JP2008105996A - Anti-inflammatory agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an odorless anti-inflammatory agent which prevents and alleviates pains accompanying inflammation of arthralgia or the like, and mitigates uncomfortable feeling due to these pains, by making effective components penetrate to diseased parts to be absorbed there safely, surely and simply through the skin. <P>SOLUTION: The anti-inflammatory agent is made a mixture in an ointment state or having a viscosity corresponding to an ointment by mixing a horse oil having a composition close to the composition of the human sebum as animal fat and oil with a mixed powder formed by blending a natural-originated methylsulfonylmethane (MSM) and aphanizomenon flos-aquae (AFA) used as health foods so as to exhibit a synergic effect, and making the mixture penetrate into the cells of a living body to be absorbed there through the skin, to make it possible to prevent and alleviate pains accompanying inflammation of arthralgia or the like, or to mitigate uncomfortable feeling. Also, the administration through the skin includes sticking of the agent utilizing a taping tape superior in pressure-sensitive adhesion, stretchability and air permeability in addition to direct application onto the skin. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention is intended to prevent, reduce, or alleviate the discomfort associated with inflammation, such as a wide range of joint pain, neuralgia, and back pain. It relates to the agent.

In recent years, products called so-called health foods have attracted attention, and various types of products have been sold. Many of these are known as supplements for the dietary life of unbalanced people, or for taking active ingredients orally for the prevention and response of lifestyle-related diseases. (Patent Document 1)
In addition, those that are applied directly to the skin of a living body and have an anti-inflammatory action for the prevention / reduction of inflammation such as joint pain, neuralgia, and back pain are also known. (Patent Document 2)

  Causes of pain due to inflammation as described above are various causes such as changes in dietary habits, lack of exercise, weight gain, body flexibility / muscular strength, bone density decline, osteoporosis, tissue damage, exercise damage, etc. Various factors are considered. And the above factors are combined and cause pain due to inflammation. In addition, the bias of nutritional components in the dietary life is due to the fact that the body's inherent defense function and metabolic ability are reduced. Therefore, a rapid biological transdermal anti-inflammatory agent that works directly on the cause of pain caused by inflammation is desired.

  According to the present inventor, methylsulfonylmethane (hereinafter referred to as MSM) is an organic sulfur compound that exists in nature and is essential for living organisms. It must also be contained in fresh milk, green-yellow vegetables, tea leaves, etc., and in human urine. In addition, MSM molecules are small and water-soluble, making the internal and external pressures of the cell membrane uniform and increasing its permeability, making active use of the properties that facilitate the rapid excretion of intracellular harmful substances and facilitate the uptake of nutrients It's a good thing.

  The general mechanism of pain will be described based on the structural diagram of the cell membrane in FIG. 1 and the explanatory diagram of the metabolic pathway of arachidonic acid involved in inflammation in FIG. The cell membrane 1 shown in the structural diagram of the cell membrane in FIG. 1 plays a role in creating an independent environment inside the cell and maintains a homeostasis (homeostasis) inside and outside the cell while exchanging materials and exchanging information with the outside world. have. The main components of the cell membrane 1 are a double polar and nonpolar phospholipid 2 and a component protein 3 embedded in the cell membrane. Furthermore, it is the peripheral protein 4 that is in charge of exchange with the outside world, and the role of the antenna is the sugar chain 5. In general, when a physical or chemical stimulus is applied to the cell membrane 1, the enzyme phospholipase A2 is activated as shown in the metabolic pathway of arachidonic acid in FIG. 2, and arachidonic acid of the cell membrane phospholipid is converted from nonpolar phospholipid 2. 6 is released. Endoperoxide prostaglandins G2 and H2 (symbol 8) are generated from arachidonic acid 7 released into the cytoplasm by activation of the enzyme cyclooxygenase (COX), and inflammation is induced by prostaglandins I2, E2, and F2 (symbol 9). , Fever and pain 10 occur. In addition, thromboxane A2 (symbol 11) causes thrombus formation and asthma attack 12. In other metabolic pathways, activation of the enzyme 5-lipoxygenase (LOX) produces 5-HPTEE (5-hydroperoxyicosatetraene) 13, which is caused by leukotrienes A4, B4, C4, D4, E4 (symbol 14). Causes inflammation and asthma attack 15.

  Conventional anti-inflammatory agents for external use relieve pain caused by inflammation by inhibiting the activation of the enzyme by chemically reacting the aforementioned free arachidonic acid. On the other hand, since MSM makes the internal and external pressures of the cell membrane uniform and enhances its permeability, the present inventor has paid attention to the effect of rapidly excluding intracellular free free arachidonic acid physically outside the membrane. The present inventor has found that by adding and mixing aphanizomenon floss aqua (hereinafter referred to as AFA) to this, the enhancement of supplementation of necessary components into the cell membrane is made more effective.

