JP2008509701A5 - - Google Patents
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- JP2008509701A5 JP2008509701A5 JP2007527563A JP2007527563A JP2008509701A5 JP 2008509701 A5 JP2008509701 A5 JP 2008509701A5 JP 2007527563 A JP2007527563 A JP 2007527563A JP 2007527563 A JP2007527563 A JP 2007527563A JP 2008509701 A5 JP2008509701 A5 JP 2008509701A5
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- JP
- Japan
- Prior art keywords
- conjugate
- subunits
- subunit
- compound
- base
- Prior art date
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57404804P | 2004-05-24 | 2004-05-24 | |
| US60/574,048 | 2004-05-24 | ||
| US11/136,245 | 2005-05-23 | ||
| US11/136,245 US20050288246A1 (en) | 2004-05-24 | 2005-05-23 | Peptide conjugated, inosine-substituted antisense oligomer compound and method |
| PCT/US2005/018213 WO2005115479A2 (en) | 2004-05-24 | 2005-05-24 | Peptide conjugated, inosine-substituted antisense oligomer compound and method |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011130577A Division JP2011172596A (ja) | 2004-05-24 | 2011-06-10 | ペプチドが結合された、イノシン置換アンチセンスオリゴマー化合物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008509701A JP2008509701A (ja) | 2008-04-03 |
| JP2008509701A5 true JP2008509701A5 (https=) | 2008-05-15 |
| JP4974890B2 JP4974890B2 (ja) | 2012-07-11 |
Family
ID=35451420
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007527563A Expired - Lifetime JP4974890B2 (ja) | 2004-05-24 | 2005-05-24 | ペプチドが結合された、イノシン置換アンチセンスオリゴマー化合物および方法 |
| JP2011130577A Withdrawn JP2011172596A (ja) | 2004-05-24 | 2011-06-10 | ペプチドが結合された、イノシン置換アンチセンスオリゴマー化合物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011130577A Withdrawn JP2011172596A (ja) | 2004-05-24 | 2011-06-10 | ペプチドが結合された、イノシン置換アンチセンスオリゴマー化合物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20050288246A1 (https=) |
| EP (1) | EP1765414B1 (https=) |
| JP (2) | JP4974890B2 (https=) |
| AT (1) | ATE529513T1 (https=) |
| AU (1) | AU2005247460B2 (https=) |
| CA (1) | CA2565103C (https=) |
| ES (1) | ES2375631T3 (https=) |
| WO (1) | WO2005115479A2 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2523672C (en) | 2003-04-29 | 2012-07-17 | Avi Biopharma, Inc. | Compositions for enhancing transport of molecules into cells |
| US20050288246A1 (en) | 2004-05-24 | 2005-12-29 | Iversen Patrick L | Peptide conjugated, inosine-substituted antisense oligomer compound and method |
| ATE498685T1 (de) | 2004-06-28 | 2011-03-15 | Univ Western Australia | Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| CA2614191C (en) * | 2005-07-13 | 2015-06-30 | Avi Biopharma, Inc. | Antisense antibacterial method and compound |
| DK2735568T3 (da) * | 2006-05-10 | 2017-11-13 | Sarepta Therapeutics Inc | Oligonukleotidanaloger med kationiske bindinger mellem underenheder |
| CA2659103C (en) * | 2006-07-12 | 2019-05-21 | The Regents Of The University Of California | Transducible delivery of nucleic acids by reversible phosphotriester charge neutralization protecting groups |
| AU2015200600B2 (en) * | 2007-06-29 | 2017-04-20 | Sarepta Therapeutics, Inc. | Tissue specific peptide conjugates and methods |
| US20100016215A1 (en) | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| CA2703931C (en) | 2007-10-26 | 2016-08-16 | Dynavax Technologies Corporation | Methods and compositions for inhibition of immune responses and autoimmunity |
