JP2008509204A - Cd80抑制剤としての免疫調整性オキソピラゾロシンノリン類 - Google Patents
Cd80抑制剤としての免疫調整性オキソピラゾロシンノリン類 Download PDFInfo
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- JP2008509204A JP2008509204A JP2007525329A JP2007525329A JP2008509204A JP 2008509204 A JP2008509204 A JP 2008509204A JP 2007525329 A JP2007525329 A JP 2007525329A JP 2007525329 A JP2007525329 A JP 2007525329A JP 2008509204 A JP2008509204 A JP 2008509204A
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- General Health & Medical Sciences (AREA)
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- Immunology (AREA)
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- Hematology (AREA)
- Pulmonology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
R1 および R3 は、独立して、H、F、Cl、Br、-NO2、-CN、F もしくはClで任意に置換されていてもよいC1-C6 アルキル、またはFで任意に置換されていてもよいC1-C6 アルコキシを表し;
R4 はカルボン酸基(-COOH)もしくはそのエステル、または -C(=O)NR6R7、-NR7C(=O)R6、-NR7C(=O)OR6、-NHC(=O)NR7R6 もしくは-NHC(=S)NR7R6 を表し、
R6 はHまたは式-(Alk)m-Q の基であり、ここで、
m は0 または1であり、
Alk は、任意に置換されていてもよい2価の直鎖もしくは分枝鎖状のC1-C12アルキレンもしくはC2-C12アルケニレンまたはC2-C12アルキニレン基、または2価のC3-C12 炭素環式基であり、これらの基は一つ以上の-O-、-S-もしくは-N(R8)-鎖(ここで、R8 はH またはC1-C4 アルキル、C3-C4 アルケニル、C3-C4アルキニルもしくはC3-C6 シクロアルキルである)を含んでいてもよい、そして
Q はH、-NR9R10(ここで、R9およびR10は独立してH、C1-C4 アルキル、C3-C4アルケニル、C3-C4 アルキニル、C3-C6 シクロアルキル、エステル基、任意に置換されていてもよい炭素環式もしくは複素環式基を表すか、あるいはR9およびR10 はそれらが結合している窒素と一緒になって環を形成し、その環は任意に置換されていてもよい)を表し;そして
本発明は、式(IA):
したがって、本発明は(R)-エナンチオマーならびに(S)-エナンチオマーおよび(RS)-エナンチオマー混合物の形態にある化合物を含む。
(i)免疫調節から恩恵を受ける疾患の治療に用いるための、特に免疫抑制のため の、N-(1-アザビシクロ[2.2.2]オクト-3-イル)-4-(6,9-ジフルオロ-3-オキソ-1,3- ジヒドロピラゾロ[4,3-c]シンノリン-2-イル)-ベンズアミド、またはその医薬的も しくは動物薬的に許容される塩、水和物もしくは溶媒和物、
をも含む。
急性播種性脳脊髄炎
副腎機能不全
アレルギー性血管炎および肉芽腫症
アミロイド症
強直性脊椎炎
喘息
自己免疫性アジソン病
自己免疫性脱毛症
自己免疫性溶血性貧血
自己免疫ニュートロジーナ(Neutrogena)
自己免疫性血小板減少性紫斑病
ベーチェット病
小脳変性
慢性活動性肝炎
慢性炎症脱髄性多発神経根障害
古典的結節性多発動脈炎
先天性副腎過形成
寒冷症
疱疹状皮膚炎
糖尿病
イートン・ランバート筋無力症候群
脳脊髄炎
結節性紅斑
グルテン感受性腸症
グッドパスチャー症候群
ギラン・バレー症候群
橋本病
甲状腺機能亢進症
特発性血色素症
中枢神経系の孤立性脈管炎
川崎病
微少変化腎疾患
多種多様な脈管炎
混合結合組織病
伝導遮断を伴う多病巣性運動神経障害
多発性硬化症
眼球クローヌス−筋クローヌス症候群
類天疱瘡
天疱瘡
悪性貧血
多発性筋炎/皮膚筋炎
感染後関節炎
原発性胆管硬化症
反応性関節炎
ライター病
網膜症
リウマチ性関節炎
硬化性胆管炎
シェーグレン症候群
スティッフマン症候群
全身性エリテマトーデス
全身性壊死性脈管炎
全身性硬化症(強皮症)
高安動脈炎
側頭動脈炎
閉塞性血栓血管炎
I型およびII型自己免疫性多腺性症候群
潰瘍性大腸炎
ブドウ膜炎
ウェーグナー肉芽腫症。
医薬は、鼻腔用もしくは吸入スプレーとして、あるいは粉末として吸入用にも製剤化され得る。
還流濃縮器、磁石攪拌装置およびガスバブラーを備えた丸底フラスコに4-(6,9-ジフルオロ-3-オキソ-1,3-ジヒドロ-ピラゾロ[4,3-c]シンノリン-2-イル)-安息香酸(300 mg)を充填した。チオニルクロライド(5 ml)を加え、得られた赤色の懸濁液を窒素雰囲気下に加熱還流した。加熱によりガスの発生が観察された。2時間還流後、澄明な赤色溶液を室温まで冷却し、過剰のチオニルクロライドを真空下に除去した。混合物を蒸発乾固して、赤色の粉末を得た。
MS: MH+ = 451.2
NMR
(d6 DMSO, 500 MHz) 1.74 (m, 1H); 1.92 (m, 2H); 2.14 (m, 1H); 2.22 (m, 1H); 2.54 (s, 1H); 3.24 (m, 4H); 3.70 (t, 1H); 4.32 (m, 1H); 7.42 (dt, 1H); 7.60 (m, 1H); 7.99 (d, 2H); 8.36 (d, 2H); 8.58 (d, 1H); 9.58 (brs, 1H).
