とする先行請求項のいずれかに記載の埋入物。
- 合成材料が非吸収性合成材料であることを特徴とする先行請求項のいずれかに記載の埋入物。
- 合成材料が熱によって可塑化しうる合成材料、とりわけ熱可塑性プラスチックであることを特徴とする先行請求項のいずれかに記載の埋入物。
- 合成材料が、溶媒に可溶性の合成材料であることを特徴とする先行請求項のいずれかに記載の埋入物。
- 合成材料が疎水性合成材料であることを特徴とする先行請求項のいずれかに記載の埋入物。
- 薄壁のものとして設計されており、とりわけ0.1〜2mm、好ましくは0.3〜0.6mmの壁厚みをもつことを特徴とする先行請求項のいずれかに記載の埋入物。
- 吹付けウェブとして設計されていることを特徴とする先行請求項のいずれかに記載の埋入物。
- メルトブローンウェブとして設計されていることを特徴とする先行請求項のいずれかに記載の埋入物。
- 抗菌剤の粒子が、ウェブ構造の個々の繊維の合成材料中に均一に分散されていることを特徴とする先行請求項のいずれかに記載の埋入物。
- 抗菌剤の粒子が、埋入物の少なくとも1つの表面で富化・濃縮されていることを特徴とする請求項1〜12のいずれかに記載の埋入物。
- 表面に位置するウェブ構造の繊維が、表面より下に位置する繊維よりも高い抗菌剤粒子濃度を有することを特徴とする請求項13に記載の埋入物。
- 少なくとも1種の抗菌剤の粒子が50〜100nmの粒度をもつことを特徴とする先行請求項のいずれかに記載の埋入物。
- 少なくとも1種の抗菌剤の粒子が、抗菌活性をもつ少なくとも1種の金属、とりわけ銀からなることを特徴とする先行請求項のいずれかに記載の埋入物。
- 少なくとも1種の抗菌剤の粒子の含量が0.1〜10重量%、とりわけ0.2〜5重量%であることを特徴とする先行請求項のいずれかに記載の埋入物。
- 先行請求項のいずれかに記載の埋入物を製造する方法であって、生体適合性合成材料を、遅くとも該埋入物の多孔性構造を成形する間、好ましくはその前に、該少なくとも1種の抗菌剤の粒子で処理することを特徴とする方法。
- 少なくとも1種の抗菌剤の粒子を付与された合成材料からなる埋入物を一回の操作で、とりわけ基材への材料塗布によって形成することを特徴とする請求項18に記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004047568A DE102004047568A1 (de) | 2004-09-24 | 2004-09-24 | Antimikrobielles Implantat mit einer flexiblen porösen Struktur |
PCT/EP2005/010256 WO2006032497A1 (de) | 2004-09-24 | 2005-09-22 | Antimikrobielles implantat mit einer flexiblen porösen struktur |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2008514248A true JP2008514248A (ja) | 2008-05-08 |
Family
ID=35722402
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007532832A Pending JP2008514248A (ja) | 2004-09-24 | 2005-09-22 | 可撓性で多孔性の構造をもつ抗菌性埋入物 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20080268011A1 (ja) |
EP (1) | EP1796750B1 (ja) |
JP (1) | JP2008514248A (ja) |
DE (1) | DE102004047568A1 (ja) |
ES (1) | ES2446105T3 (ja) |
WO (1) | WO2006032497A1 (ja) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102006028221B4 (de) * | 2006-06-14 | 2014-02-13 | Aesculap Ag | Schlauchförmige Gefäßprothese und Verfahren zu ihrer Herstellung |
DE102007052519A1 (de) | 2007-10-29 | 2009-04-30 | Aesculap Ag | Medizinisches Implantat |
EP2108382A1 (de) | 2008-04-08 | 2009-10-14 | Bayer MaterialScience AG | Silberhaltige Polyurethanharnstofflösung |
EP2108386A1 (de) | 2008-04-08 | 2009-10-14 | Bayer MaterialScience AG | Medizinische Geräte mit einer antimikrobiellen Polyurethanharnstoffbeschichtung |
EP2108383A1 (de) | 2008-04-08 | 2009-10-14 | Bayer MaterialScience AG | Medizinische Geräte mit einer antibakteriellen Polyurethanharnstoffbeschichtung |
EP2108387A1 (de) * | 2008-04-08 | 2009-10-14 | Bayer MaterialScience AG | Wässrige silberhaltige nichtionische Polyurethandispersionen |
DE102008052837A1 (de) | 2008-10-13 | 2010-04-15 | Aesculap Ag | Textiles Implantat mit Kern-Mantel-Aufbau und Verfahren zu seiner Herstellung |
DE102009007667B4 (de) * | 2009-02-05 | 2012-04-19 | Raumedic Ag | Medizinisches Arbeitsmittel sowie Verfahren und Vorrichtung zur Herstellung eines derartigen medizinischen Arbeitsmittels |
US8673018B2 (en) | 2010-02-05 | 2014-03-18 | AMx Tek LLC | Methods of using water-soluble inorganic compounds for implants |
US20120094120A1 (en) | 2010-10-18 | 2012-04-19 | PurThread Technologies, Inc. | Enhancing and preserving anti-microbial performance in fibers with pigments |
DE102011079680A1 (de) * | 2011-07-22 | 2013-01-24 | Aesculap Ag | Beschichtetes Implantat und Verfahren zu seiner Herstellung |
PL231639B1 (pl) * | 2012-04-17 | 2019-03-29 | Politechnika Lodzka | Materiał medyczny do rekonstrukcji naczyń krwionośnych oraz sposób wytwarzania materiału medycznego |
WO2015023644A2 (en) | 2013-08-12 | 2015-02-19 | PurThread Technologies, Inc. | Antimicrobial and antifungal polymer fibers, fabrics, and methods of manufacture thereof |
DE102014201889A1 (de) | 2014-02-03 | 2015-08-20 | Aesculap Ag | Medizinisches Produkt zur Anwendung bei der Behandlung von Hernien |
US9878480B1 (en) | 2014-06-24 | 2018-01-30 | PurThread Technologies, Inc. | Method for making polymer feedstock usable for generation of fiber having anti-microbial properties |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
