CN103305531A - 谷类第4组主要致敏原的dna序列和重组制品 - Google Patents
谷类第4组主要致敏原的dna序列和重组制品 Download PDFInfo
- Publication number
- CN103305531A CN103305531A CN2013102182194A CN201310218219A CN103305531A CN 103305531 A CN103305531 A CN 103305531A CN 2013102182194 A CN2013102182194 A CN 2013102182194A CN 201310218219 A CN201310218219 A CN 201310218219A CN 103305531 A CN103305531 A CN 103305531A
- Authority
- CN
- China
- Prior art keywords
- sequence
- dna
- seq
- sensitinogen
- sec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 title claims abstract description 20
- 235000013339 cereals Nutrition 0.000 title abstract description 15
- 239000013566 allergen Substances 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 20
- 229920001184 polypeptide Polymers 0.000 claims abstract description 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 19
- 108020004511 Recombinant DNA Proteins 0.000 claims abstract description 4
- 108020004414 DNA Proteins 0.000 claims description 22
- 150000001413 amino acids Chemical class 0.000 claims description 17
- 235000001014 amino acid Nutrition 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 238000006243 chemical reaction Methods 0.000 claims description 12
- 239000013604 expression vector Substances 0.000 claims description 11
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 238000010367 cloning Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 abstract description 21
- 108090000623 proteins and genes Proteins 0.000 abstract description 21
- 238000002360 preparation method Methods 0.000 abstract description 19
- 102000004169 proteins and genes Human genes 0.000 abstract description 11
- 238000003745 diagnosis Methods 0.000 abstract description 7
- 230000035772 mutation Effects 0.000 abstract description 6
- 238000001727 in vivo Methods 0.000 abstract description 5
- 238000005215 recombination Methods 0.000 abstract description 5
- 230000006798 recombination Effects 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
- 238000000338 in vitro Methods 0.000 abstract description 2
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 abstract 2
- 206010048908 Seasonal allergy Diseases 0.000 abstract 1
- 230000000774 hypoallergenic effect Effects 0.000 abstract 1
- 201000004338 pollen allergy Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 description 24
- 208000026935 allergic disease Diseases 0.000 description 21
- 230000007815 allergy Effects 0.000 description 14
- 241000209504 Poaceae Species 0.000 description 12
- 235000007340 Hordeum vulgare Nutrition 0.000 description 10
- 235000018102 proteins Nutrition 0.000 description 10
- 241001329985 Triticeae Species 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 241000209219 Hordeum Species 0.000 description 8
- 108010076504 Protein Sorting Signals Proteins 0.000 description 8
- 210000001744 T-lymphocyte Anatomy 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 230000009610 hypersensitivity Effects 0.000 description 7
- 241000209056 Secale Species 0.000 description 6
- 241000209140 Triticum Species 0.000 description 6
- 235000021307 Triticum Nutrition 0.000 description 6
- 210000004899 c-terminal region Anatomy 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 102000001708 Protein Isoforms Human genes 0.000 description 5
- 108010029485 Protein Isoforms Proteins 0.000 description 5
- 230000002052 anaphylactic effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000009169 immunotherapy Methods 0.000 description 5
- 244000052363 Cynodon dactylon Species 0.000 description 4
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 4
- 206010070834 Sensitisation Diseases 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 4
- 230000003321 amplification Effects 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 238000003199 nucleic acid amplification method Methods 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 230000008313 sensitization Effects 0.000 description 4
- 244000025254 Cannabis sativa Species 0.000 description 3
- 240000004585 Dactylis glomerata Species 0.000 description 3
- 206010022998 Irritability Diseases 0.000 description 3
- 238000000586 desensitisation Methods 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 230000004544 DNA amplification Effects 0.000 description 2
