JP2008512486A5 - - Google Patents
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- JP2008512486A5 JP2008512486A5 JP2007531384A JP2007531384A JP2008512486A5 JP 2008512486 A5 JP2008512486 A5 JP 2008512486A5 JP 2007531384 A JP2007531384 A JP 2007531384A JP 2007531384 A JP2007531384 A JP 2007531384A JP 2008512486 A5 JP2008512486 A5 JP 2008512486A5
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- JP
- Japan
- Prior art keywords
- disease
- pharmaceutical composition
- inhibitor
- agonist
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 7
- 239000003112 inhibitor Substances 0.000 claims 5
- 229940126033 PPAR agonist Drugs 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 239000002307 peroxisome proliferator activated receptor agonist Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 208000024172 Cardiovascular disease Diseases 0.000 claims 3
- 229940124754 PPAR-alpha/gamma agonist Drugs 0.000 claims 3
- 101000712605 Theromyzon tessulatum Theromin Proteins 0.000 claims 3
- 229940122388 Thrombin inhibitor Drugs 0.000 claims 3
- 239000003472 antidiabetic agent Substances 0.000 claims 3
- 239000002220 antihypertensive agent Substances 0.000 claims 3
- 230000001906 cholesterol absorption Effects 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 230000009977 dual effect Effects 0.000 claims 3
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 3
- 239000002461 renin inhibitor Substances 0.000 claims 3
- 229940086526 renin-inhibitors Drugs 0.000 claims 3
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 3
- 239000003868 thrombin inhibitor Substances 0.000 claims 3
- PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 claims 2
- PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 claims 2
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims 2
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims 2
- 102100033868 Cannabinoid receptor 1 Human genes 0.000 claims 2
- 101710187010 Cannabinoid receptor 1 Proteins 0.000 claims 2
- 229940122904 Glucagon receptor antagonist Drugs 0.000 claims 2
- 206010022489 Insulin Resistance Diseases 0.000 claims 2
- 206010057852 Nicotine dependence Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 229960002478 aldosterone Drugs 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 229940127003 anti-diabetic drug Drugs 0.000 claims 2
- 239000000883 anti-obesity agent Substances 0.000 claims 2
- 229940127088 antihypertensive drug Drugs 0.000 claims 2
- 229940125710 antiobesity agent Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 230000005586 smoking cessation Effects 0.000 claims 2
- 230000000391 smoking effect Effects 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- NKOHRVBBQISBSB-UHFFFAOYSA-N 5-[(4-hydroxyphenyl)methyl]-1,3-thiazolidine-2,4-dione Chemical compound C1=CC(O)=CC=C1CC1C(=O)NC(=O)S1 NKOHRVBBQISBSB-UHFFFAOYSA-N 0.000 claims 1
- NMTKJEZOWHRAQY-UHFFFAOYSA-N 8-[(6-methoxyisoquinolin-4-yl)methyl]-1-methyl-3-(2-methylpropyl)-7h-purine-2,6-dione Chemical group CC(C)CN1C(=O)N(C)C(=O)C(N2)=C1N=C2CC1=CN=CC2=CC=C(OC)C=C21 NMTKJEZOWHRAQY-UHFFFAOYSA-N 0.000 claims 1
- 239000005541 ACE inhibitor Substances 0.000 claims 1
- 206010054196 Affect lability Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 239000005552 B01AC04 - Clopidogrel Substances 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 229940127291 Calcium channel antagonist Drugs 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000022497 Cocaine-Related disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 206010014950 Eosinophilia Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010022562 Intermittent claudication Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 102000023984 PPAR alpha Human genes 0.000 claims 1
- 108010028924 PPAR alpha Proteins 0.000 claims 1