| USRE48468E1 (en) | 2007-10-26 | 2021-03-16 | Biomarin Technologies B.V. | Means and methods for counteracting muscle disorders |
| AU2008317566B2 (en) | 2007-10-26 | 2014-05-01 | Academisch Ziekenhuis Leiden | Means and methods for counteracting muscle disorders |
| EP2119783A1 (en) | 2008-05-14 | 2009-11-18 | Prosensa Technologies B.V. | Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means |
| CN112574988A (zh) | 2008-10-24 | 2021-03-30 | 萨雷普塔治疗公司 | 用于dmd的多外显子跳跃组合物 |
| CA2759899A1 (en) * | 2009-04-24 | 2010-10-28 | Prosensa Technologies B.V. | Oligonucleotide comprising an inosine for treating dmd |
| US20110269665A1 (en) | 2009-06-26 | 2011-11-03 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| US20130079382A1 (en) | 2009-10-12 | 2013-03-28 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
| LT2499249T (lt) | 2009-11-12 | 2018-12-27 | The University Of Western Australia | Priešprasmės molekulės ir patologijų gydymo būdai |
| US9506057B2 (en) | 2010-03-26 | 2016-11-29 | Integrated Dna Technologies, Inc. | Modifications for antisense compounds |
| KR20200133284A (ko) | 2010-05-28 | 2020-11-26 | 사렙타 쎄러퓨틱스, 인코퍼레이티드 | 변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체 |
| CN103153346A (zh) * | 2010-06-16 | 2013-06-12 | 戴纳瓦克斯技术公司 | 使用tlr7和/或tlr9抑制剂的治疗方法 |
| WO2012031243A2 (en) | 2010-09-03 | 2012-03-08 | Avi Biopharma, Inc. | dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS |
| AU2011299233B2 (en) | 2010-09-07 | 2016-09-15 | Integrated Dna Technologies, Inc. | Modifications for antisense compounds |
| CN102523750B (zh) | 2010-09-15 | 2015-08-12 | 日本精工株式会社 | 向心滚子轴承用保持架 |
| US9161948B2 (en) * | 2011-05-05 | 2015-10-20 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| WO2012150960A1 (en) * | 2011-05-05 | 2012-11-08 | Avi Biopharma, Inc. | Peptide oligonucleotide conjugates |
| EA202090338A1 (ru) | 2011-11-18 | 2021-04-30 | Сарепта Терапьютикс, Инк. | Функционально-модифицированные олигонуклеотиды и их субъединицы |
| CN112251436A (zh) | 2012-01-27 | 2021-01-22 | 比奥马林技术公司 | 治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸 |
| US9950001B2 (en) | 2012-08-20 | 2018-04-24 | The Regents Of The University Of California | Polynucleotides having bioreversible groups |
| US10077443B2 (en) | 2012-11-15 | 2018-09-18 | Roche Innovation Center Copenhagen A/S | Oligonucleotide conjugates |
| NZ731587A (en) | 2013-03-14 | 2021-07-30 | Sarepta Therapeutics Inc | Exon skipping compositions for treating muscular dystrophy |
| CA2906812A1 (en) | 2013-03-15 | 2014-09-18 | Sarepta Therapeutics, Inc. | Improved compositions for treating muscular dystrophy |
| SG10201811729PA (en) | 2013-12-12 | 2019-02-27 | Life Technologies Corp | Membrane-penetrating peptides to enhance transfection and compositions and methods for using same |
| US9790495B2 (en) | 2014-05-16 | 2017-10-17 | Oregon State University | Antisense antibacterial compounds and methods |
| AU2015264449B2 (en) * | 2014-05-19 | 2022-05-05 | Board Of Regents, The University Of Texas System | Antisense antibacterial compounds and methods |
| CA3249464A1 (en) | 2014-12-31 | 2025-11-29 | Univ Texas | Antisense antibacterial compounds and methods |