  Conventional health foods are mainly taken orally, and after digestion and absorption, all the components are not necessarily delivered efficiently and efficiently to necessary parts of the living body. Furthermore, depending on the individual difference of the living body, the possibility that the functional balance of each organ of the living body may be lost during the digestion and absorption process due to the intake of the component cannot be denied.

  For this reason, in most cases, the above-mentioned inflammation occurs in a part of the living body that is relatively close to the skin, so that the pain caused by inflammation can be directly penetrated into the affected area using MSM powder through the skin and has a relaxing effect (immediate effect). In addition, AFA powder is mixed to adjust the preventive effect (slow-acting effect) of inflammation, and this is mixed with horse oil that is similar to the composition of human sebum as animal oil at a certain ratio and applied to the living epidermis Therefore, it was necessary to increase the permeability and to have an inflammation relieving effect, immediate effect and curability by the synergistic effect of the components.

JP 2004-113141 A JP 2004-149441 A

  Since the present inventor is considered to be the oldest organism in the earth that has inhabited AFA since 3.5 billion years ago and is the prototype of somatic cells, AFA, which can be said to be somatic cells themselves, is directly transmitted through the skin. It is intended to promote the rapid repair of damaged somatic cells by supplementing them. And for the pain caused by inflammation, MSM powder and AFA powder for the purpose of maintaining health and strengthening nutrition including strengthening anti-inflammatory action and animal fats are mixed with horse oil that is close to the composition of human sebum. And providing a direct and highly effective anti-inflammatory agent that can be applied and pasted percutaneously.

  In addition, the object of the present invention is to allow the user to easily permeate and absorb the above-mentioned health food through the skin to the affected area, and to directly cause pain etc. by a physical mechanism different from conventional oral and external anti-inflammatory agents. The excess free arachidonic acid is excreted out of the cell and the function of the cell is restored. In addition, this method can provide an effective odorless anti-inflammatory agent.

  In order to achieve the above-mentioned object, the present invention appropriately mixes naturally-derived ingredients used as health foods in order to obtain a synergistic effect, and promptly removes them from the skin using an optimal method. It is intended to provide an odorless anti-inflammatory agent that can be absorbed and penetrated into sites having symptoms such as pain due to inflammation.

  The present invention according to claim 1 is an animal having excellent skin permeability close to the composition of human sebum (particularly the composition of fatty acids) obtained by mixing a mixture of natural MSM powder and AFA powder in a certain ratio. It is intended to obtain an anti-inflammatory agent that can be applied to the skin of a living body by mixing it with a certain amount of oil and fat to make an ointment-like or similar mixture.

  The present invention according to claim 2 provides the anti-inflammatory agent according to claim 1, wherein the mixing ratio of the MSM powder and the AFA powder is 1 to 0.25 to 4 in weight ratio.

  The present invention described in claim 3 is a white powder of at least 30-90 mesh, the MSM powder is naturally derived, has an MSM purity of 99.0% or more, a melting point of 107 ° C. or more, an ash content of 0.2% or less, and moisture content. The anti-inflammatory agent according to claim 1 or 2, which is 0.3% or less.

  The present invention according to claim 4 is a 30-90 mesh green powder in which at least AFA powder is a natural material, nutrients are 60-70 g protein, carbohydrates 15-25 g, lipids 1-8 g, vitamins and minerals per 100 g 2 to 8 g, chlorophyll a is 0.5 to 1.2 g, and the water content is 1 to 5 g. 3. The anti-inflammatory agent according to claim 1 or 2 is obtained.

  According to the fifth aspect of the present invention, in order to promote penetration and absorption of the living body through the skin, MSM powder and AFA powder are fixed to 1 part by weight of horse oil close to the composition of human sebum as animal fat. The anti-inflammatory agent according to any one of claims 1 to 4, wherein the mixed powder blended at a ratio of 0.1 to 4 parts by weight is mixed and dispersed into an ointment or a mixture having a viscosity equivalent thereto. To get.

  The present invention according to claim 6 is characterized in that horse oil, MSM powder and AFA powder, which are close to the composition of human sebum as animal fat, are fixed in a certain ratio on the adhesive surface of the taping tape having adhesiveness, stretchability and breathability. The anti-inflammatory agent according to any one of claims 1 to 5, wherein the mixture is made into an ointment and is made stickable to the skin of a living body.

  The present invention will be described in detail below for each of the claims. In the present invention according to any one of claims 1 to 6, MSM powder and AFA powder as essential active ingredients are mixed at an appropriate ratio so as to produce a synergistic effect as described later, It is necessary to mix horse oil close to the composition of sebum in a certain ratio to make an ointment or a mixture having a viscosity equivalent thereto.

