JP2007538046A5 - - Google Patents
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- Publication number
- JP2007538046A5 JP2007538046A5 JP2007517236A JP2007517236A JP2007538046A5 JP 2007538046 A5 JP2007538046 A5 JP 2007538046A5 JP 2007517236 A JP2007517236 A JP 2007517236A JP 2007517236 A JP2007517236 A JP 2007517236A JP 2007538046 A5 JP2007538046 A5 JP 2007538046A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- phenyl
- azabicycloaryl
- cycloalkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 125000000217 alkyl group Chemical group 0.000 claims 33
- -1 cycloalkoxy-alkoxy Chemical group 0.000 claims 28
- 229910052739 hydrogen Inorganic materials 0.000 claims 22
- 239000001257 hydrogen Substances 0.000 claims 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
- 125000001475 halogen functional group Chemical group 0.000 claims 12
- 125000005647 linker group Chemical group 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- 125000004952 trihaloalkoxy group Chemical group 0.000 claims 12
- 125000004385 trihaloalkyl group Chemical group 0.000 claims 12
- 150000001408 amides Chemical group 0.000 claims 10
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 9
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 9
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000005113 hydroxyalkoxy group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000004858 cycloalkoxyalkyl group Chemical group 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 208000002193 Pain Diseases 0.000 claims 5
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 4
- 125000001620 monocyclic carbocycle group Chemical group 0.000 claims 4
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 208000011580 syndromic disease Diseases 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000032841 Bulimia Diseases 0.000 claims 2
- 206010006550 Bulimia nervosa Diseases 0.000 claims 2
- 206010010904 Convulsion Diseases 0.000 claims 2
- 208000012661 Dyskinesia Diseases 0.000 claims 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 2
- 230000006735 deficit Effects 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 2
- 125000001543 furan-2,5-diyl group Chemical group O1C(=CC=C1*)* 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 208000013403 hyperactivity Diseases 0.000 claims 2
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims 1
- FFXRXZSONYGWKE-UHFFFAOYSA-N 5-[4-[(4-acetamidobenzoyl)amino]phenyl]-n-(1-azabicyclo[2.2.2]octan-3-yl)furan-2-carboxamide Chemical compound C1=CC(NC(=O)C)=CC=C1C(=O)NC1=CC=C(C=2OC(=CC=2)C(=O)NC2C3CCN(CC3)C2)C=C1 FFXRXZSONYGWKE-UHFFFAOYSA-N 0.000 claims 1
- XFUBNCPHMCXJLX-UHFFFAOYSA-N 5-[4-[(4-acetamidophenyl)carbamoylamino]phenyl]-n-(1-azabicyclo[2.2.2]octan-3-yl)furan-2-carboxamide Chemical compound C1=CC(NC(=O)C)=CC=C1NC(=O)NC1=CC=C(C=2OC(=CC=2)C(=O)NC2C3CCN(CC3)C2)C=C1 XFUBNCPHMCXJLX-UHFFFAOYSA-N 0.000 claims 1
- JOLXTDAVMNGZTN-UHFFFAOYSA-N 5-[4-[(4-aminobenzoyl)amino]phenyl]-n-(1-azabicyclo[2.2.2]octan-3-yl)furan-2-carboxamide Chemical compound C1=CC(N)=CC=C1C(=O)NC1=CC=C(C=2OC(=CC=2)C(=O)NC2C3CCN(CC3)C2)C=C1 JOLXTDAVMNGZTN-UHFFFAOYSA-N 0.000 claims 1
- FATWOPZMWSTGSH-UHFFFAOYSA-N 5-[4-[(4-aminophenyl)carbamoylamino]phenyl]-n-(1-azabicyclo[2.2.2]octan-3-yl)furan-2-carboxamide Chemical compound C1=CC(N)=CC=C1NC(=O)NC1=CC=C(C=2OC(=CC=2)C(=O)NC2C3CCN(CC3)C2)C=C1 FATWOPZMWSTGSH-UHFFFAOYSA-N 0.000 claims 1
- XAUYBWYEIJSSFK-UHFFFAOYSA-N 5-[4-[(4-nitrophenyl)carbamoylamino]phenyl]furan-2-carboxylic acid Chemical compound O1C(C(=O)O)=CC=C1C(C=C1)=CC=C1NC(=O)NC1=CC=C([N+]([O-])=O)C=C1 XAUYBWYEIJSSFK-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 208000000103 Anorexia Nervosa Diseases 0.000 claims 1
- 206010002660 Anoxia Diseases 0.000 claims 1
