JP2008501681A5 - - Google Patents
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- Publication number
- JP2008501681A5 JP2008501681A5 JP2007514883A JP2007514883A JP2008501681A5 JP 2008501681 A5 JP2008501681 A5 JP 2008501681A5 JP 2007514883 A JP2007514883 A JP 2007514883A JP 2007514883 A JP2007514883 A JP 2007514883A JP 2008501681 A5 JP2008501681 A5 JP 2008501681A5
- Authority
- JP
- Japan
- Prior art keywords
- urinary incontinence
- extract
- isoflavone
- pumpkin seed
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010046543 Urinary incontinence Diseases 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 28
- 239000007901 soft capsule Substances 0.000 claims description 28
- 235000003687 soy isoflavones Nutrition 0.000 claims description 23
- 241001618264 Rubus coreanus Species 0.000 claims description 22
- 239000008171 pumpkin seed oil Substances 0.000 claims description 22
- 229940092309 Pumpkin seed extract Drugs 0.000 claims description 12
- 230000001225 therapeutic Effects 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 5
- 229940023488 Pill Drugs 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims description 2
- 230000001070 adhesive Effects 0.000 claims description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 235000003599 food sweetener Nutrition 0.000 claims description 2
- 239000003205 fragrance Substances 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000000314 lubricant Substances 0.000 claims description 2
- 239000003765 sweetening agent Substances 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 229930003231 vitamins Natural products 0.000 claims description 2
- 229940088594 Vitamin Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 description 26
- 235000008696 isoflavones Nutrition 0.000 description 26
- 229930012948 isoflavones Natural products 0.000 description 26
- 230000000694 effects Effects 0.000 description 13
- 239000000843 powder Substances 0.000 description 13
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 11
- 229940067606 Lecithin Drugs 0.000 description 11
- 235000010445 lecithin Nutrition 0.000 description 11
- 239000000787 lecithin Substances 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 10
- 239000002775 capsule Substances 0.000 description 9
- 239000003814 drug Substances 0.000 description 9
- 240000007842 Glycine max Species 0.000 description 8
- 235000010469 Glycine max Nutrition 0.000 description 8
- 210000002700 Urine Anatomy 0.000 description 8
- 108010010803 Gelatin Proteins 0.000 description 7
- 229920000159 gelatin Polymers 0.000 description 7
- 239000008273 gelatin Substances 0.000 description 7
- 235000019322 gelatine Nutrition 0.000 description 7
- 235000011852 gelatine desserts Nutrition 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 210000003205 Muscles Anatomy 0.000 description 6
- 210000003708 Urethra Anatomy 0.000 description 6
- 210000003932 Urinary Bladder Anatomy 0.000 description 6
- 229940079593 drugs Drugs 0.000 description 5
- 235000013376 functional food Nutrition 0.000 description 5
- 230000027939 micturition Effects 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 231100000486 side effect Toxicity 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 241001548492 Coreus Species 0.000 description 4
- 241000220223 Fragaria Species 0.000 description 4
- 235000016623 Fragaria vesca Nutrition 0.000 description 4
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 4
- 241001092459 Rubus Species 0.000 description 4
- 240000001980 Cucurbita pepo Species 0.000 description 3
- 229920001353 Dextrin Polymers 0.000 description 3
- 239000004375 Dextrin Substances 0.000 description 3
- 241000408747 Lepomis gibbosus Species 0.000 description 3
- 206010033799 Paralysis Diseases 0.000 description 3