  MSM is an organic sulfur compound indispensable for living organisms, and is a natural nutritional component present in almost all living organisms. MSM is a substance contained in many foods, but since the intake of processed foods is increasing, most organic sulfur is destroyed by washing, processing, cooking, etc., so the sulfur required for the living body is deficient It is an element necessary for supplementing the organic sulfur compound essential for the living body.

  MSM is also very effective in alleviating and improving pain caused by inflammation such as arthritis and rheumatism. The fact that the sulfur component has an anti-inflammatory effect is also apparent from the coping method that all pains are alleviated by soaking in a hot spring containing a large amount of sulfur, and the present inventor has made this one of the constitutions of the invention. did.

  The reason why MSM has an effect of suppressing inflammation such as joint pain is because the molecule of MSM is very small and water-soluble, and therefore has the property of being easily absorbed into cells. In addition, MSM absorbed into cells makes it possible to equalize the internal and external pressures of the cell membrane and prevent pressure from accumulating in cells, tissues, and joints. Furthermore, it has a function of increasing the permeability of the cell membrane, and as a result, excess can be discharged from the cell and the inflow of nutrients into the cell can be promoted. Thereby, the pain accompanying inflammation is relieved and the countermeasure for prevention becomes possible.

  The MSM standard applied to the present invention will be described below.

  Next, AFA is a natural food that contains not only proteins, carbohydrates and lipids, but also vitamins (especially B), minerals, pigments, and active enzymes in abundant amounts, and contains almost all of the nutrients essential for living cells. Furthermore, these nutrients have a component structure close to somatic cells and are digested and absorbed by the living body almost 100%.

  One of the indirect causes of inflammation such as joint pain is the presence of excess reactive oxygen that causes cell acidification. The function to control these is originally in the cells, and this function declines due to aging or dietary distortion, but daily intake of antioxidants or enzyme SOD compensates for the deterioration of the function. The utility of AFA is effective for repairing and regenerating such once damaged cells, and promotes cell metabolism, and the present inventor made use of the utility of such AFA as a constituent element.

  The balance of essential amino acids and essential fatty acids in AFA is close to the ideal value required for cells, vitamins and minerals are all necessary for cells, and enzymes involved in antioxidant and anti-inflammatory effects It also contains dyes, nucleic acids and the like. Therefore, it has been discovered and actively used that it is a substance that can ingest all of the components that strengthen the function and reinforce the metabolism of cells.

Next, the AFA standard is described.
AFA is a pure natural blue algae (Blue Green Algae) native to Klamath Lake in Oregon, USA.

Next, the manufacturing method of AFA is described.
First step: Collecting AFA floating at 1-2 m below the surface of the water at Klamath Lake, Oregon, from July to October.
Second step: Microfiltration with a filter A special foreign filter combination of about 0.1 microns is used to remove foreign particles from collected AFA.
Third step: Centrifugation Next, impurities such as sand and silt are removed from the AFA at room temperature using a centrifugal separator. The size of the filtered AFA is about 8-12 microns.
Fourth Step: Freeze Storage The filtered AFA is flash-frozen at −40 ° C. and then stored in the freezer until the freeze-drying process.
Fifth step: Freeze-drying method The dried frozen material is sublimated and dried with a freeze-drying device in a vacuum of 1/1000 of an atmospheric pressure.
Further, as another drying method, it may be spray-dried, that is, after passing through a centrifugal filtration device, sprayed from the drying tower of the spray-drying device, and instantaneously dried with hot air of 150 to 200 ° C.
Sixth step: sieve (sieving) powder into 30-90 mesh powder.

  Next, the properties of horse oil will be described. Although horse oil is an animal fat and oil, it contains a lot of unsaturated fatty acid α-linolenic acid, and it is close to the fatty acid composition of human sebum, including its balance with saturated fatty acid, and has excellent skin penetration. It was used actively. Moreover, it refine | purifies through processes, such as deoxidation, degumming, deodorizing, filtration, extraction, and specific gravity is 0.90-0.95 at 50 degreeC. The melting point is not higher than room temperature, particularly not higher than 10 ° C., and the liquid at room temperature improves the permeability to the skin. In addition, as a method of adjusting the melting point in order to have an appropriate viscosity for application to the living body epidermis, there are hydrogenation or blending with a high melting point wax such as beeswax.

