JP2008514227A5 - - Google Patents
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- Publication number
- JP2008514227A5 JP2008514227A5 JP2007534532A JP2007534532A JP2008514227A5 JP 2008514227 A5 JP2008514227 A5 JP 2008514227A5 JP 2007534532 A JP2007534532 A JP 2007534532A JP 2007534532 A JP2007534532 A JP 2007534532A JP 2008514227 A5 JP2008514227 A5 JP 2008514227A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- polypeptide
- sequence
- seq
- muscle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091033319 polynucleotide Proteins 0.000 claims description 109
- 102000040430 polynucleotide Human genes 0.000 claims description 109
- 239000002157 polynucleotide Substances 0.000 claims description 109
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 52
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 49
- 229920001184 polypeptide Polymers 0.000 claims description 48
- 238000000034 method Methods 0.000 claims description 43
- 239000002773 nucleotide Substances 0.000 claims description 29
- 125000003729 nucleotide group Chemical group 0.000 claims description 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
- 201000010099 disease Diseases 0.000 claims description 26
- 210000003205 muscle Anatomy 0.000 claims description 20
- 239000013598 vector Substances 0.000 claims description 20
- 230000000295 complement effect Effects 0.000 claims description 19
- 108090000790 Enzymes Proteins 0.000 claims description 17
- 102000004190 Enzymes Human genes 0.000 claims description 17
- 230000014509 gene expression Effects 0.000 claims description 17
- 241001465754 Metazoa Species 0.000 claims description 16
- 239000012634 fragment Substances 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 15
- 230000000692 anti-sense effect Effects 0.000 claims description 10
- 230000002401 inhibitory effect Effects 0.000 claims description 8
- 239000000556 agonist Substances 0.000 claims description 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
- 239000005557 antagonist Substances 0.000 claims description 6
- 102000004961 Furin Human genes 0.000 claims description 5
- 108090001126 Furin Proteins 0.000 claims description 5
- 101710118538 Protease Proteins 0.000 claims description 5
- 239000013604 expression vector Substances 0.000 claims description 5
- 230000037257 muscle growth Effects 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 3
- 230000002452 interceptive effect Effects 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- 230000002441 reversible effect Effects 0.000 claims description 3
- 201000000585 muscular atrophy Diseases 0.000 claims 17
- 206010028289 Muscle atrophy Diseases 0.000 claims 13
- 230000020763 muscle atrophy Effects 0.000 claims 10
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 4
- 208000030507 AIDS Diseases 0.000 claims 3
- 206010006895 Cachexia Diseases 0.000 claims 3
- 206010061216 Infarction Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000007574 infarction Effects 0.000 claims 3
- 201000006938 muscular dystrophy Diseases 0.000 claims 3
- 230000002107 myocardial effect Effects 0.000 claims 3
- 210000004165 myocardium Anatomy 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 206010028311 Muscle hypertrophy Diseases 0.000 claims 2
- 108091030071 RNAI Proteins 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000001010 compromised effect Effects 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000009368 gene silencing by RNA Effects 0.000 claims 2
- 230000012042 muscle hypertrophy Effects 0.000 claims 2
- 230000003387 muscular Effects 0.000 claims 2
- 210000003098 myoblast Anatomy 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 230000002797 proteolythic effect Effects 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 206010003694 Atrophy Diseases 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 claims 1
- 241000282994 Cervidae Species 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- 241000283086 Equidae Species 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 206010020880 Hypertrophy Diseases 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 claims 1
- 238000000636 Northern blotting Methods 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 241000286209 Phasianidae Species 0.000 claims 1
