JP2008094736A - Antioxidative plant extract and external preparation, cosmetic, bath medicine and detergent containing the extract - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain an antioxidative plant extract that is safe to the skin and has an excellent sense of use and an antioxidative effect, an external preparation, a cosmetic, a bath medicine and a detergent composition. <P>SOLUTION: The antioxidative plant extract comprises an extract of a mixture of Coptis japonica Makino, Phellodendron amurense Ruprecht, Scutellaria baicalensis Georgi and Gardenia jasminoides Ellis. The antioxidative external preparation, the cosmetic, the bath medicine and the detergent composition contain each the extract. A medicine obtained by decocting the crude medicines in a fixed ratio is called Ourengedokutou in traditional Chinese medicine and is said to have an effect on nasal bleeding, sleeplessness, neurosis, gastritis, hangover, stale blood, dizziness, palpitation by internal use. The extract of the mixture of these crude medicines has synergistic antioxidative effect in comparison with an extract of single crude medicine and takes effect on antiaging action such as chapped skin, prevention of wrinkles, etc., by an external use. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an antioxidant plant extract and cosmetics, bath preparations and detergent compositions containing the extract, and rough skin and wrinkles are generated by eliminating active oxygen generated in skin cells. The present invention relates to an antioxidant plant extract effective for preventing skin aging and the like, and a cosmetic, a bath preparation and a detergent composition containing the extract.

  When human skin is in a healthy state, it has moderate homeostasis and usually does not require special care, but various environmental factors (eg temperature change, humidity change, light, contact with water, etc.) ) Often causes changes and problems. For example, exposure to ultraviolet rays generates active oxygen in the dermis, and this active oxygen causes collagen and hyaluronic acid to become fragmented, leading to aging phenomena such as skin wrinkles.

  Conventionally, in order to prevent skin aging, various antioxidant plant extracts have been used in addition to antioxidants such as ascorbic acid and α-tocopherol. For example, one or two or more kinds of plant extracts selected from leguminous onionis, mistletoe mistletoe, urchinaceae sabacusin, and asteraceae eucalyptus are blended as antioxidants. One or more extracts selected from the group consisting of external preparations for skin (Patent Document 1), purple pepper, glaze, semi-summer, cinnamon, cinnamon bark, yellow ginseng, carrots, licorice and ginger as a radical scavenger And a radical scavenger (Patent Document 2).

JP 2003-267822 A Japanese Patent Laid-Open No. 02-193930

  However, conventional antioxidant components have not yet been satisfied in terms of touch, durability of the antioxidant effect, and safety.

  The present invention solves such a problem, and contains an antioxidant plant extract that is safe to the skin and has a synergistic antioxidant effect, and an anti-aging action on the skin. The cosmetics, bath preparations and detergent compositions shown are provided.

  In order to solve the above-mentioned problems, the present inventors searched various plant extracts and mixtures thereof. As a result, extracts having the same composition as that of Kampo's formula (Orendetoto) are synergistically superior. The present invention was completed by finding that it exhibits an antioxidant effect. That is, the present invention is an antioxidant plant extract composed of an extract of a mixture of auren, autaku, ougon and sanshishi, and more specifically 0.2 to 3.8 parts (parts by mass, the same shall apply hereinafter) of 0. It is an antioxidant plant extract comprising an extract of a mixture of 2 to 3.8 parts, Ogon 0.3 to 7.5 parts and Sanshishi 0.2 to 5 parts. , An antioxidant plant extract composed of an extract of a mixture of 0.6 to 3 parts of buckwheat, 1.2 to 6 parts of hornon, and 0.8 to 4 parts of Sanshishi. It is an antioxidant plant extract consisting of an extract of 3 parts, a mixture of 1.1 to 2.3 parts of buckwheat, 2.1 to 4.5 parts of buckwheat and 1.4 to 3 parts of sanshishi, more specifically water. Or extraction with alcohols or mixtures thereof Antioxidant plant extract, cosmetic composition, bath preparation composition or detergent composition, characterized in that it is an antioxidant plant extract as a product, and contains the antioxidant plant extract .

  The plants used in the present invention are shown below, and any of them can use leaves, stems, roots, flowers, seeds or whole plants. In addition, herbal medicines originating from the following plants may be used.

（１） Ouren: Coptis japonica Makino, C. chinensis Franchet, C. Deltoides CYCheng et Hsiao or C. teeta Wallich
(2) Buckwheat: Bark excluding pericarp of Phellodendron amurense Ruprecht or Phellodendron chinense Schneider (Rutaceae)
(3) Ogon: Roots excluding pericytes of Scutellaria baicalensis Georgi (Lamiaceae)
(4) Sanshishi: The fruit of Gardenia jasminoides Ellis (Rubiaceae), but the type of each herbal medicine is not limited to this, and varieties, homologous species, and other related species can also be used.

  Auren Gokuto is a combination of 4 kinds of Aureen, Aubaku, Ougon, Sanshishi, and decocted. If you take this decoction for people who are relatively healthy and tend to be annoyed with redheads , Nose bleeding, insomnia, neurosis, gastritis, hangover, bloody thrombosis, dizziness, pest control [Natural Product Pharmacy (Shuji Itokawa, Taichi Omoto, Masahiro Nagai, Riki Furuya, Published by Asakura Shoten, April 10, 1987 version)].

  Astragalus is a pruritus, rash, discolored skin, hot flashes, and a burning sensation of the affected area, and it is said that it is more effective by internal use if the affected area is not dry. Edited by Yakuren Kampo Special Committee, supervised by Ministry of Health and Welfare, Pharmacy Bureau, published by Yakuho Jihosha, April 30, 1992, 4th edition, 12 prints)].

  The active ingredient is extracted from these plants using a suitable solvent. Examples of the solvent include water, alcohols (for example, lower alcohols such as methanol, absolute ethanol, and ethanol, or polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, and dipropylene glycol). Any mixture can be used. Moreover, after extraction, the extract is diluted or concentrated and dried as necessary.

  The production method is not particularly limited, and may be in the range of the boiling point of the solvent at normal temperature or normal pressure, and a microwave extraction method or a supercritical extraction method may be used. After extraction, filtration or ion exchange resin may be used for adsorption, decolorization, and purification to form a solution, paste, gel, or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and usual means generally applied depending on the extracted substance may be arbitrarily selected.

  The herbal medicine used in the present invention provides a highly effective extract from those extracted by combining four types, and preferably a highly effective extract is obtained from a combination of four types extracted at a specific ratio. Therefore, it is more effective than those extracted individually from each other, arbitrarily extracted by combining up to three kinds of plants, and mixed with each extract or extract. In addition, since the antioxidant effect improves more by extracting and combining 4 types of plants, and the result that the improvement effect with respect to rough skin becomes further favorable, what was extracted combining 4 types of plants, preferably Is considered to be sufficiently meaningful to use a combination of four types extracted at a specific ratio.

  The compounding amount of each herbal medicine used in the present invention is a collection of experienced Chinese medicine prescriptions (published by Nippon Shokudo Co., Ltd., 9th edition, 1993), and a guide to general Chinese medicine prescriptions (edited by the National Pharmacopoeia Special Committee, Ministry of Health and Welfare) Supervised by the Ministry of Affairs, published by Yakuho Jihosha, published on April 30, 1992, 4th edition, 12th edition), but the preferred blending amount is 0.2 to 3.8 parts of urene (mass parts, the same applies hereinafter) ), 0.2 to 3.8 parts of buckwheat, 0.3 to 7.5 parts of buckwheat, and 0.2 to 5 parts of sushi, and more preferably 0.6 to 3 parts of auren, 0.6 to 3 parts of buckwheat. , 1.2 to 6 parts ougon and 0.8 to 4 parts sanshishi, most preferably 1.1 to 2.3 parts oulen, 1.1 to 2.3 parts oyster, 2.1 to 4.5 ougon Part and Sanshishi 1.4-3 parts.