First, the mechanism by which a synergistic effect is produced by mixing MSM and AFA will be described with reference to the drawings. FIG. 1 shows the structure of a general cell membrane, FIG. 3 shows the cell structure of cyanobacteria (AFA), and FIG. 4 shows the conversion process of sulfur containing MSM. Cyanobacteria play an important role in the sulfur cycle in nature. That is, the cyanobacteria absorb inorganic sulfur 18 from the outside into cells containing DNA 17 through the cell wall 16 of FIG. 3 to convert it into organic sulfur, and release volatile dimethyl sulfide (DMS) 19 to the outside. This DMS is an ozone layer in the atmosphere as shown in FIG. 4, and passes through dimethyl sulfoxide (DMSO) 20 and then dimethyl sulfone (DMSO ₂ , which is another name for MSM, and its chemical formula is shown in 21) 21 Is converted to These are dissolved in water vapor in the atmosphere, dissolved in rain, returned to the ground, and absorbed and concentrated by plants.
Thus, AFA, a kind of blue-green algae, has a close relationship with MSM in the sulfur cycle, and as shown in FIG. 5, MSM, an organic sulfur compound, positively affects AFA cells. It is taken in.
In addition, many of the proteins contained in AFA are called glycoproteins (glycoproteins), and they function as information exchanges with the outside in the cell membrane shown in the structural diagram of the cell membrane in FIG. It is easy to be accepted by the sugar chain 5 of the peripheral protein 4 that is. As shown in FIG. 6, AFA incorporating MSM is easily received in the cell membrane receptor. Next, as shown in FIG. 7, the osmotic function of the cell membrane is enhanced by the characteristics of MSM transferred from the AFA to the cytoplasm 23. Therefore, by mixing MSM and AFA rather than using each of them alone, it is quickly received by the cell membrane of the living body and efficiently discharges excess to the outside of the cell membrane, and replenishes active ingredients that promote metabolism into the cell membrane. We discovered that we can do it and used it positively.

  According to the production method of the present invention, horse oil close to the composition of human sebum is mixed into a mixture of the MSM powder and AFA powder in a predetermined amount at a specified blending ratio, and at a normal temperature using a normal impeller agitator or the like. It is mixed and dispersed into an ointment or a mixture having a viscosity equivalent thereto.

  In the present invention, the above-described two-component MSM powder and AFA powder are first mixed so as to exhibit a synergistic effect. In other words, AFA that has incorporated MSM is quickly recognized and induced by the cell membrane and is rapidly received by the cell membrane, and then the MSM effect enhances the permeability of the cell membrane, expelling excess substances from the cell membrane and removing necessary substances from the cell membrane. Infiltrate inside. Further, these components are mixed and dispersed in horse oil close to the composition of human sebum in order to efficiently and effectively absorb and penetrate these components into the skin.

  As described above, since it also contains components that alleviate joint pain and other inflammation and promote metabolism, it is possible to reinforce the anti-inflammatory action and prevent the onset of arthritis and the like.

  When the above-mentioned essential components, MSM powder, and AFA powder are mixed, the application range of the mixing ratio in which the present invention can be carried out is as follows: MSM powder 1 to AFA powder 0.25 (FIG. Reference numeral C) to 4 (figure 8 sign F), and the preferred recommended range of the present invention is MSM powder 1 to AFA powder 0.5 (figure 8 sign D) to 1 (figure 8) by weight ratio as shown in FIG. 8 sign E). However, it is not always necessary to be within this recommended range, and in this case, it is calculated with an emphasis on immediate effect in consideration of the balance between the mitigation and prevention effects against inflammation.

FIG. 8 shows an evaluation of the effect of alleviating and preventing inflammation by the weight ratio of MSM powder and AFA powder. As the weight ratio of MSM powder increases from 1 on the left to 5-7 on the right, the inflammation mitigating effect, that is, the immediate effect increases, but 7-10 (MSM powder alone) decreases the immediate effect. . By adding AFA powder in this way, there is a mixing ratio (MSM powder is in a range of 2 or more by weight) that is greater than the effect of the MSM powder alone. On the other hand, as the weight ratio of AFA powder increases from 1 on the right to 5 on the left, the preventive effect of inflammation, that is, the delayed effect increases, but 5-10 (AFA powder alone) decreases the delayed effect. . Thus, there exists a mixing ratio (AFA powder is 2 or more by weight ratio) which becomes larger than the effect of a single AFA powder by adding MSM powder.
In FIG. 8, the symbol A indicates that the MSM powder has a weight ratio of 2 to 8 and the AFA powder has a weight ratio of 8 to 2. That is, MSM powder 1 to AFA powder 0.25 (sign C) to 4 (sign F) is an application range of the mixing ratio according to the present invention, which is more effective than each simple substance. Moreover, the code | symbol B is the range whose MSM powder is 5 to 6.7 by weight ratio, and AFA is the range which is 5 to 3.3 by weight ratio. That is, MSM powder 1 to AFA powder 0.5 (symbol D) to 1 (symbol E) is a recommended range of a preferable mixing ratio in the present invention. These mixing ratios are recommended when the immediate effect is mainly considered.

