JP2007538004A

JP2007538004A - シヌクレイノパチーを治療する方法

シヌクレイノパチーを治療する方法 Download PDF

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Publication number: JP2007538004A
Authority: JP; Japan
Prior art keywords: alkyl; alkyloxy; hydrogen; amino; hydroxy
Prior art date: 2004-03-18
Legal status : Pending

Application number

JP2007504171A

Other languages

English (en)

Japanese (ja)

Other versions

JP2007538004A5 (https=

Inventor

ピーターティー．ランズベリー，

チーファリュー，

Current Assignee

Brigham and Womens Hospital Inc

Original Assignee

Brigham and Womens Hospital Inc

Priority date

2004-03-18

Filing date

2005-03-18

Publication date

2007-12-27

2005-03-18 Application filed by Brigham and Womens Hospital Inc filed Critical Brigham and Womens Hospital Inc

2007-12-27 Publication of JP2007538004A publication Critical patent/JP2007538004A/ja

2008-05-15 Publication of JP2007538004A5 publication Critical patent/JP2007538004A5/ja

Status Pending legal-status Critical Current

Links

208000032859 Synucleinopathies Diseases 0.000 title claims abstract description 39
150000001875 compounds Chemical class 0.000 claims abstract description 185
238000000034 method Methods 0.000 claims abstract description 169
239000003528 protein farnesyltransferase inhibitor Substances 0.000 claims abstract description 102
229940124226 Farnesyltransferase inhibitor Drugs 0.000 claims abstract description 95
150000003839 salts Chemical group 0.000 claims abstract description 80
239000002253 acid Substances 0.000 claims abstract description 60
208000009829 Lewy Body Disease Diseases 0.000 claims abstract description 53
206010067889 Dementia with Lewy bodies Diseases 0.000 claims abstract description 52
208000018737 Parkinson disease Diseases 0.000 claims abstract description 52
208000001089 Multiple system atrophy Diseases 0.000 claims abstract description 42
125000000217 alkyl group Chemical group 0.000 claims description 892
125000003545 alkoxy group Chemical group 0.000 claims description 321
239000001257 hydrogen Substances 0.000 claims description 309
229910052739 hydrogen Inorganic materials 0.000 claims description 309
150000002431 hydrogen Chemical class 0.000 claims description 257
125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 143
150000003254 radicals Chemical class 0.000 claims description 134
-1 4,4-dimethyloxazolyl Chemical group 0.000 claims description 115
125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims description 86
125000004093 cyano group Chemical group *C#N 0.000 claims description 77
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 73
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 72
125000003118 aryl group Chemical group 0.000 claims description 69
125000001475 halogen functional group Chemical group 0.000 claims description 66
125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims description 62
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 60
238000007792 addition Methods 0.000 claims description 58
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 51
