JP2007252367A5 - - Google Patents

Claims (13)

  The fermentation broth of microorganisms or cultured cells is filtered through a separation membrane, the product is recovered from the filtrate, the unfiltered liquid is retained or refluxed in the fermentation broth, and the fermentation raw material is added to the fermentation broth A method for producing a chemical by continuous fermentation, wherein a porous membrane having pores with an average pore diameter of 0.01 μm or more and less than 1 μm is used as the separation membrane, and the transmembrane pressure difference is 0.1 to 20 kPa. A method for producing a chemical product by continuous fermentation, characterized by subjecting to filtration in the range described above. The pure water permeability coefficient of the porous membrane is 2 × 10 ⁻⁹ m ³ / m ² / s / pa or more and 6 × 10 ⁻⁷ m ³ / m ² / s / pa or less. The manufacturing method of the chemical product by continuous fermentation of description.   The average pore diameter of the porous membrane is in the range of 0.01 µm or more and less than 0.2 µm, and the standard deviation of the average pore diameter is 0.1 µm or less. A method for producing chemicals by continuous fermentation.   The method for producing a chemical product by continuous fermentation according to any one of claims 1 to 3, wherein the porous membrane has a membrane surface roughness of 0.1 µm or less.   The method for producing a chemical product by continuous fermentation according to any one of claims 1 to 4, wherein the porous membrane is a porous membrane including a porous resin layer.   The method for producing a chemical product by continuous fermentation according to any one of claims 1 to 5, wherein the membrane material of the porous membrane contains polyvinylidene fluoride.   The method for producing a chemical product by continuous fermentation according to any one of claims 1 to 6, wherein the fermentation broth of the microorganism or cultured cell and the fermentation raw material contain saccharides.   The method for producing a chemical product by continuous fermentation according to any one of claims 1 to 7, wherein the chemical product is an organic acid or an alcohol.   The fermentation broth of microorganisms or cultured cells is filtered through a separation membrane, the product is recovered from the filtrate, the unfiltered liquid is retained or refluxed in the fermentation broth, and the fermentation raw material is added to the fermentation broth An apparatus for producing a chemical product by continuous fermentation, comprising a fermentation reaction vessel for fermenting and culturing microorganisms or cultured cells, and a separation membrane inside the fermentation reaction vessel connected via a fermentation culture fluid circulation means A membrane separation tank for filtering the fermentation broth and a means for controlling the transmembrane differential pressure of the separation membrane in the range of 0.1 to 20 kPa. A continuous fermentation apparatus characterized by being a membrane. The transmembrane pressure of the separation membrane, a continuous fermentation apparatus according to claim 9, wherein the controller controls the liquid level difference of the fermentation broth and the porous membrane treated water by the water head difference control device. The continuous fermentation apparatus according to claim 9 or 10 , wherein the transmembrane pressure difference of the separation membrane is controlled by a pressurizing pump or / and a suction pump. Continuous fermentation apparatus according to any one of the transmembrane pressure of the separation membrane, the claim 9, characterized in that controlled by the pressure of the gas or liquid 11. The continuous fermentation apparatus according to any one of claims 9 to 12 , wherein the fermentation culture medium circulation means is a circulation pump.