JP2008506416A5 - - Google Patents
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- Publication number
- JP2008506416A5 JP2008506416A5 JP2007522698A JP2007522698A JP2008506416A5 JP 2008506416 A5 JP2008506416 A5 JP 2008506416A5 JP 2007522698 A JP2007522698 A JP 2007522698A JP 2007522698 A JP2007522698 A JP 2007522698A JP 2008506416 A5 JP2008506416 A5 JP 2008506416A5
- Authority
- JP
- Japan
- Prior art keywords
- syncytial
- cell
- rhythm
- cells
- genetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000004027 cell Anatomy 0.000 claims 94
- 238000000034 method Methods 0.000 claims 63
- 230000002068 genetic effect Effects 0.000 claims 47
- 230000033764 rhythmic process Effects 0.000 claims 29
- 108090000623 proteins and genes Proteins 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 238000000338 in vitro Methods 0.000 claims 6
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 6
- 210000000130 stem cell Anatomy 0.000 claims 6
- 210000002565 arteriole Anatomy 0.000 claims 3
- 210000001367 artery Anatomy 0.000 claims 3
- 210000004413 cardiac myocyte Anatomy 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 210000000981 epithelium Anatomy 0.000 claims 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 3
- 210000004185 liver Anatomy 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 210000002460 smooth muscle Anatomy 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- OZLGRUXZXMRXGP-UHFFFAOYSA-N Fluo-3 Chemical group CC1=CC=C(N(CC(O)=O)CC(O)=O)C(OCCOC=2C(=CC=C(C=2)C2=C3C=C(Cl)C(=O)C=C3OC3=CC(O)=C(Cl)C=C32)N(CC(O)=O)CC(O)=O)=C1 OZLGRUXZXMRXGP-UHFFFAOYSA-N 0.000 claims 2
- 238000003708 edge detection Methods 0.000 claims 2
- 239000011521 glass Substances 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58941604P | 2004-07-19 | 2004-07-19 | |
| PCT/US2005/025735 WO2006020322A2 (en) | 2004-07-19 | 2005-07-19 | Assay system for monitoring the effects of genetically engineered cells to alter function of a syncytium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008506416A JP2008506416A (ja) | 2008-03-06 |
| JP2008506416A5 true JP2008506416A5 (https=) | 2008-09-04 |
Family
ID=35908008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007522698A Withdrawn JP2008506416A (ja) | 2004-07-19 | 2005-07-19 | 遺伝子組み換えされた細胞が合胞体の機能を変える効果を監視するための分析システム |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8192929B2 (https=) |
| EP (1) | EP1781371A4 (https=) |
| JP (1) | JP2008506416A (https=) |
| WO (1) | WO2006020322A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009120082A2 (en) * | 2008-03-27 | 2009-10-01 | Academisch Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for influencing electrical activity of cells |
| US20110144028A1 (en) * | 2009-12-11 | 2011-06-16 | Vinod Sharma | Modulating cellular electrophysiology |
| SG11201807223UA (en) * | 2016-03-23 | 2018-09-27 | Univ Columbia | CANCER TREATMENT BASED ON DELIVERY OF OLIGOES VIA GAP JUNCTIONS FROM HUMAN MESENCHYMAL STEM CELLS (hMSC) |
| DE102016223423B4 (de) * | 2016-11-25 | 2018-06-07 | Universität Rostock | Verfahren, Vorrichtung und Kit zur Bestimmung der kardialen Erregungsleitung |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2296704C (en) * | 1997-07-14 | 2010-10-19 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| US6776987B1 (en) * | 1998-01-13 | 2004-08-17 | Massachusetts Institute Of Technology | Enhancement of cardiac chronotropy |
| US6410236B1 (en) * | 1999-09-01 | 2002-06-25 | The Regents Of The University Of Michigan | Correcting diastolic dysfunction in heart failure |
| EP1324780A4 (en) * | 2000-09-06 | 2005-06-22 | Univ Johns Hopkins | METHODS OF TREATING CARDIAC ARRHYTHMIA |
| EP1379869A4 (en) * | 2001-03-15 | 2004-08-11 | Xiao Yong Fu | METHOD FOR THERAPEUTICALLY TREATING A CLINICALLY DETECTED CARDIOPATHOLOGICAL FORM IN A MAMMAL |
| WO2002098287A2 (en) * | 2001-06-06 | 2002-12-12 | The Trustees Of Columbia University In The City Of New York | A high throughput biological heart rate monitor that is molecularly determined |
| US20030082153A1 (en) * | 2001-10-22 | 2003-05-01 | The Government Of The United States Of America | Stem cells that transform to beating cardiomyocytes |
| US7794702B2 (en) * | 2003-01-15 | 2010-09-14 | The Trustees Of Columbia University In The City Of New York | Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures |
| US8859273B2 (en) * | 2003-12-24 | 2014-10-14 | Medtronic, Inc. | Methods of using HCN genes to treat cardiac arrhythmias |
-
2005
- 2005-07-19 US US11/792,426 patent/US8192929B2/en not_active Expired - Fee Related
- 2005-07-19 JP JP2007522698A patent/JP2008506416A/ja not_active Withdrawn
- 2005-07-19 WO PCT/US2005/025735 patent/WO2006020322A2/en not_active Ceased
- 2005-07-19 EP EP05826808A patent/EP1781371A4/en not_active Withdrawn
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