JP2008504004A5 - - Google Patents
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- Publication number
- JP2008504004A5 JP2008504004A5 JP2006544263A JP2006544263A JP2008504004A5 JP 2008504004 A5 JP2008504004 A5 JP 2008504004A5 JP 2006544263 A JP2006544263 A JP 2006544263A JP 2006544263 A JP2006544263 A JP 2006544263A JP 2008504004 A5 JP2008504004 A5 JP 2008504004A5
- Authority
- JP
- Japan
- Prior art keywords
- allergen
- specific
- sec
- ige
- est
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013566 allergen Substances 0.000 description 9
- 210000001744 T-lymphocyte Anatomy 0.000 description 7
- 239000012634 fragment Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 230000000172 allergic effect Effects 0.000 description 4
- 208000010668 atopic eczema Diseases 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 229960004784 allergens Drugs 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 108020004705 Codon Proteins 0.000 description 2
- 241000209219 Hordeum Species 0.000 description 2
- 235000007340 Hordeum vulgare Nutrition 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 229940074608 allergen extract Drugs 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000000586 desensitisation Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000009169 immunotherapy Methods 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 108020005345 3' Untranslated Regions Proteins 0.000 description 1
- 101150033839 4 gene Proteins 0.000 description 1
- 108020003589 5' Untranslated Regions Proteins 0.000 description 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
- 206010002199 Anaphylactic shock Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 238000011238 DNA vaccination Methods 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 206010048908 Seasonal allergy Diseases 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 108091023045 Untranslated Region Proteins 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000001024 immunotherapeutic effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 201000004338 pollen allergy Diseases 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10359351A DE10359351A1 (de) | 2003-12-16 | 2003-12-16 | DNA-Sequenz und rekombinante Herstellung von Gruppe-4 Majorallergenen aus Getreiden |
| DE10359351.9 | 2003-12-16 | ||
| PCT/EP2004/013664 WO2005059136A2 (de) | 2003-12-16 | 2004-12-01 | Dna-sequenz und rekombinante herstellung von gruppe-4 majorallergenen aus getreiden |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008504004A JP2008504004A (ja) | 2008-02-14 |
| JP2008504004A5 true JP2008504004A5 (cg-RX-API-DMAC7.html) | 2011-04-28 |
| JP4960102B2 JP4960102B2 (ja) | 2012-06-27 |
Family
ID=34683486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006544263A Expired - Fee Related JP4960102B2 (ja) | 2003-12-16 | 2004-12-01 | 穀物からの４群主要アレルゲンのｄｎａ配列および組換え製剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7935347B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2261336B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4960102B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN103305531A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE501257T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004299600A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0417736A (cg-RX-API-DMAC7.html) |
| CA (3) | CA2549573C (cg-RX-API-DMAC7.html) |
| DE (2) | DE10359351A1 (cg-RX-API-DMAC7.html) |
| ES (3) | ES2363015T3 (cg-RX-API-DMAC7.html) |
| PL (3) | PL2261337T3 (cg-RX-API-DMAC7.html) |
| PT (3) | PT2261336E (cg-RX-API-DMAC7.html) |
| RU (1) | RU2373283C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005059136A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10359351A1 (de) * | 2003-12-16 | 2005-07-21 | Merck Patent Gmbh | DNA-Sequenz und rekombinante Herstellung von Gruppe-4 Majorallergenen aus Getreiden |