  Horse oil used in claims 1 and 5 to 6 of the present invention is very similar in composition of human sebum and its fatty acids. In particular, the proportion of α-linolenic acid, which is an unsaturated fatty acid, is also similar, and it is active that it smoothly penetrates the skin of the living body, protects cells and activates metabolism, and prevents invasion of bacteria and the like. Used for It is a well-known fact that horse oil has been used as a folklore medicine since ancient times around the world.

  FIG. 9 shows the alleviation / prevention effect on inflammation and the absorption / penetration of the mixture into the skin when a mixture of MSM powder and AFA powder is mixed with horse oil. In FIG. 9, the symbol G indicates that the weight ratio of horse oil is 9 to 2, and the mixture of MSM powder and AFA powder is 1 to 8 in weight ratio. That is, it is the range of horse oil 1 pair mixture 0.11 (code | symbol I)-4 (code | symbol L). When the weight ratio of horse oil exceeds 9, absorption / penetration into the skin becomes saturated, and when the mixture exceeds 8 weight ratio, the inflammation prevention / relief effect becomes saturated. Therefore, the range of this code G is the application range of the mixing ratio of the present invention. Moreover, the code | symbol H is the weight ratio of horse oil 8-8, and the mixture of MSM powder and AFA powder is 2-5 by weight ratio. That is, a recommended range of the mixing ratio of the present invention is 0.25 (sign J) to 1 (sign K) of horse oil to one mixture. This is a range obtained from the results of emphasizing absorption and penetration into the skin while maintaining the necessary mitigation and prevention effects on inflammation. However, it is not necessarily limited to this ratio depending on the situation.

  Next, the invention according to claim 6 is a method for rapidly absorbing and penetrating a site having symptoms such as pain due to inflammation through the skin. Thus, a taping tape excellent in adhesiveness, stretchability, breathability and the like is applied to a normal ointment. Apply and use what was adjusted to have a viscosity almost equal to the type (ointment). The taping tape is widely used particularly for the purpose of supporting muscles that move the joints, and the tape to which the active ingredient is attached makes it possible to adjust and select the contact time with the skin.

  According to the inventions described in claims 1 to 5, each substance composed of MSM and AFA, which are effective in preventing and / or alleviating inflammation such as joint pain, neuralgia, and back pain, are mixed so as to obtain a synergistic effect. It is possible to mix horse oil with a composition similar to that of human sebum into an ointment or a mixture with viscosity equivalent to this, and to penetrate and absorb directly from the skin of the living body to a site with painful symptoms such as inflammation. Because it was made, the pain was quickly recovered and was effective immediately. It is also convenient to use because it is an odorless anti-inflammatory agent. Furthermore, the anti-inflammatory agent according to the present invention is a naturally-derived component and has no side effects on the living body and can be used with peace of mind by users.

  According to the invention described in claim 6, a mixture of horse oil, MSM powder and AFA powder, which is close to the composition of human sebum, is mixed at a certain ratio on the adhesive surface of the tape, which has adhesiveness, elasticity and breathability. Since the dispersed ointment is placed, it is convenient to use as an anti-inflammatory agent.

  As described above, according to the present invention, natural MSM powder and AFA powder, which have an effect of preventing and / or alleviating inflammation such as joint pain, neuralgia, and back pain, are mixed to obtain a synergistic effect. By mixing horse oil close to the composition of human sebum into an ointment-like or a mixture with viscosity equivalent to this, it is penetrated and absorbed directly from the percutaneous into sites with symptoms such as inflammation. An anti-inflammatory agent with rapid recovery and immediate effect and curability was obtained. It is also convenient for use because of its odorless anti-inflammatory agent. Furthermore, the anti-inflammatory agent according to the present invention is a naturally-derived component and has no side effects on the living body and can be used with peace of mind by users.

  Next, examples of the anti-inflammatory agent according to the present invention will be described together with a table.

  What changed the compounding example of each component about the anti-inflammatory agent which concerns on this invention, and its effect are shown to (1)-(30) of Table 3.

  In Table 3, anti-inflammatory agents having different blends of MSM and AFA powder were applied to the affected area every day before going to bed, and the state of pain was observed over time. The test subjects were 3 men and women in their 40s, 50s and 60s with pains such as joint pain, low back pain, and stiff shoulders, for a total of 18 people. In addition, the appearance of immediate effect in anti-inflammatory action indicates the number of days that the subject felt that the pain was relieved, and the appearance of delayed action indicates the number of months of healing when the recurrence of pain became less felt. ing.

