JP2007525521A5 - - Google Patents

Info

Publication number

JP2007525521A5

JP2007525521A5 JP2007501006A JP2007501006A JP2007525521A5 JP 2007525521 A5 JP2007525521 A5 JP 2007525521A5 JP 2007501006 A JP2007501006 A JP 2007501006A JP 2007501006 A JP2007501006 A JP 2007501006A JP 2007525521 A5 JP2007525521 A5 JP 2007525521A5

Authority

JP

Japan

Prior art keywords

compound

group

alkyl

hcv

pharmaceutical composition

Prior art date

2005-02-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 51
• 241000711549 Hepacivirus C Species 0.000 claims 17
• 239000008194 pharmaceutical composition Substances 0.000 claims 15
• 125000000217 alkyl group Chemical group 0.000 claims 9
• 229940079322 interferon Drugs 0.000 claims 9
• 239000000203 mixture Substances 0.000 claims 9
• 125000000753 cycloalkyl group Chemical group 0.000 claims 8
• 125000000623 heterocyclic group Chemical group 0.000 claims 8
• 125000003118 aryl group Chemical group 0.000 claims 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
• 125000001072 heteroaryl group Chemical group 0.000 claims 7
• 102000014150 Interferons Human genes 0.000 claims 6
• 108010050904 Interferons Proteins 0.000 claims 6
• 108091005804 Peptidases Proteins 0.000 claims 6
• 239000004365 Protease Substances 0.000 claims 6
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 6
• 238000000034 method Methods 0.000 claims 5
• 125000003342 alkenyl group Chemical group 0.000 claims 4
• 125000000304 alkynyl group Chemical group 0.000 claims 4
• 239000003443 antiviral agent Substances 0.000 claims 4
• 125000004404 heteroalkyl group Chemical group 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 239000012453 solvate Substances 0.000 claims 4
• 239000003937 drug carrier Substances 0.000 claims 3
• 150000002148 esters Chemical class 0.000 claims 3
• -1 heteroalkenyl Chemical group 0.000 claims 3
• 125000004446 heteroarylalkyl group Chemical group 0.000 claims 3
• 229920001184 polypeptide Polymers 0.000 claims 3
• 102000004196 processed proteins & peptides Human genes 0.000 claims 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical group N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 2
• 125000003710 aryl alkyl group Chemical group 0.000 claims 2
• 125000001475 halogen functional group Chemical group 0.000 claims 2
• 229960000329 ribavirin Drugs 0.000 claims 2
• HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 2
• 229910052717 sulfur Inorganic materials 0.000 claims 2
• RGICCULPCWNRAB-UHFFFAOYSA-N 2-[2-(2-hexoxyethoxy)ethoxy]ethanol Chemical compound CCCCCCOCCOCCOCCO RGICCULPCWNRAB-UHFFFAOYSA-N 0.000 claims 1
• JGLMVXWAHNTPRF-CMDGGOBGSA-N CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O Chemical compound CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O JGLMVXWAHNTPRF-CMDGGOBGSA-N 0.000 claims 1
• 101100240520 Caenorhabditis elegans nhr-14 gene Proteins 0.000 claims 1
• 208000005176 Hepatitis C Diseases 0.000 claims 1
• OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 1
• 229930194542 Keto Natural products 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 125000003545 alkoxy group Chemical group 0.000 claims 1
• 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims 1
• 125000005194 alkoxycarbonyloxy group Chemical group 0.000 claims 1
• 125000003282 alkyl amino group Chemical group 0.000 claims 1
• 125000002877 alkyl aryl group Chemical group 0.000 claims 1
• 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 1
• 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
• 125000004422 alkyl sulphonamide group Chemical group 0.000 claims 1
• 125000004414 alkyl thio group Chemical group 0.000 claims 1
• 125000005281 alkyl ureido group Chemical group 0.000 claims 1
• 125000001769 aryl amino group Chemical group 0.000 claims 1
• 125000004391 aryl sulfonyl group Chemical group 0.000 claims 1
• 125000004421 aryl sulphonamide group Chemical group 0.000 claims 1
• 125000005110 aryl thio group Chemical group 0.000 claims 1
• 125000004104 aryloxy group Chemical group 0.000 claims 1
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
• 150000003857 carboxamides Chemical class 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• 125000004093 cyano group Chemical group *C#N 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 230000001747 exhibiting effect Effects 0.000 claims 1
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 125000000468 ketone group Chemical group 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
• 229910052760 oxygen Inorganic materials 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
• 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1
• 238000003419 tautomerization reaction Methods 0.000 claims 1
• 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 0 C*(*)C(*)CN Chemical compound C*(*)C(*)CN 0.000 description 8