  In addition to the essential antioxidant plant extract of the present invention, the antioxidant external preparation composition, cosmetic composition, bath composition and detergent composition according to the present invention are, for example, cosmetics as described below. It can be produced by using a base, an additive and the like that are usually used in the above.

(1) Various fats and oils: avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber oil, safflower Oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, Coconut oil, beef tallow, lard, or hydrogenated products of these oils (hardened oil, etc.).

(2) Waxes: beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax, squalene, squalane, pristane and the like.

(3) Mineral oil: liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcrystalline wax and the like.

(4) Fatty acids: natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid, 2 -Synthetic fatty acids such as ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) Alcohols: natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

(6) Polyhydric alcohols: ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, glycerin, diglycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters: isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate , Diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.

(8) Metal soaps: aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, saccharides or water-soluble polymer compounds: gum arabic, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose or esters thereof , Trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethylchitin or chitosan, hydroxyalkyl (C2 to C4) chitin or chitosan to which alkylene (C2 to C4) oxide such as ethylene oxide is added, small molecule Chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, heparin, ethylcellulose, methyl Cellulose, carboxymethyl cellulose, carboxyethyl cellulose, carboxyethyl cellulose sodium, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide, polypropylene oxide, etc. Polyalkylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, polyethyleneimine and the like.

(10) Surfactant: Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt), Amphoteric surfactant [carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant], nonionic surfactant Agents (ether type nonionic surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing type nonionic surfactants), other surfactants Agents (natural surfactants, derivatives of protein hydrolysates, polymer surfactants, surfactants containing titanium and silicon, Tsu carbon-based surface active agent), such as.

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), Riboflavin (vitamin B2), pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acid, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or derivatives thereof, vitamin D group: Ergocalciferol (vitamin D2), cholecalciferol (vitamin D3), dihydrotaxosterol, vitamin E group: vitamin E or derivatives thereof, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2 , Menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, .gamma.-oryzanol, orotic acid, vitamin P such (rutin, eriocitrin, hesperidin), and vitamin U.

(12) Various amino acids: valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxy Amino acid derivatives such as lysine, arginine, ornithine, histidine, and their sulfates, phosphates, nitrates, citrates, or pyrrolidone carboxylic acids.

(13) Various additives derived from plant or animal materials: These are processed in a conventional manner according to the product type and form to be added (for example, pulverization, milling, washing, hydrolysis, fermentation, Purify, squeeze, extract, fractionate, filter, dry, pulverize, granulate, dissolve, sterilize, adjust pH, deodorize, decolorize, etc.) And serve.

  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided, or the processing performed later. Usually, water, a water-soluble organic solvent (for example, ethanol, propylene glycol) , 1,3-butylene glycol, and the like) are preferably used. However, when it is not preferable to contain an organic solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. The thing extracted and extracted may be sufficient.

  In addition, when using additives derived from plant or animal-based ingredients for systemic or topical external preparations and cosmetics, skin and hair are protected, touch and texture are improved, flexibility is added, and irritation is alleviated. , Aroma stress relief, cell activation (cell aging prevention), inflammation suppression, skin and hair quality improvement, rough skin prevention and improvement, hair growth, hair growth, hair loss prevention, glossiness, cleansing effect, fatigue In addition to cosmetic effects such as relaxation, blood flow promotion, and bathing effects, effects such as flavoring, deodorization, thickening, antiseptic and buffering can also be expected.

  In addition to this, various cosmetic and pharmaceutical effects of each of the known raw materials are expected, and by combining these, the intended effect can be promoted or multifunctional. It is also possible to make the product expected to be effective.

