JP2008500365A5 - - Google Patents
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- JP2008500365A5 JP2008500365A5 JP2007515351A JP2007515351A JP2008500365A5 JP 2008500365 A5 JP2008500365 A5 JP 2008500365A5 JP 2007515351 A JP2007515351 A JP 2007515351A JP 2007515351 A JP2007515351 A JP 2007515351A JP 2008500365 A5 JP2008500365 A5 JP 2008500365A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- amount
- weight
- present
- disintegrant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- UIIMBOGNXHQVGW-UHFFFAOYSA-M NaHCO3 Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 10
- 239000007884 disintegrant Substances 0.000 claims 8
- 230000003482 proton pump inhibitor Effects 0.000 claims 8
- 239000000612 proton pump inhibitor Substances 0.000 claims 8
- 239000002775 capsule Substances 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 4
- 239000011230 binding agent Substances 0.000 claims 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 4
- 235000020828 fasting Nutrition 0.000 claims 4
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 4
- 230000037098 T max Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- WNROFYMDJYEPJX-UHFFFAOYSA-K Aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 2
- 229960003563 Calcium Carbonate Drugs 0.000 claims 2
- 229960001681 Croscarmellose Sodium Drugs 0.000 claims 2
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N Esomeprazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L Magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims 2
- VTHJTEIRLNZDEV-UHFFFAOYSA-L Magnesium hydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M Potassium bicarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims 2
- 239000003159 antacid agent Substances 0.000 claims 2
- 230000001458 anti-acid Effects 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 2
- 239000000314 lubricant Substances 0.000 claims 2
- 239000001095 magnesium carbonate Substances 0.000 claims 2
- 239000011776 magnesium carbonate Substances 0.000 claims 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims 2
- 239000000347 magnesium hydroxide Substances 0.000 claims 2
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims 2
- 239000000395 magnesium oxide Substances 0.000 claims 2
- 229960000381 omeprazole Drugs 0.000 claims 2
- 239000011736 potassium bicarbonate Substances 0.000 claims 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims 2
- 235000015497 potassium bicarbonate Nutrition 0.000 claims 2
- 229940094025 potassium bicarbonate Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 2
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 2
- 239000001187 sodium carbonate Substances 0.000 claims 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- SUBDBMMJDZJVOS-XMMPIXPASA-N (R)-omeprazole Chemical compound C([S@@](=O)C=1NC2=CC=C(C=C2N=1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-XMMPIXPASA-N 0.000 claims 1
- MJIHNNLFOKEZEW-UHFFFAOYSA-N Dexlansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- XAPRFLSJBSXESP-UHFFFAOYSA-N Oxycinchophen Chemical group N=1C2=CC=CC=C2C(C(=O)O)=C(O)C=1C1=CC=CC=C1 XAPRFLSJBSXESP-UHFFFAOYSA-N 0.000 claims 1
- 230000037165 Serum Concentration Effects 0.000 claims 1
- 230000035852 Tmax Effects 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229960004770 esomeprazole Drugs 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims 1
- 229960003174 lansoprazole Drugs 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57464604P | 2004-05-25 | 2004-05-25 | |
| US57466304P | 2004-05-25 | 2004-05-25 | |
| PCT/US2005/018585 WO2005115474A1 (en) | 2004-05-25 | 2005-05-25 | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008500365A JP2008500365A (ja) | 2008-01-10 |
| JP2008500365A5 true JP2008500365A5 (es) | 2008-05-08 |
Family
ID=35450661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007515351A Pending JP2008500365A (ja) | 2004-05-25 | 2005-05-25 | 酸分泌を阻害するために有用な薬学的製剤ならびにその製造方法および使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1750767A4 (es) |
| JP (1) | JP2008500365A (es) |
| CA (1) | CA2566655C (es) |
| MX (1) | MXPA06013585A (es) |
| WO (1) | WO2005115474A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2068841B1 (en) * | 2006-10-05 | 2018-09-26 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
| EP2647381A4 (en) * | 2010-12-03 | 2015-12-23 | Takeda Pharmaceutical | MELTING TABLET |
| JP6641626B2 (ja) * | 2015-12-25 | 2020-02-05 | エスエス製薬株式会社 | 制酸用医薬組成物 |
| KR102006777B1 (ko) * | 2018-01-29 | 2019-10-08 | 주식회사 종근당 | 에스오메프라졸 및 탄산수소나트륨을 포함하는 약제학적 제제 |
| KR102080023B1 (ko) | 2018-01-29 | 2020-02-21 | 주식회사 종근당 | 에스오메프라졸 및 탄산수소나트륨을 포함하는 안정한 약제학적 조성물 |
| US20220233514A1 (en) * | 2018-08-23 | 2022-07-28 | Chong Kun Dang Pharmaceutical Corp. | Pharmaceutical preparation having excellent dissolution properties, containing esomeprazole and sodium bicarbonate |
| CN114555082A (zh) * | 2019-07-26 | 2022-05-27 | 株式会社钟根堂 | 包含埃索美拉唑及碳酸氢钠的稳定的药剂学组合物 |
| KR102573842B1 (ko) * | 2020-02-21 | 2023-09-01 | 주식회사 종근당 | 방출특성이 우수한 에스오메프라졸 및 탄산수소나트륨의 약제학적 조성물 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
| US5622719A (en) | 1993-09-10 | 1997-04-22 | Fuisz Technologies Ltd. | Process and apparatus for making rapidly dissolving dosage units and product therefrom |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US6645988B2 (en) * | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
| DK1411900T4 (da) * | 2001-06-01 | 2014-01-27 | Pozen Inc | Farmaceutiske sammensætninger til den koordinerede frigørelse af NSAIDs |
| MXPA06000529A (es) * | 2003-07-18 | 2006-08-11 | Santarus Inc | Formulaciones farmaceuticas utiles para inhibir la secrecion de acido y metodos para elaborarlas y utilizarlas. |
| EP1718303A4 (en) * | 2004-02-10 | 2010-09-01 | Santarus Inc | COMBINATION OF INHIBITOR OF PROTON PUMP, BUFFER AND NON-STEROIDAL ANTI-INFLAMMATORY DRUG |
| CA2561700A1 (en) * | 2004-04-16 | 2005-12-15 | Santarus, Inc. | Combination of proton pump inhibitor, buffering agent, and prokinetic agent |
-
2005
- 2005-05-25 MX MXPA06013585A patent/MXPA06013585A/es active IP Right Grant
- 2005-05-25 CA CA2566655A patent/CA2566655C/en not_active Expired - Fee Related
- 2005-05-25 EP EP05755940A patent/EP1750767A4/en not_active Withdrawn
- 2005-05-25 WO PCT/US2005/018585 patent/WO2005115474A1/en active Application Filing
- 2005-05-25 JP JP2007515351A patent/JP2008500365A/ja active Pending
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