JP2008504289A5 - - Google Patents

Info

Publication number

JP2008504289A5

JP2008504289A5 JP2007518346A JP2007518346A JP2008504289A5 JP 2008504289 A5 JP2008504289 A5 JP 2008504289A5 JP 2007518346 A JP2007518346 A JP 2007518346A JP 2007518346 A JP2007518346 A JP 2007518346A JP 2008504289 A5 JP2008504289 A5 JP 2008504289A5

Authority

JP

Japan

Prior art keywords

antibody

substitution

amino acid

alanine

substituted

Prior art date

2005-06-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 210000004027 cell Anatomy 0.000 claims description 21
• 238000000034 method Methods 0.000 claims description 21
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 6
• 210000004962 mammalian cell Anatomy 0.000 claims description 5
• 238000006467 substitution reaction Methods 0.000 claims 29
• 235000004279 alanine Nutrition 0.000 claims 16
• 125000003275 alpha amino acid group Chemical group 0.000 claims 13
• 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 12
• 235000001014 amino acid Nutrition 0.000 claims 11
• 125000000539 amino acid group Chemical group 0.000 claims 10
• 235000003704 aspartic acid Nutrition 0.000 claims 10
• CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 10
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Chemical group OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 10
• 239000000427 antigen Substances 0.000 claims 7
• 102000036639 antigens Human genes 0.000 claims 7
• 108091007433 antigens Proteins 0.000 claims 7
• 238000004519 manufacturing process Methods 0.000 claims 6
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical group C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 4
• 238000010494 dissociation reaction Methods 0.000 claims 3
• 230000005593 dissociations Effects 0.000 claims 3
• 239000002773 nucleotide Substances 0.000 claims 3
• 125000003729 nucleotide group Chemical group 0.000 claims 3
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
• 230000035772 mutation Effects 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 description 4
• 210000005260 human cell Anatomy 0.000 description 3
• 210000004698 lymphocyte Anatomy 0.000 description 3
• 241000124008 Mammalia Species 0.000 description 2
• 230000013595 glycosylation Effects 0.000 description 2
• 238000006206 glycosylation reaction Methods 0.000 description 2
• 230000004048 modification Effects 0.000 description 2
• 238000012986 modification Methods 0.000 description 2
• DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 1
• 241000701024 Human betaherpesvirus 5 Species 0.000 description 1
• 101100321817 Human parvovirus B19 (strain HV) 7.5K gene Proteins 0.000 description 1
• 108700002232 Immediate-Early Genes Proteins 0.000 description 1
• 102000003792 Metallothionein Human genes 0.000 description 1
• 108090000157 Metallothionein Proteins 0.000 description 1
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
• 241000700618 Vaccinia virus Species 0.000 description 1
• 241000700605 Viruses Species 0.000 description 1
• 230000007248 cellular mechanism Effects 0.000 description 1
• 238000003776 cleavage reaction Methods 0.000 description 1
• 230000007246 mechanism Effects 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 230000001323 posttranslational effect Effects 0.000 description 1
• 230000009145 protein modification Effects 0.000 description 1
• 102000004169 proteins and genes Human genes 0.000 description 1
• 238000003259 recombinant expression Methods 0.000 description 1
• 230000007017 scission Effects 0.000 description 1
• 241000701161 unidentified adenovirus Species 0.000 description 1
• 239000013598 vector Substances 0.000 description 1