- 206010066218 Stress urinary incontinence Diseases 0.000 description 3
- 235000019425 dextrin Nutrition 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 235000020236 pumpkin seed Nutrition 0.000 description 3
- 235000012424 soybean oil Nutrition 0.000 description 3
- 239000003549 soybean oil Substances 0.000 description 3
- 235000000832 Ayote Nutrition 0.000 description 2
- 235000009854 Cucurbita moschata Nutrition 0.000 description 2
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 description 2
- 229940088597 Hormone Drugs 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 208000000921 Urge Urinary Incontinence Diseases 0.000 description 2
- 230000003416 augmentation Effects 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 235000002378 plant sterols Nutrition 0.000 description 2
- 235000015136 pumpkin Nutrition 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 1
- HMFKFHLTUCJZJO-UHFFFAOYSA-N 2-{2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCOCC(OCCO)C1OCC(OCCO)C1OCCO HMFKFHLTUCJZJO-UHFFFAOYSA-N 0.000 description 1
- UVKFSMBPRQBNCH-UHFFFAOYSA-M 4,4-diphenylbutan-2-yl-ethyl-dimethylazanium;bromide Chemical compound [Br-].C=1C=CC=CC=1C(CC(C)[N+](C)(C)CC)C1=CC=CC=C1 UVKFSMBPRQBNCH-UHFFFAOYSA-M 0.000 description 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- 229940063834 Carboxymethylcellulose Sodium Drugs 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 206010013990 Dysuria Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229960002493 Emepronium Bromide Drugs 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 229960000855 Flavoxate Drugs 0.000 description 1
- SPIUTQOUKAMGCX-UHFFFAOYSA-N Flavoxate Chemical compound C1=CC=C2C(=O)C(C)=C(C=3C=CC=CC=3)OC2=C1C(=O)OCCN1CCCCC1 SPIUTQOUKAMGCX-UHFFFAOYSA-N 0.000 description 1
- 229960000304 Folic Acid Drugs 0.000 description 1
- 206010021639 Incontinence Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- DLNKOYKMWOXYQA-APPZFPTMSA-N L-Norpseudoephedrine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 description 1
- 206010027304 Menopausal symptom Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 206010033809 Paralysis flaccid Diseases 0.000 description 1
- 229960000395 Phenylpropanolamine Drugs 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 210000002307 Prostate Anatomy 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 208000006641 Skin Disease Diseases 0.000 description 1
- 229960003604 Testosterone Drugs 0.000 description 1
- 229960001295 Tocopherol Drugs 0.000 description 1
- 206010046494 Urge incontinence Diseases 0.000 description 1
- 229940029983 VITAMINS Drugs 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 229940021016 Vitamin IV solution additives Drugs 0.000 description 1
- 230000003187 abdominal Effects 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000001058 adult Effects 0.000 description 1
- 229960003473 androstanolone Drugs 0.000 description 1
- 230000001396 anti-anti-diuretic Effects 0.000 description 1
- 230000001078 anti-cholinergic Effects 0.000 description 1
- 230000001754 anti-pyretic Effects 0.000 description 1
- 230000003078 antioxidant Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 1
- 230000003177 cardiotonic Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 125000003346 cobalamin group Chemical group 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 150000001904 cucurbitacins Chemical class 0.000 description 1
- 230000001882 diuretic Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000592 few side effect Toxicity 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 235000009408 lignans Nutrition 0.000 description 1
- 229930013686 lignans Natural products 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000003340 mental Effects 0.000 description 1