| US10849917B2 (en) | 2015-06-01 | 2020-12-01 | Sarepta Therapeutics, Inc. | Antisense-induced exon exclusion in type VII collagen |
| EP3302489A4 (en) | 2015-06-04 | 2019-02-06 | Sarepta Therapeutics, Inc. | METHOD AND COMPOUNDS FOR THE TREATMENT OF DISEASES AND SUFFERING IN CONNECTION WITH LYMPHOCYTES |
| CA3006748A1 (en) * | 2015-12-15 | 2017-06-22 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| AU2016379399B2 (en) * | 2015-12-23 | 2022-12-08 | Board Of Regents, The University Of Texas System | Antisense antibacterial compounds and methods |
| CA3021267A1 (en) | 2016-04-18 | 2017-10-26 | Sarepta Therapeutics, Inc. | Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene |
| JP2019532027A (ja) | 2016-08-17 | 2019-11-07 | ソルスティス バイオロジクス,リミティッド | ポリヌクレオチド構築物 |
| SMT202200366T1 (it) | 2016-12-19 | 2022-11-18 | Sarepta Therapeutics Inc | Coniugati di oligomeri per salto di esone per distrofia muscolare |
| WO2019006455A1 (en) | 2017-06-30 | 2019-01-03 | Solstice Biologics, Ltd. | AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF |
| WO2019079637A2 (en) * | 2017-10-18 | 2019-04-25 | Sarepta Therapeutics, Inc. | ANTISENSE OLIGOMERIC COMPOUNDS |
| EP3850096A1 (en) | 2018-09-11 | 2021-07-21 | Amgen Inc. | Purification methods for guanine-rich oligonucleotides |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5525465A (en) * | 1987-10-28 | 1996-06-11 | Howard Florey Institute Of Experimental Physiology And Medicine | Oligonucleotide-polyamide conjugates and methods of production and applications of the same |
| US5087617A (en) * | 1989-02-15 | 1992-02-11 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oligonucleotides |
| US5670617A (en) * | 1989-12-21 | 1997-09-23 | Biogen Inc | Nucleic acid conjugates of tat-derived transport polypeptides |
| GB9209032D0 (en) | 1992-04-25 | 1992-06-10 | Ciba Geigy Ag | New peptide derivatives |
| CA2135642C (en) | 1992-08-21 | 1999-12-14 | James G. Barsoum | Tat-derived transport polypeptides |
| ATE208634T1 (de) * | 1993-01-07 | 2001-11-15 | Univ Jefferson | Modulation der proliferation von glatten muskelzellen durch antisense inhibition von c-myc |
| US5849727A (en) * | 1996-06-28 | 1998-12-15 | Board Of Regents Of The University Of Nebraska | Compositions and methods for altering the biodistribution of biological agents |
| IL132941A0 (en) * | 1997-05-21 | 2001-03-19 | Univ Leland Stanford Junior | Composition and method for enhancing transport across biological membranes |
| CA2340884A1 (en) | 1998-08-25 | 2000-03-02 | Human Genome Sciences, Inc. | 49 human secreted proteins |
| JP2002535015A (ja) * | 1999-01-29 | 2002-10-22 | エイブイアイ バイオファーマ, インコーポレイテッド | 標的rnaを検出するための非侵襲性方法 |
| CA2365984A1 (en) * | 1999-04-08 | 2000-10-19 | Oasis Biosciences, Inc. | Antisense oligonucleotides comprising universal and/or degenerate bases |
| KR100708573B1 (ko) | 1999-05-24 | 2007-04-18 | 에이브이아이 바이오파마 인코포레이티드 | 다낭 신장 질환의 치료를 위한 c-myc에 대한 안티센스 |
| US6875747B1 (en) | 1999-05-24 | 2005-04-05 | Avi Bio Pharma, Inc. | Antisense to c-myc for treatment of polycystic kidney disease |
| US6303573B1 (en) * | 1999-06-07 | 2001-10-16 | The Burnham Institute | Heart homing peptides and methods of using same |
| US6669951B2 (en) | 1999-08-24 | 2003-12-30 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