| US9920101B2 (en) | 2014-03-31 | 2018-03-20 | Boehringer Ingelheim Vetmedica Gmbh | Modular antigen transportation molecules and uses therof |
| KR20180061338A (ko) | 2015-09-30 | 2018-06-07 | 베링거잉겔하임베트메디카게엠베하 | 동물에서의 개선된 모듈러 항원 수송 분자 및 이의 용도 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5762943A (en) * | 1996-05-14 | 1998-06-09 | Ribi Immunochem Research, Inc. | Methods of treating type I hypersensitivity using monophosphoryl lipid A |
| DE19918682A1 (de) * | 1999-04-23 | 2000-10-26 | Merck Patent Gmbh | DNA-Sequenz und rekombinante Herstellung eines Graminaen-Allergens |
| US7214786B2 (en) * | 2000-12-14 | 2007-05-08 | Kovalic David K | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| EP1402037A1 (en) * | 2001-06-22 | 2004-03-31 | Syngenta Participations AG | Plant genes involved in defense against pathogens |
| AUPR779201A0 (en) * | 2001-09-20 | 2001-10-11 | University Of Melbourne, The | Immunotherapeutic and immunoprophylactic reagents |
| WO2003025008A2 (en) | 2001-09-21 | 2003-03-27 | Affinium Pharmaceuticals, Inc. | Bacterial polypeptides involved in protein processing |
| CA2491038C (en) * | 2002-06-25 | 2017-04-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Dna sequence and preparation of grass pollen allergen phl p4 by recombinant methods |
| DE10359351A1 (de) * | 2003-12-16 | 2005-07-21 | Merck Patent Gmbh | DNA-Sequenz und rekombinante Herstellung von Gruppe-4 Majorallergenen aus Getreiden |
-
2003
- 2003-12-16 DE DE10359351A patent/DE10359351A1/de not_active Withdrawn
-
2004
- 2004-12-01 DE DE502004012294T patent/DE502004012294D1/de not_active Expired - Lifetime
- 2004-12-01 PT PT100096775T patent/PT2261336E/pt unknown
- 2004-12-01 EP EP10009677.5A patent/EP2261336B1/de not_active Expired - Lifetime
- 2004-12-01 CN CN2013102182194A patent/CN103305531A/zh active Pending
- 2004-12-01 CA CA2549573A patent/CA2549573C/en not_active Expired - Fee Related
- 2004-12-01 PL PL10009678T patent/PL2261337T3/pl unknown
- 2004-12-01 ES ES04803421T patent/ES2363015T3/es not_active Expired - Lifetime
- 2004-12-01 JP JP2006544263A patent/JP4960102B2/ja not_active Expired - Fee Related
- 2004-12-01 PT PT04803421T patent/PT1709177E/pt unknown
- 2004-12-01 CA CA2945267A patent/CA2945267A1/en not_active Abandoned
- 2004-12-01 CA CA2873261A patent/CA2873261C/en not_active Expired - Fee Related
- 2004-12-01 EP EP04803421A patent/EP1709177B1/de not_active Expired - Lifetime
- 2004-12-01 RU RU2006125511/13A patent/RU2373283C2/ru not_active IP Right Cessation
- 2004-12-01 AU AU2004299600A patent/AU2004299600A1/en not_active Abandoned
- 2004-12-01 ES ES10009678.3T patent/ES2443302T3/es not_active Expired - Lifetime
- 2004-12-01 US US10/583,089 patent/US7935347B2/en not_active Expired - Fee Related
- 2004-12-01 ES ES10009677.5T patent/ES2442951T3/es not_active Expired - Lifetime
- 2004-12-01 PL PL04803421T patent/PL1709177T3/pl unknown
- 2004-12-01 BR BRPI0417736-3A patent/BRPI0417736A/pt not_active Application Discontinuation
- 2004-12-01 PT PT100096783T patent/PT2261337E/pt unknown
- 2004-12-01 CN CNA2004800372314A patent/CN1894410A/zh active Pending
- 2004-12-01 EP EP10009678.3A patent/EP2261337B1/de not_active Expired - Lifetime
- 2004-12-01 PL PL10009677T patent/PL2261336T3/pl unknown
- 2004-12-01 WO PCT/EP2004/013664 patent/WO2005059136A2/de not_active Ceased
- 2004-12-01 AT AT04803421T patent/ATE501257T1/de active
-
2010
- 2010-11-16 US US12/947,361 patent/US9309297B2/en not_active Expired - Fee Related
-
2015
- 2015-12-17 US US14/972,633 patent/US20170246317A1/en not_active Abandoned
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