JP2006519208A5 - - Google Patents
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- Publication number
- JP2006519208A5 JP2006519208A5 JP2006502001A JP2006502001A JP2006519208A5 JP 2006519208 A5 JP2006519208 A5 JP 2006519208A5 JP 2006502001 A JP2006502001 A JP 2006502001A JP 2006502001 A JP2006502001 A JP 2006502001A JP 2006519208 A5 JP2006519208 A5 JP 2006519208A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- diaza
- bicyclo
- furan
- methanone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 208000002193 Pain Diseases 0.000 claims description 10
- 208000004296 neuralgia Diseases 0.000 claims description 3
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims description 2
- 206010019233 Headaches Diseases 0.000 claims description 2
- 208000019695 Migraine disease Diseases 0.000 claims description 2
- 208000010886 Peripheral nerve injury Diseases 0.000 claims description 2
- 208000004983 Phantom Limb Diseases 0.000 claims description 2
- 206010056238 Phantom pain Diseases 0.000 claims description 2
- 208000004550 Postoperative Pain Diseases 0.000 claims description 2
- 230000001154 acute effect Effects 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 206010027599 migraine Diseases 0.000 claims description 2
- 208000021722 neuropathic pain Diseases 0.000 claims description 2
- 230000000306 recurrent effect Effects 0.000 claims description 2
- -1 nitro, 2-nitro-phenyl 2-nitro-4-methyl-phenyl Chemical group 0.000 claims 27
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000001475 halogen functional group Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- LJGHYPLBDBRCRZ-UHFFFAOYSA-N 3-(3-aminophenyl)sulfonylaniline Chemical group NC1=CC=CC(S(=O)(=O)C=2C=C(N)C=CC=2)=C1 LJGHYPLBDBRCRZ-UHFFFAOYSA-N 0.000 claims 2
- LUQVCHRDAGWYMG-UHFFFAOYSA-N 4-phenylbenzamide Chemical compound C1=CC(C(=O)N)=CC=C1C1=CC=CC=C1 LUQVCHRDAGWYMG-UHFFFAOYSA-N 0.000 claims 2
- 125000004199 4-trifluoromethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C(F)(F)F 0.000 claims 2
- 241001024304 Mino Species 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 229940047889 isobutyramide Drugs 0.000 claims 2
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- JTCCAXFNCOUGIM-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-(2-phenyl-1,3-oxazol-5-yl)methanone Chemical compound C1CN(CC2)CCC2N1C(=O)C(O1)=CN=C1C1=CC=CC=C1 JTCCAXFNCOUGIM-UHFFFAOYSA-N 0.000 claims 1
- RDPGJJQCQBWKHB-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-(5-nitrofuran-2-yl)methanone Chemical compound O1C([N+](=O)[O-])=CC=C1C(=O)N1C(CC2)CCN2CC1 RDPGJJQCQBWKHB-UHFFFAOYSA-N 0.000 claims 1
- DSQXFWNFACVYBM-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone Chemical compound C1CN(CC2)CCC2N1C(=O)C(O1)=NN=C1C1=CC=CC=C1 DSQXFWNFACVYBM-UHFFFAOYSA-N 0.000 claims 1
- UFSFIYCYNOTBHE-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-[5-(2-nitrophenyl)furan-2-yl]methanone Chemical compound [O-][N+](=O)C1=CC=CC=C1C1=CC=C(C(=O)N2C3CCN(CC3)CC2)O1 UFSFIYCYNOTBHE-UHFFFAOYSA-N 0.000 claims 1
- KZTBGMWRHBBBPK-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-[5-(2-phenylethynyl)furan-2-yl]methanone Chemical compound C1CN(CC2)CCC2N1C(=O)C(O1)=CC=C1C#CC1=CC=CC=C1 KZTBGMWRHBBBPK-UHFFFAOYSA-N 0.000 claims 1
- GQIFXRMBIAUXKQ-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-[5-(3,5-dichlorophenoxy)furan-2-yl]methanone Chemical compound ClC1=CC(Cl)=CC(OC=2OC(=CC=2)C(=O)N2C3CCN(CC3)CC2)=C1 GQIFXRMBIAUXKQ-UHFFFAOYSA-N 0.000 claims 1