- 241000976983 Anoxia Species 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 108010009685 Cholinergic Receptors Proteins 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 208000026097 Factitious disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000001456 Jet Lag Syndrome Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 241000208125 Nicotiana Species 0.000 claims 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000010886 Peripheral nerve injury Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 206010034912 Phobia Diseases 0.000 claims 1
- 208000005374 Poisoning Diseases 0.000 claims 1
- 208000008348 Post-Concussion Syndrome Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 208000005107 Premature Birth Diseases 0.000 claims 1
- 206010036590 Premature baby Diseases 0.000 claims 1
- 206010036618 Premenstrual syndrome Diseases 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 206010052276 Pseudodementia Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 102000034337 acetylcholine receptors Human genes 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 238000001467 acupuncture Methods 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 230000007953 anoxia Effects 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 229940049706 benzodiazepine Drugs 0.000 claims 1
- 208000028683 bipolar I disease Diseases 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229960003920 cocaine Drugs 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 229960002069 diamorphine Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 206010013932 dyslexia Diseases 0.000 claims 1
- 210000000750 endocrine system Anatomy 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 201000009863 inflammatory diarrhea Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims 1
- 230000029849 luteinization Effects 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- FVPJQYCFKFHERE-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-(4-benzamidophenyl)furan-2-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C(O1)=CC=C1C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1 FVPJQYCFKFHERE-UHFFFAOYSA-N 0.000 claims 1
- DHYLXJPQQJGELU-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-[4-(carbamoylamino)phenyl]furan-2-carboxamide Chemical compound C1=CC(NC(=O)N)=CC=C1C1=CC=C(C(=O)NC2C3CCN(CC3)C2)O1 DHYLXJPQQJGELU-UHFFFAOYSA-N 0.000 claims 1
- FBJFLYCGUCJCKL-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-[4-(ethylcarbamoylamino)phenyl]furan-2-carboxamide Chemical compound C1=CC(NC(=O)NCC)=CC=C1C1=CC=C(C(=O)NC2C3CCN(CC3)C2)O1 FBJFLYCGUCJCKL-UHFFFAOYSA-N 0.000 claims 1
- GIROIHHOPDXMMD-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-[4-(phenylcarbamoylamino)phenyl]furan-2-carboxamide Chemical compound C=1C=C(C=2OC(=CC=2)C(=O)NC2C3CCN(CC3)C2)C=CC=1NC(=O)NC1=CC=CC=C1 GIROIHHOPDXMMD-UHFFFAOYSA-N 0.000 claims 1
- GNPDFUZVVRDNCE-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-[4-[(4-nitrobenzoyl)amino]phenyl]furan-2-carboxamide Chemical compound C1=CC([N+](=O)[O-])=CC=C1C(=O)NC1=CC=C(C=2OC(=CC=2)C(=O)NC2C3CCN(CC3)C2)C=C1 GNPDFUZVVRDNCE-UHFFFAOYSA-N 0.000 claims 1
- LATCUWREDXMXKX-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-[4-[[4-(cyclopropanecarbonylamino)benzoyl]amino]phenyl]furan-2-carboxamide Chemical compound C=1C=C(C(=O)NC=2C=CC(=CC=2)C=2OC(=CC=2)C(=O)NC2C3CCN(CC3)C2)C=CC=1NC(=O)C1CC1 LATCUWREDXMXKX-UHFFFAOYSA-N 0.000 claims 1
- LUEBXIMGOWHNNE-UHFFFAOYSA-N n-(1-azabicyclo[2.2.2]octan-3-yl)-5-[4-[[4-(prop-2-enoylamino)benzoyl]amino]phenyl]furan-2-carboxamide Chemical compound C1=CC(NC(=O)C=C)=CC=C1C(=O)NC1=CC=C(C=2OC(=CC=2)C(=O)NC2C3CCN(CC3)C2)C=C1 LUEBXIMGOWHNNE-UHFFFAOYSA-N 0.000 claims 1
- 201000003631 narcolepsy Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 208000019906 panic disease Diseases 0.000 claims 1
- 208000028591 pheochromocytoma Diseases 0.000 claims 1
- 208000019899 phobic disease Diseases 0.000 claims 1
- 231100000572 poisoning Toxicity 0.000 claims 1
- 230000000607 poisoning effect Effects 0.000 claims 1