Specific plants used as raw materials include, for example, almond, eye, blue quail, aoki, Aokiri or Kenashiaogiri, Aotsuki-rafuji, acacia, red pepper, red currant, red grape, redwood (logwood), red-crowned, red, red or yellow Aki larch, Akinire, Aguahe (Omanten palm), Akebi, Asa, Maruba asagao or Asagao, Hydrangea, Ashitaba, Azuki, Acerola, Asenyaku, Achilla (Anchorana), Anise, Abemaki, Ama, Amacha, Amachaa, Amacha (Amaranthus, Hypochondriacus), Amigasayuri or Baba (Amaranthus, Hypochondriacus) Mo, Arcana (Arkanna), Argarovo (Cabbage), Altea, Arnica, Alpinia or Katsumadai (Suzukuku), Aloe, Aloe Vera, Angelica, Apricot or Honzu, Ansokkou, Igakouzorina, Ikarisou or Yatsuma Taikoshi (Isoyokakuta) , Yew, Strawberry, Fig, Ichihatsu, Ichibi, Ichiyakusou, Ginkgo biloba, Itohimegi, Locust Bean, Inazuna (Tailexi), Inubibi (Honagainubiyu), Rice, Inondo, Ibukikosou, Nettle, Iranian Iran, Iwa tobacco, Iwa tobacco, Iwa tobacco, Iwa cigarette , Wheat (Chibusanoki), Spiraea, Warbler, Japanese duckweed, Duckweed, Usbasaicin or Keirinsaishin or Oshusaishin Usbenia mushroom, Usbenitachaoi, Nepenthes, Udo or Shishido, Unyadegato (Unkalia, Cats Claw), Uba tea, Ume, Vulgara, Uwaurushi (Kusakokemo), Unsumikan, Estragon, Ezocogi, Echinashibisugakue Or Cassia Tora, El Campre, Elderberry, Elemi, Elingi or Pre-Lotus Elinge, Enju, Ogi or Kibanaougi, Okarasuuri (Karokon), Oguruma, Ootsuki Rafuji, Obaco, Toucanami, Obanaokera or Okera, Obera , Steller's chabushi, sea hawthorn or hawthorn, seisei (narukoyuri, kagulmabanarukoyuri), yukisanoyuki or sasano Yuki, Barley, Oshigusa, Oka, Okazeri, Oguruma, Okra, Panax Ginseng or Tochibaninjin, Hypericum or Ginseng or Hypericum Hypericum, Odrichospodium, Onomomi, Onigorori, Nigorio , Halibut, ominae, yuuko, dutch mustard (watercress), dutch jellies, dutch honey bees, olives, oregano, orange, silkworm, cacao, oysters, scallops, oysters or cantris, cassia, casino oysters, oaks, cascarilla, cascarilla Sagrada, gypsophila, cynomolgus, kaniwa, valerian, birch or fern birch, pumpkin, kapok, Japanese cabbage , Cattail, chamomile or roman chamomile, camilla deer, camouflage (camo duck), calax salmon man, crow cucumber or cinnamon cucumber, crow birch, oats, guarana, carahoo, karaya, karin, garcinia, kawamidori, kawadashi, kawara kawade Carrot, Kawaramugi, Kansui, Kanzo, Kantara Asa, Candelilla, Ganto, Canna, Raspberry (Ezo Strawberry, Dutch Strawberry, Shrimp Strawberry, Maple Strawberry, Maple Strawberry, European Raspberry), Kiwi, Kikarasuri, Kyoji, Chrysanthemum, Chrysanthemum Bark, pheasant, kizuta, kidachi aloe, kidachiha mint, kina, linden (shinkona, red linden), quinoa Quinoa), kihada, gymnema sylvestre, cabbage, cabbage, cucumber, gyory, kiraja saponaria, kiraya, giraffe, kumquat, betel, guinea pig, guava, guayule, quellus infectria, cucumber, kuco Gooseberry, Ginseng, Gardenia, Kunugi, Kupuas, Kumazasa, Kumamatsura, Clara, Cranberry, Chestnut, Curkurigo Latifolia, Grapefruit, Chrysanthemum, Scarlet Mochi, Kurobana Hioki Koshi, Gunby Tuna (Sekimei, Sekimeishi), Keii Kenashi Sartorii rose, Gentiana, Gennoshouko, Kemponashi (Kigushi), Kokisekoku, Kishimizukan (Koji, Tachibana) , Tiger beetle, buckle mandarin, sagamikoji, ponkan, santara, koshinbara, kouseihakka, kozo, kocha, kohone, kohon, kouliang, koryokukyo, cilantro, kouren, koganebana, kobemo, coconut palm, coconut palm, coffee , Kobushi or magnolia, burdock, kobotanru, sesame, sesame seedling, trash, honeysuckle or binankazura or pine bush, wheat, rice or rice bran, rice oil, cola acuminata, cola vera, coloha, colombo, kondurango, kombu, konnyaku, comfrey , Sisal (Sisal Asa), Saxima button eel or Syna button eel or Cinnamon, Sakura (Oshima cherry, Yamazakura, Oyamazakura, Edhigashi, (Cherry tree, cherry tree, cherry tree, cherry tree, cherry tree, butterfly cherry, butterfly, cherry tree, cherry tree, cherry tree, cherry tree, pomegranate, sweet cherry, sweet cherry, sweet potato, sweet cherry, saffron, pomegranate) , Salvia (Sage), Sagaki Kyo, Sawagurumi, Sangre de Grado (Croton), Salamander, Sancyn carrot, Sanshuyu, Salamander, Sandscon, Shea (Kalite), Cyanoki, Shiitake, Zion, Diquitaris, Sikunshi, Perilla or Aojiso Or Chile-swordfish or Catamenziso, Rosewood, Shinanoki, Shinohonoki, Sinarenyo, Shimeji (Hinshimeji, Shakashimeji, Hatake-shimeji, Hatake-shimeji, Oshiroi-shimeji (Bunashimeji, Honjimeshi, Shirotamogitake), Shimotsetsu, Potato, Peonies, Shajin, Jasmine (Matsurika), Janohige, Shukukonkamiso, Shukushamitsu, Juzudama, Shuro, Zouzan hydrangea, Shobu, Shozuk, Shiroshiroshi, Shirokushi, Shirogoshi, Shirogoshi, Shirogashi (Small squirrels), white butterfly, white minten, cinchona sylbra, ginkgo biloba, cinnamon, watermelon, honeysuckle, sorrel, swimberry, stevia, strawberry, succulent, horsetail, sedgefish, plum, spruce, red pine, larch , Hawthorn, dandelion, horse chestnut (marronnier), pear, sunflower, elderberry (Elder), Alaska spruce (Juniper), Achillea millefolium (milfoil), Rose rose, Aurora butterfly, Atlantic mistletoe, Atlantic mint or Astragalus vulgaris, Horseradish, Sekisho, Sekkoku, Cedron , Celery, Senkyu, Senshinren, Sendang, Senburi, Senna, Senninsou, Soka, Buckwheat, Somerna potato, Daiou, Daikon, Soybean, Daidai, Takasaburo, Takatodai, Takakawabi, Dark Sweet Cherry, Tachiaoi, Tachikoso (Time), Tachidokoro ), Twillow, Tamarind, Onion, Tamshiba, Taranoki, Tarwi, Tanjin, Dandelion or Shirobana Dandelion or Mouko Dandelion, Da Maru, Cherry, Chigaya, Chikutsujinjin, Chicory, Chunky Piedra (Kantachi Komikansou), Ginseng, Chrysanthemum, Korean Artemisia, Choreimaitake, Chorogi, Tsukimiso, Tsukuritake (mushroom), camellia, camellia, clover, tsutsukuzu, , Tsurudokudami, Tsuruna, Tsuru carrot, Tsukibuki, Deiko, Teuchigurumi, Duberry, Tengusa, Tencha, Tendaiyaku, Toga, Tokazura, Pepper, Touki, Tokinsenka (Marigold), Tonabena, Corn or Corn, Tosenin Gentian, Tokusa, Dokudami, Tokone, Toshishi or Mamedaoshi or Nekakazura, Tochu, Toneriko, Tomato, Tragacanth, Triaca Soss, Tormentilla, Doronoki, Trolley, Nigeria berry, Chinese yam or Yam, Nagii Kada (Butcher Bloom), Naginata jujube, Natsuna, Rapeseed, Solid bean or Natehaki, Natsumikan, Natsume, Naniwaibara, Navena, Nangko, Naruco Karamushi, Nigaki, Mugwort, Kay or Nikkei or Ceylon Nikkei or Yabu Nikkei or Keishi, Japanese leek, elderberry, garlic, Nurde, Leek, Nemoki or Neb or Nebi or Nemurioki or Jigokubana, Nosami, Neubara, Yarrow, Rosewood, Rose , Pineapple, hibiscus (Busouge, Furinbussouge, Roselle), Hailindou, Hakamaurabosi, Huxen, Hakuruberry, Jacobe, Hazel , Hasilidokoro, Basil, Lotus, Parsley (Netherlands Jeri), Hadakamugi, Batata, Bee or Makake, Patchouli, Hakka, Barley (Yokuinin), Hanasuge, Banana, Hanahakka, Hanabishi (Shinshiri, Shishitsuri), Vanilla Bins, Hahakobusa , Paprika, clam or honey bee, hamasge, habishi, hamanasu (maikai flower), hakuboufu, hamamelis, rose, agaric (agaric, white-bellied agaric), haran, parulis (agricultural) ), Harunire, Harindou, Handaikai, Pannoki, Hinogi, Hikarutsu Carrot, Puer Tea, Pecan Nuts, Higanbana, Hishi, Pistachio, Beet, Hitotsuba, Human Baenida, Hinata Taikozuchi, Hinoki, Hiba, Castor, Sunflower, Bell Pepper, Himeuzu, Himegama, Himematsutake, Pimenta, Bikushi, Byakuyu, Hiyu, Blowout, Toucan , Fujibacama, Fujibean, Grape, Beech, Fuyumushinatsutake, Brazilian licorice, Brazilian carrot, Black currant, Blackberry, Plum, Fruceraria, Blueberry, Prunes, Blond psyllium, Bundow, Hazelnut, Loofah, Safflower , Henken, Belladonna, Berry, Permianburg, Astragalus or Stingweed, Boysenberry, Butterberry or Sardine or Nendoroid or Hahagigi A, Butterflies, Apricots, Bowfish, Spinach, Physalis, Physalis, Bokeh, Sorrel, Prunus giraffes, Sorrels, Barnacles, Bodaiju, Buttons, Buttons, Hops, Jojoba, Bordeaux, Water berries, Hononiku, Honsenkoku , Maou, maca, macadamia nuts, macri, mugwa, magnolia sprengueri, mashua (Tamanosenhalen, Kyukonkinrenka), matatabi, matsukasa, pine, matsuhod, matico (cordon sillo), maryoram (hanakakka), malvano jarro, mulberry , Mangosteen, Manzanya (Andesca mitselle), Mangougurumi, Mandarin, Mannentake, Pheasant, Mishimashiko, Mizuoobako or Mizuasagao, Mi Zokukushi, Misohagi, Mitsanagi or Niwayanagi, Mitsuwashi, Mitsuba, Green Hazel, Mimosa, Myouga, Miracle Fruit, Myrrh, Milobaran, Wheat Wark, Mukge, Mukunoki, Mukuroji, Munya, Murasakikibuchi, Osamaki , Meowugi, Melaroika, Melissa, Merilot, Melon, Moukomugigi, Mosouchiku, Mogi (Pepper), Mokko, Momijidaio, Peach, Moyashi, Morello Cherry, Morohaya, Yakawa Murasakiimo, Yakuchi, Yagurumaha, Yagurumaha , Yacon, Yashabushi or Himeyashabushi or Oobaya Shabushi, Yachiyanagi, Yatsude, Mistletoe, Willow (Kawayanagi, Tachiyanagi, Weeping willow) Red Willow, Pussy Willow, Incolye, Kinu Willow, Koryanagi, Unryu Willow, Miyama Willow, Palm, Sorbus Willow, Obayanagi, Tairikukinyanagi, Foxwood Willow, Yuzugariya, Tobacco Yucca or flevifolia, Yuzu, Lily, Yoroigusa, Mugwort, Ligan, Lime, Rye, Lacanca, Raspberry, Latania (Clamelia), Lackey or Shallot, Lavender, Longan, Agave (Relican agave, Fuchlin agave), Ryochia, Apple, Lebass or Suavisimus, Reishi, Lettuce (Chisha), Red Currant, Lemon, Lemongrass, Les Line or Sina forsythia, Rengesou, Rouyashi, Lokon (Yoshi), loganberry, rosemary (Rosmarinus officinalis), rose hip (Novara), wasabi, and the like Burnet.

