JP2009065970A5 - - Google Patents

Claims (8)

  The fermentation broth of microorganisms or cultured cells is filtered through a separation membrane, the product is recovered from the filtrate, the unfiltered liquid is retained or refluxed in the fermentation broth, and the fermentation raw material is added to the fermentation broth A method for producing a chemical product by continuous fermentation, wherein the fermentation broth is filtered using a porous membrane having pores having an average pore diameter of 0.01 μm or more and less than 1 μm as the separation membrane, A method for producing a chemical product by continuous fermentation, wherein a part of a fermentation broth containing microorganisms or cultured cells is extracted from the fermentation broth.   The method for producing a chemical product by continuous fermentation according to claim 1, wherein the filtration treatment is performed with a transmembrane pressure difference in the range of 0.1 to 20 kPa. The pure water permeability coefficient of the porous membrane is 2 × 10 ⁻⁹ m ³ / m ² / s / pa or more and 6 × 10 ⁻⁷ m ³ / m ² / s / pa or less. 3. A method for producing a chemical product by continuous fermentation according to any one of items 1 to 2.   The average pore diameter of the porous membrane is in the range of 0.01 µm or more and less than 0.2 µm, and the standard deviation of the average pore diameter is 0.1 µm or less. The manufacturing method of the chemical by continuous fermentation in any one.   The method for producing a chemical product by continuous fermentation according to any one of claims 1 to 4, wherein the porous membrane has a membrane surface roughness of 0.1 µm or less.   The method for producing a chemical product by continuous fermentation according to any one of claims 1 to 5, wherein the porous membrane is a porous membrane including a porous resin layer.   The method for producing a chemical product by continuous fermentation according to any one of claims 1 to 6, wherein the membrane material of the porous membrane contains polyvinylidene fluoride.   The liquid of an amount substantially equal to the volume of the fermentation broth containing microorganisms or cultured cells extracted out of the system is added to the fermentation broth. A method for producing chemicals by continuous fermentation.