- 229940080774 Peroxisome proliferator-activated receptor gamma agonist Drugs 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000025569 Tobacco Use disease Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 201000004810 Vascular dementia Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 claims 1
- 239000000400 angiotensin II type 1 receptor blocker Substances 0.000 claims 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 229940030600 antihypertensive agent Drugs 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 229940097320 beta blocking agent Drugs 0.000 claims 1
- 239000000480 calcium channel blocker Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000005961 cardioprotection Effects 0.000 claims 1
- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 claims 1
- 201000006145 cocaine dependence Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 230000001882 diuretic effect Effects 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- OLNTVTPDXPETLC-XPWALMASSA-N ezetimibe Chemical group N1([C@@H]([C@H](C1=O)CC[C@H](O)C=1C=CC(F)=CC=1)C=1C=CC(O)=CC=1)C1=CC=C(F)C=C1 OLNTVTPDXPETLC-XPWALMASSA-N 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 230000009610 hypersensitivity Effects 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 206010021654 increased appetite Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000028709 inflammatory response Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 208000021156 intermittent vascular claudication Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 229940020573 plavix Drugs 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 201000001474 proteinuria Diseases 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 239000000779 smoke Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000005665 thrombophilia Diseases 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- ZXIBCJHYVWYIKI-PZJWPPBQSA-N ximelagatran Chemical group C1([C@@H](NCC(=O)OCC)C(=O)N2[C@@H](CC2)C(=O)NCC=2C=CC(=CC=2)C(\N)=N\O)CCCCC1 ZXIBCJHYVWYIKI-PZJWPPBQSA-N 0.000 claims 1
- 229960001522 ximelagatran Drugs 0.000 claims 1
- 229940051223 zetia Drugs 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60831004P | 2004-09-09 | 2004-09-09 | |
| US60957704P | 2004-09-14 | 2004-09-14 | |
| US68973805P | 2005-06-10 | 2005-06-10 | |
| PCT/US2005/032224 WO2006029349A1 (en) | 2004-09-09 | 2005-09-08 | Combination of organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008512486A JP2008512486A (ja) | 2008-04-24 |
| JP2008512486A5 true JP2008512486A5 (https=) | 2008-10-23 |
Family
ID=35385557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531384A Withdrawn JP2008512486A (ja) | 2004-09-09 | 2005-09-08 | 有機化合物の組み合わせ |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20070299047A1 (https=) |
| EP (1) | EP1791600A1 (https=) |
| JP (1) | JP2008512486A (https=) |
| KR (1) | KR20070106677A (https=) |
| AR (1) | AR050631A1 (https=) |
| AU (1) | AU2005282290B2 (https=) |
| BR (1) | BRPI0515185A (https=) |
| CA (1) | CA2578290A1 (https=) |
| GT (1) | GT200500246A (https=) |
| MX (1) | MX2007002879A (https=) |
| PE (1) | PE20060594A1 (https=) |
| TW (1) | TW200621220A (https=) |
| WO (1) | WO2006029349A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE521512C2 (sv) | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| ES2285233T3 (es) | 2002-12-20 | 2007-11-16 | Niconovum Ab | Un material en particulas que contiene nicotina y celulosa microcristalina fisicamente y quimicamente estable. |
| US9402809B2 (en) | 2006-03-16 | 2016-08-02 | Niconovum Usa, Inc. | Snuff composition |
| EP1972335A1 (en) * | 2007-03-23 | 2008-09-24 | Krka | Solid dosage forms comprising aliskiren and pharmaceutically acceptable salts thereof |