  In addition, other seawaters such as sea salt, dried seawater, dead sea or Atlantic or Pacific seawater (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango), such as Sea mud or mud in various regions such as Italy, France, Germany, Eifel and Franceburg (Contained components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide) Strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone and so on.

  As seaweeds, seaweed [Green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaonori, Susiaoonori, Hiraonori), seaweed [Brown algae: Kombu, Macub Hosome Kombu, Mitsuishi Kombu), Wakame, Hirome, Aowakame, Giant Kelp (Macrocystis pirifera, Macrocystis integrofolia, Hijiki, Hibamata), seaweed [Red algae: Hijirimen, Maxa (Tengusa)], Nettle, cypress, prickly pear, caterpillar, yatabegusa, yui-kiri, striped primrose, crested beetle, spruce rhinoceros, crested rhinoceros, giraffe rhinoceros, ginseng giraffe, horned mackerel Mata, carrageen (Yahazutsunomata), Ezotsunomata, Togetsunomata, Hirakotoji, Kotojitsunomata, Suginori, Shikin'nori, Kainori, Ibotsunomata, Yareusubanori, Kagiusubanori, Sujiusubanori, Haiusubanori, Akamomijinori] and the like as a representative.

  In addition, animal-derived materials include poultry extract, bovine, porcine or human placenta extract, porcine or bovine stomach, duodenum or intestinal extract or its degradation product, porcine or bovine spleen extract Or a degradation product thereof, an extract of porcine or bovine brain tissue, a water-soluble collagen, a collagen derivative such as acylated collagen, a collagen hydrolyzate, elastin, an elastin hydrolyzate, a water-soluble elastin derivative, keratin and a degradation product thereof, or Derivatives thereof, silk proteins and degradation products thereof or derivatives thereof, porcine or bovine blood cell protein degradation products (globin peptides), porcine or bovine hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, Casein and its degradation products or their derivatives, skim milk powder and their degradation products or their derivatives, lactoferrin or their degradation products, chicken Component, fish meat decomposition products such as.

(14) Microbial culture metabolite yeast metabolite, yeast extract, natto metabolite, natto extract, rice fermented extract, rice bran fermented extract, euglena extract, lactic acid fermented milk or skim milk or trehalose or derivatives thereof Such.

(15) α-hydroxy acids, glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments silicic anhydride, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, Bengala, black iron oxide, gunjo, chromium oxide, chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt, dihydroxy Dimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-aminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, paradimethylaminobenzoic acid) Amyl, octyl paradimethylaminobenzoate, etc.), methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, paramethoxycinnamate) Octyl acid, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, diparamethoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene salicylate) Glycol, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (such as methyl anthranilate), urocanic acid derivatives (such as urocanic acid, ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives , Imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives Allantoin derivatives, nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, soribenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, Escalol, zinc oxide, talc, kaolin, etc.

(18) Whitening agent: p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound, benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, Pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivative, kojic acid or its derivative, naphthol or its derivative Naphthol glycosides or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract, ellagic acid, lucinol and the like.

(19) Tyrosinase activity inhibitor: vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or a derivative thereof (hydroquinone benzyl ether, etc.), kojic acid or a derivative thereof, naphthol or a derivative thereof, Naphthol glycoside or derivative thereof, vitamin E or derivative thereof, N-acetyltyrosine or derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, lucinol, silk extract, plant extract (camomile , Mulberry, touki, firewood, clara, mugwort, honeysuckle, yellowfin, dolphin, matsuhod, barley, nettle, hops, hawthorn, eucalyptus, yarrow, artea, keihi, mankei, hamamelis, yamagwa Life-extending grass, bellflower, toshishi, sequel, shot dried, mahuang, senkyu, dokatsu, psycho, boufu, hamboufu, gongo, peony, peonies, genus shochu, kurkon, licorice, pentaploid, aloe, shouma, safflower, green tea, tea, Asen).

(20) Melanin pigment reduction / decomposition substance: phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether), vitamin C or its derivative ( Vitamin C phosphate magnesium salt, vitamin C glucoside) and the like.

(21) Turnover promoting action / cell activator: hydroquinone, lactic acid bacteria extract, placenta extract, ganoderma extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe , Ogon, Horsetail, Gentian, Burdock, Sikon, Carrot, Clam, Hop, Yokuinin, Odorikosou, Semburi, Toki, Ginseng, Achacha, Hypericum, Cucumber, Pleurotus, Rosemary, Parsley).

(22) Astringent: succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compounds) and the like.

(23) Lipid peroxide production inhibitor: β-carotene, plant extract (sesame culture cells, hamcha, hypericum, clams, clove, melissa, birch, birch, sage, rosemary, minamitenji, agetsu, ginkgo, green tea), etc. .

(24) Anti-inflammatory agents: ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or Its salt, glycyrrhetinic acid or its salt, licorice extract, sicon extract, age extract, allantoin, etc.

(25) Antibacterial / bactericidal / disinfectant: Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T , Salicy powder, iodine compound, iodoform, sorbic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p -Chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, Irgasan CH3565, halocarban, hexachlorophene, chlorohex Gin, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octyl Phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, potassium lauroyl sarcosine, etc.), cationic surfactants (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, Hexamine, brilliant green, malachite green, crystal violet, jamal, photosensitizer 01 No., photosensitizer No. 201, photosensitizer No. 401, N- long chain acyl basic amino acid derivative and its acid shark salts, zinc oxide, hinokitiol, etc. sophora root.

(26) Moisturizer: glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt , Sodium lactate, mini sasanishiki extract, natto bacteria metabolite, natto extract and so on.

(27) Elastase activity inhibitor: diisopropyl fluorophosphate, plant extract (Ogon, Hypericum, Clara, Mulberry leaf, Keihi, Genso pepper, Comfrey, Sage, Elderberry, Bodaige, Buttonpi), seaweed extract and the like.

(28) Hair preparation: selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castari tincture, pepper tincture, pepper tincture, quinine hydrochloride, strong ammonia water, potassium bromate, sodium bromate, Such as thioglycolic acid.

(29) Antiandrogens: follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendrone, etc.

(30) Peripheral vascular blood flow promoter: Vitamin E or its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, toki extract, cephalanthin, carpronium chloride, minoxidil and the like.