- 231100000324 minimal toxicity Toxicity 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000019645 odor Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000003449 preventive Effects 0.000 description 1
- -1 propiperine Chemical compound 0.000 description 1
- 230000001107 psychogenic Effects 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 235000011649 selenium Nutrition 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000001235 sensitizing Effects 0.000 description 1
- 230000001953 sensory Effects 0.000 description 1
- 231100000197 serious side effect Toxicity 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229930003799 tocopherols Natural products 0.000 description 1
- 229960004045 tolterodine Drugs 0.000 description 1
- OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 230000002485 urinary Effects 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 235000016804 zinc Nutrition 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020040041631A KR100462173B1 (ko) | 2004-06-08 | 2004-06-08 | 요실금 예방 및 치료용 조성물 |
| PCT/KR2004/001482 WO2005120530A1 (en) | 2004-06-08 | 2004-06-21 | Composition for prevention and treatment of urinary incontinence |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008501681A JP2008501681A (ja) | 2008-01-24 |
| JP2008501681A5 true JP2008501681A5 (ko) | 2010-10-21 |
| JP4621250B2 JP4621250B2 (ja) | 2011-01-26 |
Family
ID=35502821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007514883A Expired - Fee Related JP4621250B2 (ja) | 2004-06-08 | 2004-06-21 | 尿失禁の予防及び治療用組成物 |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP4621250B2 (ko) |
| KR (1) | KR100462173B1 (ko) |
| CN (1) | CN1964729B (ko) |
| HK (1) | HK1103010A1 (ko) |
| WO (1) | WO2005120530A1 (ko) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5344882B2 (ja) * | 2008-10-09 | 2013-11-20 | 株式会社 エス・ネット | 家畜用飼料 |
| KR101362539B1 (ko) * | 2011-10-11 | 2014-02-14 | 씨제이제일제당 (주) | 과민성방광 증후군 예방 및 치료용 조성물 |
| JP6761705B2 (ja) * | 2016-02-01 | 2020-09-30 | 株式会社日本健康食品研究所 | ５α−リダクターゼ阻害剤及び泌尿器系疾患治療・予防用組成物ならびにこれらの製造方法 |
| CN106490613A (zh) * | 2016-10-21 | 2017-03-15 | 桂林淮安天然保健品开发有限公司 | 含有南瓜籽油保健品的制备方法 |
| JP7058939B2 (ja) * | 2016-12-28 | 2022-04-25 | 小林製薬株式会社 | ホスホジエステラーゼ５活性阻害用組成物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0873342A (ja) * | 1994-09-05 | 1996-03-19 | Ichimaru Pharcos Co Ltd | 覆盆子抽出物含有皮膚外用剤または浴用剤 |
| JPH09124498A (ja) * | 1995-02-10 | 1997-05-13 | Suntory Ltd | Ｇｏｄタイプのエラジタンニンを有効成分とする抗アレルギー作用剤並びにこれを配合した食品及び医薬品 |
| JPH09124497A (ja) * | 1995-02-10 | 1997-05-13 | Suntory Ltd | Ｇｏｄタイプのエラジタンニンを有効成分とするヒアルロニダーゼ阻害剤並びにこれを配合した医薬品及び化粧品 |
| JPH09176019A (ja) * | 1995-12-26 | 1997-07-08 | Suntory Ltd | 糖質分解消化酵素阻害剤並びにこれを配合した医薬品および飲食品 |
| JPH10236965A (ja) * | 1997-02-26 | 1998-09-08 | Maruzen Pharmaceut Co Ltd | 抗アレルギー剤 |
| JP2000319191A (ja) * | 1999-03-05 | 2000-11-21 | Takeda Chem Ind Ltd | サイクリックｇｍｐ特異的ホスホジエステラーゼ阻害剤および性的機能障害改善薬 |
| JP2000290192A (ja) * | 1999-04-05 | 2000-10-17 | Hide Tatsuzaki | 排尿障害治療剤 |
| JP2001342142A (ja) * | 2000-06-01 | 2001-12-11 | Nissui Pharm Co Ltd | 泌尿器系疾患予防治療用組成物 |
| US6326366B1 (en) * | 2000-08-22 | 2001-12-04 | Protein Technologies International | Hormone replacement therapy |
| AUPQ968700A0 (en) * | 2000-08-28 | 2000-09-21 | Intreat Pty Limited | Treatment of urinary incontinence |
| KR100542898B1 (ko) * | 2002-10-24 | 2006-01-11 | 학교법인 중앙대학교 | 요실금 예방과 치료를 위한 생약제 추출물 및 이의 제조방법 |
-
2004
- 2004-06-08 KR KR1020040041631A patent/KR100462173B1/ko not_active IP Right Cessation
- 2004-06-21 WO PCT/KR2004/001482 patent/WO2005120530A1/en active Application Filing
- 2004-06-21 CN CN2004800432851A patent/CN1964729B/zh not_active Expired - Fee Related
- 2004-06-21 JP JP2007514883A patent/JP4621250B2/ja not_active Expired - Fee Related
-
2007
- 2007-07-12 HK HK07107449.5A patent/HK1103010A1/xx unknown
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