JP2008506369A - 慢性c型肝炎患者における肝臓線維化進行速度を予測するための方法およびキット - Google Patents

慢性c型肝炎患者における肝臓線維化進行速度を予測するための方法およびキット Download PDF

Info

Publication number
JP2008506369A
JP2008506369A JP2007519976A JP2007519976A JP2008506369A JP 2008506369 A JP2008506369 A JP 2008506369A JP 2007519976 A JP2007519976 A JP 2007519976A JP 2007519976 A JP2007519976 A JP 2007519976A JP 2008506369 A JP2008506369 A JP 2008506369A
Authority
JP
Japan
Prior art keywords
cyp2d6
individual
liver
liver fibrosis
progression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2007519976A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008506369A5 (enExample
Inventor
ラン オレン,
Original Assignee
メディカル リサーチ ファンド オブ テル アヴィヴ ソラスキー メディカル センター
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メディカル リサーチ ファンド オブ テル アヴィヴ ソラスキー メディカル センター filed Critical メディカル リサーチ ファンド オブ テル アヴィヴ ソラスキー メディカル センター
Publication of JP2008506369A publication Critical patent/JP2008506369A/ja
Publication of JP2008506369A5 publication Critical patent/JP2008506369A5/ja
Abandoned legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/172Haplotypes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Addiction (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007519976A 2004-07-01 2005-06-30 慢性c型肝炎患者における肝臓線維化進行速度を予測するための方法およびキット Abandoned JP2008506369A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58417904P 2004-07-01 2004-07-01
PCT/IL2005/000700 WO2006003654A2 (en) 2004-07-01 2005-06-30 Methods and kits for predicting liver fibrosis progression rate in chronic hepatitis c patients

Publications (2)

Publication Number Publication Date
JP2008506369A true JP2008506369A (ja) 2008-03-06
JP2008506369A5 JP2008506369A5 (enExample) 2008-08-07

Family

ID=35783231

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007519976A Abandoned JP2008506369A (ja) 2004-07-01 2005-06-30 慢性c型肝炎患者における肝臓線維化進行速度を予測するための方法およびキット

Country Status (5)

Country Link
US (1) US20080299094A1 (enExample)
EP (1) EP1778861A4 (enExample)
JP (1) JP2008506369A (enExample)
CA (1) CA2572569A1 (enExample)
WO (1) WO2006003654A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022551190A (ja) * 2019-10-14 2022-12-07 ファームジェネティクス ゲーエムベーハー 機能性チトクロームp450インビトロアッセイ

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9740817B1 (en) 2002-10-18 2017-08-22 Dennis Sunga Fernandez Apparatus for biological sensing and alerting of pharmaco-genomic mutation
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
US8039212B2 (en) * 2007-11-05 2011-10-18 Celera Corporation Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
RU2354975C1 (ru) * 2007-12-06 2009-05-10 Елена Борисовна Романова Способ прогноза быстрого прогрессирования заболевания у больных хроническим гепатитом с
WO2010099432A2 (en) * 2009-02-26 2010-09-02 The Johns Hopkins University Recognition of cyp2e1 epitopes
ES2644725T3 (es) 2009-03-19 2017-11-30 Universite D'angers Método no invasivo para evaluar la progresión de la fibrosis hepática
BR112012001931A2 (pt) * 2009-07-31 2017-07-18 Centre Hospitalier Univ Vaudois métodos para diagnosticar ou prever o resultado de hepatite c em pacientes infectados com hcv
CN102031286B (zh) * 2010-06-08 2013-08-28 广州益善生物技术有限公司 染色体9p21区段和KIF6基因SNP检测液相芯片以及特异性引物
CN102010897B (zh) * 2010-06-08 2013-08-28 广州益善生物技术有限公司 KIF6、apo E基因和染色体9p21区段SNP检测液相芯片
CN102010901B (zh) * 2010-06-08 2013-08-28 广州益善生物技术有限公司 apo E基因和染色体9p21区段SNP检测液相芯片以及特异性引物
CN102304564B (zh) * 2011-04-29 2013-08-28 广州益善生物技术有限公司 一种染色体15q25区段SNP检测的特异性引物和液相芯片
WO2013150002A1 (en) * 2012-04-03 2013-10-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for determining if a subject is predisposed to fast progression of liver fibrosis
WO2015109608A1 (zh) * 2014-01-27 2015-07-30 财团法人生技医疗科技政策研究中心 药物引发毒性的风险性筛检方法
CN106834453B (zh) * 2017-01-17 2020-12-25 北京大学第一医院 一种检测慢性乙肝或hbv携带者是否为肝癌易感人群的试剂盒及方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022551190A (ja) * 2019-10-14 2022-12-07 ファームジェネティクス ゲーエムベーハー 機能性チトクロームp450インビトロアッセイ

Also Published As

Publication number Publication date
WO2006003654A2 (en) 2006-01-12
CA2572569A1 (en) 2006-01-12
WO2006003654A3 (en) 2007-12-06
EP1778861A2 (en) 2007-05-02
EP1778861A4 (en) 2008-11-19
US20080299094A1 (en) 2008-12-04

Similar Documents

Publication Publication Date Title
JP6749431B2 (ja) 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途
JP6839779B2 (ja) スタチンの応答および心血管疾患に関連する遺伝子多型、その検出方法ならびに使用
JP6448149B2 (ja) 肝線維症に関連する遺伝的多型、その検出方法および使用
JP6316994B2 (ja) 心筋梗塞に関連する遺伝的多型、その検出方法および使用
JP2008506369A (ja) 慢性c型肝炎患者における肝臓線維化進行速度を予測するための方法およびキット
US10927414B2 (en) Methods and kits for determining predisposition to develop kidney diseases
CN1533435A (zh) 用于诊断及治疗胰岛素抗性及相关病症之方法和试剂
US20020090622A1 (en) Chemical compounds
US20100028924A1 (en) Method Of Diagnosing Pon1-Hdl Associated Lipid Disorders
US20100167285A1 (en) Methods and agents for evaluating inflammatory bowel disease, and targets for treatment
US20120157379A1 (en) Gastric Inhibitory Peptide Variants and Their Uses
US20060257850A1 (en) Methods of treatment and diagnosis of patients with hepatitis c infection
CA2826522C (en) Genetic polymorphism in pnlpa3 associated with liver fibrosis methods of detection and uses thereof
EP2186907A1 (en) X-chromosomal variation as a diagnostic and therapeutic marker for the progression to AIDS
US20070122803A1 (en) Methods for the detection of polymorphisms in the human oatpf gene
US20040171010A1 (en) Methods
WO2003106709A1 (en) Methods for detecting polymorphisms using arms or rflp
WO2003091277A2 (en) Haplotypes of the cetp gene

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080616

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080616

A762 Written abandonment of application

Free format text: JAPANESE INTERMEDIATE CODE: A762

Effective date: 20100830

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100924