- 238000011238 DNA vaccination Methods 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 240000003857 Holcus lanatus Species 0.000 description 2
- 240000005979 Hordeum vulgare Species 0.000 description 2
- 241000209082 Lolium Species 0.000 description 2
- 240000004296 Lolium perenne Species 0.000 description 2
- 230000005867 T cell response Effects 0.000 description 2
- 108020005038 Terminator Codon Proteins 0.000 description 2
- 208000030961 allergic reaction Diseases 0.000 description 2
- 208000003455 anaphylaxis Diseases 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 239000013611 chromosomal DNA Substances 0.000 description 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 230000036647 reaction Effects 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 238000003259 recombinant expression Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- YXXURDJTDAAEPH-UHFFFAOYSA-N 2-aminopropanethioic s-acid Chemical compound CC(N)C(S)=O YXXURDJTDAAEPH-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 206010002199 Anaphylactic shock Diseases 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 108010033276 Peptide Fragments Proteins 0.000 description 1
- 102000007079 Peptide Fragments Human genes 0.000 description 1
- 241000746983 Phleum pratense Species 0.000 description 1
- 241000209049 Poa pratensis Species 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 208000002205 allergic conjunctivitis Diseases 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000024998 atopic conjunctivitis Diseases 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000012928 buffer substance Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000004957 immunoregulator effect Effects 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000002655 kraft paper Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 229940126619 mouse monoclonal antibody Drugs 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10359351A DE10359351A1 (de) | 2003-12-16 | 2003-12-16 | DNA-Sequenz und rekombinante Herstellung von Gruppe-4 Majorallergenen aus Getreiden |
| DE10359351.9 | 2003-12-16 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2004800372314A Division CN1894410A (zh) | 2003-12-16 | 2004-12-01 | 谷类第4组主要致敏原的dna序列和重组制品 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103305531A true CN103305531A (zh) | 2013-09-18 |
Family
ID=34683486
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013102182194A Pending CN103305531A (zh) | 2003-12-16 | 2004-12-01 | 谷类第4组主要致敏原的dna序列和重组制品 |
| CNA2004800372314A Pending CN1894410A (zh) | 2003-12-16 | 2004-12-01 | 谷类第4组主要致敏原的dna序列和重组制品 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2004800372314A Pending CN1894410A (zh) | 2003-12-16 | 2004-12-01 | 谷类第4组主要致敏原的dna序列和重组制品 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7935347B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2261336B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4960102B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN103305531A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE501257T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004299600A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0417736A (cg-RX-API-DMAC7.html) |
| CA (3) | CA2549573C (cg-RX-API-DMAC7.html) |
| DE (2) | DE10359351A1 (cg-RX-API-DMAC7.html) |
| ES (3) | ES2363015T3 (cg-RX-API-DMAC7.html) |
| PL (3) | PL2261337T3 (cg-RX-API-DMAC7.html) |
| PT (3) | PT2261336E (cg-RX-API-DMAC7.html) |
| RU (1) | RU2373283C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005059136A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10359351A1 (de) * | 2003-12-16 | 2005-07-21 | Merck Patent Gmbh | DNA-Sequenz und rekombinante Herstellung von Gruppe-4 Majorallergenen aus Getreiden |
| US9920101B2 (en) | 2014-03-31 | 2018-03-20 | Boehringer Ingelheim Vetmedica Gmbh | Modular antigen transportation molecules and uses therof |
| KR20180061338A (ko) | 2015-09-30 | 2018-06-07 | 베링거잉겔하임베트메디카게엠베하 | 동물에서의 개선된 모듈러 항원 수송 분자 및 이의 용도 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5762943A (en) * | 1996-05-14 | 1998-06-09 | Ribi Immunochem Research, Inc. | Methods of treating type I hypersensitivity using monophosphoryl lipid A |