In Table 3, (1) to (6) are MSM simple substance and 80 mesh powder, and (25) to (30) are AFA simple substance and 60 mesh powder.
(7) to (12) are MSM 800 mg, 30 mesh powder, purity 99.8%, melting point 107 ° C., ash content 0.1%, moisture content 0.1%. AFA was 200 mg, 90 mesh powder, nutrients were 70 g protein per 100 g, carbohydrates 25 g, lipids 1 g, vitamins and minerals 2 g, chlorophyll a 1.2 g, and water 1 g.
(13) to (18) are MSM of 500 mg, 80 mesh powder, purity of 99.8%, melting point of 107 ° C., ash content of 0.2%, and water content of 0.3%. AFA was 500 mg, 60 mesh powder, and nutrients were 70 g protein per 100 g, 15 g carbohydrate, 5 g lipid, 5 g vitamin / mineral, 1 g chlorophyll a, and 4 g water.
(19) to (24) are MSM of 200 mg, 90 mesh powder, purity of 99.0%, melting point of 107 ° C., ash content of 0.1%, and water content of 0.3%. AFA was 800 mg, 30 mesh powder, and nutrients were 60 g protein per 100 g, 20 g carbohydrates, 8 g lipids, 8 g vitamins / minerals, 0.5 g chlorophyll a, and 3.5 g water.
Thus, MSM powder is at least a 30-90 mesh powder of natural origin, if the purity is 99.0% or more, the melting point is 107 ° C or more, the ash content is 0.2% or less, and the water content is 0.3% or less Good. The AFA powder is at least a 30-90 mesh green powder made from natural materials. Nutrients are 60-70 g protein per 100 g, 15-25 g carbohydrates, 1-8 g lipids, 2-8 g vitamins and minerals, chlorophyll a Of 0.5 to 1.2 g and moisture of 1 to 5 g.

From Table 3, (1) to (6) using MSM powder alone have a slow effect with an immediate effect of 3 to 4 days and a delayed effect of 7 to 8 months. Moreover, in the case of (25)-(30) which used the powder of AFA independently, an immediate effect is late | slow with 5-8 days and a delayed effect is 7-8 months. Compared with these, the examples (7) to (24) of the present invention have an immediate effect as early as 1 to 3 days and a delayed effect as 3 to 5 months due to the synergistic effect of MSM and AFA. The number is fast and has excellent anti-inflammatory action. (Corresponding to claims 1 to 5)
In Table 3, horse oil, which reinforces absorption and penetration into the skin, has a one-to-one ratio to the mixture of MSM powder and AFA powder in order to effectively exhibit immediate and delayed effects on inflammation. Mixed with.

  Next, Table 4 shows the evaluation of compatibility of MSM powder and AFA powder mixed with horse oil close to the composition of human sebum in direct application and use on taping tape. In addition to these evaluations, in the remarks column, the penetration and absorption of each mixture into the skin and the viscosity compared to those of a commonly used ointment type (ointment type) are shown. In the viscosity comparison column, “slightly high”, “slightly low”, and “pretty low” mean “viscosity similar to an ointment” in the present invention.

In order to produce a mixture for direct application, a mixture of MSM powder and AFA powder that has a viscosity equivalent to or slightly lower than the usual ointment type (ointment form) is a horse oil close to the composition of human sebum To mix and disperse.
In addition, to produce a mixture for taping tape, the mixture of MSM powder and AFA powder is close to the composition of human sebum so that it has a viscosity equivalent to or equivalent to the ointment type (ointment type) that is usually used. Mix and disperse in horse oil.

In Table 4, “appropriate” when applied directly to the skin has a viscosity that remains firmly on the epidermis when applied to the skin, and “appropriately applied” means that it is slightly out of the viscosity range but can be used. is there.
In addition, “appropriate” in sticking tape has a viscosity that stays firmly on the adhesive surface when placed on the adhesive surface of the tape, and “appropriately” means that it is slightly out of the viscosity range but can be used. It is. In addition, “appropriate” in penetrating / absorbing means that it penetrates the skin smoothly with a slight rubbing when applied to the skin, and “appropriately conforming” means that the degree of friction is slightly large. It can be used.

In Table 4, in (1) to (18), the MSM powder is 800 to 200 mg, and the AFA powder is 200 to 800 mg. Moreover, horse oil is 500-5000 mg.
In (1) to (3), MSM is a naturally derived 80 mesh powder having a purity of 99.8%, a melting point of 107 ° C., an ash content of 0.2%, and a moisture content of 0.3%. AFA is a 60 mesh powder. Nutrients are 70g protein per 100g, carbohydrates 15g, lipids 5g, vitamins and minerals 5g, chlorophyll a 1g, and moisture 4g.
In (4) to (18), MSM is a naturally derived 30 mesh powder having a purity of 99.8%, a melting point of 107 ° C., an ash content of 0.1%, and a water content of 0.1%. AFA is 80 mesh powder, and nutrients are 70g protein per 100g, carbohydrates 25g, lipids 1g, vitamins / minerals 2g, chlorophyll a 1.2g and moisture 1g.
Thus, the MSM powder is a white powder of at least 30 to 90 mesh derived from nature, having a purity of 99.0% or more, a melting point of 107 ° C or more, an ash content of 0.2% or less, and a water content of 0.3% or less. I just need it. The AFA powder is at least a 30-90 mesh green powder of natural materials. Nutrients are 60-70 g of protein, 15-25 g of carbohydrates, 1-8 g of lipids, 2-8 g of vitamins and minerals, chlorophyll a per 100 g. Is 0.5 to 1.2 g and the water content may be 1 to 5 g.