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US5019096A (en) * | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
JPH06293611A (ja) * | 1993-04-05 | 1994-10-21 | Asahi Chem Ind Co Ltd | 抗菌性材料 |
WO1996003165A1 (en) * | 1994-07-21 | 1996-02-08 | Vascutek Limited | Prostheses for the abdominal wall |
WO1998057680A2 (en) * | 1997-06-17 | 1998-12-23 | Medtronic, Inc. | Medical device for delivering a therapeutic substance |
US20010010022A1 (en) * | 1999-12-08 | 2001-07-26 | Martin Dauner | Medical product, method for its manufacture and use |
JP2001340375A (ja) * | 2000-05-31 | 2001-12-11 | Toyobo Co Ltd | 創傷被覆材 |
WO2003045448A1 (en) * | 2001-11-20 | 2003-06-05 | The University Of Nottingham | Impregnation of polymeric substrates with antimicrobial substances using superficial fluids |
JP2004256794A (ja) * | 2003-02-03 | 2004-09-16 | Takashima:Kk | 抗菌性ポリウレタンフォーム |
Family Cites Families (12)
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DE3110681A1 (de) * | 1981-03-19 | 1982-09-30 | Jürgen Dr.med. 5024 Brauweiler Eitenmüller | Material fuer knochenimplantate, verfahren zu seiner herstellung und seine verwendung |
ATE88324T1 (de) * | 1984-12-28 | 1993-05-15 | Johnson Matthey Plc | Antimikrobielle zusammensetzungen. |
US5133090A (en) * | 1988-02-11 | 1992-07-28 | The Trustees Of Columbia University In The City Of New York | Antiviral glove |
JPH0767895A (ja) | 1993-06-25 | 1995-03-14 | Sumitomo Electric Ind Ltd | 抗菌性人工血管及び抗菌性手術用縫合糸 |
US6013106A (en) | 1997-01-22 | 2000-01-11 | St. Jude Medical, Inc. | Medical article with adhered antimicrobial metal ions and related methods |
US6273875B1 (en) * | 1998-08-17 | 2001-08-14 | Edwards Lifesciences Corporation | Medical devices having improved antimicrobial/antithrombogenic properties |
DE19912648A1 (de) * | 1999-03-20 | 2000-09-21 | Aesculap Ag & Co Kg | Flächiges Implantat, Verfahren zu seiner Herstellung und Verwendung in der Chirurgie |
US20030040809A1 (en) * | 1999-03-20 | 2003-02-27 | Helmut Goldmann | Flat implant for use in surgery |
DE19936059A1 (de) * | 1999-07-30 | 2001-02-01 | J Peter Guggenbichler | Verfahren zur Herstellung von antimikrobiellen Kunststoffkörpern |
DE10043151A1 (de) * | 2000-08-31 | 2002-03-28 | Peter Steinruecke | Knochenzement mit antimikrobieller Wirksamkeit |
BR0314743A (pt) * | 2002-09-26 | 2005-07-26 | Angiotech Int Ag | Envoltórios perivasculares |
US8088158B2 (en) * | 2002-12-20 | 2012-01-03 | Boston Scientific Scimed, Inc. | Radiopaque ePTFE medical devices |
-
2004
- 2004-09-24 DE DE102004047568A patent/DE102004047568A1/de not_active Ceased
-
2005
- 2005-09-22 JP JP2007532832A patent/JP2008514248A/ja active Pending
- 2005-09-22 US US11/663,595 patent/US20080268011A1/en not_active Abandoned
- 2005-09-22 WO PCT/EP2005/010256 patent/WO2006032497A1/de active Application Filing
- 2005-09-22 EP EP05794777.2A patent/EP1796750B1/de not_active Not-in-force
- 2005-09-22 ES ES05794777.2T patent/ES2446105T3/es active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5019096A (en) * | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
JPH06293611A (ja) * | 1993-04-05 | 1994-10-21 | Asahi Chem Ind Co Ltd | 抗菌性材料 |
WO1996003165A1 (en) * | 1994-07-21 | 1996-02-08 | Vascutek Limited | Prostheses for the abdominal wall |
WO1998057680A2 (en) * | 1997-06-17 | 1998-12-23 | Medtronic, Inc. | Medical device for delivering a therapeutic substance |
US20010010022A1 (en) * | 1999-12-08 | 2001-07-26 | Martin Dauner | Medical product, method for its manufacture and use |
JP2001340375A (ja) * | 2000-05-31 | 2001-12-11 | Toyobo Co Ltd | 創傷被覆材 |
WO2003045448A1 (en) * | 2001-11-20 | 2003-06-05 | The University Of Nottingham | Impregnation of polymeric substrates with antimicrobial substances using superficial fluids |
JP2004256794A (ja) * | 2003-02-03 | 2004-09-16 | Takashima:Kk | 抗菌性ポリウレタンフォーム |
Also Published As
Publication number | Publication date |
---|---|
WO2006032497A1 (de) | 2006-03-30 |
DE102004047568A1 (de) | 2006-04-13 |
ES2446105T3 (es) | 2014-03-06 |
US20080268011A1 (en) | 2008-10-30 |
EP1796750B1 (de) | 2014-01-08 |
EP1796750A1 (de) | 2007-06-20 |
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