(31) Local stimulants: chili pepper tincture, capsaicin, capsaicin glycoside, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(32) Metabolic active agent: Photosensitive element 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placenta extract, biotin, pentadecanoic acid glyceride and the like.

(33) Antiseborrheic agents: pyridoxine or derivatives thereof, sulfur, vitamin B6 and the like.

(34) Keratolytic agents: resorcin, salicylic acid, lactic acid and the like.

(35) Bath warming agents: sodium hydrogen carbonate, sodium carbonate, sodium sesquicarbonate, sodium sulfate, dry sodium sulfate, anhydrous sodium sulfate, anhydrous silicic acid, calcium silicate, and the like.

(36) Fragrance: Natural animal fragrance such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil , Cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil , Otsuka perfume essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, trout balsam essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, persimmon essential oil, hiba essential oil, sandalwood essential oil, petitgren essential oil, bay essential oil, vetiva essential oil, Berga Plant essential oils such as coconut essential oil, peru balsam essential oil, boad rose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, Japanese mint mint essential oil Such. Synthetic perfume ingredients include aliphatic hydrocarbons, terpene hydrocarbons, aromatic hydrocarbons and other hydrocarbons, aliphatic alcohols, terpene alcohols, aromatic alcohols and other alcohols, aliphatic ethers, aromatic ethers and other ethers Oxides, aliphatic oxides, terpene oxides, aliphatic aldehydes, terpene aldehydes, hydrogenated aromatic aldehydes, aldehydes such as thioaldehydes, aromatic aldehydes, aliphatic ketones, terpene ketones, hydrogenated aromatics Ketones such as aromatic ketones, aliphatic cyclic ketones, non-benzene aromatic ketones, aromatic ketones, acetals, ketals, phenols, phenol ethers, fatty acids, terpene carboxylic acids, hydrogenated aromatic carboxylic acids, Acids such as aromatic carboxylic acids, acid amides, aliphatic lactones Lactones such as cyclic lactones, terpene lactones, hydrogenated aromatic lactones, aromatic lactones, aliphatic esters, furan carboxylic acid esters, aliphatic cyclic carboxylic acid esters, esters such as aromatic carboxylic acid esters, Nitrogen-containing compounds such as nitromusks, nitriles, amines, pyridines, quinolines, pyrrole and indole. More specific examples of synthetic fragrances include, for example, 1996 published by Chemical Industry Daily, Motoichi Into (Synthetic fragrance chemistry and product knowledge), 1969, by Stefan Arcamder (Perfume and Flavor Chemicals <Perfume and) Flavors described in Flavor Chemicals>) and the like can be suitably used. The main fragrances are shown below. Aldehyde C6-C12, anisaldehyde, acetal R, acetophenone, acetyl cedrene, adoxal, allyl amyl glycolate, allyl cyclohexane propionate, alpha damascon, beta damascon, delta damascon, ambrette lid, ambroxan, amyl Cinnamic aldehyde, amyl cinnamic aldehyde dimethyl acetal, amyl valericate, amyl salicylate, isoamyl acetate, isoamyl salicylate, uranium thiol, acetyl urgenol, bacdanol, benzyl acetate, benzyl alcohol, benzyl salicylate, bergamyl acetate, bornyl acetate , Butyl butyrate, para tertiary butyl cyclohexanol, para tertiary butyl Chlohexyl acetate, ortho-tertiary butylcyclohexanol, benzaldehyde, benzyl formate, potassium olefin, cashemalan, carvone, cedro amber, cedryl acetate, cedrol, cerythrid, cinnamic alcohol, cinnamaldehyde, cis jasmon, citral, citral Dimethyl acetal, citrusal, citronellol, citronellyl acetate, citronellyl formate, citronellyl nitrile, cyclaset, cyclamenaldehyde, cyclaprop, caron, coumarin, cinnamyl acetate, delta C6-C13 lactone, dimethylbenzyl carbinol, dihydrojasmon , Dihydrolinalol, dihydromyrcenol, dimethol, dimyrcetol, di Enyl oxide, ethyl vanillin, eugenol, fluitate, fenthyl alcohol, phenylethylphenyl cetate, galakisolid, gamma C6-C13 lactone, geraniol, geranyl acetate, geranyl formate, geranyl nitrile, hedion, helional, heliotropin, cis-3- Hexenol, cis-3-hexenyl acetate, cis-3-hexenyl salicylate, hexyl cinnamamic aldehyde, hexyl salicylate, hyacinth dimethyl acetal, hydrotropic alcohol, hydroxy citronellal, indole, innon, isobornyl acetate, isocyclo Citral, iso-E super, isoyuugenol, isononyl acetate, isobutyl quinoline, jasmar, di Examples include jasmolactone, jasmofilan, coabon, ligustral, lyial, lime oxide, limonene, linalool, linalool oxide, and linalyl acetate.

(37) Dye: Colorant Red cabbage dye, red rice dye, akane dye, anato dye, squid dye, turmeric dye, enju dye, krill dye, koji dye, caramel, gold, silver, gardenia dye, corn dye, onion dye , Tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin etc.

  Others, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, cooling agents, stabilizers, emulsifiers, animal / plant proteins or their degradation products, animal / plant polysaccharides or the like Degradation products, animal / plant glycoproteins or their degradation products, anti-inflammatory agents / antiallergic agents, wound treatment agents, foams / foaming agents, thickeners, oral preparations, deodorants / deodorants, enzymes, etc. In combination with these, various additive or synergistic effects can be expected.

  The cosmetic composition, bath preparation composition, and detergent composition of the present invention are liquid, emulsion, base, gel, powder (powder), granule, pellet, stick, solid, etc., respectively. It may be provided as any form.

  Cosmetic compositions include lotion, milky lotion, cream, oil, ointment, pack, lip, lipstick, foundation, eyeliner, blusher, mascara, eye shadow, nail polish / pedicure, nail coating, nail coating removal Agent, shaving agent, shampoo, rinse, hair treatment, hair tonic, hair spray, hair cream, hair lotion, hair conditioner, hair restorer, permanent liquid, hair dye, hand soap / body soap, toothpaste, mouthwash , Facial cleansers and soaps.

  The bath agent composition is used by bathing in bath water at the time of bathing, and may be in any form such as liquid, powder, granule, solid or gel. In the case of powder, granule or solid, it is also possible to produce the antioxidant plant extract of the present invention by spraying it in a liquid state and drying it without drying.

  Examples of the detergent composition include daily kitchen detergent, bathroom, basin or toilet detergent, glass cleaner, glasses / contact lens cleaner, car cleaner, and building material cleaner.

  In addition, it can be impregnated in sanitary goods, wet type tissue paper, non-woven fabric, paper towel, cotton and the like.

  In the cosmetic composition and the detergent composition of the present invention, the antioxidant plant extract is used as a dry extract containing about 0.001 to 5% by mass, preferably about 0.01 to 1% by mass. Good properties can be obtained. Moreover, in a bath agent composition, it can be used at 0.001-99 mass%, Preferably when it contains 0.1-30 mass%, usability is good and a favorable result is obtained. The amount used in one batch may be set so that the concentration in the hot water when actually used is 0.00001 to 0.01% by mass, preferably about 0.0005 to 0.005% by mass.

  The production examples, test examples, and formulation examples will be described below, but the present invention is not limited thereto.

[Example 1]
500 ml of water was added to the mixture of herring herbs, ie, 1.5 g of Auren, 1.5 g of Oubak, 3 g of Ogon, and 2 g of Sanshishi, followed by reflux extraction for 1 hour. Subsequently, this was filtered to obtain an extract, and further concentrated and dried to obtain 5 g of a yellow powdery extract of the present invention.