| US11241420B2 (en) | 2007-04-11 | 2022-02-08 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| EP3788877B1 (en) * | 2007-04-11 | 2024-08-07 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| AU2013201888B2 (en) * | 2007-04-11 | 2016-02-25 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| US20160331729A9 (en) | 2007-04-11 | 2016-11-17 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| IE20070928A1 (en) * | 2007-12-21 | 2009-09-30 | Giuliani Int Ltd | Multi target ligands |
| WO2009154230A1 (ja) * | 2008-06-17 | 2009-12-23 | 持田製薬株式会社 | 非アルコール性脂肪肝炎の予防／改善・治療薬 |
| SI2805746T1 (sl) | 2009-02-16 | 2020-10-30 | Nogra Pharma Limited | Alkilamido spojine in njihova uporaba |
| CN102348457A (zh) | 2009-03-11 | 2012-02-08 | 奥默罗斯公司 | 预防和治疗成瘾的组合物和方法 |
| WO2011100659A2 (en) * | 2010-02-12 | 2011-08-18 | Kitov Pharmaceutical Ltd. | Ameliorating drug-induced elevations in blood pressure by adjunctive use of antihypertensive drugs |
| CN103476410B (zh) * | 2011-01-11 | 2020-02-21 | 戴麦里克斯生物科学有限公司 | 联合疗法 |
| WO2013071077A1 (en) | 2011-11-09 | 2013-05-16 | Cornell University | The use of pan-ppar agonists for prevention and treatment of huntington's disease and tauopathies |
| CA2864059C (en) | 2012-02-09 | 2020-04-28 | Nogra Pharma Limited | Methods of treating fibrosis |
| EP3834888A4 (en) * | 2018-08-10 | 2022-05-11 | Servicio Andaluz De Salud | MEANS OF TREATMENT OF ALCOHOL ABUSE |
| EP4495101A3 (en) | 2019-02-08 | 2025-04-30 | Nogra Pharma Limited | Process of making 3-(4'-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof |
| EP4255427B1 (en) | 2020-12-03 | 2024-11-06 | Delta 4 GmbH | Clopidogrel for use in the treatment of focal segmental glomerulosclerosis (fsgs) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3800038A (en) * | 1972-04-21 | 1974-03-26 | Biolog Concepts Inc | Uterine administraton of eutectic solid solutions of steroid hormones in a steroidal lipid carrier |
| FR2530247B1 (fr) * | 1982-07-13 | 1986-05-16 | Sanofi Sa | Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique |
| US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| TWI238827B (en) * | 1995-12-21 | 2005-09-01 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
| US6488961B1 (en) * | 1996-09-20 | 2002-12-03 | Ethypharm, Inc. | Effervescent granules and methods for their preparation |
| US6071539A (en) * | 1996-09-20 | 2000-06-06 | Ethypharm, Sa | Effervescent granules and methods for their preparation |
| US7019010B2 (en) * | 2001-09-27 | 2006-03-28 | Novertis Ag | Combinations |
| TW200303742A (en) * | 2001-11-21 | 2003-09-16 | Novartis Ag | Organic compounds |
| EP1638963B1 (en) * | 2003-05-20 | 2009-09-09 | Novartis AG | N-acyl nitrogen heterocycles as ligands of peroxisome proliferator-activated receptors |
-
2005
- 2005-09-07 GT GT200500246A patent/GT200500246A/es unknown
- 2005-09-07 AR ARP050103737A patent/AR050631A1/es unknown
- 2005-09-07 PE PE2005001034A patent/PE20060594A1/es not_active Application Discontinuation
- 2005-09-08 EP EP05796483A patent/EP1791600A1/en not_active Withdrawn
- 2005-09-08 MX MX2007002879A patent/MX2007002879A/es not_active Application Discontinuation
- 2005-09-08 KR KR1020077007858A patent/KR20070106677A/ko not_active Withdrawn
- 2005-09-08 JP JP2007531384A patent/JP2008512486A/ja not_active Withdrawn
- 2005-09-08 CA CA002578290A patent/CA2578290A1/en not_active Abandoned
- 2005-09-08 WO PCT/US2005/032224 patent/WO2006029349A1/en not_active Ceased
- 2005-09-08 US US11/574,994 patent/US20070299047A1/en not_active Abandoned
- 2005-09-08 TW TW094130818A patent/TW200621220A/zh unknown
- 2005-09-08 BR BRPI0515185-6A patent/BRPI0515185A/pt not_active IP Right Cessation
- 2005-09-08 AU AU2005282290A patent/AU2005282290B2/en not_active Expired - Fee Related
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