125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 41
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 38
125000004953 trihalomethyl group Chemical group 0.000 claims description 38
125000004951 trihalomethoxy group Chemical group 0.000 claims description 31
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 29
125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims description 29
229960003638 dopamine Drugs 0.000 claims description 29
125000004448 alkyl carbonyl group Chemical group 0.000 claims description 28
125000001424 substituent group Chemical group 0.000 claims description 28
239000003136 dopamine receptor stimulating agent Substances 0.000 claims description 27
125000003282 alkyl amino group Chemical group 0.000 claims description 26
125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 23
ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims description 22
230000037396 body weight Effects 0.000 claims description 21
239000003543 catechol methyltransferase inhibitor Substances 0.000 claims description 21
239000000812 cholinergic antagonist Substances 0.000 claims description 21
239000002243 precursor Substances 0.000 claims description 21
108010007508 Farnesyltranstransferase Proteins 0.000 claims description 20
102000007317 Farnesyltranstransferase Human genes 0.000 claims description 20
208000012902 Nervous system disease Diseases 0.000 claims description 20
229910052760 oxygen Inorganic materials 0.000 claims description 20
102000010909 Monoamine Oxidase Human genes 0.000 claims description 19
108010062431 Monoamine oxidase Proteins 0.000 claims description 19
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 18
125000002883 imidazolyl group Chemical group 0.000 claims description 18
239000001301 oxygen Substances 0.000 claims description 18
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 15
125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 14
125000004457 alkyl amino carbonyl group Chemical group 0.000 claims description 14
125000003806 alkyl carbonyl amino group Chemical group 0.000 claims description 14
150000001413 amino acids Chemical class 0.000 claims description 14
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 14
229910052717 sulfur Chemical group 0.000 claims description 14
125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims description 13
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 13
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 12
125000004076 pyridyl group Chemical group 0.000 claims description 12
239000011593 sulfur Chemical group 0.000 claims description 12
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 11
125000004414 alkyl thio group Chemical group 0.000 claims description 9
125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 8
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 8
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
125000004104 aryloxy group Chemical group 0.000 claims description 6
230000008569 process Effects 0.000 claims description 5
ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims description 4
125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
239000000544 cholinesterase inhibitor Substances 0.000 claims description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 3
PLHJCIYEEKOWNM-UHFFFAOYSA-N 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one Chemical compound CN1C=NC=C1C(N)(C=1C=C2C(C=3C=C(Cl)C=CC=3)=CC(=O)N(C)C2=CC=1)C1=CC=C(Cl)C=C1 PLHJCIYEEKOWNM-UHFFFAOYSA-N 0.000 claims description 2
229940039856 aricept Drugs 0.000 claims description 2
125000005129 aryl carbonyl group Chemical group 0.000 claims description 2
125000005110 aryl thio group Chemical group 0.000 claims description 2
125000001309 chloro group Chemical group Cl* 0.000 claims description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
125000004997 halocarbonyl group Chemical group 0.000 claims description 2
229960004640 memantine Drugs 0.000 claims description 2
BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims description 2
125000001624 naphthyl group Chemical group 0.000 claims description 2
229910052757 nitrogen Inorganic materials 0.000 claims description 2
125000004356 hydroxy functional group Chemical group O* 0.000 claims 83
125000005843 halogen group Chemical group 0.000 claims 80
229940099362 Catechol O methyltransferase inhibitor Drugs 0.000 claims 18
229940081615 DOPA decarboxylase inhibitor Drugs 0.000 claims 18
229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 18
239000000534 dopa decarboxylase inhibitor Substances 0.000 claims 18
239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 claims 18
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 13
125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 10
239000005022 packaging material Substances 0.000 claims 9
PMZDQRJGMBOQBF-UHFFFAOYSA-N 1H-quinolin-4-one Natural products C1=CC=C2C(O)=CC=NC2=C1 PMZDQRJGMBOQBF-UHFFFAOYSA-N 0.000 claims 2
WOYOASASOHZEDR-UHFFFAOYSA-N 4-(3-chlorophenyl)-6-[(4-chlorophenyl)-hydroxy-(3-methylimidazol-4-yl)methyl]-1-methylquinolin-2-one Chemical compound CN1C=NC=C1C(O)(C=1C=C2C(C=3C=C(Cl)C=CC=3)=CC(=O)N(C)C2=CC=1)C1=CC=C(Cl)C=C1 WOYOASASOHZEDR-UHFFFAOYSA-N 0.000 claims 2
ZMLMGCPNMBRTKN-UHFFFAOYSA-N 6-[(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-ethoxyphenyl)-1-methylquinolin-2-one;hydrate;hydrochloride Chemical compound O.Cl.CCOC1=CC=CC(C=2C3=CC(=CC=C3N(C)C(=O)C=2)C(C=2N(C=NC=2)C)C=2C=CC(Cl)=CC=2)=C1 ZMLMGCPNMBRTKN-UHFFFAOYSA-N 0.000 claims 2
QOFQBGVDXIFFKM-UHFFFAOYSA-N 6-[(4-chlorophenyl)-hydroxy-(3-methylimidazol-4-yl)methyl]-4-(3-ethoxyphenyl)-1-methylquinolin-2-one Chemical compound CCOC1=CC=CC(C=2C3=CC(=CC=C3N(C)C(=O)C=2)C(O)(C=2N(C=NC=2)C)C=2C=CC(Cl)=CC=2)=C1 QOFQBGVDXIFFKM-UHFFFAOYSA-N 0.000 claims 2
ALKQAQOKGRWMSJ-UHFFFAOYSA-N 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-ethoxyphenyl)-1-methylquinolin-2-one Chemical compound CCOC1=CC=CC(C=2C3=CC(=CC=C3N(C)C(=O)C=2)C(N)(C=2N(C=NC=2)C)C=2C=CC(Cl)=CC=2)=C1 ALKQAQOKGRWMSJ-UHFFFAOYSA-N 0.000 claims 2