- 241000700159 Rattus Species 0.000 claims 1
- 241000282887 Suidae Species 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 108010091748 peptide A Proteins 0.000 claims 1
- 244000144977 poultry Species 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ535696 | 2004-09-30 | ||
| NZ53569604A NZ535696A (en) | 2004-09-30 | 2004-09-30 | Myostatin splice variants ( MSV ) |
| NZ53839605 | 2005-02-22 | ||
| NZ538396 | 2005-02-22 | ||
| PCT/NZ2005/000250 WO2006036074A1 (en) | 2004-09-30 | 2005-09-30 | Myostatin isoform |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008514227A JP2008514227A (ja) | 2008-05-08 |
| JP2008514227A5 true JP2008514227A5 (https=) | 2008-10-23 |
| JP5335239B2 JP5335239B2 (ja) | 2013-11-06 |
Family
ID=36119161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534532A Expired - Fee Related JP5335239B2 (ja) | 2004-09-30 | 2005-09-30 | ミオスタチンアイソフォーム |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20080118487A1 (https=) |
| EP (1) | EP1799709B1 (https=) |
| JP (1) | JP5335239B2 (https=) |
| AT (1) | ATE552272T1 (https=) |
| CA (1) | CA2582940A1 (https=) |
| WO (1) | WO2006036074A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100898149B1 (ko) | 2007-04-05 | 2009-05-19 | 주식회사 에스엔피 제네틱스 | 소의 근내지방도와 연관되어 있는 티틴-캡 다형성 |
| HRP20251426T1 (hr) | 2013-05-06 | 2026-01-02 | Scholar Rock, Inc. | Sastavi i postupci za modulaciju faktora rasta |
| WO2019195679A1 (en) * | 2018-04-06 | 2019-10-10 | Intrexon Corporation | Tilapia with enhanced growth characteristics |
| CN113474013B (zh) | 2019-03-01 | 2024-06-21 | 神户天然物化学株式会社 | 肌肉生长抑制素剪接变体衍生蛋白对肌肉生长抑制素信号的抑制及其利用 |
| US20240229036A9 (en) * | 2021-02-26 | 2024-07-11 | Knc Laboratories Co., Ltd. | Nucleic acid medicine expressing splicing variant of myostatin |
| CN115201474A (zh) * | 2022-08-12 | 2022-10-18 | 万华普曼生物工程有限公司 | 一种新型冠状病毒抗体的快速检测试剂盒及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4487325A (en) | 1982-07-06 | 1984-12-11 | Owens-Illinois, Inc. | Crown closures and containers |
| US7393682B1 (en) * | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| US5874409A (en) * | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
| WO1998033887A1 (en) | 1997-02-05 | 1998-08-06 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| US6656475B1 (en) * | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| US6369201B1 (en) * | 1998-02-19 | 2002-04-09 | Metamorphix International, Inc. | Myostatin multimers |
| US7056512B1 (en) | 1999-07-20 | 2006-06-06 | Pharmexa A/S | Method for down-regulating GDF-8 activity |
| US7368534B2 (en) * | 2000-01-18 | 2008-05-06 | Orico Limited | Myostatin and mimetics thereof |
| CA2484941A1 (en) | 2002-07-24 | 2004-02-05 | Intercell Ag | Antigens encoded by alternative reading frame from pathogenic viruses |
| EP2192129A1 (en) * | 2002-09-16 | 2010-06-02 | Johns Hopkins University | Metalloprotease activation of myostatin, and methods of modulating myostatin activity |
| NZ529860A (en) * | 2003-11-28 | 2006-10-27 | Ovita Ltd | Muscle growth regulator mighty and use in promoting muscle mass and treating muscle wasting diseases |
| CA2551877A1 (en) * | 2003-12-31 | 2005-07-21 | Schering-Plough Ltd. | Neutralizing epitope-based growth enhancing vaccine |
| NZ538097A (en) | 2005-02-07 | 2006-07-28 | Ovita Ltd | Method and compositions for improving wound healing |
| US20070190056A1 (en) | 2006-02-07 | 2007-08-16 | Ravi Kambadur | Muscle regeneration compositions and uses therefor |
| US8309068B2 (en) * | 2006-08-03 | 2012-11-13 | Myostin Therapeutics Pty Ltd. | Isolated polypeptides and methods of improving muscle strength |
-
2005
- 2005-09-30 US US11/576,449 patent/US20080118487A1/en not_active Abandoned
- 2005-09-30 AT AT05790714T patent/ATE552272T1/de active
- 2005-09-30 WO PCT/NZ2005/000250 patent/WO2006036074A1/en not_active Ceased
- 2005-09-30 JP JP2007534532A patent/JP5335239B2/ja not_active Expired - Fee Related
- 2005-09-30 CA CA002582940A patent/CA2582940A1/en not_active Abandoned
- 2005-09-30 EP EP05790714A patent/EP1799709B1/en not_active Expired - Lifetime
-
2011
- 2011-04-12 US US13/085,263 patent/US8455448B2/en not_active Expired - Fee Related
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