JP2008509974A5 - - Google Patents
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- JP2008509974A5 JP2008509974A5 JP2007526560A JP2007526560A JP2008509974A5 JP 2008509974 A5 JP2008509974 A5 JP 2008509974A5 JP 2007526560 A JP2007526560 A JP 2007526560A JP 2007526560 A JP2007526560 A JP 2007526560A JP 2008509974 A5 JP2008509974 A5 JP 2008509974A5
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- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- integer
- alkyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 15
- 125000004432 carbon atom Chemical group C* 0.000 claims 11
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000001188 haloalkyl group Chemical group 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000003282 alkyl amino group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000004438 haloalkoxy group Chemical group 0.000 claims 5
- -1 chloro, bromo, iodo, hydroxy Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000004103 aminoalkyl group Chemical group 0.000 claims 3
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 125000005429 oxyalkyl group Chemical group 0.000 claims 3
- 125000005592 polycycloalkyl group Polymers 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 150000003951 lactams Chemical group 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- FOHWFQYMMMHCSA-UHFFFAOYSA-N 2,2-dimethyl-n-(10-oxo-9-azabicyclo[3.3.2]decan-5-yl)dodecanamide Chemical compound C1CCC2CCCC1(NC(=O)C(C)(C)CCCCCCCCCC)C(=O)N2 FOHWFQYMMMHCSA-UHFFFAOYSA-N 0.000 claims 1
- WXJYAFKCMBQGGL-UHFFFAOYSA-N 2,2-dimethyl-n-(3-oxo-2-azabicyclo[2.2.2]octan-4-yl)dodecanamide Chemical compound C1CC2CCC1(NC(=O)C(C)(C)CCCCCCCCCC)C(=O)N2 WXJYAFKCMBQGGL-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000029725 Metabolic bone disease Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- YZCKVEUIGOORGS-IGMARMGPSA-N Protium Chemical compound [1H] YZCKVEUIGOORGS-IGMARMGPSA-N 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims 1
- 125000005189 alkyl hydroxy group Chemical group 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- NLUNLVTVUDIHFE-UHFFFAOYSA-N cyclooctylcyclooctane Chemical group C1CCCCCCC1C1CCCCCCC1 NLUNLVTVUDIHFE-UHFFFAOYSA-N 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 244000000056 intracellular parasite Species 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- VHRSBTQCOTVVPZ-UHFFFAOYSA-N n-(10-oxo-9-azabicyclo[3.3.2]decan-5-yl)adamantane-1-carboxamide Chemical compound C1CCC(NC2=O)CCCC12NC(=O)C1(C2)CC(C3)CC2CC3C1 VHRSBTQCOTVVPZ-UHFFFAOYSA-N 0.000 claims 1
- UVBHVPDUWUPTII-UHFFFAOYSA-N n-(3-oxo-2-azabicyclo[2.2.2]octan-4-yl)adamantane-1-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NC1(C(N2)=O)CCC2CC1 UVBHVPDUWUPTII-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001172 regenerating effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000037380 skin damage Effects 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- 230000029812 viral genome replication Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0418375A GB2418426A (en) | 2004-08-18 | 2004-08-18 | Alpha-(acylamino)-bicyclolactam derivatives for treatment of inflammatory disorders |
| PCT/GB2005/003139 WO2006018609A2 (en) | 2004-08-18 | 2005-08-10 | Anti-inflammatory agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008509974A JP2008509974A (ja) | 2008-04-03 |
| JP2008509974A5 true JP2008509974A5 (cg-RX-API-DMAC7.html) | 2008-10-02 |
Family
ID=33042220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007526560A Pending JP2008509974A (ja) | 2004-08-18 | 2005-08-10 | 抗炎症剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8008288B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1781290B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2008509974A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE490773T1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2577274A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE602005025228D1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB2418426A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006018609A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2418426A (en) | 2004-08-18 | 2006-03-29 | Univ Cambridge Tech | Alpha-(acylamino)-bicyclolactam derivatives for treatment of inflammatory disorders |
| GB2418427A (en) | 2004-09-02 | 2006-03-29 | Univ Cambridge Tech | Ligands for G-protein coupled receptors |
| US7662967B2 (en) | 2007-08-02 | 2010-02-16 | Cambridge Enterprise Limited | Anti-inflammatory compounds and compositions |
| GB2452696B (en) | 2007-08-02 | 2009-09-23 | Cambridge Entpr Ltd | 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions |
| GB2455539B (en) * | 2007-12-12 | 2012-01-18 | Cambridge Entpr Ltd | Anti-inflammatory compositions and combinations |
| GB201009603D0 (en) | 2010-06-08 | 2010-07-21 | Cambridge Entpr Ltd | Anti-inflammatory agent |
| CN113274400B (zh) * | 2021-06-07 | 2022-07-12 | 四川大学 | 四面体框架核酸在治疗多发性硬化症的药物中的用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19541283A1 (de) * | 1995-11-06 | 1997-05-07 | Boehringer Ingelheim Kg | Neue Aminosäurederivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| JP3690052B2 (ja) | 1997-03-24 | 2005-08-31 | Ｊｓｒ株式会社 | オイルゲル化剤 |
| US6989435B2 (en) | 1997-09-11 | 2006-01-24 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
| US6395282B1 (en) * | 1998-04-16 | 2002-05-28 | University Of Rochester | Immunogenic conjugates of Gram-negative bacterial autoinducer molecules |
| HK1039784A1 (zh) | 1999-01-12 | 2002-05-10 | Cambridge Enterprise Limited | 抑制或增强炎症反應的化合物及方法 |
| DE10305922A1 (de) | 2002-06-10 | 2004-03-04 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| CA2547651C (en) | 2003-12-01 | 2015-06-23 | Cambridge University Technical Services Limited | Anti-inflammatory agents |
| AU2005212073B2 (en) | 2004-02-18 | 2010-07-08 | Kyorin Pharmaceutical Co., Ltd. | Bicyclic amide derivatives |
| GB2418426A (en) | 2004-08-18 | 2006-03-29 | Univ Cambridge Tech | Alpha-(acylamino)-bicyclolactam derivatives for treatment of inflammatory disorders |
| GB2418427A (en) * | 2004-09-02 | 2006-03-29 | Univ Cambridge Tech | Ligands for G-protein coupled receptors |
| US7803794B2 (en) | 2005-06-15 | 2010-09-28 | Cambridge Enterprise Limited | Anti-inflammatory agents |
-
2004
- 2004-08-18 GB GB0418375A patent/GB2418426A/en not_active Withdrawn
-
2005
- 2005-08-10 WO PCT/GB2005/003139 patent/WO2006018609A2/en not_active Ceased
- 2005-08-10 DE DE602005025228T patent/DE602005025228D1/de not_active Expired - Lifetime
- 2005-08-10 AT AT05794113T patent/ATE490773T1/de not_active IP Right Cessation
- 2005-08-10 JP JP2007526560A patent/JP2008509974A/ja active Pending
- 2005-08-10 EP EP05794113A patent/EP1781290B1/en not_active Expired - Lifetime
- 2005-08-10 CA CA002577274A patent/CA2577274A1/en not_active Abandoned
- 2005-08-10 US US11/573,851 patent/US8008288B2/en not_active Expired - Fee Related
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