ビアコア: KD = 0.35 nM
TR-Fret: EC50 = 0.82 nM
ビオチン化されたヒトCD80(hCD80-BT)は、CD28と結合してT-細胞の活性化を引き起こす膜結合受容体分子(CD80)の組み換え可溶形態である。CD80とCD28の間の相互作用は、広範に研究されている(Collinsら、2002)。ビオチン化されたヒトHLA-A2-taxは、コントロール蛋白質として用いられている、膜結合受容体分子の組み換え可溶形態であり、本化合物と相互作用すると考えられていない。
ビアコアS51(商標)を、ランニング緩衝液を用いて30 μl/分の流速で運転した。溶媒効果のデータ補正のために、化合物とDMSO標準溶液が注入された。データは自動的に記録され、ビアコアS51評価ソフトウエアを用いて分析された。
Collins AVら、(2002) Immunity 17, 201-210 "The interaction properties of costimulatory molecules revisited"。
本化合物が、CD80-CD28相互作用の阻害剤としての活性を測定するために、無細胞ホモジニアス時間分解蛍光(HT-Fret)分析において試験された。
この分析において、ユーロピウムおよびアロフィコシアニン(APC)が、CD28 およびCD80と間接的に結合(抗体リンカーを介して)して複合体を形成し、ユーロピウムとAPCが接近してシグナルを発生する。この複合体は、次の6つの蛋白質:蛍光標識1、リンカー抗体1、CD28融合蛋白質、CD80融合蛋白質、リンカー抗体2および蛍光標識2を含む。以下の表にこれらの試薬をより詳細に記載する。
非特異的相互作用は、CD80マウスFabフラグメント融合蛋白質の代わりに、マウスFabフラグメント(C215)(1.9μg/ml)を用いて、測定された。
この分析は、最終容量30μlでのブラック384ウェルプレート中で行われた。分析緩衝液:50mM Tris-HCl、150mM NaCl pH7.8、使用直前に添加された0.1% BSA (w/v)を含む。
第1測定:励起340nm、発光665nm、遅延50μs、ウインドー時間200μs。
第2測定:励起340nm、発光615nm、遅延50μs、ウインドー時間200μs。
計数は、蛍光クロスオーバー、クエンチングおよびバックグラウンドに対して、自動的に補正された。
Claims (8)
- N-(1-アザ-ビシクロ[2.2.2]オクト-3-イル)-4-(6,9-ジフルオロ-3-オキソ-1,3-ジヒドロ-ピラゾロ[4,3-c]シンノリン-2-イル)ベンズアミド、またはその塩、水和物もしくは溶媒和物。
- (R)-エナンチオマーの形態にある請求項1に記載の化合物。
- 請求項1または2に記載の化合物を医薬的もしくは動物薬的に許容される賦形剤もしくは担体とともに含む、医薬もしくは動物薬組成物。
- 免疫調節により恩恵を受ける疾患の治療用の請求項1または2に記載の化合物。
- 免疫調節により恩恵を受ける疾患の治療用医薬の製造における、請求項1または2に記載の化合物の使用。
- 請求項1または2に記載の化合物の免疫調節有効量を、そのような治療を必要とする哺乳動物に投与することを含む、ヒトを含む哺乳動物における免疫調節方法。
- 免疫調節が免疫抑制である、請求項4に記載の使用、請求項5に記載の使用または請求項6に記載の方法のための化合物。
- 疾患が、自己免疫疾患、リュウマチ性関節炎、多発性硬化症、糖尿病、喘息、移植、全身性狼瘡紅班または乾癬である、請求項4に記載の使用、請求項5に記載の使用又は請求項6に記載の方法のための化合物。
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4591589A (en) * | 1985-01-16 | 1986-05-27 | Roussel Uclaf | 2-aryl pyrazolo[4,3-c]cinnolin-3-ones |
JPS61161285A (ja) * | 1984-12-28 | 1986-07-21 | ルセル−ユクラフ | ピラゾロ〔4,3−c〕シンノリン−3−オンの誘導体、それらの塩類、これらの製造法、薬剤としての使用、これらを含有する組成物及び中間体生成物 |
JPH07285952A (ja) * | 1994-04-08 | 1995-10-31 | Fujisawa Pharmaceut Co Ltd | 新規複素環誘導体 |
JP2000506884A (ja) * | 1996-03-20 | 2000-06-06 | アストラ・フアーマシユウテイカルズ・リミテツド | 医薬的に有用な化合物 |
JP2002507208A (ja) * | 1997-06-27 | 2002-03-05 | メルク シヤープ エンド ドーム リミテツド | Gaba−a受容体リガンドとしての三環ピラゾロ−ピリダジノン類似体 |
JP2005501033A (ja) * | 2001-07-04 | 2005-01-13 | アクティブ バイオテック エイビー | 新規免疫調節性化合物 |
