JP2008506369A5 - - Google Patents
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- Publication number
- JP2008506369A5 JP2008506369A5 JP2007519976A JP2007519976A JP2008506369A5 JP 2008506369 A5 JP2008506369 A5 JP 2008506369A5 JP 2007519976 A JP2007519976 A JP 2007519976A JP 2007519976 A JP2007519976 A JP 2007519976A JP 2008506369 A5 JP2008506369 A5 JP 2008506369A5
- Authority
- JP
- Japan
- Prior art keywords
- cyp2d6
- individual
- liver fibrosis
- locus
- liver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 claims 32
- 102100021704 Cytochrome P450 2D6 Human genes 0.000 claims 32
- 208000019425 cirrhosis of liver Diseases 0.000 claims 24
- 238000000034 method Methods 0.000 claims 18
- 108700028369 Alleles Proteins 0.000 claims 6
- 230000002503 metabolic effect Effects 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 108090000790 Enzymes Proteins 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 101150037123 APOE gene Proteins 0.000 claims 3
- 102100029470 Apolipoprotein E Human genes 0.000 claims 3
- 108010001202 Cytochrome P-450 CYP2E1 Proteins 0.000 claims 3
- 108010081668 Cytochrome P-450 CYP3A Proteins 0.000 claims 3
- 102100024889 Cytochrome P450 2E1 Human genes 0.000 claims 3
- 102100039208 Cytochrome P450 3A5 Human genes 0.000 claims 3
- 241000711549 Hepacivirus C Species 0.000 claims 3
- 150000003838 adenosines Chemical class 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010019851 Hepatotoxicity Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000006454 hepatitis Diseases 0.000 claims 2
- 231100000283 hepatitis Toxicity 0.000 claims 2
- 231100000304 hepatotoxicity Toxicity 0.000 claims 2
- 230000007686 hepatotoxicity Effects 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 210000005229 liver cell Anatomy 0.000 claims 2
- 208000019423 liver disease Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 238000004806 packaging method and process Methods 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical class O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 1
- 210000005228 liver tissue Anatomy 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 230000037323 metabolic rate Effects 0.000 claims 1
- 239000005022 packaging material Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58417904P | 2004-07-01 | 2004-07-01 | |
| PCT/IL2005/000700 WO2006003654A2 (en) | 2004-07-01 | 2005-06-30 | Methods and kits for predicting liver fibrosis progression rate in chronic hepatitis c patients |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008506369A JP2008506369A (ja) | 2008-03-06 |
| JP2008506369A5 true JP2008506369A5 (enExample) | 2008-08-07 |
Family
ID=35783231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007519976A Abandoned JP2008506369A (ja) | 2004-07-01 | 2005-06-30 | 慢性ｃ型肝炎患者における肝臓線維化進行速度を予測するための方法およびキット |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20080299094A1 (enExample) |
| EP (1) | EP1778861A4 (enExample) |
| JP (1) | JP2008506369A (enExample) |
| CA (1) | CA2572569A1 (enExample) |
| WO (1) | WO2006003654A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9740817B1 (en) | 2002-10-18 | 2017-08-22 | Dennis Sunga Fernandez | Apparatus for biological sensing and alerting of pharmaco-genomic mutation |
| US8346482B2 (en) | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
| US8039212B2 (en) * | 2007-11-05 | 2011-10-18 | Celera Corporation | Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof |
| RU2354975C1 (ru) * | 2007-12-06 | 2009-05-10 | Елена Борисовна Романова | Способ прогноза быстрого прогрессирования заболевания у больных хроническим гепатитом с |
| WO2010099432A2 (en) * | 2009-02-26 | 2010-09-02 | The Johns Hopkins University | Recognition of cyp2e1 epitopes |
| ES2644725T3 (es) | 2009-03-19 | 2017-11-30 | Universite D'angers | Método no invasivo para evaluar la progresión de la fibrosis hepática |
| BR112012001931A2 (pt) * | 2009-07-31 | 2017-07-18 | Centre Hospitalier Univ Vaudois | métodos para diagnosticar ou prever o resultado de hepatite c em pacientes infectados com hcv |
| CN102031286B (zh) * | 2010-06-08 | 2013-08-28 | 广州益善生物技术有限公司 | 染色体9p21区段和KIF6基因SNP检测液相芯片以及特异性引物 |
| CN102010897B (zh) * | 2010-06-08 | 2013-08-28 | 广州益善生物技术有限公司 | KIF6、apo E基因和染色体9p21区段SNP检测液相芯片 |
| CN102010901B (zh) * | 2010-06-08 | 2013-08-28 | 广州益善生物技术有限公司 | apo E基因和染色体9p21区段SNP检测液相芯片以及特异性引物 |
| CN102304564B (zh) * | 2011-04-29 | 2013-08-28 | 广州益善生物技术有限公司 | 一种染色体15q25区段SNP检测的特异性引物和液相芯片 |
| WO2013150002A1 (en) * | 2012-04-03 | 2013-10-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for determining if a subject is predisposed to fast progression of liver fibrosis |
| WO2015109608A1 (zh) * | 2014-01-27 | 2015-07-30 | 财团法人生技医疗科技政策研究中心 | 药物引发毒性的风险性筛检方法 |
| CN106834453B (zh) * | 2017-01-17 | 2020-12-25 | 北京大学第一医院 | 一种检测慢性乙肝或hbv携带者是否为肝癌易感人群的试剂盒及方法 |
| AT523014B1 (de) * | 2019-10-14 | 2025-09-15 | Pharmgenetix Gmbh | Funktionaler Cytochrom P450 in vitro-Test |
-
2005
- 2005-06-30 WO PCT/IL2005/000700 patent/WO2006003654A2/en not_active Ceased
- 2005-06-30 CA CA002572569A patent/CA2572569A1/en not_active Abandoned
- 2005-06-30 JP JP2007519976A patent/JP2008506369A/ja not_active Abandoned
- 2005-06-30 US US11/631,340 patent/US20080299094A1/en not_active Abandoned
- 2005-06-30 EP EP05756877A patent/EP1778861A4/en not_active Withdrawn
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