- XGPOLGZOWNUHAQ-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-[5-(3-nitrophenyl)furan-2-yl]methanone Chemical compound [O-][N+](=O)C1=CC=CC(C=2OC(=CC=2)C(=O)N2C3CCN(CC3)CC2)=C1 XGPOLGZOWNUHAQ-UHFFFAOYSA-N 0.000 claims 1
- RSNBYPOHHFTGQR-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-[5-(4-methyl-2-nitrophenyl)furan-2-yl]methanone Chemical compound [O-][N+](=O)C1=CC(C)=CC=C1C1=CC=C(C(=O)N2C3CCN(CC3)CC2)O1 RSNBYPOHHFTGQR-UHFFFAOYSA-N 0.000 claims 1
- PQJGRVDZIMMNNW-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-[5-(4-nitrophenyl)furan-2-yl]methanone Chemical compound C1=CC([N+](=O)[O-])=CC=C1C1=CC=C(C(=O)N2C3CCN(CC3)CC2)O1 PQJGRVDZIMMNNW-UHFFFAOYSA-N 0.000 claims 1
- VSOWCIMCDKXVRC-UHFFFAOYSA-N 1,4-diazabicyclo[3.2.2]nonan-4-yl-[5-[3-(trifluoromethyl)phenyl]furan-2-yl]methanone Chemical compound FC(F)(F)C1=CC=CC(C=2OC(=CC=2)C(=O)N2C3CCN(CC3)CC2)=C1 VSOWCIMCDKXVRC-UHFFFAOYSA-N 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- GMWCDXPTTQVSCQ-UHFFFAOYSA-N CC(=O)NC1=CC=CC(C=2OC(=CC=2)C(=O)N2C3CCN(CC3)CC2)=C1.CC(=O)NC1=CC=CC=C1C1=CC=C(C(=O)N2C3CCN(CC3)CC2)O1 Chemical compound CC(=O)NC1=CC=CC(C=2OC(=CC=2)C(=O)N2C3CCN(CC3)CC2)=C1.CC(=O)NC1=CC=CC=C1C1=CC=C(C(=O)N2C3CCN(CC3)CC2)O1 GMWCDXPTTQVSCQ-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- YSUYMUMFCXCBCU-UHFFFAOYSA-N [5-(2-amino-4-methylphenyl)furan-2-yl]-(1,4-diazabicyclo[3.2.2]nonan-4-yl)methanone Chemical compound NC1=CC(C)=CC=C1C1=CC=C(C(=O)N2C3CCN(CC3)CC2)O1 YSUYMUMFCXCBCU-UHFFFAOYSA-N 0.000 claims 1
- QELUQQRTYJZTSY-UHFFFAOYSA-N [5-(2-aminophenyl)furan-2-yl]-(1,4-diazabicyclo[3.2.2]nonan-4-yl)methanone Chemical compound NC1=CC=CC=C1C1=CC=C(C(=O)N2C3CCN(CC3)CC2)O1 QELUQQRTYJZTSY-UHFFFAOYSA-N 0.000 claims 1
- JCNNFDOJIGHJCS-UHFFFAOYSA-N [5-(3-aminophenyl)furan-2-yl]-(1,4-diazabicyclo[3.2.2]nonan-4-yl)methanone Chemical compound NC1=CC=CC(C=2OC(=CC=2)C(=O)N2C3CCN(CC3)CC2)=C1 JCNNFDOJIGHJCS-UHFFFAOYSA-N 0.000 claims 1
- BFOOVNFGBZQNPI-UHFFFAOYSA-N [5-[2-chloro-5-(trifluoromethyl)phenyl]furan-2-yl]-(1,4-diazabicyclo[3.2.2]nonan-4-yl)methanone Chemical compound FC(F)(F)C1=CC=C(Cl)C(C=2OC(=CC=2)C(=O)N2C3CCN(CC3)CC2)=C1 BFOOVNFGBZQNPI-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- XYTYWYBRUVRDGB-UHFFFAOYSA-N n-(benzenesulfonyl)-n-[4-[5-(1,4-diazabicyclo[3.2.2]nonane-4-carbonyl)furan-2-yl]phenyl]benzenesulfonamide Chemical compound C1CN(CC2)CCC2N1C(=O)C(O1)=CC=C1C(C=C1)=CC=C1N(S(=O)(=O)C=1C=CC=CC=1)S(=O)(=O)C1=CC=CC=C1 XYTYWYBRUVRDGB-UHFFFAOYSA-N 0.000 claims 1
- JEDMMMAPCJBWJU-UHFFFAOYSA-N n-[4-[5-(1,4-diazabicyclo[3.2.2]nonane-4-carbonyl)furan-2-yl]phenyl]-2-methylpropanamide Chemical compound C1=CC(NC(=O)C(C)C)=CC=C1C1=CC=C(C(=O)N2C3CCN(CC3)CC2)O1 JEDMMMAPCJBWJU-UHFFFAOYSA-N 0.000 claims 1
- QZGHAGYWPNKMDA-UHFFFAOYSA-N n-[4-[5-(1,4-diazabicyclo[3.2.2]nonane-4-carbonyl)furan-2-yl]phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1C1=CC=C(C(=O)N2C3CCN(CC3)CC2)O1 QZGHAGYWPNKMDA-UHFFFAOYSA-N 0.000 claims 1
- QUCXTILYASISGG-UHFFFAOYSA-N n-[4-[5-(1,4-diazabicyclo[3.2.2]nonane-4-carbonyl)furan-2-yl]phenyl]benzamide Chemical compound C=1C=C(C=2OC(=CC=2)C(=O)N2C3CCN(CC3)CC2)C=CC=1NC(=O)C1=CC=CC=C1 QUCXTILYASISGG-UHFFFAOYSA-N 0.000 claims 1