JP2006520372A (ja) * | 2003-03-14 | 2006-09-07 | アヴィデックス リミテッド | 免疫調節複素環化合物 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB629412A (en) | 1946-12-24 | 1949-09-20 | Geigy Ag J R | Manufacture of metallisable monoazo dyestuffs of the pyrazolone series |
US3576637A (en) | 1967-04-20 | 1971-04-27 | Konishiroku Photo Ind | Lith-type of emulsion containing pyrozolone |
DE3626221A1 (de) | 1986-08-02 | 1988-02-04 | Agfa Gevaert Ag | Farbfotografisches aufzeichnungsmaterial zur herstellung farbiger aufsichtsbilder |
US4906644A (en) | 1986-11-20 | 1990-03-06 | Mitsubishi Kasei Corporation | Lipid-peroxide formation inhibiting composition and novel compounds useful therefor |
DE3903993A1 (de) | 1989-02-10 | 1990-08-16 | Basf Ag | Diarylsubstituierte heterocyclische verbindungen, ihre herstellung und arzneimittel daraus |
WO2003004485A1 (en) | 2001-07-05 | 2003-01-16 | Takeda Chemical Industries, Ltd. | Benzo-fused 5-membered hetrocycle compounds, process for preparation of the same, and use thereof |
EP1562944B1 (en) | 2002-11-22 | 2007-02-14 | Active Biotech AB | Pyrazoloquinolines with immunomodulating activity |
ATE425164T1 (de) | 2002-12-16 | 2009-03-15 | Active Biotech Ab | Tetrazyklische immunmodulierende verbindungen |
GB0325644D0 (en) | 2003-11-04 | 2003-12-10 | Avidex Ltd | Immuno ihibitory pyrazolone compounds |
GB0411770D0 (en) | 2004-05-26 | 2004-06-30 | Avidex Ltd | Immuno inhibitory heterocyclic compouds |
DK1776366T3 (da) | 2004-08-09 | 2009-02-16 | Medigene Ltd | Immunomodulerende oxopyrazolocinnoliner som CD80-inhibitorer |
GB0603522D0 (en) | 2006-02-22 | 2006-04-05 | Avidex Ltd | Kinase inhibition |
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Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61161285A (ja) * | 1984-12-28 | 1986-07-21 | ルセル−ユクラフ | ピラゾロ〔4,3−c〕シンノリン−3−オンの誘導体、それらの塩類、これらの製造法、薬剤としての使用、これらを含有する組成物及び中間体生成物 |
US4591589A (en) * | 1985-01-16 | 1986-05-27 | Roussel Uclaf | 2-aryl pyrazolo[4,3-c]cinnolin-3-ones |
JPH07285952A (ja) * | 1994-04-08 | 1995-10-31 | Fujisawa Pharmaceut Co Ltd | 新規複素環誘導体 |
JP2000506884A (ja) * | 1996-03-20 | 2000-06-06 | アストラ・フアーマシユウテイカルズ・リミテツド | 医薬的に有用な化合物 |
JP2002507208A (ja) * | 1997-06-27 | 2002-03-05 | メルク シヤープ エンド ドーム リミテツド | Gaba−a受容体リガンドとしての三環ピラゾロ−ピリダジノン類似体 |
JP2005501033A (ja) * | 2001-07-04 | 2005-01-13 | アクティブ バイオテック エイビー | 新規免疫調節性化合物 |
JP2006520372A (ja) * | 2003-03-14 | 2006-09-07 | アヴィデックス リミテッド | 免疫調節複素環化合物 |
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