JP2007533604A - ヒドロキシエチルセルロースに基づく生体接着性ゲル - Google Patents
ヒドロキシエチルセルロースに基づく生体接着性ゲル Download PDFInfo
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- JP2007533604A JP2007533604A JP2006522300A JP2006522300A JP2007533604A JP 2007533604 A JP2007533604 A JP 2007533604A JP 2006522300 A JP2006522300 A JP 2006522300A JP 2006522300 A JP2006522300 A JP 2006522300A JP 2007533604 A JP2007533604 A JP 2007533604A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- Reproductive Health (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
- Gynecology & Obstetrics (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
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- Endocrinology (AREA)
- Rheumatology (AREA)
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- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Adhesives Or Adhesive Processes (AREA)
Abstract
Description
−最大約24時間に及ぶ薬物の放出;
−酸性基の存在により特徴づけられ、そのために媒体のイオン強度の影響を受け易く、塩基による中和を時として必要とするゲル化剤/生体接着剤を含まないこと;
−異なる物理化学的性質を有する薬物、特に、水可溶性薬物と実質的に水に不溶の脂溶性薬物とを担持する可能性;
−治療の時間とコストの削減。
組成 割合
精製水 81.9%
グリセロール 12.9%
クロルヘキシジン ジグルコネート、20%溶液w/v 2.7%
ヒドロキシエチルセルロース(Natrosol250HX) 2.5%
実施例2−イブプロフェン膣ゲル
組成 割合
イブプロフェン 0.100%
ベンザルコニウム クロライド 0.150%
ポリオキシエチエン−20−モノエチル エーテル(Brij 58)
0.500%
ヒドロキシエチルセルロース(Natrosol250HX) 2.500%
ジエチレン グリコール モノエチル エステル(Transcutol P)
10.000%
精製水 86.750%
実施例3−エコナゾールナイトレート膣ゲル
組成 割合
エコナゾール ナイトレート 1.000%
ベンザルコニウム クロライド 0.150%
ヒドロキシエチルセルロース(Natrosol250HX) 2.500%
ポリソルベート80(Tween80) 4.000%
グリセロール 10.000%
ジエチレン グリコール モノエチル エステル(Transcutol P)
40.000%
精製水 42.350%
実施例4−膣ゲルの生体接着性の研究
生体接着性を、適当に改変したロイド動力計を用いてin vitroで測定した。測定基体(ウサギの胃粘膜、またはポリプロピレン)を、接着剤で上部支持体に固定し、この支持体を可動性のクロスバーに接続して、下部支持体上に表面を均一にカバーするように200mgの試験製剤をおいた。製剤と基体との間を緊密に接触させた(30s)後、2つの表面が離れるまで規定の一定速度でクロスバーを上昇させた。
結果を表1に示す。
拡散媒体:乳酸バッファ、pH4.0
拡散体積:50mL
温度:37±0.5℃
攪拌速度:50rpm
サンプル量:1.5g
放出面積:4.5cm2
放出膜:セルロースアセテート 0.45μm
ゲルからの薬物放出試験を、4.5cm2の表面積を有するセルロースアセテート膜を備えた拡散セルを用いて実施した。塗布したゲルの量は1.5gであった。自動化システムにより、定められた時間に予め決定されたサンプルアリコートを採取し、ただちにUV分光光度計254nmで判読した。
Claims (6)
- 唯一のゲル化剤および生体接着剤としてヒドロキシエチルセルロースを含む、有効成分および/または活性成分の送達のための水性生体接着性ゲルの形態の組成物。
- 有効成分および/または活性成分の膣内送達のための、請求項1に記載の水性ゲルの形態の組成物。
- さらに、グリセロール、ジエチレングリコールモノエチルエーテル、界面活性剤、保存料および酸性化剤を含む、請求項1または2に記載の組成物。
- 1から5重量%のヒドロキシエチルセルロースと、25から90重量%の水と、5から25重量%のグリセロールと、5から50重量%のジエチレングリコールモノエチルエーテルと、0.01から10重量%の界面活性剤と、0.05から1重量%の保存料と、0.01から1重量%の酸性化剤とを含有する請求項3に記載の組成物。
- 有効構成成分として、抗真菌剤、殺菌剤、抗菌剤、抗生剤、鎮痛剤、局部麻酔剤、抗ヒスタミン剤、抗炎症剤、避妊剤、ホルモン剤、またはこれらの組合せを含有している、請求項1から4のいずれか一項に記載の組成物。
- 有効成分が、エコナゾール、ミコナゾール、フルコナゾール、シクロピロクスオラミン、ニフラテル、ナイスタチン、クロルヘキシジン、イブプロフェン、ケトプロフェン、ナプロキセン、ベンジダミン、ベンザルコニウムクロライドまたはその他の四級アンモニウム殺菌剤、およびノノキシノール−9から選択される、請求項5に記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT001640A ITMI20031640A1 (it) | 2003-08-08 | 2003-08-08 | Base per gel bioadesivi. |
ITMI2003A001640 | 2003-08-08 | ||
PCT/EP2004/008577 WO2005014047A1 (en) | 2003-08-08 | 2004-07-30 | Bioadhesive gel based on hydroxyethylcellulose |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007533604A true JP2007533604A (ja) | 2007-11-22 |