- MKRXWUYXBMOMFV-UHFFFAOYSA-N n-[4-[5-(1,4-diazabicyclo[3.2.2]nonane-4-carbonyl)furan-2-yl]phenyl]cyclopropanecarboxamide Chemical compound C=1C=C(C=2OC(=CC=2)C(=O)N2C3CCN(CC3)CC2)C=CC=1NC(=O)C1CC1 MKRXWUYXBMOMFV-UHFFFAOYSA-N 0.000 claims 1
- YBBICDNRBJYUCE-UHFFFAOYSA-N n-[4-[5-(1,4-diazabicyclo[3.2.2]nonane-4-carbonyl)furan-2-yl]phenyl]formamide Chemical compound C1=CC(NC=O)=CC=C1C1=CC=C(C(=O)N2C3CCN(CC3)CC2)O1 YBBICDNRBJYUCE-UHFFFAOYSA-N 0.000 claims 1
- GHYBOARVXBXLES-UHFFFAOYSA-N n-[4-[5-(1,4-diazabicyclo[3.2.2]nonane-4-carbonyl)furan-2-yl]phenyl]propanamide Chemical compound C1=CC(NC(=O)CC)=CC=C1C1=CC=C(C(=O)N2C3CCN(CC3)CC2)O1 GHYBOARVXBXLES-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 201000010099 disease Diseases 0.000 description 6
- 208000035475 disorder Diseases 0.000 description 6
- 210000003169 central nervous system Anatomy 0.000 description 2
- 230000001713 cholinergic effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 210000001428 peripheral nervous system Anatomy 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 description 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 description 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000016160 smooth muscle contraction Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44987103P | 2003-02-27 | 2003-02-27 | |
| DKPA200300310 | 2003-02-27 | ||
| DKPA200300940 | 2003-06-24 | ||
| US48202203P | 2003-06-25 | 2003-06-25 | |
| PCT/EP2004/050079 WO2004076453A1 (en) | 2003-02-27 | 2004-02-04 | Novel diazabicyclic aryl derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006519208A JP2006519208A (ja) | 2006-08-24 |
| JP2006519208A5 true JP2006519208A5 (https=) | 2010-10-07 |
Family
ID=32931427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006502001A Ceased JP2006519208A (ja) | 2003-02-27 | 2004-02-04 | 新規ジアザビシクロアリール誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7678788B2 (https=) |
| EP (1) | EP1599476B1 (https=) |
| JP (1) | JP2006519208A (https=) |
| AT (1) | ATE445618T1 (https=) |
| AU (1) | AU2004215658B2 (https=) |
| BR (1) | BRPI0407216A (https=) |
| CA (1) | CA2518675A1 (https=) |
| DE (1) | DE602004023586D1 (https=) |
| MX (1) | MXPA05006861A (https=) |
| NZ (1) | NZ540998A (https=) |
| WO (1) | WO2004076453A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0202430D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
| SE0202465D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New compounds |
| EP1603585A2 (en) | 2003-03-14 | 2005-12-14 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74 |
| TW200529860A (en) * | 2003-12-22 | 2005-09-16 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
| DE602005015682D1 (de) | 2004-02-04 | 2009-09-10 | Neurosearch As | Dimere azacyclische verbindungen und deren verwendung |
| JP2007520527A (ja) * | 2004-02-04 | 2007-07-26 | ノイロサーチ アクティーゼルスカブ | ニコチン性アセチルコリン受容体リガンドとしてのジアザ２環式アリール誘導体 |
| NZ551712A (en) | 2004-05-07 | 2010-07-30 | Memory Pharm Corp | 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparations and uses thereof |
| US7514450B2 (en) | 2004-05-19 | 2009-04-07 | Neurosearch A/S | Azabicyclic aryl derivatives |
| TWI454262B (zh) | 2006-11-02 | 2014-10-01 | Targacept Inc | 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺 |
| SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
| GB0723814D0 (en) * | 2007-12-05 | 2008-01-16 | Glaxo Group Ltd | Compounds |
| DE102008015032A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte Pyrazolamide und ihre Verwendung |