  In the case of direct application and tape sticking use, (4) to (9) in which horse oil is mixed 1 to 1.5 times with a mixture of MSM powder and AFA powder has an appropriate viscosity. These formulation examples serve as a guide for the amount used per day. (Corresponding to claims 5 to 6)

MSM is manufactured by American Ingredient. This product is a product from Teda pine, and when taken orally as a health food, the recommended daily intake is 1 to 1.5 g. When it is mixed with AFA and used in a transdermal manner as in the invention, 1 g or less is sufficient.
Table 5 shows the component composition of MSM powder and its characteristics.

In Table 5, “optimum” in penetrability means that it penetrates smoothly into the skin when applied to the skin, and “suitable” means that the friction penetrates to some extent. "Appropriately conforming" means that the degree of friction is slightly large, but it can be used, and "unsuitable" indicates that it does not easily penetrate even after a long period of friction. In addition, “optimal” in the mixing property indicates that a slight amount of stirring is sufficient when mixing with AFA powder and horse oil, and “appropriate” means that general mechanical stirring is sufficient. “Appropriately applicable” means that mechanical agitation requires time but can be used.
MSM powder tends to solidify as the number of meshes increases, but it can be used by adding 0.5% of silicon dioxide.

  As shown in Table 5, the composition of (5) and (6) is about 99.8% for MSM powder, about 80 mesh, moisture is 0.3% or less, and 0.5% of silicon dioxide is added to the skin. It is excellent in permeability and mixing with other components, and is more suitable for use because the powder is less likely to solidify. However, other compositions can be applied. For example, the purity of MSM is 99.0% or more, the water content is 0.3% or less, the ash content is 0.2% or less, and 30 to 90 mesh can be used.

Next, AFA used Blue Green Algae manufactured by Klamath Valley Botanicals. When taken orally as a health food, the recommended daily intake is usually 1 to 1.5 g, but 1 g or less is sufficient when mixed with MSM and used transdermally as in the present invention. It is.
Table 6 shows the component contents and characteristics of the AFA powder.

  In Table 6, “appropriate” in penetrability means that it penetrates the skin smoothly when it is applied to the skin, and “appropriately fit” means that the degree of friction is somewhat. Large but can be used. In addition, “adequate” in the mixing property means that general mechanical agitation is sufficient when mixing with MSM powder and horse oil, and “appropriately” means that mechanical agitation requires time. “Unsuitable” indicates that a long period of mechanical stirring is required.

  As shown in Table 6, the composition of (5) and (6) of AFA powder with 60 mesh and water content of 5 g or less is excellent in skin permeability and miscibility with other components, but other compositions are also applicable. Is possible. For example, nutrients are 60-70 g protein per 100 g, 15-25 g carbohydrates, 1-8 g lipids, 2-8 g vitamins and minerals, 1-5 g water, 30-90 mesh, and can be used. .

  Table 7 shows the characteristics of horse oil.

In Table 7, “optimum” in penetrating / absorbing means that it penetrates the skin smoothly when it is applied to the skin, and “suitable” means that the friction penetrates to some extent. "Appropriately conforming" means that the degree of friction is slightly large but can be used. In addition, “optimum” in elongation indicates that the elongation to the skin is very excellent, “suitable” indicates that the elongation is excellent, and “appropriately” means that Although the degree of elongation is slightly inferior, it can be used.
In addition, “optimal” in the mixing property indicates that a slight stirring is sufficient when mixing with the MSM powder and the AFA powder, and “appropriate” indicates that a general mechanical stirring is sufficient. “Appropriately applicable” means that mechanical agitation requires time but can be used.

  In the examples, pure horse oil produced by Hitoyoshi Agricultural Co., Ltd. was used as the horse oil. Moreover, the tape used for sticking in the Example is Battlewin Cerapore tape manufactured by Nichiban Co., Ltd., having a width of 75 mm and a length of 100 mm. In addition, the pasting type in an Example stuck what applied the half amount of the component by the mixing | blending of Table 4 to the affected part for about 12 hours. As a frequency of use per day, it is a guide to stick these two times.

  The above-described embodiments are merely examples of the anti-inflammatory agent in the present invention, and the components, the mixing ratios, the constituent materials / materials, and the processes are not limited to those described above.

