JP2007527898A5 - - Google Patents
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- Publication number
- JP2007527898A5 JP2007527898A5 JP2007502337A JP2007502337A JP2007527898A5 JP 2007527898 A5 JP2007527898 A5 JP 2007527898A5 JP 2007502337 A JP2007502337 A JP 2007502337A JP 2007502337 A JP2007502337 A JP 2007502337A JP 2007527898 A5 JP2007527898 A5 JP 2007527898A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- alkoxy
- alkyl
- substituted
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 34
- 239000001257 hydrogen Substances 0.000 claims 34
- -1 2,2-difluoroethoxy Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 18
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 15
- 150000001204 N-oxides Chemical class 0.000 claims 13
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000003830 C1- C4 alkylcarbonylamino group Chemical group 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 208000023504 respiratory system disease Diseases 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04100989 | 2004-03-10 | ||
| EP05100539 | 2005-01-27 | ||
| PCT/EP2005/051022 WO2005085203A1 (en) | 2004-03-10 | 2005-03-08 | Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007527898A JP2007527898A (ja) | 2007-10-04 |
| JP2007527898A5 true JP2007527898A5 (https=) | 2008-04-24 |
Family
ID=34921315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007502337A Withdrawn JP2007527898A (ja) | 2004-03-10 | 2005-03-08 | ジフルオロエトキシ置換された新規のヒドロキシ−６−フェニルフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20070259909A1 (https=) |
| EP (1) | EP1725532A1 (https=) |
| JP (1) | JP2007527898A (https=) |
| KR (1) | KR20070011349A (https=) |
| AU (1) | AU2005219581A1 (https=) |
| BR (1) | BRPI0508471A8 (https=) |
| CA (1) | CA2558532A1 (https=) |
| IL (1) | IL177498A0 (https=) |
| NO (1) | NO20064491L (https=) |
| WO (1) | WO2005085203A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4587294B2 (ja) * | 2002-08-29 | 2010-11-24 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４インヒビターとしての２−ヒドロキシ−６−フェニルフェナントリジン |
| ATE353217T1 (de) | 2002-08-29 | 2007-02-15 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren |
| CA2556086C (en) | 2004-02-18 | 2014-04-01 | Altana Pharma Ag | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| PL2589599T4 (pl) * | 2004-03-03 | 2015-06-30 | Takeda Gmbh | Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4 |
| EP1725534A1 (en) * | 2004-03-10 | 2006-11-29 | Altana Pharma AG | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| PL1856093T3 (pl) | 2005-03-02 | 2010-05-31 | Takeda Gmbh | Chlorowodorek (2R,4aR,10bR)-6-(2,6-dimetoksy-pirydyn-3-ylo)-9-etoksy-8-metoksy-1,2,3,4,4a,10b-heksahydrofenantrydyn-2-olu |
| ES2460897T3 (es) | 2007-10-04 | 2014-05-14 | F. Hoffmann-La Roche Ag | Derivados de ciclopropil aril amida y usos de los mismos |
| CN103936661B (zh) * | 2014-04-04 | 2016-08-24 | 常州大学 | 一种6-烷基菲啶衍生物的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9707233A (pt) * | 1996-01-31 | 1999-07-20 | Byk Gulden Lomberg Chem Fab | Fenantridinas |
| US6127378A (en) * | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| SI0889886T1 (en) * | 1996-03-26 | 2003-02-28 | Altana Pharma Ag | Novel phenanthridines substituted in the 6 position |
| PT998460E (pt) * | 1997-07-25 | 2004-07-30 | Altana Pharma Ag | Novos derivados de tetrazole |
| JP2001510827A (ja) * | 1997-07-25 | 2001-08-07 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 置換６−フェニルフェナントリジン |
| DK1075477T3 (da) * | 1998-05-05 | 2003-06-30 | Altana Pharma Ag | Nye benzonaphthyridin-N-oxider |
| TR200501553T2 (tr) * | 1999-01-15 | 2005-06-21 | Altana Pharma Ag | PDE-IV inhibe edici aktivitesi olan fenilfenantridinler |
| JP4587294B2 (ja) * | 2002-08-29 | 2010-11-24 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４インヒビターとしての２−ヒドロキシ−６−フェニルフェナントリジン |
| ATE353217T1 (de) * | 2002-08-29 | 2007-02-15 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren |
-
2005
- 2005-03-08 WO PCT/EP2005/051022 patent/WO2005085203A1/en not_active Ceased
- 2005-03-08 JP JP2007502337A patent/JP2007527898A/ja not_active Withdrawn
- 2005-03-08 BR BRPI0508471A patent/BRPI0508471A8/pt not_active IP Right Cessation
- 2005-03-08 EP EP05716950A patent/EP1725532A1/en not_active Withdrawn
- 2005-03-08 US US10/591,472 patent/US20070259909A1/en not_active Abandoned
- 2005-03-08 KR KR1020067020295A patent/KR20070011349A/ko not_active Withdrawn
- 2005-03-08 AU AU2005219581A patent/AU2005219581A1/en not_active Abandoned
- 2005-03-08 CA CA002558532A patent/CA2558532A1/en not_active Abandoned
-
2006
- 2006-08-15 IL IL177498A patent/IL177498A0/en unknown
- 2006-10-03 NO NO20064491A patent/NO20064491L/no not_active Application Discontinuation