239000002532 enzyme inhibitor Substances 0.000 claims 2
229940125532 enzyme inhibitor Drugs 0.000 claims 2
125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims 2
VSGPVHSTVTXREH-UHFFFAOYSA-N quinolin-4-one Chemical compound C1=CC=C[C]2C(=O)C=CN=C21 VSGPVHSTVTXREH-UHFFFAOYSA-N 0.000 claims 2
URZJLQQKSKBTAG-UHFFFAOYSA-N quinolin-7-ylmethanamine Chemical compound C1=CC=NC2=CC(CN)=CC=C21 URZJLQQKSKBTAG-UHFFFAOYSA-N 0.000 claims 2
MJCLSOLIVLXCLP-UHFFFAOYSA-N tetrazolo[1,5-a]quinolin-7-ylmethanamine Chemical compound C1=CC2=NN=NN2C2=CC=C(CN)C=C12 MJCLSOLIVLXCLP-UHFFFAOYSA-N 0.000 claims 2
SUMXFQRFMMRQJN-UHFFFAOYSA-N (4-chlorophenyl)-(3-methylimidazol-4-yl)-(5-phenylimidazo[1,2-a]quinolin-7-yl)methanol Chemical compound CN1C=NC=C1C(O)(C=1C=C2C(N3C=CN=C3C=C2C=2C=CC=CC=2)=CC=1)C1=CC=C(Cl)C=C1 SUMXFQRFMMRQJN-UHFFFAOYSA-N 0.000 claims 1
VLYOWFSEQNDOCR-UHFFFAOYSA-N (4-chlorophenyl)-(3-methylimidazol-4-yl)-[5-(3-methylphenyl)tetrazolo[1,5-a]quinolin-7-yl]methanamine Chemical compound CC1=CC=CC(C=2C3=CC(=CC=C3N3N=NN=C3C=2)C(N)(C=2N(C=NC=2)C)C=2C=CC(Cl)=CC=2)=C1 VLYOWFSEQNDOCR-UHFFFAOYSA-N 0.000 claims 1
BSYDYMQDGQNDHZ-UHFFFAOYSA-N (4-chlorophenyl)-[5-(3-chlorophenyl)-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl]-(3-methylimidazol-4-yl)methanol Chemical compound C12=CC(C(O)(C=3N(C=NC=3)C)C=3C=CC(Cl)=CC=3)=CC=C2N2C(C)=NN=C2C=C1C1=CC=CC(Cl)=C1 BSYDYMQDGQNDHZ-UHFFFAOYSA-N 0.000 claims 1
XKBOADWPZLOLCO-UHFFFAOYSA-N (4-chlorophenyl)-[5-(3-chlorophenyl)tetrazolo[1,5-a]quinazolin-7-yl]-(3-methylimidazol-4-yl)methanamine Chemical compound CN1C=NC=C1C(N)(C=1C=C2C(N3N=NN=C3N=C2C=2C=C(Cl)C=CC=2)=CC=1)C1=CC=C(Cl)C=C1 XKBOADWPZLOLCO-UHFFFAOYSA-N 0.000 claims 1
DMWYQXADRYJCSG-UHFFFAOYSA-N (4-chlorophenyl)-[5-(3-chlorophenyl)tetrazolo[1,5-a]quinazolin-7-yl]-(3-methylimidazol-4-yl)methanol Chemical compound CN1C=NC=C1C(O)(C=1C=C2C(N3N=NN=C3N=C2C=2C=C(Cl)C=CC=2)=CC=1)C1=CC=C(Cl)C=C1 DMWYQXADRYJCSG-UHFFFAOYSA-N 0.000 claims 1
UJCWQUZQUHGGIA-UHFFFAOYSA-N 3-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one Chemical compound CN1C=NC=C1C(N)(C=1C(N(C)C2=CC=CC=C2C=1C=1C=C(Cl)C=CC=1)=O)C1=CC=C(Cl)C=C1 UJCWQUZQUHGGIA-UHFFFAOYSA-N 0.000 claims 1
MGOMHMNFQVWVKE-UHFFFAOYSA-N 4-(3-chlorophenyl)-6-[(4-chlorophenyl)-imidazol-1-ylmethyl]-1-(2-methoxyethyl)quinolin-2-one;oxalic acid Chemical compound OC(=O)C(O)=O.C=1C(=O)N(CCOC)C2=CC=C(C(C=3C=CC(Cl)=CC=3)N3C=NC=C3)C=C2C=1C1=CC=CC(Cl)=C1 MGOMHMNFQVWVKE-UHFFFAOYSA-N 0.000 claims 1
LNMVKTAEIBQKGC-UHFFFAOYSA-N 4-(3-chlorophenyl)-6-[(4-chlorophenyl)-imidazol-1-ylmethyl]-1-methylquinolin-2-one Chemical compound C=1C(=O)N(C)C2=CC=C(C(C=3C=CC(Cl)=CC=3)N3C=NC=C3)C=C2C=1C1=CC=CC(Cl)=C1 LNMVKTAEIBQKGC-UHFFFAOYSA-N 0.000 claims 1
MZVKRULJPCXOEV-UHFFFAOYSA-N 4-(3-chlorophenyl)-6-[(4-chlorophenyl)-imidazol-1-ylmethyl]-1h-quinolin-2-one Chemical compound C1=CC(Cl)=CC=C1C(N1C=NC=C1)C1=CC=C(NC(=O)C=C2C=3C=C(Cl)C=CC=3)C2=C1 MZVKRULJPCXOEV-UHFFFAOYSA-N 0.000 claims 1