JP4855935B2 JP4855935B2 (ja) | 2012-01-18 |
Family
ID=34131212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006522300A Active JP4855935B2 (ja) | 2003-08-08 | 2004-07-30 | ヒドロキシエチルセルロースに基づく生体接着性ゲル |
Country Status (16)
Country | Link |
---|---|
US (2) | US20070031479A1 (ja) |
EP (1) | EP1651274B1 (ja) |
JP (1) | JP4855935B2 (ja) |
CN (1) | CN1832760B (ja) |
AT (1) | ATE395084T1 (ja) |
BR (1) | BRPI0413446A (ja) |
CA (1) | CA2535123C (ja) |
CY (1) | CY1108548T1 (ja) |
DE (1) | DE602004013787D1 (ja) |
DK (1) | DK1651274T3 (ja) |
ES (1) | ES2305818T3 (ja) |
IT (1) | ITMI20031640A1 (ja) |
PL (1) | PL1651274T3 (ja) |
PT (1) | PT1651274E (ja) |
SI (1) | SI1651274T1 (ja) |
WO (1) | WO2005014047A1 (ja) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
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CN100394919C (zh) * | 2006-03-01 | 2008-06-18 | 杨军 | 一种用于治疗阴道疾病的药物组合物 |
US8433851B2 (en) | 2007-08-16 | 2013-04-30 | International Business Machines Corporation | Reducing wiring congestion in a cache subsystem utilizing sectored caches with discontiguous addressing |
US9452173B2 (en) | 2013-01-31 | 2016-09-27 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US9446131B2 (en) | 2013-01-31 | 2016-09-20 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US9433680B2 (en) | 2013-01-31 | 2016-09-06 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
CN106310266A (zh) * | 2015-07-09 | 2017-01-11 | 王强 | 一种预防或治疗粘膜疾病的组合物及制备方法 |
CN106038477A (zh) * | 2016-06-14 | 2016-10-26 | 上海通用药业股份有限公司 | 一种含有噻康唑的阴道用凝胶的制备方法 |
CN106109398A (zh) * | 2016-06-14 | 2016-11-16 | 上海通用药业股份有限公司 | 一种含有噻康唑的阴道用凝胶 |
BR112018077430A2 (pt) * | 2016-07-08 | 2019-04-02 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A | composição farmacêutica. |
IT201900000388A1 (it) * | 2019-01-10 | 2020-07-10 | L N Age S R L | Composizione per l'uso nel trattamento di lesioni vaginali, del glande ed anali |
EA202290122A1 (ru) * | 2019-06-21 | 2022-03-17 | Альфасигма С.П.А. | Фармацевтические композиции в форме геля, содержащие ксилоглюкан и спирты, для регулируемого высвобождения активных ингредиентов |
CN111557897B (zh) * | 2020-07-07 | 2023-06-23 | 温州海鹤药业有限公司 | 一种含有硝呋太尔的药物组合物及其制备方法 |
EP4389228A1 (en) | 2022-12-21 | 2024-06-26 | Lacer, S.A.U. | Oral care composition containing cellulosic polymers |
Citations (10)
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JPH04217925A (ja) * | 1990-03-27 | 1992-08-07 | Nippon Saafuakutanto Kogyo Kk | 新規な解熱消炎鎮痛剤組成物 |
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JPH09255556A (ja) * | 1996-03-25 | 1997-09-30 | Ota Seiyaku Kk | 医薬組成物 |
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2003
- 2003-08-08 IT IT001640A patent/ITMI20031640A1/it unknown
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2004
- 2004-07-30 EP EP04763658A patent/EP1651274B1/en active Active
- 2004-07-30 CA CA2535123A patent/CA2535123C/en active Active
- 2004-07-30 BR BRPI0413446-0A patent/BRPI0413446A/pt not_active Application Discontinuation