| CA2381425A1 (en) | 1999-08-24 | 2001-03-01 | Cellgate, Inc. | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties |
| US7229961B2 (en) | 1999-08-24 | 2007-06-12 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into ocular tissues |
| US20030104622A1 (en) | 1999-09-01 | 2003-06-05 | Robbins Paul D. | Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses |
| US20020009491A1 (en) | 2000-02-14 | 2002-01-24 | Rothbard Jonathan B. | Compositions and methods for enhancing drug delivery across biological membranes and tissues |
| US6559279B1 (en) | 2000-09-08 | 2003-05-06 | Isis Pharmaceuticals, Inc. | Process for preparing peptide derivatized oligomeric compounds |
| US20040170955A1 (en) * | 2000-09-08 | 2004-09-02 | Wadih Arap | Human and mouse targeting peptides identified by phage display |
| EP1191097A1 (en) * | 2000-09-21 | 2002-03-27 | Leids Universitair Medisch Centrum | Induction of exon skipping in eukaryotic cells |
| WO2002038764A2 (en) | 2000-11-10 | 2002-05-16 | The Regents Of The University Of California | Il-17 receptor-like protein, uses thereof, and modulation of catabolic activity of il-17 cytokines on bone and cartilage |
| EP1364201A4 (en) * | 2001-02-06 | 2005-01-05 | Univ Auburn | LIGAND SENSOR DEVICES AND USES THEREOF |
| WO2002062989A2 (en) | 2001-02-08 | 2002-08-15 | Sequitur, Inc. | Methods of light activated release 0f ligands from endosomes |
| MXPA03007358A (es) * | 2001-02-16 | 2004-12-13 | Cellgate Inc | Transportadores que contienen porciones de arginina separadas. |
| US7456146B2 (en) | 2001-05-09 | 2008-11-25 | Ghc Research Development Corporation | Lytic peptide prodrugs |
| JP2004537517A (ja) * | 2001-05-17 | 2004-12-16 | エイブイアイ バイオファーマ, インコーポレイテッド | c−mycアンチセンスオリゴマーを使用した、癌を処置するための併用アプローチ |
| JP3735292B2 (ja) | 2001-07-26 | 2006-01-18 | 三菱重工業株式会社 | ダイエット効果のある健康食品および製剤 |
| US6645974B2 (en) * | 2001-07-31 | 2003-11-11 | Merck & Co., Inc. | Androgen receptor modulators and methods for use thereof |
| US20090075377A1 (en) | 2001-08-03 | 2009-03-19 | Arbor Vita Corporation | Molecular interactions in cells |
| AU2002359679B2 (en) * | 2001-12-11 | 2009-01-08 | Cellgate, Inc. | Guanidinium transport reagents and conjugates |
| WO2004084805A2 (en) | 2003-03-19 | 2004-10-07 | The J. David Gladstone Institutes | Acetylated tat polypeptides and methods of use thereof |
| CA2523672C (en) * | 2003-04-29 | 2012-07-17 | Avi Biopharma, Inc. | Compositions for enhancing transport of molecules into cells |
| PL2784084T5 (pl) | 2003-07-08 | 2024-12-02 | Novartis Pharma Ag | Przeciwciała antagonistyczne heterologicznych polipeptydów il-17a/f |
| US20050203041A1 (en) | 2003-09-23 | 2005-09-15 | Mourich Dan V. | Antisense compound and method for selectively killing activated T cells |
| US20050222068A1 (en) | 2003-10-23 | 2005-10-06 | Mourich Dan V | Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells |
| US7786151B2 (en) * | 2004-01-09 | 2010-08-31 | Kinopharma, Inc. | Therapeutic composition of treating abnormal splicing caused by the excessive kinase induction |
| EP1713332A4 (en) | 2004-01-23 | 2010-08-18 | Avi Biopharma Inc | ANTISENSE OLIGOMERS AND METHOD FOR INDUCTION OF IMMUNOTHERAPY AND IMMUNOSUPPRESSION |