- 206010036596 premature ejaculation Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 230000020341 sensory perception of pain Effects 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 230000016160 smooth muscle contraction Effects 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 0 CIB*IC1C(CC2)C=NN2C1 Chemical compound CIB*IC1C(CC2)C=NN2C1 0.000 description 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 description 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57209904P | 2004-05-19 | 2004-05-19 | |
| DKPA200400799 | 2004-05-19 | ||
| PCT/EP2005/052107 WO2005111033A2 (en) | 2004-05-19 | 2005-05-10 | Novel azabicyclic aryl derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007538046A JP2007538046A (ja) | 2007-12-27 |
| JP2007538046A5 true JP2007538046A5 (https=) | 2008-06-26 |
Family
ID=34968161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007517236A Abandoned JP2007538046A (ja) | 2004-05-19 | 2005-05-10 | 新規なアザビシクロアリール誘導体 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7514450B2 (https=) |
| EP (1) | EP1751150A2 (https=) |
| JP (1) | JP2007538046A (https=) |
| WO (1) | WO2005111033A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| PE20060437A1 (es) | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
| GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| US7932247B2 (en) * | 2004-11-15 | 2011-04-26 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
| GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| US20070275960A1 (en) * | 2006-01-25 | 2007-11-29 | Synta Pharmaceuticals Corp. | Phenyl and pyridyl compounds for inflammation and immune-related uses |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| JP6223563B2 (ja) | 2013-10-14 | 2017-11-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 選択的に置換されたキノリン化合物 |
| CN105636945B (zh) | 2013-10-14 | 2017-11-17 | 卫材R&D管理有限公司 | 选择性取代的喹啉化合物 |
| WO2016100184A1 (en) | 2014-12-16 | 2016-06-23 | Forum Pharmaceuticals, Inc. | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
| MX2017016231A (es) | 2015-06-10 | 2018-11-29 | Axovant Sciences Gmbh | Compuestos de aminobencisoxazol como agonistas de receptores a7-nicotínicos de acetilcolina. |
| WO2017027600A1 (en) | 2015-08-12 | 2017-02-16 | Forum Pharmaceuticals, Inc. | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI233805B (en) * | 1999-07-01 | 2005-06-11 | Fujisawa Pharmaceutical Co | Stabilized pharmaceutical composition in lyophilized form as antifungal agent |
| US6492386B2 (en) | 2000-08-18 | 2002-12-10 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl compounds for treatment of disease |
| US6492385B2 (en) * | 2000-08-18 | 2002-12-10 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| WO2002017358A2 (en) | 2000-08-21 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists) |
| US6599916B2 (en) | 2000-08-21 | 2003-07-29 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| EP1311505A2 (en) | 2000-08-21 | 2003-05-21 | PHARMACIA & UPJOHN COMPANY | Quinuclidine-substituted heteroaryl moieties for treatment of disease ( nicotinic acetylcholine receptor ligands ) |
| EP1394152A4 (en) * | 2001-04-19 | 2005-02-02 | Eisai Co Ltd | 2-IMINOIMIDAZOLE DERIVATIVES (1) |
| US6919359B2 (en) | 2001-11-08 | 2005-07-19 | Pfizer Inc | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease |
| CN1675204A (zh) | 2002-06-10 | 2005-09-28 | 拜耳医药保健股份公司 | 2－杂芳基甲酰胺 |
| MXPA05006861A (es) | 2003-02-27 | 2005-12-12 | Neurosearch As | Derivados arildiazabiciclicos novedosos. |
-
2005
- 2005-05-10 JP JP2007517236A patent/JP2007538046A/ja not_active Abandoned
- 2005-05-10 EP EP05743125A patent/EP1751150A2/en not_active Withdrawn
- 2005-05-10 US US10/591,871 patent/US7514450B2/en not_active Expired - Fee Related
- 2005-05-10 WO PCT/EP2005/052107 patent/WO2005111033A2/en not_active Ceased
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