[Example 2]
500 L of water was added to each of the mixed herbal medicines, ie, 1.5 kg of Auren, 1.5 kg of Oubak, 3 kg of Ogon, and 2 kg of Sanshishi, and refluxed for 1 hour. Subsequently, this was filtered to obtain an extract, and further concentrated and dried to obtain 3.5 kg of a yellow powdery extract of the present invention.

[Example 3]
500 ml of a 30% ethanol aqueous solution was added to each mixture of herring herbs, ie, 1.5 g of Auren, 1.5 g of Oubak, 3 g of Ogon, and 2 g of Sanshishi, followed by reflux extraction for 1 hour. Next, this was filtered to obtain 450 ml of the extract of the present invention.

[Comparative Example 1]
93.75 ml of 30% aqueous ethanol solution was added to 1.5 g of urene, followed by reflux extraction for 1 hour. Next, this was filtered to obtain 85 ml of an extract.

[Comparative Example 2]
To 1.5 g of buckwheat, 93.75 ml of 30% aqueous ethanol solution was added, followed by reflux extraction for 1 hour. Next, this was filtered to obtain 85 ml of an extract.

[Comparative Example 3]
187.5 ml of 30% ethanol aqueous solution was added to 3 g of orgone, and the mixture was refluxed for 1 hour. Next, this was filtered to obtain 170 ml of an extract.

[Comparative Example 4]
125 g of 30% ethanol aqueous solution was added to 2 g of Sanshishi, followed by reflux extraction for 1 hour. Next, this was filtered to obtain 115 ml of an extract.

[Comparative Example 5]
85 ml of the Auren extract of Comparative Example 1, 85 ml of the Aoba extract of Comparative Example 2, 170 ml of the Augon extract of Comparative Example 3, and 115 ml of the Sanshishi extract of Comparative Example 4 were mixed to obtain 455 ml of the extract mixture of Comparative Example 5. It was.

[Test Example 1] Safety test, evaluation of skin irritation In order to evaluate the skin irritation of the antioxidant plant extract of the present invention, a patch test was conducted with 45 healthy persons (men and women aged 24 to 58). It was.
(Sample) A product obtained by swelling the antioxidant plant extract obtained in Examples 1 and 2 with purified water (Method) For each sample, a skin sensitization test tape “Fin Chamber” (manufactured by Taisho Pharmaceutical Co., Ltd.) The test was performed by applying occlusion for 24 hours to the subject's upper arm flexor and the inner forehead. That is, the sample was removed at the time when 24 hours had passed after the application, and after 1 hour, the skin condition was observed and judged, and the average value was shown in Table 1.
(Criteria) Judgment was performed according to the following criteria.
(+) Positive: Those with erythema. (±) false positive: Minor erythema or suspected erythema. (-) Negative: No reaction was observed.

  From Table 1, the antioxidant plant extract by this invention did not recognize skin irritation.

[Test Example 2] Antioxidant Test Using the antioxidant of Example 3, 2,2-diphenyl-1-picrylhydrazyl (hereinafter referred to as DPPH) radical scavenging activity was measured to evaluate the antioxidant action. As a comparative control, the result of measurement using the extract mixture of Comparative Example 5 under the same conditions was used.

The DPPH radical scavenging activity was measured as follows. Using Example 3 and Comparative Example 5 as samples, 2 ml of each sample prepared at each concentration is placed in a test tube, then 2 ml of 0.1 M acetate buffer (pH = 5.5) is added, and finally 2,2- 1 ml of diphenyl-1-picrylhydrazyl (DPPH) ethanol solution is added. This was allowed to stand at room temperature for 30 minutes, and then the absorbance (S) of light having a wavelength of 517 nm derived from the DPPH radical was measured. When the absorbance when each production example is not added is defined as (A), the DPPH radical elimination rate of each production example can be expressed by the following formula (1).
DPPH radical scavenging rate (%) = [1- (S) / (A)] × 100 Formula (1)
Further, the amount of each sample (IC50 (mg)) required to halve the DPPH radical was calculated from the graph. Values obtained from the measurement data of Example 3 are shown in Table 2, and Comparative Example 5 is shown in Table 3.

  Comparing the IC50 values in Table 2 and Table 3, the plant extract according to the present invention exhibits DPPH radical scavenging action in a smaller amount than the conventional extract extracted individually, and is extracted simultaneously after mixing each herbal medicine. , Found to have an excellent antioxidant effect.

  As a result of the above, the antioxidant plant extract according to the present invention is superior in anti-oxidation to those obtained by mixing each herbal medicine after it has been extracted by simultaneous extraction after mixing each herbal medicine. I found it effective.

Production of various external preparation compositions Various external preparation compositions according to the present invention were produced. Although the formulation example is shown below, this invention is not limited to these. All formulation examples are shown in parts by mass. All the antioxidant plant extracts of the present invention were those produced in Example 2.

[Example 4]
According to Formulation Example 1, a cosmetic base in which purified water is mixed with moisturizers such as 1,3-butylene glycol and glycerin, skin nutrients such as oleyl alcohol, and preservatives and ethyl alcohol in which a fragrance is dissolved at room temperature. To the preparation, 0.3% of the antioxidant plant extract of the present invention was blended to prepare the lotion of the present invention.

Formulation Example 1 (Lotion)
1,3-butylene glycol 6.0
Glycerin 4.0
Oleyl alcohol 0.1
Polyoxyethylene monolaurate (20)
Sorbitan 0.5
Polyoxyethylene (15) lauryl ether 0.5
Ethyl alcohol 10.0
Preservative 0.1
Fragrance 0.1
Antioxidant plant extract of the present invention 0.3
Purified water 78.4
Total 100.0

[Example 5]
In accordance with Formulation Example 2, prepare a mixture of humectants such as 1,3-butylene glycol and glycerin in purified water as the aqueous phase, and 0.3% of the antioxidant plant extract of the present invention. did. As the oil phase part, a solid oil component such as beeswax, cetyl alcohol and petrolatum, a liquid oil component such as squalane, an oily component such as an antiseptic and a surfactant, and the mixture heated to about 80 ° C. were prepared. A thickener such as quince seed was added to the aqueous phase heated to about 80 ° C., and the oil phase was gradually added and emulsified while stirring with a homomixer to obtain the emulsion of the present invention.

Formulation example 2 (milky lotion)
Cetyl alcohol 1.0
Beeslow 0.5
Octyldodecanol 2.0
Vaseline 2.0
Squalane 6.0
Ethyl alcohol 5.0
Glycerin 4.0
1,3-butylene glycol 4.0
Polyethylene glycol monooleate (10) 1.0
Lipophilic glyceryl monostearate 1.0
Quince Seed (Quince Seed) 1.0
Preservative 0.1
Fragrance 0.1
Antioxidant plant extract of the present invention 0.3
Purified water 72.0
Total 100.0

[Example 6]
In accordance with Formulation Example 3, as the water phase part, purified water mixed with a moisturizing agent such as 1,3-butylene glycol and polyethylene glycol 1500 was prepared. 3% was blended. As the oil phase part, a solid oil component such as stearic acid, stearyl alcohol and hydrogenated lanolin, a liquid oil component such as squalane and octyldodecanol, and oily components such as preservatives and surfactants were prepared. When the water phase portion was gradually heated and reached about 80 ° C., the oil phase portion heated to almost the same temperature was added little by little and emulsified to obtain the cream of the present invention.