| DE19918682A1 (de) * | 1999-04-23 | 2000-10-26 | Merck Patent Gmbh | DNA-Sequenz und rekombinante Herstellung eines Graminaen-Allergens |
| US7214786B2 (en) * | 2000-12-14 | 2007-05-08 | Kovalic David K | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| EP1402037A1 (en) * | 2001-06-22 | 2004-03-31 | Syngenta Participations AG | Plant genes involved in defense against pathogens |
| AUPR779201A0 (en) * | 2001-09-20 | 2001-10-11 | University Of Melbourne, The | Immunotherapeutic and immunoprophylactic reagents |
| WO2003025008A2 (en) | 2001-09-21 | 2003-03-27 | Affinium Pharmaceuticals, Inc. | Bacterial polypeptides involved in protein processing |
| CA2491038C (en) * | 2002-06-25 | 2017-04-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Dna sequence and preparation of grass pollen allergen phl p4 by recombinant methods |
| DE10359351A1 (de) * | 2003-12-16 | 2005-07-21 | Merck Patent Gmbh | DNA-Sequenz und rekombinante Herstellung von Gruppe-4 Majorallergenen aus Getreiden |
-
2003
- 2003-12-16 DE DE10359351A patent/DE10359351A1/de not_active Withdrawn
-
2004
- 2004-12-01 DE DE502004012294T patent/DE502004012294D1/de not_active Expired - Lifetime
- 2004-12-01 PT PT100096775T patent/PT2261336E/pt unknown
- 2004-12-01 EP EP10009677.5A patent/EP2261336B1/de not_active Expired - Lifetime
- 2004-12-01 CN CN2013102182194A patent/CN103305531A/zh active Pending
- 2004-12-01 CA CA2549573A patent/CA2549573C/en not_active Expired - Fee Related
- 2004-12-01 PL PL10009678T patent/PL2261337T3/pl unknown
- 2004-12-01 ES ES04803421T patent/ES2363015T3/es not_active Expired - Lifetime
- 2004-12-01 JP JP2006544263A patent/JP4960102B2/ja not_active Expired - Fee Related
- 2004-12-01 PT PT04803421T patent/PT1709177E/pt unknown
- 2004-12-01 CA CA2945267A patent/CA2945267A1/en not_active Abandoned
- 2004-12-01 CA CA2873261A patent/CA2873261C/en not_active Expired - Fee Related
- 2004-12-01 EP EP04803421A patent/EP1709177B1/de not_active Expired - Lifetime
- 2004-12-01 RU RU2006125511/13A patent/RU2373283C2/ru not_active IP Right Cessation
- 2004-12-01 AU AU2004299600A patent/AU2004299600A1/en not_active Abandoned
- 2004-12-01 ES ES10009678.3T patent/ES2443302T3/es not_active Expired - Lifetime
- 2004-12-01 US US10/583,089 patent/US7935347B2/en not_active Expired - Fee Related
- 2004-12-01 ES ES10009677.5T patent/ES2442951T3/es not_active Expired - Lifetime
- 2004-12-01 PL PL04803421T patent/PL1709177T3/pl unknown
- 2004-12-01 BR BRPI0417736-3A patent/BRPI0417736A/pt not_active Application Discontinuation
- 2004-12-01 PT PT100096783T patent/PT2261337E/pt unknown
- 2004-12-01 CN CNA2004800372314A patent/CN1894410A/zh active Pending
- 2004-12-01 EP EP10009678.3A patent/EP2261337B1/de not_active Expired - Lifetime
- 2004-12-01 PL PL10009677T patent/PL2261336T3/pl unknown
- 2004-12-01 WO PCT/EP2004/013664 patent/WO2005059136A2/de not_active Ceased
- 2004-12-01 AT AT04803421T patent/ATE501257T1/de active
-
2010
- 2010-11-16 US US12/947,361 patent/US9309297B2/en not_active Expired - Fee Related
-
2015
- 2015-12-17 US US14/972,633 patent/US20170246317A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9789178B2 (en) | DNA sequence, and recombinant preparation of the grass pollen allergen Lol p 4 | |
| US7862828B2 (en) | Allergy vaccines containing hybrid polypeptides | |
| JP5363441B2 (ja) | 低減したアレルギー誘発性および保持されたＴ細胞反応性を有するＰｈｌｐ５ａ誘導体 | |
| JP4264257B2 (ja) | 熱ショックタンパク質に由来する免疫調節ペプチドとその使用 | |
| CN103305531A (zh) | 谷类第4组主要致敏原的dna序列和重组制品 | |
| RU2238321C2 (ru) | Последовательность днк и получение аллергена злаковых рекомбинантным способом | |
| CN100391970C (zh) | 草花粉过敏原Phl p4 的 DNA 序列和用重组方法进行的制备 | |
| RU2409589C2 (ru) | ВАРИАНТ АЛЛЕРГЕНА ГРУППЫ I ИЗ Роасеае, ХАРАКТЕРИЗУЮЩИЙСЯ СНИЖЕННОЙ АЛЛЕРГЕННОСТЬЮ И СОХРАНЕННОЙ Т-КЛЕТОЧНОЙ РЕАКТИВНОСТЬЮ (ВАРИАНТЫ), КОДИРУЮЩАЯ ЕГО МОЛЕКУЛА ДНК И ЕГО ПРИМЕНЕНИЕ | |
| AU2012205288B2 (en) | DNA-sequence and recombinant production of group 4 major allergens from cereals | |
| ALBRECHT et al. | Allergic Diseases | |
| AU2008200490A1 (en) | Immunomodulatory peptides derived from heat shock proteins and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130918 |