JP2008532561A5 - - Google Patents
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- Publication number
- JP2008532561A5 JP2008532561A5 JP2008516423A JP2008516423A JP2008532561A5 JP 2008532561 A5 JP2008532561 A5 JP 2008532561A5 JP 2008516423 A JP2008516423 A JP 2008516423A JP 2008516423 A JP2008516423 A JP 2008516423A JP 2008532561 A5 JP2008532561 A5 JP 2008532561A5
- Authority
- JP
- Japan
- Prior art keywords
- reporter molecule
- isotype
- mammal
- substrate
- pan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000003964 Histone deacetylase Human genes 0.000 claims 63
- 108090000353 Histone deacetylase Proteins 0.000 claims 63
- 239000000758 substrate Substances 0.000 claims 52
- 241000124008 Mammalia Species 0.000 claims 46
- 239000003112 inhibitor Substances 0.000 claims 25
- 238000000034 method Methods 0.000 claims 25
- 210000001124 body fluid Anatomy 0.000 claims 24
- 239000012190 activator Substances 0.000 claims 22
- 239000010839 body fluid Substances 0.000 claims 22
- 230000006196 deacetylation Effects 0.000 claims 14
- 238000003381 deacetylation reaction Methods 0.000 claims 14
- 238000001727 in vivo Methods 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 108010044467 Isoenzymes Proteins 0.000 claims 1
- 230000021738 protein deacetylation Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61196404P | 2004-09-22 | 2004-09-22 | |
| PCT/IB2005/004207 WO2007135471A1 (en) | 2004-09-22 | 2005-09-21 | Histone deacetylase whole cell enzyme assay |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008532561A JP2008532561A (ja) | 2008-08-21 |
| JP2008532561A5 true JP2008532561A5 (https=) | 2008-10-30 |
Family
ID=38093181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008516423A Withdrawn JP2008532561A (ja) | 2004-09-22 | 2005-09-21 | ヒストンデアセチラーゼのホールセル酵素アッセイ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060063210A1 (https=) |
| EP (1) | EP1922414A4 (https=) |
| JP (1) | JP2008532561A (https=) |
| AU (1) | AU2005336881A1 (https=) |
| CA (1) | CA2581356A1 (https=) |
| WO (1) | WO2007135471A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6897220B2 (en) * | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| WO2008095296A1 (en) * | 2007-02-05 | 2008-08-14 | Methylgene Inc. | Class ii histone deacetylase whole cell enzyme assay |
| US8030344B2 (en) * | 2007-03-13 | 2011-10-04 | Methylgene Inc. | Inhibitors of histone deacetylase |
| US9636298B2 (en) | 2014-01-17 | 2017-05-02 | Methylgene Inc. | Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2093292A2 (en) * | 2000-03-24 | 2009-08-26 | Methylgene, Inc. | Inhibition of specific histone deacetylase isoforms |
-
2005
- 2005-09-21 EP EP05858685A patent/EP1922414A4/en not_active Withdrawn
- 2005-09-21 CA CA002581356A patent/CA2581356A1/en not_active Abandoned
- 2005-09-21 AU AU2005336881A patent/AU2005336881A1/en not_active Abandoned
- 2005-09-21 US US11/231,528 patent/US20060063210A1/en not_active Abandoned
- 2005-09-21 JP JP2008516423A patent/JP2008532561A/ja not_active Withdrawn
- 2005-09-21 WO PCT/IB2005/004207 patent/WO2007135471A1/en not_active Ceased
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