AWPASKYXIYDLEO-UHFFFAOYSA-N 4-(3-chlorophenyl)-6-[1-(4-chlorophenyl)-1-(5-methylimidazol-1-yl)ethyl]-1-methylquinolin-2-one Chemical compound CC1=CN=CN1C(C)(C=1C=C2C(C=3C=C(Cl)C=CC=3)=CC(=O)N(C)C2=CC=1)C1=CC=C(Cl)C=C1 AWPASKYXIYDLEO-UHFFFAOYSA-N 0.000 claims 1
NMHLBRAQOAZCOS-UHFFFAOYSA-N 4-(3-chlorophenyl)-6-[1-(4-chlorophenyl)-2-hydroxy-1-imidazol-1-ylethyl]-1-methylquinolin-2-one Chemical compound C=1C(=O)N(C)C2=CC=C(C(CO)(C=3C=CC(Cl)=CC=3)N3C=NC=C3)C=C2C=1C1=CC=CC(Cl)=C1 NMHLBRAQOAZCOS-UHFFFAOYSA-N 0.000 claims 1
SGJOGMWFOAJBCD-UHFFFAOYSA-N 6-[1-(4-chlorophenyl)-2-hydroxy-1-imidazol-1-ylethyl]-1-methyl-4-phenylquinolin-2-one Chemical compound C=1C(=O)N(C)C2=CC=C(C(CO)(C=3C=CC(Cl)=CC=3)N3C=NC=C3)C=C2C=1C1=CC=CC=C1 SGJOGMWFOAJBCD-UHFFFAOYSA-N 0.000 claims 1
CNGNFBHSSFAFHP-UHFFFAOYSA-N 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-3-(3-chlorophenyl)-1-azatricyclo[7.3.1.05,13]trideca-3,5,7,9(13)-tetraen-2-one Chemical compound CN1C=NC=C1C(N)(C=1C2=C3N(C(C(C=4C=C(Cl)C=CC=4)=C2)=O)CCCC3=CC=1)C1=CC=C(Cl)C=C1 CNGNFBHSSFAFHP-UHFFFAOYSA-N 0.000 claims 1
GHWACRIYHWJERU-UHFFFAOYSA-N 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1,3-dimethyl-4h-quinazolin-2-one Chemical compound C12=CC(C(N)(C=3N(C=NC=3)C)C=3C=CC(Cl)=CC=3)=CC=C2N(C)C(=O)N(C)C1C1=CC=CC(Cl)=C1 GHWACRIYHWJERU-UHFFFAOYSA-N 0.000 claims 1
JVAQVSBUXYDHFX-UHFFFAOYSA-N 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinazolin-2-one Chemical compound CN1C=NC=C1C(N)(C=1C=C2C(C=3C=C(Cl)C=CC=3)=NC(=O)N(C)C2=CC=1)C1=CC=C(Cl)C=C1 JVAQVSBUXYDHFX-UHFFFAOYSA-N 0.000 claims 1
HAOBPBDFPYHWNM-UHFFFAOYSA-N 7-[(4-fluorophenyl)-imidazol-1-ylmethyl]-5-phenylimidazo[1,2-a]quinoline Chemical compound C1=CC(F)=CC=C1C(N1C=NC=C1)C1=CC=C2N3C=CN=C3C=C(C=3C=CC=CC=3)C2=C1 HAOBPBDFPYHWNM-UHFFFAOYSA-N 0.000 claims 1
ZMHSZUPSHKAYRM-UHFFFAOYSA-N C1=CC(Cl)=CC=C1C(N1C=NC=C1)C(C=C1C(=CC2=O)C=3C=C(Cl)C=CC=3)=CC3=C1N2CCC3 Chemical compound C1=CC(Cl)=CC=C1C(N1C=NC=C1)C(C=C1C(=CC2=O)C=3C=C(Cl)C=CC=3)=CC3=C1N2CCC3 ZMHSZUPSHKAYRM-UHFFFAOYSA-N 0.000 claims 1
VBIFXVSOOUGGQS-UHFFFAOYSA-N Cn1cc(N)nc1-c1ccc(Cl)cc1 Chemical compound Cn1cc(N)nc1-c1ccc(Cl)cc1 VBIFXVSOOUGGQS-UHFFFAOYSA-N 0.000 claims 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
150000004682 monohydrates Chemical class 0.000 claims 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
HDZJRNOMBDDFMJ-UHFFFAOYSA-N quinazolin-7-ylmethanol Chemical compound C1=NC=NC2=CC(CO)=CC=C21 HDZJRNOMBDDFMJ-UHFFFAOYSA-N 0.000 claims 1
LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims 1
RDBBFCMDRBOXIG-UHFFFAOYSA-N quinolin-7-ylmethanol Chemical compound C1=CC=NC2=CC(CO)=CC=C21 RDBBFCMDRBOXIG-UHFFFAOYSA-N 0.000 claims 1
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WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 16
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GKFPROVOIQKYTO-UZLBHIALSA-N methyl (2s)-2-[[4-[[(2r)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylsulfanylbutanoate Chemical compound CSCC[C@@H](C(=O)OC)NC(=O)C1=CC=C(NC[C@@H](N)CS)C=C1C1=CC=CC=C1 GKFPROVOIQKYTO-UZLBHIALSA-N 0.000 description 15
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