| DE102008015033A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008062878A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte Furancarboxamide und ihre Verwendung |
| DE102008062863A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| CA2822357A1 (en) | 2010-12-22 | 2012-06-28 | Abbvie Inc. | Hepatitis c inhibitors and uses thereof |
| WO2020163248A1 (en) | 2019-02-04 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| CN114126613A (zh) | 2019-02-05 | 2022-03-01 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
| CN113661162A (zh) | 2019-02-06 | 2021-11-16 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7122339B2 (en) * | 1998-10-09 | 2006-10-17 | Medical Research Council | Method for generating diversity |
| FR2791678B1 (fr) | 1999-03-30 | 2001-05-04 | Synthelabo | Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique |
| NZ513575A (en) * | 1999-05-04 | 2003-07-25 | Neurosearch As | Heteroaryl diazabicycloalkanes useful for treating or preventing a disease or a disorder responsive to the activity of nAChR modulators |
| FR2804430B1 (fr) * | 2000-01-28 | 2002-03-22 | Sanofi Synthelabo | Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique |
| FR2809730B1 (fr) * | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo[3.2.2] nonanebenzoxazole, -benzothiazole et -benzimidazole, leur preparation et leur application therapeutique |
| FR2809731B1 (fr) * | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique |
| US20020086871A1 (en) | 2000-12-29 | 2002-07-04 | O'neill Brian Thomas | Pharmaceutical composition for the treatment of CNS and other disorders |
| ATE348829T1 (de) * | 2001-02-06 | 2007-01-15 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen zur behandlung von störungen des zns oder anderen erkrankungen |
| FR2832712B1 (fr) | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique |
| FR2832713B1 (fr) | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique |
| WO2004004396A1 (en) | 2002-06-26 | 2004-01-08 | Nokia Corporation | Method and network element for optimisation of radio resource utilisation in a radio access network |
| SE0202430D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
| SE0202465D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New compounds |
| EP1785425B1 (en) | 2002-09-30 | 2009-03-25 | NeuroSearch A/S | 1,4-Diazabicycloalkane derivatives, their preparation and use |
-
2004
- 2004-02-04 DE DE602004023586T patent/DE602004023586D1/de not_active Expired - Lifetime
- 2004-02-04 AU AU2004215658A patent/AU2004215658B2/en not_active Ceased
- 2004-02-04 WO PCT/EP2004/050079 patent/WO2004076453A1/en not_active Ceased
- 2004-02-04 EP EP04707948A patent/EP1599476B1/en not_active Expired - Lifetime
- 2004-02-04 JP JP2006502001A patent/JP2006519208A/ja not_active Ceased
- 2004-02-04 US US10/547,157 patent/US7678788B2/en active Active
- 2004-02-04 NZ NZ540998A patent/NZ540998A/en not_active IP Right Cessation
- 2004-02-04 MX MXPA05006861A patent/MXPA05006861A/es active IP Right Grant
- 2004-02-04 AT AT04707948T patent/ATE445618T1/de not_active IP Right Cessation
- 2004-02-04 CA CA002518675A patent/CA2518675A1/en not_active Abandoned
- 2004-02-04 BR BR0407216-2A patent/BRPI0407216A/pt not_active Application Discontinuation
-
2010
- 2010-01-27 US US12/694,952 patent/US20100130483A1/en not_active Abandoned
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