Formulation Example 3 (Cream)
Stearic acid 2.0
Stearyl alcohol 6.0
Hydrogenated lanolin 4.0
Squalane 9.0
Octyldodecanol 10.0
1,3-butylene glycol 6.0
Polyethylene glycol 1500 4.0
Polyoxyethylene (25) cetyl ether 3.0
Glycerol monostearate 2.0
Preservative 0.1
Fragrance 0.1
Antioxidant plant extract of the present invention 0.3
Purified water 53.5
Total 100.0

[Example 7]
In accordance with Formulation Example 4, a moisturizer such as 1,3-butylene glycol and glycerin was added to purified water, and 0.3% of the antioxidant plant extract of the present invention was added thereto. This is heated to 70 to 80 ° C., a thickener such as carboxymethyl cellulose, a film agent such as polyvinyl alcohol is added and dissolved by stirring, and a solution obtained by dissolving a preservative, a surfactant, etc. in ethyl alcohol is added. Solubilized to obtain a pack of the present invention.

Formulation example 4 (pack)
Polyvinyl alcohol 15.0
Carboxymethylcellulose 5.0
1,3-butylene glycol 4.0
Glycerin 1.0
Ethyl alcohol 12.0
Preservative 0.1
Fragrance 0.1
Antioxidant plant extract of the present invention 0.3
Polyoxyethylene oleyl ether 0.5
Purified water 62.0
Total 100.0

[Example 8]
In accordance with Formulation Example 5, the water phase portion was formulated with a humectant such as 1,3-butylene glycol in purified water and 0.5% of the antioxidant plant extract of the present invention. The oil phase part is prepared by mixing preservatives and surfactants with solid oils such as beeswax, paraffin wax, microcrystalline wax, higher fatty acids, semi-solids such as petrolatum and lanolin, and liquid oils such as liquid paraffin. Dissolved by heating. Next, the water phase part was heated and dissolved at 80 ° C., and the oil phase part heated to the same degree was gradually added and emulsified with stirring to obtain the ointment of the present invention. The antioxidant plant extract in the present invention is optionally blended in an external composition base, but when the external composition consists of an aqueous phase and an oil phase, it is usually in the aqueous phase part. It is preferable to mix.

Formulation Example 5 (ointment)
Beeswax 1.0
Paraffin wax 2.5
Microcrystalline wax 0.5
Stearic acid 2.0
Cetyl alcohol 1.0
Behenyl alcohol 3.0
Polyoxyethylene monostearate (20)
Sorbitan 1.0
Tetraoleic acid polyoxyethylene (60)
Sorbitan 1.0
Self-emulsifying glyceryl monostearate 1.5
Liquid paraffin 5.0
Lanolin 1.0
Vaseline 4.0
1,3-butylene glycol 5.0
Preservative 0.1
Fragrance 0.1
Antioxidant plant extract of the present invention 0.5
Purified water 70.8
Total 100.0

[Example 9]
In accordance with Formulation Example 6, purified water containing a humectant such as glycerin or urea was prepared as an aqueous phase, and 0.5% of the antioxidant plant extract of the present invention was added thereto. As the oil phase part, a mixture of solid oils such as cetanol and petrolatum, liquid oils such as liquid paraffin, tocopherol acetate and vitamin D, preservatives, surfactants and other oily components was prepared. When the water phase part was gradually heated and reached about 80 ° C., the oil phase part heated to substantially the same temperature was added little by little and emulsified to obtain the hand cream of the present invention.

Formulation Example 6 (hand cream)
Cetanol 4.0
Vaseline 2.0
Liquid paraffin 10.0
Tocopherol acetate 0.1
Vitamin D 0.1
Urea 2.0
Glycerin 20.0
Polyoxyethylene (60)
Glycerol isostearate 2.5
Glycerol monostearate 1.5
Preservative 0.1
Fragrance 0.1
Antioxidant plant extract of the present invention 0.5
Purified water 57.1
Total 100.0

[Example 10]
In accordance with Formulation Example 7, a mixture of known humectants such as 1,3-butylene glycol and polyethylene glycol 1500 in purified water as an aqueous phase is prepared, and the antioxidant plant extract of the present invention is added to this. .5% blended. As the oil phase part, a solid oil component such as stearic acid, stearyl alcohol and glyceryl monostearate, a liquid oil component such as squalane and octyldodecanol, and oily components such as preservatives and surfactants were prepared. When the water phase is gradually heated to about 80 ° C., the oil phase heated to almost the same temperature is added little by little and emulsified to obtain a cream. To this was gradually added purified water in which potassium hydroxide was dissolved, and the mixture was saponified to obtain the face-washing cream of the present invention.

Formulation Example 7 (face wash cream)
Stearic acid 2.0
Stearyl alcohol 6.0
Hydrogenated lanolin 4.0
Squalane 9.0
Octyldodecanol 10.0
1,3-butylene glycol 6.0
Polyethylene glycol 1500 4.0
Polyoxyethylene (25) cetyl ether 3.0
Glycerol monostearate 2.0
Potassium hydroxide 0.5
Preservative 0.1
Fragrance 0.1
Antioxidant plant extract of the present invention 0.5
Purified water 52.8
Total 100.0

[Example 11]
In accordance with Formulation Example 8, a mixture of purified water and a moisturizing agent such as propylene glycol and O- [2-hydroxy-3-trimethylammoniopropyl] hydroxyethylcellulose as purified water is prepared as an aqueous phase part. 0.5% of antioxidant plant extract was blended. As the oil phase part, a blend of oily components such as polyoxyethylene (2) sodium lauryl ether sulfate, sodium lauryl sulfate, coconut oil fatty acid amidopropyl betaine, highly polymerized methylpolysiloxane, ethylene glycol distearate was prepared. When the water phase portion was gradually heated and reached about 80 ° C., the oil phase portion heated to almost the same temperature was added little by little and stirred to obtain the hair shampoo of the present invention.

Formulation Example 8 (hair shampoo)
Polyoxyethylene (2) sodium lauryl ether sulfate 9.0
Sodium lauryl sulfate 4.0
Palm oil fatty acid amidopropyl betaine 3.0
Highly polymerized methylpolysiloxane 2.0
Methyl polysiloxane 1.0
Palm oil fatty acid monoethanolamide 1.0
Propylene glycol 2.0
O- [2-hydroxy-3-trimethylammoniopropyl] hydroxyethylcellulose chloride 0.5
Ethylene glycol distearate 2.0
Preservative 0.1
Fragrance 0.1
Antioxidant plant extract of the present invention 0.5
Purified water 74.8
Total 100.0

[Example 12]
According to the formulation example 9, what mixed known moisturizers, such as glycerol, with the purified water as an aqueous phase part was prepared, and the antioxidant plant extract of this invention was mix | blended with 0.5%. Contains oil components such as solid oils such as stearyltrimethylammonium chloride, stearyl alcohol and cetyl alcohol, liquid oils such as highly polymerized methylpolysiloxane, methylpolysiloxane and liquid paraffin, preservatives and surfactants as the oil phase part I prepared what I did. When the water phase portion was gradually heated and reached about 80 ° C., the oil phase portion heated to almost the same temperature was added little by little and emulsified to obtain the hair rinse of the present invention.

Formulation Example 9 (hair rinse)
Stearyltrimethylammonium chloride 2.0
Stearyl alcohol 1.0
Cetyl alcohol 2.0
Highly polymerized methylpolysiloxane 2.0
Methyl polysiloxane 1.0
Liquid paraffin 1.0
Glycerin 6.0
Preservative 0.1
Fragrance 0.1
Antioxidant plant extract of the present invention 0.5
Purified water 84.3
Total 100.0

[Example 13]
According to the formulation example 10, what mixed known moisturizers, such as propylene glycol and glycerol, with purified water as an aqueous phase part was prepared, and 0.5% of the antioxidant plant extract of this invention was mix | blended with this. As the oil phase part, a blend of oily components such as polyoxyethylene (2) sodium lauryl ether sulfate, triethanolamine lauryl sulfate, coconut oil fatty acid amidopropyl betaine, and ethylene glycol distearate was prepared. When the water phase part was gradually heated and reached about 80 ° C., the oil phase part heated to substantially the same temperature was added little by little and stirred to obtain the body soap of the present invention.