The structure of a cell membrane. Explanatory drawing of the metabolic pathway of arachidonic acid involved in inflammation. Cell structure diagram of cyanobacteria (AFA). Explanatory drawing of the conversion process of sulfur. Penetration chart of MSM into cyanobacteria (AFA). Penetration of cyanobacteria (AFA) into somatic cells. Penetration of MSM and AFA components into the cytoplasm. The evaluation figure of the inflammation prevention- alleviation effect by the mixing ratio of MSM powder and AFA powder. Evaluation chart of absorption / penetration into skin and prevention / relief effect of inflammation by mixing ratio of MSM powder and AFA powder (mixture) and horse oil.

Explanation of symbols

1 Cell membrane 2 Phospholipid 3 Constituent protein 4 Peripheral protein 5 Sugar chain 6 of peripheral protein Arachidonic acid 7 of cell membrane phospholipid 7 Release of arachidonic acid into the cytoplasm 8 Endoperoxide prostaglandins G2, H2
9 Prostaglandins I2, E2, F2
10 Inflammation, fever, pain 11 Thromboxane A2
12 Thrombus formation, asthma attack 13 5-HPTEE (5-hydroperoxyicosatetraene)
14 Leukotrienes A4, B4, C4, D4, E4
15 Inflammation, asthma attack 16 Cell wall 17 DNA
18 Sulfur 19 Dimethyl sulfide (DMS)
20 Dimethylsulfoxide (DMSO)
21 Dimethylsulfone (DMSO ₂ )
= Methylsulfonylmethane (MSM) and MSM chemical formula 22 MSM (Promoting penetration)
23 Cytoplasm 24 AFA
25 Discharge of waste products to the extracellular space 26 Transfer of MSM and AFA components to the cytoplasm A Application range of mixing ratio of MSM powder and AFA powder B Recommended range of mixing ratio of MSM powder and AFA powder C Weight ratio MSM powder 8 pairs Point D of AFA powder 2 Weight ratio MSM powder 6.7 to AFA powder 3.3 Point E Weight ratio MSM powder 5 to AFA powder 5 Point F Weight ratio MSM powder 2 to AFA powder 8 Point G MSM powder and AFA Application range of mixing ratio of powder (mixture) and horse oil H Recommended range of mixing ratio of MSM powder and AFA powder (mixture) and horse oil I Weight ratio 9 points of horse oil to mixture 1 J Weight ratio 8 ratio of horse oil to mixture Point 2 2 Weight ratio Horse oil 5 to Mixture 5 Point L Weight ratio Horse oil 2 to Mixture 8 Point

Claims (6)

  A mixture of natural methyl sulfonyl methane (MSM) powder and aphanizomenon floss aqua (AFA) powder in a certain ratio is mixed with animal-like sebum (particularly fatty acid composition). An anti-inflammatory agent that is mixed in oil and fat at a certain ratio to form an ointment or a mixture having a viscosity equivalent to this, and can be applied to the skin of a living body.   The anti-inflammatory agent according to claim 1, wherein the mixing ratio of the methylsulfonylmethane (MSM) powder and the aphanizomenon furosqua (AFA) powder is 1 to 0.25 to 4 by weight ratio. .   Methylsulfonylmethane (MSM) powder is a white powder of at least 30 to 90 mesh derived from nature, has a methylsulfonylmethane (MSM) purity of 99.0% or higher, a melting point of 107 ° C or higher, and an ash content of 0 The anti-inflammatory agent according to claim 1 or 2, wherein the anti-inflammatory agent is 2% or less and water content is 0.3% or less.   Afanizomenon Floss Aqua (AFA) powder is at least a 30-90 mesh green powder of natural materials. Nutrients are 60-70 g protein per 100 g, 15-25 g carbohydrates, 1-8 g lipids, vitamins and minerals 3 to 8 g, chlorophyll a is 0.5 to 1.2 g, and the water content is 1 to 5 g.   Methylsulfonylmethane (MSM) powder and aphanizomenon froth aqua are used for 1 part by weight of horse oil that is similar to the composition of human sebum as animal oil to promote penetration and absorption into the skin through the body. 5. A mixed powder in which (AFA) powder is blended at a certain ratio is mixed and dispersed at a ratio of 0.1 to 4 parts by weight to form an ointment or a mixture having a viscosity equivalent thereto. The anti-inflammatory agent described in 1.   Horse oil, methylsulfonylmethane (MSM) powder and aphanizomenon floss aqua (AFA), which are close to the composition of human sebum as animal fat, on the adhesive surface of adhesive tape, stretchable and breathable taping tape 6. The anti-inflammatory agent according to any one of claims 1 to 5, wherein a mixture in which a powder is mixed at a constant ratio to form an ointment is disposed so that it can be attached to the skin of a living body.