JP2008104451A5 - - Google Patents

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JP2008104451A5
JP2008104451A5 JP2007200458A JP2007200458A JP2008104451A5 JP 2008104451 A5 JP2008104451 A5 JP 2008104451A5 JP 2007200458 A JP2007200458 A JP 2007200458A JP 2007200458 A JP2007200458 A JP 2007200458A JP 2008104451 A5 JP2008104451 A5 JP 2008104451A5
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lactic acid
producing
continuous fermentation
microorganism
porous membrane
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JP2007200458A
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JP5141126B2 (en
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本発明の連続発酵法によるＤ−乳酸の製造方法の好ましい態様によれば、前記の微生物が、バシラス（Ｂａｃｉｌｌｕｓ）属に属することであり、バシラス（Ｂａｃｉｌｌｕｓ）属に属する微生物がバシラス・ラエボラクティカス（Ｂａｃｉｌｌｕｓ ｌａｅｖｏｌａｃｔｉｃｕｓ）であることである。According to a preferred embodiment of the method for producing D-lactic acid by the continuous fermentation method of the present invention, the microorganism belongs to the genus Bacillus, and the microorganism belonging to the genus Bacillus is Bacillus laevolacti. It is a cas (Bacillus laevolyticus).

Claims (12)

Ｄ−乳酸を生産する能力を有する微生物もしくは培養細胞の培養液を分離膜で濾過し、濾液から生産物を回収するとともに未濾過液を培養液に保持または還流し、かつ、発酵原料を培養液に追加する連続発酵によるＤ−乳酸の製造方法であって、該分離膜として平均細孔径が０.０１μｍ以上１μｍ未満の多孔性膜を用い、膜間差圧を０.１から２０ｋＰａの範囲として濾過処理することを特徴とする連続発酵によるＤ−乳酸の製造方法。   The culture solution of microorganisms or cultured cells having the ability to produce D-lactic acid is filtered through a separation membrane, the product is recovered from the filtrate, the unfiltered solution is retained or refluxed, and the fermentation raw material is used as the culture solution. A method for producing D-lactic acid by continuous fermentation added to the above, wherein a porous membrane having an average pore size of 0.01 μm or more and less than 1 μm is used as the separation membrane, and the transmembrane pressure difference is in the range of 0.1 to 20 kPa. A method for producing D-lactic acid by continuous fermentation, characterized by performing a filtration treatment. 多孔性膜の純水透過係数が、２×１０−９ｍ３／ｍ２／ｓ／ｐａ以上６×１０−７ｍ３／ｍ２／ｓ／ｐａ以下であることを特徴とする請求項１記載の連続発酵によるＤ−乳酸の製造方法。 The pure water permeability coefficient of the porous membrane is 2 × 10 −9 m 3 / m 2 / s / pa or more and 6 × 10 −7 m 3 / m 2 / s / pa or less. The manufacturing method of D-lactic acid by continuous fermentation of description. 多孔性膜の平均細孔径が０.０１μｍ以上０.２μｍ未満であり、かつ、該平均細孔径の標準偏差が０.１μｍ以下であることを特徴とする請求項１または２記載の連続発酵によるＤ−乳酸の製造方法。   3. The continuous fermentation according to claim 1, wherein the porous membrane has an average pore diameter of 0.01 μm or more and less than 0.2 μm, and a standard deviation of the average pore diameter of 0.1 μm or less. A method for producing D-lactic acid. 多孔性膜の膜表面粗さが０.１μｍ以下であることを特徴とする請求項１から３のいずれかに記載の連続発酵によるＤ−乳酸の製造方法。   The method for producing D-lactic acid by continuous fermentation according to any one of claims 1 to 3, wherein the membrane surface roughness of the porous membrane is 0.1 µm or less. 多孔性膜が多孔性樹脂層を含む多孔性膜である請求項１から４のいずれかに記載のＤ−乳酸の製造方法。   The method for producing D-lactic acid according to any one of claims 1 to 4, wherein the porous membrane is a porous membrane comprising a porous resin layer. 多孔性膜の膜素材にポリフッ化ビニリデン系樹脂を用いることを特徴とする請求項１から５のいずれかに記載の連続発酵によるＤ−乳酸の製造方法。   The method for producing D-lactic acid by continuous fermentation according to any one of claims 1 to 5, wherein a polyvinylidene fluoride resin is used as a membrane material of the porous membrane. 微生物が、バシラス（Ｂａｃｉｌｌｕｓ）属に属することを特徴とする請求項１から６のいずれかに記載の連続発酵によるＤ−乳酸の製造方法。The method for producing D-lactic acid by continuous fermentation according to any one of claims 1 to 6, wherein the microorganism belongs to the genus Bacillus. 微生物が、バシラス・ラエボラクティカス（Ｂａｃｉｌｌｕｓ ｌａｅｖｏｌａｃｔｉｃｕｓ）であることを特徴とする請求項１から７のいずれかに記載の連続発酵によるＤ−乳酸の製造方法。The method for producing D-lactic acid by continuous fermentation according to any one of claims 1 to 7, wherein the microorganism is Bacillus laevolacticus. 微生物が、Ｄ−乳酸デヒドロゲナーゼの酵素活性を増強している微生物であることを特徴とする請求項１から６のいずれかに記載の連続発酵によるＤ−乳酸の製造方法。   The method for producing D-lactic acid by continuous fermentation according to any one of claims 1 to 6, wherein the microorganism is a microorganism having enhanced enzyme activity of D-lactic acid dehydrogenase. 微生物が、Ｄ−乳酸デヒドロゲナーゼをコードする遺伝子を組み込んだ組換え微生物であることを特徴とする請求項９記載の連続発酵によるＤ−乳酸の製造方法。 The method for producing D-lactic acid by continuous fermentation according to claim 9, wherein the microorganism is a recombinant microorganism into which a gene encoding D-lactic acid dehydrogenase is incorporated. 組換え微生物が酵母であることを特徴とする請求項１０記載の連続発酵によるＤ−乳酸の製造方法。 The method for producing D-lactic acid by continuous fermentation according to claim 10, wherein the recombinant microorganism is yeast. Ｄ−乳酸デヒドロゲナーゼをコードする遺伝子が、ラクトバチルス・プランタラム（Ｌａｃｔｏｂａｃｉｌｌｕｓ ｐｌａｎｔａｒｕｍ）、およびペディオコッカス・アシディラクティシ（Ｐｅｄｉｏｃｏｃｃｕｓａｃｉｄｉｌａｃｔｉｃｉ）、およびバシラス・ラエボラクティカス（Ｂａｃｉｌｌｕｓ ｌａｅｖｏｌａｃｔｉｃｕｓ）由来の遺伝子であることを特徴とする請求項９から１１のいずれかに記載の連続発酵によるＤ−乳酸の製造方法。
The gene encoding D-lactate dehydrogenase is derived from Lactobacillus plantarum, Pediococcus acidilactici, and Bacillus laevolacticus The method for producing D-lactic acid by continuous fermentation according to any one of claims 9 to 11.
JP2007200458A 2006-09-26 2007-08-01 Method for producing D-lactic acid by continuous fermentation Expired - Fee Related JP5141126B2 (en)

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