Formulation Example 10 (Body soap)
Polyoxyethylene (2) sodium lauryl ether sulfate 15.0
Lauryl sulfate triethanolamine 5.0
Palm oil fatty acid amidopropyl betaine 5.0
Ethylene glycol distearate 2.0
Glycerol monopalmitate 1.0
Adsorption refined lanolin 2.0
Glycerin 2.0
Propylene glycol 3.0
Preservative 0.1
Fragrance 0.1
Antioxidant plant extract of the present invention 0.5
Purified water 64.3
Total 100.0

[Example 14]
According to the formulation example 11, what mixed titanium oxide, antiseptic | preservative, and the fragrance | flavor was prepared for the base for soap, and 1.0% of the antioxidant plant extract of this invention was mix | blended with this. This was die-cut and finished to obtain the solid soap of the present invention.

Formulation Example 11 (Soap)
Soap base 97.3
Titanium oxide 0.2
Preservative 0.5
Fragrance 1.0
Antioxidant plant extract of the present invention 1.0
Total 100.0

[Example 15]
In accordance with Formulation Example 12, a base agent for a bath prepared by adding a perfume and the like to sodium sulfate and sodium hydrogen carbonate is prepared, and 2.0% of the antioxidant plant extract of the present invention is blended to prepare the bath for the present invention. It was set as the agent a.

Formulation Example 12 (Bath Agent a)
Sodium sulfate 48.0
Sodium bicarbonate 48.0
Fragrance 2.0
Antioxidant plant extract of the present invention 2.0
Total 100.0

[Example 16]
According to Formulation Example 13, a surfactant was blended with oily components such as liquid paraffin, jojoba oil, preservative, and dissolved at about 60 ° C. A fragrance | flavor, purified water, etc. were added to this, the antioxidant plant extract of this invention was mix | blended 2.0%, and it was set as the bath agent b of this invention.

Formulation Example 13 (Bath Agent b)
Polyoxyethylene (5) oleyl ether 10.0
Liquid paraffin 80.0
Jojoba oil 5.0
Preservative 0.2
Fragrance 1.8
Antioxidant plant extract of the present invention 2.0
Purified water 1.0
Total 100.0

[Example 17]
According to Formulation Example 14, a cosmetic base prepared by mixing hair nutrients such as assembly extract, tocopherol acetate, pantothenyl ethyl ether, etc. with ethyl alcohol in which preservatives, fragrances and the like are dissolved at room temperature is purified. Water and 0.3% of the antioxidant plant extract of the present invention were blended to obtain a hair restorer of the present invention.

Formulation Example 14 (Hair restorer)
Ethyl alcohol 60.0
Assembly extract 5.0
Tocopherol acetate 0.2
Pantothenyl ethyl ether 0.2
Propylene glycol 5.0
Preservative 0.1
Fragrance 0.2
Antioxidant plant extract of the present invention 0.3
Purified water 29.0
Total 100.0

[Example 18]
In accordance with Formulation Example 15, as a water phase part, a mixture of purified water with a known humectant such as glycerin, a thickener such as sodium carboxymethylcellulose, carrageenan, etc. is prepared, and dicalcium phosphate dihydrate, anhydrous silicic acid. Then, sodium lauryl sulfate was mixed and 0.3% of the antioxidant plant extract of the present invention was blended. Sodium saccharin, a fragrance, and a preservative were added to a part of the purified water, and this was mixed and deaerated into the aqueous phase part to obtain a toothpaste of the present invention.

Formulation Example 15 (Toothpaste)
Dicalcium phosphate dihydrate 45.0
Silica anhydride 2.0
Glycerin 15.0
Sodium carboxymethylcellulose 1.0
Carrageenan 0.3
Sodium lauryl sulfate 1.5
Saccharin sodium 0.1
Preservative 0.1
Fragrance 0.1
Antioxidant plant extract of the present invention 0.3
Purified water 34.6
Total 100.0

[Example 19]
According to Formulation Example 16, glycerin and polyoxyethylene hydrogenated castor oil were added and dissolved in purified water. To this, 1-menthol and a fragrance dissolved in ethyl alcohol were added and mixed and dissolved. Further, sodium saccharin and chlorhexidine gluconate were added and dissolved, and 0.3% of the antioxidant plant extract of the present invention was blended to make the mouthwash of the present invention.

Formulation Example 16 (Mouth Wash)
Ethyl alcohol 40.0
Glycerin 10.0
Polyoxyethylene hydrogenated castor oil 1.0
1-menthol 0.5
Saccharin sodium 0.05
Chlorhexidine gluconate 0.02
Fragrance 0.1
Antioxidant plant extract of the present invention 0.3
Purified water 48.03
Total 100.0

[Example 20]
According to the formulation example 17, what mixed polypropylene glycol, ethyl alcohol, and antiseptic | preservative in purified water as an aqueous phase part was prepared, and 0.3% of the antioxidant plant extract of this invention was mix | blended with this. As an oil phase part, what mix | blended polyoxyethylene (2) sodium dodecyl sulfate, lauryl glucoside, and the fragrance | flavor oil component was prepared. When the water phase portion was gradually heated and reached about 80 ° C., the oil phase portion was added little by little and stirred to obtain the dishwashing detergent of the present invention.

Formulation Example 17 (Dishwashing detergent)
Polyoxyethylene (2)
Sodium dodecyl sulfate 15.0
Lauryl glucoside 12.5
Ethyl alcohol 5.0
Polypropylene glycol 3.0
Preservative 0.1
Fragrance 0.1
Antioxidant plant extract of the present invention 0.3
Purified water 64.0
Total 100.0

  The antioxidant plant extract of the present invention is safe for the skin, has a good feeling of use, has a synergistic antioxidant effect, and is an external preparation, cosmetic, bath preparation and detergent composition useful for preventing skin aging. Etc. can be provided.

Claims (10)

  Antioxidant plant extract consisting of an extract of a mixture of auren, abou, gon and sanshishi.   From an extract of a mixture of 0.2 to 3.8 parts of aurene (parts by mass, the same shall apply hereinafter), 0.2 to 3.8 parts of buckwheat, 0.3 to 7.5 parts of ougon and 0.2 to 5 parts of sashishi An antioxidant plant extract.   Antioxidant plant extract comprising an extract of a mixture of 0.6 to 3 parts of auren, 0.6 to 3 parts of buckwheat, 1.2 to 6 parts of hornon, and 0.8 to 4 parts of sanshishi.   Antioxidant plant extract consisting of an extract of a mixture of 1.1 to 2.3 parts of auren, 1.1 to 2.3 parts of buckwheat, 2.1 to 4.5 parts of hornon, and 1.4 to 3 parts of sanshishi .   The antioxidant plant extract according to any one of claims 1 to 4, which is an extract of water, alcohols or a mixture thereof.   The antioxidant plant extract according to any one of claims 1 to 5, wherein the amount of the extraction solvent is 10 to 100 times the amount of the extract.   An antioxidant external preparation composition comprising the antioxidant plant extract according to any one of claims 1 to 6.   A cosmetic composition comprising the antioxidant plant extract according to any one of claims 1 to 6.   A bath agent composition comprising the antioxidant plant extract according to any one of claims 1 to 6.   A detergent composition comprising the antioxidant plant extract according to any one of claims 1 to 6.