JP2008208038A5 - - Google Patents
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- Publication number
- JP2008208038A5 JP2008208038A5 JP2007043783A JP2007043783A JP2008208038A5 JP 2008208038 A5 JP2008208038 A5 JP 2008208038A5 JP 2007043783 A JP2007043783 A JP 2007043783A JP 2007043783 A JP2007043783 A JP 2007043783A JP 2008208038 A5 JP2008208038 A5 JP 2008208038A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl group
- group
- formula
- composition
- nrf2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000000203 mixture Substances 0.000 claims 15
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 14
- 201000010099 disease Diseases 0.000 claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 101000588302 Homo sapiens Nuclear factor erythroid 2-related factor 2 Proteins 0.000 claims 11
- 102100031701 Nuclear factor erythroid 2-related factor 2 Human genes 0.000 claims 11
- 235000013399 edible fruits Nutrition 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 239000012453 solvate Substances 0.000 claims 11
- 230000004913 activation Effects 0.000 claims 10
- 241001070947 Fagus Species 0.000 claims 9
- 235000010099 Fagus sylvatica Nutrition 0.000 claims 9
- 239000004480 active ingredient Substances 0.000 claims 8
- 125000004430 oxygen atom Chemical group O* 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 238000002360 preparation method Methods 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 230000036542 oxidative stress Effects 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 230000037303 wrinkles Effects 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- UTYWJBMBGFMTQG-UHFFFAOYSA-N 1-(4-methyl-5-oxooxolan-3-yl)ethyl acetate Chemical compound CC(=O)OC(C)C1COC(=O)C1C UTYWJBMBGFMTQG-UHFFFAOYSA-N 0.000 claims 2
- IFTDMXLIJXJGAS-UHFFFAOYSA-N 2-(5-ethyloxolan-2-yl)acetic acid Chemical compound CCC1CCC(CC(O)=O)O1 IFTDMXLIJXJGAS-UHFFFAOYSA-N 0.000 claims 2
- UFECLJRYNAOWOI-UHFFFAOYSA-N 2-phenylpyran-4-one Chemical compound O=C1C=COC(C=2C=CC=CC=2)=C1 UFECLJRYNAOWOI-UHFFFAOYSA-N 0.000 claims 2
- WZGGLCJULKAURB-UHFFFAOYSA-N 4-(1-hydroxyethyl)-3-methyloxolan-2-one Chemical compound CC(O)C1COC(=O)C1C WZGGLCJULKAURB-UHFFFAOYSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 1
- BOIHAPODUXHNBA-UHFFFAOYSA-N 1-phenylpentane-1,3-diol Chemical compound CCC(O)CC(O)C1=CC=CC=C1 BOIHAPODUXHNBA-UHFFFAOYSA-N 0.000 claims 1
- IFNRDWSKKNGFGN-UHFFFAOYSA-N 2-(2-formylpyrrol-1-yl)-4-methylpentanoic acid Chemical compound CC(C)CC(C(O)=O)N1C=CC=C1C=O IFNRDWSKKNGFGN-UHFFFAOYSA-N 0.000 claims 1
- QKBQWVMXPGSNTK-UHFFFAOYSA-N 4-acetyl-3-methyloxolan-2-one Chemical group CC1C(C(C)=O)COC1=O QKBQWVMXPGSNTK-UHFFFAOYSA-N 0.000 claims 1
- YFNSPPHTAARSPD-UHFFFAOYSA-N 4-phenyloxolan-2-one Chemical compound C1OC(=O)CC1C1=CC=CC=C1 YFNSPPHTAARSPD-UHFFFAOYSA-N 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000005623 Carcinogenesis Diseases 0.000 claims 1
- 208000017667 Chronic Disease Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 241000795548 Mycoleptodonoides aitchisonii Species 0.000 claims 1
- 206010040954 Skin wrinkling Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000036952 cancer formation Effects 0.000 claims 1
- 231100000504 carcinogenesis Toxicity 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 230000005976 liver dysfunction Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000003223 protective agent Substances 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007043783A JP2008208038A (ja) | 2007-02-23 | 2007-02-23 | Ｎｒｆ２活性化剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007043783A JP2008208038A (ja) | 2007-02-23 | 2007-02-23 | Ｎｒｆ２活性化剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008208038A JP2008208038A (ja) | 2008-09-11 |
| JP2008208038A5 true JP2008208038A5 (enExample) | 2010-04-08 |
Family
ID=39784669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007043783A Withdrawn JP2008208038A (ja) | 2007-02-23 | 2007-02-23 | Ｎｒｆ２活性化剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2008208038A (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5725469B2 (ja) * | 2010-11-15 | 2015-05-27 | 学校法人北里研究所 | 骨分化阻害剤およびその製造方法 |
| JP6113265B2 (ja) * | 2012-03-30 | 2017-04-12 | ネステク ソシエテ アノニム | ４−オキソ−２−ペンテン酸及び心血管の健康 |
| KR101777497B1 (ko) * | 2016-02-03 | 2017-09-12 | 제주대학교 산학협력단 | 4-하이드록시-2,3-디메틸-2-노넨-4-올라이드 또는 3-하이드록시-4,7-메가스티그마디엔-9-원을 유효성분으로 포함하는 염증질환 또는 면역질환의 예방 및 치료용 약제학적 조성물 |
| JP7105532B2 (ja) * | 2017-05-10 | 2022-07-25 | ロート製薬株式会社 | 後眼部疾患の予防、改善、又は治療用組成物 |
| KR101829587B1 (ko) * | 2017-07-21 | 2018-02-19 | 제주대학교 산학협력단 | 4-하이드록시-2,3-디메틸-2-노넨-4-올라이드를 유효성분으로 포함하는 염증질환 또는 면역질환의 예방 및 치료용 약제학적 조성물 |
-
2007
- 2007-02-23 JP JP2007043783A patent/JP2008208038A/ja not_active Withdrawn
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