JP2007538027A - エストリオール及びエステトロールプロドラッグ類 - Google Patents

エストリオール及びエステトロールプロドラッグ類 Download PDF

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Publication number
JP2007538027A
JP2007538027A JP2007517048A JP2007517048A JP2007538027A JP 2007538027 A JP2007538027 A JP 2007538027A JP 2007517048 A JP2007517048 A JP 2007517048A JP 2007517048 A JP2007517048 A JP 2007517048A JP 2007538027 A JP2007538027 A JP 2007538027A
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JP
Japan
Prior art keywords
group
sulfamoylbenzoate
trien
compound according
tert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007517048A
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English (en)
Japanese (ja)
Other versions
JP2007538027A5 (es
Inventor
ビルバ，ラルフ
ドレーシャー，ペーター
リンク，スフェン
エルガー，バルター
シュナイダー，ビルギット
ヒリシュ，アレクサンダー
レデルセン，グドルン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer Schering Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34969311&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2007538027(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma AG filed Critical Bayer Schering Pharma AG
Publication of JP2007538027A publication Critical patent/JP2007538027A/ja
Publication of JP2007538027A5 publication Critical patent/JP2007538027A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007517048A 2004-05-21 2005-05-10 エストリオール及びエステトロールプロドラッグ類 Pending JP2007538027A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004025985A DE102004025985A1 (de) 2004-05-21 2004-05-21 Estriol- und Estetrol-Prodrugs
PCT/EP2005/005258 WO2005113576A1 (de) 2004-05-21 2005-05-10 Aminosulfonyl- oder aminosulfonylamino-substituierte phenyl-ester als estriol-und estetrol-prodrugs

Publications (2)

Publication Number Publication Date
JP2007538027A true JP2007538027A (ja) 2007-12-27
JP2007538027A5 JP2007538027A5 (es) 2008-06-26

Family

ID=34969311

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007517048A Pending JP2007538027A (ja) 2004-05-21 2005-05-10 エストリオール及びエステトロールプロドラッグ類

Country Status (11)

Country Link
EP (1) EP1747231A1 (es)
JP (1) JP2007538027A (es)
AR (1) AR049108A1 (es)
DE (1) DE102004025985A1 (es)
GT (1) GT200500120A (es)
PA (1) PA8633801A1 (es)
PE (1) PE20060314A1 (es)
SV (1) SV2006002122A (es)
TW (1) TW200612962A (es)
UY (1) UY28910A1 (es)
WO (1) WO2005113576A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007538025A (ja) * 2004-05-21 2007-12-27 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト エストラジオールプロドラッグ

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10027887A1 (de) 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
DE102005057224A1 (de) * 2005-11-29 2007-05-31 Bayer Schering Pharma Ag Prodrugs ERß-selektiver Substanzen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE102005057408A1 (de) * 2005-11-30 2007-05-31 Bayer Schering Pharma Ag Sulfamoylsulfonat-Prodrugs
CN100396693C (zh) * 2006-11-08 2008-06-25 浙江大学 1,4-孕二烯-16β-甲基-17α,21-二羟基物的制备方法
CN102079771B (zh) * 2010-12-10 2012-10-03 郑州大学 具有抗肿瘤活性的雌甾氨基酸酯化合物及其合成方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB915129A (en) * 1958-08-04 1963-01-09 Roussel Uclaf New steroid compounds and a process for their preparation
GB1272688A (en) * 1968-12-31 1972-05-03 Rech Chimiques Et Ind Mar Lab Sulphamido-steroids and the preparation thereof
WO2001081364A1 (fr) * 2000-04-24 2001-11-01 Kyowa Hakko Kogyo Co., Ltd. Derives d'estra-1,3,5(10)-triene
WO2002000679A2 (en) * 2000-06-28 2002-01-03 Novartis Ag 9.alpha.-chloro-6.alpha.-fluoro-17.alpha.-hydroxy-16-methyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. by a cyclic acyl group
JP2003534386A (ja) * 2000-05-31 2003-11-18 シエーリング アクチエンゲゼルシャフト スルホンアミド基を有する化合物及びこれらの化合物を含む医薬組成物
WO2005005451A1 (en) * 2003-07-11 2005-01-20 Glaxo Group Limited Specific glucocorticosteroid compound having anti- inflammatory activity
WO2005047303A2 (en) * 2003-11-12 2005-05-26 Solvay Pharmaceuticals Gmbh NOVEL 17β HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS
JP2007538025A (ja) * 2004-05-21 2007-12-27 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト エストラジオールプロドラッグ

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001234A (en) * 1987-04-16 1991-03-19 The Upjohn Company Cyclic hydrocarbons with an aminoalkyl sidechain
US5116828A (en) * 1989-10-26 1992-05-26 Nippon Zoki Pharmaceutical Co., Ltd. Pharmaceutical composition for treatment of osteoporosis
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
DE19712488A1 (de) * 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB915129A (en) * 1958-08-04 1963-01-09 Roussel Uclaf New steroid compounds and a process for their preparation
GB1272688A (en) * 1968-12-31 1972-05-03 Rech Chimiques Et Ind Mar Lab Sulphamido-steroids and the preparation thereof
WO2001081364A1 (fr) * 2000-04-24 2001-11-01 Kyowa Hakko Kogyo Co., Ltd. Derives d'estra-1,3,5(10)-triene
JP2003534386A (ja) * 2000-05-31 2003-11-18 シエーリング アクチエンゲゼルシャフト スルホンアミド基を有する化合物及びこれらの化合物を含む医薬組成物
WO2002000679A2 (en) * 2000-06-28 2002-01-03 Novartis Ag 9.alpha.-chloro-6.alpha.-fluoro-17.alpha.-hydroxy-16-methyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. by a cyclic acyl group
WO2005005451A1 (en) * 2003-07-11 2005-01-20 Glaxo Group Limited Specific glucocorticosteroid compound having anti- inflammatory activity
WO2005047303A2 (en) * 2003-11-12 2005-05-26 Solvay Pharmaceuticals Gmbh NOVEL 17β HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS
JP2007538025A (ja) * 2004-05-21 2007-12-27 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト エストラジオールプロドラッグ

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007538025A (ja) * 2004-05-21 2007-12-27 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト エストラジオールプロドラッグ

Also Published As

Publication number Publication date
TW200612962A (en) 2006-05-01
PE20060314A1 (es) 2006-05-25
DE102004025985A1 (de) 2005-12-15
GT200500120A (es) 2006-01-24
AR049108A1 (es) 2006-06-28
UY28910A1 (es) 2005-12-30
EP1747231A1 (de) 2007-01-31
WO2005113576A1 (de) 2005-12-01
PA8633801A1 (es) 2006-03-24
SV2006002122A (es) 2006-05-09

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