| WO2005077333A2 (en) * | 2004-02-10 | 2005-08-25 | University Of Florida Research Foundation, Inc. | Gel-based delivery of recombinant adeno-associated virus vectors |
| US7402574B2 (en) | 2004-03-12 | 2008-07-22 | Avi Biopharma, Inc. | Antisense composition and method for treating cancer |
| US20050288246A1 (en) | 2004-05-24 | 2005-12-29 | Iversen Patrick L | Peptide conjugated, inosine-substituted antisense oligomer compound and method |
| US20060014712A1 (en) * | 2004-05-30 | 2006-01-19 | Cemines, Inc. | Controlled delivery of therapeutic compounds |
| ATE498685T1 (de) | 2004-06-28 | 2011-03-15 | Univ Western Australia | Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon |
| CA2572151A1 (en) | 2004-06-30 | 2006-08-24 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a non-phosphate backbone linkage |
| US7947645B2 (en) | 2004-09-02 | 2011-05-24 | Cognosci, Inc. | APO E analogs and methods for their use |
| US7429481B2 (en) | 2004-09-14 | 2008-09-30 | University Of Pittsburgh | Targeting viruses using a modified sindbis glycoprotein |
| US8129352B2 (en) | 2004-09-16 | 2012-03-06 | Avi Biopharma, Inc. | Antisense antiviral compound and method for treating ssRNA viral infection |
| US8357664B2 (en) | 2004-10-26 | 2013-01-22 | Avi Biopharma, Inc. | Antisense antiviral compound and method for treating influenza viral infection |
| US7524829B2 (en) | 2004-11-01 | 2009-04-28 | Avi Biopharma, Inc. | Antisense antiviral compounds and methods for treating a filovirus infection |
| NZ538097A (en) | 2005-02-07 | 2006-07-28 | Ovita Ltd | Method and compositions for improving wound healing |
| AU2006213686A1 (en) | 2005-02-09 | 2006-08-17 | Avi Bio Pharma, Inc. | Antisense composition and method for treating muscle atrophy |
| CA2596509A1 (en) | 2005-02-14 | 2006-08-24 | Wyeth | Interleukin-17f antibodies and other il-17f signaling antagonists and uses therefor |
| JP2008539209A (ja) | 2005-04-26 | 2008-11-13 | カリヨン−シーティーティー リミテッド | 診断及び治療剤 |
| CA2614191C (en) | 2005-07-13 | 2015-06-30 | Avi Biopharma, Inc. | Antisense antibacterial method and compound |
| US7790694B2 (en) * | 2005-07-13 | 2010-09-07 | Avi Biopharma Inc. | Antisense antibacterial method and compound |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| US8329668B2 (en) | 2005-09-08 | 2012-12-11 | Avi Biopharma, Inc. | Antisense antiviral compound and method for treating picornavirus infection |
| US8524676B2 (en) | 2005-09-08 | 2013-09-03 | Sarepta Therapeutics, Inc. | Method for treating enterovirus or rhinovirus infection using antisense antiviral compounds |
| EP1941275B1 (en) | 2005-09-29 | 2013-07-24 | Medimmune, Inc. | Method of identifying membrane lg specific antibodies and use thereof for targeting immunoglobulin-producing precursor cells |
| CA2628093A1 (en) | 2005-11-08 | 2007-05-18 | Avi Biopharma, Inc. | Antisense oligonucleotide analog compounds targeting proprocessed ctla-4 mrna |
| US8501704B2 (en) | 2005-11-08 | 2013-08-06 | Sarepta Therapeutics, Inc. | Immunosuppression compound and treatment method |
| CA2644262C (en) | 2006-03-07 | 2016-01-05 | Avi Biopharma, Inc. | Antisense antiviral compound and method for treating arenavirus infection |
| DK2735568T3 (da) | 2006-05-10 | 2017-11-13 | Sarepta Therapeutics Inc | Oligonukleotidanaloger med kationiske bindinger mellem underenheder |