- 2004-07-30 AT AT04763658T patent/ATE395084T1/de active
- 2004-07-30 WO PCT/EP2004/008577 patent/WO2005014047A1/en active IP Right Grant
- 2004-07-30 SI SI200430777T patent/SI1651274T1/sl unknown
- 2004-07-30 US US10/567,890 patent/US20070031479A1/en not_active Abandoned
- 2004-07-30 PT PT04763658T patent/PT1651274E/pt unknown
- 2004-07-30 DE DE602004013787T patent/DE602004013787D1/de active Active
- 2004-07-30 DK DK04763658T patent/DK1651274T3/da active
- 2004-07-30 JP JP2006522300A patent/JP4855935B2/ja active Active
- 2004-07-30 CN CN200480022719XA patent/CN1832760B/zh active Active
- 2004-07-30 PL PL04763658T patent/PL1651274T3/pl unknown
- 2004-07-30 ES ES04763658T patent/ES2305818T3/es active Active
-
2008
- 2008-07-30 CY CY20081100793T patent/CY1108548T1/el unknown
-
2011
- 2011-11-10 US US13/293,484 patent/US8790685B2/en active Active
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH01102029A (ja) * | 1987-09-17 | 1989-04-19 | Boehringer Ingelheim Internatl Gmbh | 局所用医薬製剤及びその製造方法 |
JPH01193230A (ja) * | 1987-12-04 | 1989-08-03 | Dr Karl Thomae Gmbh | 器官及び器官の部分の癒着防止用組成物 |
JPH04217925A (ja) * | 1990-03-27 | 1992-08-07 | Nippon Saafuakutanto Kogyo Kk | 新規な解熱消炎鎮痛剤組成物 |
JPH05178763A (ja) * | 1991-02-19 | 1993-07-20 | Nippon Saafuakutanto Kogyo Kk | 難溶解性薬物溶解剤組成物 |
JPH11502809A (ja) * | 1995-03-17 | 1999-03-09 | ゲブロ ブロシェック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 局所用医薬組成物、その製造方法、およびこの組成物の使用 |
JPH09255556A (ja) * | 1996-03-25 | 1997-09-30 | Ota Seiyaku Kk | 医薬組成物 |
JPH11513035A (ja) * | 1996-06-12 | 1999-11-09 | ザ、プロクター、エンド、ギャンブル、カンパニー | 風邪の治療用の局所用組成物の製造のためのh2拮抗剤の使用 |
JP2001525820A (ja) * | 1997-05-14 | 2001-12-11 | ガレン(ケミカルズ)リミティド | 局所組成物 |
WO2002011768A1 (en) * | 2000-08-03 | 2002-02-14 | Antares Pharma Ipl Ag | Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels |
JP2004505931A (ja) * | 2000-08-03 | 2004-02-26 | アンタレス ファルマ アイピーエル アクチェンゲゼルシャフト | 適切な治療水準を保証する活性化合物の経皮投与及び/又は経粘膜投与のための新規組成物 |
WO2003020210A2 (en) * | 2001-08-29 | 2003-03-13 | Umd, Inc. | Vaginal delivery of chemotherapeutic agents and inhibitors of membrane efflux systems for cancer therapy |
JP2005507874A (ja) * | 2001-08-29 | 2005-03-24 | ユーエムディー, インコーポレイテッド | 癌治療のための化学療法剤及び膜流出システム阻害剤の経膣送達 |
Also Published As
Publication number | Publication date |
---|---|
PT1651274E (pt) | 2008-08-11 |
US8790685B2 (en) | 2014-07-29 |
EP1651274B1 (en) | 2008-05-14 |
ITMI20031640A1 (it) | 2005-02-09 |
ATE395084T1 (de) | 2008-05-15 |
CN1832760B (zh) | 2010-06-23 |
US20120083515A1 (en) | 2012-04-05 |
SI1651274T1 (sl) | 2008-10-31 |
DK1651274T3 (da) | 2008-09-08 |
DE602004013787D1 (de) | 2008-06-26 |
ES2305818T3 (es) | 2008-11-01 |
CA2535123A1 (en) | 2005-02-17 |
BRPI0413446A (pt) | 2006-10-17 |
PL1651274T3 (pl) | 2008-10-31 |
CY1108548T1 (el) | 2014-04-09 |
JP4855935B2 (ja) | 2012-01-18 |
WO2005014047A1 (en) | 2005-02-17 |
CA2535123C (en) | 2012-06-26 |
US20070031479A1 (en) | 2007-02-08 |
CN1832760A (zh) | 2006-09-13 |
EP1651274A1 (en) | 2006-05-03 |
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