| US8785407B2 (en) | 2006-05-10 | 2014-07-22 | Sarepta Therapeutics, Inc. | Antisense antiviral agent and method for treating ssRNA viral infection |
| AU2006345724B2 (en) | 2006-06-30 | 2013-11-21 | Lakewood-Amedex, Inc. | Compositions and methods for the treatment of muscle wasting |
| AU2007282224B2 (en) | 2006-08-11 | 2013-08-29 | Vico Therapeutics B.V. | Methods and means for treating DNA repeat instability associated genetic disorders |
| US20080199961A1 (en) | 2006-08-25 | 2008-08-21 | Avi Biopharma, Inc. | ANTISENSE COMPOSITION AND METHOD FOR INHIBITION OF miRNA BIOGENESIS |
| US20080267978A1 (en) | 2006-08-28 | 2008-10-30 | Mary Zutter | Anti-angiogenic targets for cancer therapy |
| EP3034083B1 (en) | 2006-09-21 | 2020-12-09 | University of Rochester | Antisense oligonucleotides for use in treating myotonic dystrophy |
| FR2908999B1 (fr) | 2006-11-29 | 2012-04-27 | Biomerieux Sa | Nouveau medicament destine a l'inhibition, la prevention ou le traitement de la polyarthrite rhumatoide. |
| EP1938802A1 (en) | 2006-12-22 | 2008-07-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Interfering RNAs targeting pro-inflammatory cytokines |
| EP3443976A1 (en) * | 2007-06-29 | 2019-02-20 | Sarepta Therapeutics, Inc. | Tissue specific peptide conjugates and methods |
| US20100016215A1 (en) | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| US20110300154A1 (en) | 2007-08-21 | 2011-12-08 | Children's Medical Center Corporation | Treatment of airway hyperreactivity |
| EP2235034B1 (en) | 2007-12-28 | 2016-11-23 | Sarepta Therapeutics, Inc. | Immunomodulatory agents and methods of use |
| US20110130346A1 (en) | 2008-05-30 | 2011-06-02 | Isis Innovation Limited | Peptide conjugates for delvery of biologically active compounds |
| CN112574988A (zh) | 2008-10-24 | 2021-03-30 | 萨雷普塔治疗公司 | 用于dmd的多外显子跳跃组合物 |
| AU2009335740B2 (en) | 2008-12-17 | 2016-04-21 | Sarepta Therapeutics, Inc. | Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis |
| US20110269665A1 (en) | 2009-06-26 | 2011-11-03 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| ES2816898T3 (es) | 2010-05-13 | 2021-04-06 | Sarepta Therapeutics Inc | Compuestos que modulan la actividad de señalización de las interleucinas 17 y 23 |
| US9161948B2 (en) | 2011-05-05 | 2015-10-20 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
-
2005
- 2005-05-23 US US11/136,245 patent/US20050288246A1/en not_active Abandoned
- 2005-05-24 WO PCT/US2005/018213 patent/WO2005115479A2/en not_active Ceased
- 2005-05-24 JP JP2007527563A patent/JP4974890B2/ja not_active Expired - Lifetime
- 2005-05-24 AT AT05754332T patent/ATE529513T1/de not_active IP Right Cessation
- 2005-05-24 AU AU2005247460A patent/AU2005247460B2/en not_active Expired
- 2005-05-24 CA CA2565103A patent/CA2565103C/en not_active Expired - Lifetime
- 2005-05-24 EP EP05754332A patent/EP1765414B1/en not_active Expired - Lifetime
- 2005-05-24 ES ES05754332T patent/ES2375631T3/es not_active Expired - Lifetime
-
2008
- 2008-03-31 US US12/060,135 patent/US8053420B2/en active Active
-
2011
- 2011-06-10 JP JP2011130577A patent/JP2011172596A/ja not_active Withdrawn
- 2011-09-23 US US13/243,341 patent/US8877725B2/en not_active Expired - Lifetime
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