JP2007524412A5 - - Google Patents
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- JP2007524412A5 JP2007524412A5 JP2006551370A JP2006551370A JP2007524412A5 JP 2007524412 A5 JP2007524412 A5 JP 2007524412A5 JP 2006551370 A JP2006551370 A JP 2006551370A JP 2006551370 A JP2006551370 A JP 2006551370A JP 2007524412 A5 JP2007524412 A5 JP 2007524412A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- use according
- bound
- antibody
- folate receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 102000006815 folate receptor Human genes 0.000 claims 10
- 108020005243 folate receptor Proteins 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 239000003446 ligand Substances 0.000 claims 8
- -1 maleimide-hydroxysuccinimide ester Chemical class 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 108091034117 Oligonucleotide Proteins 0.000 claims 4
- 239000000032 diagnostic agent Substances 0.000 claims 4
- 229940039227 diagnostic agent Drugs 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 230000002245 ribonucleolytic effect Effects 0.000 claims 4
- 239000003053 toxin Substances 0.000 claims 4
- 231100000765 toxin Toxicity 0.000 claims 4
- 108700012359 toxins Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
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- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical group OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 claims 2
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- FPVKHBSQESCIEP-UHFFFAOYSA-N (8S)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol Natural products C1C(O)C(CO)OC1N1C(NC=NCC2O)=C2N=C1 FPVKHBSQESCIEP-UHFFFAOYSA-N 0.000 claims 1
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- VSNHCAURESNICA-NJFSPNSNSA-N 1-oxidanylurea Chemical compound N[14C](=O)NO VSNHCAURESNICA-NJFSPNSNSA-N 0.000 claims 1
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| CN102526610A (zh) * | 2011-12-20 | 2012-07-04 | 宋涛 | 一种治疗多发性大动脉炎的中药 |
| US20140079636A1 (en) * | 2012-04-16 | 2014-03-20 | Dinesh U. Chimmanamada | Targeted therapeutics |
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| KR101659855B1 (ko) | 2014-05-08 | 2016-09-26 | 국립암센터 | 엽산을 포함하는 광역학 진단 또는 치료용 결합체 및 그를 포함하는 광역학 진단 또는 치료용 조성물 |
| KR101646577B1 (ko) * | 2014-08-14 | 2016-08-09 | 원광대학교산학협력단 | 엽산수용체 표적용 화합물 또는 이의 약학적으로 허용가능한 염과, 이를 유효성분으로 포함하는 암 예방, 진단 또는 치료용 조성물 |
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| US5108921A (en) * | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
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| WO1998016254A1 (en) * | 1996-10-17 | 1998-04-23 | Immunomedics, Inc. | Non-antigenic toxin-conjugate and fusion protein of internalizing receptor system |
| IL119627A (en) * | 1996-11-17 | 2002-03-10 | Yissum Res Dev Co | PHARMACEUTICAL PREPARATIONS FOR THE CONTROLLED-RELEASE OF AN ACTIVE AGENT COMPRISING AT LEAST ONE β-LACTAM ANTIBIOTIC AGENT |
| ES2248898T3 (es) * | 1997-05-02 | 2006-03-16 | The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services | Inmunotoxinas que comprenden una proteina onc dirigida contra celulas malignas. |
| US6083677A (en) * | 1998-04-29 | 2000-07-04 | Eastman Kodak Company | Photographic element containing yellow dye-forming photographic coupler |
| WO1999066951A2 (en) * | 1998-06-22 | 1999-12-29 | Immunomedics, Inc. | Use of bi-specific antibodies for pre-targeting diagnosis and therapy |
| US6962702B2 (en) * | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
| US7138103B2 (en) * | 1998-06-22 | 2006-11-21 | Immunomedics, Inc. | Use of bi-specific antibodies for pre-targeting diagnosis and therapy |
| US7052872B1 (en) * | 1999-06-22 | 2006-05-30 | Immunomedics, Inc. | Bi-specific antibodies for pre-targeting diagnosis and therapy |
| US20030099629A1 (en) * | 1999-03-11 | 2003-05-29 | Immunomedics, Inc. | Recombinant onconase and chemical conjugates and fusion proteins of recombinant onconase |
| US20040043030A1 (en) * | 2001-07-31 | 2004-03-04 | Immunomedics, Inc. | Polymeric delivery systems |
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| EP1572242B1 (en) * | 2002-12-13 | 2014-04-16 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
| CN1767860A (zh) * | 2003-01-31 | 2006-05-03 | 免疫医疗公司 | 施用治疗和诊断剂的方法和组合物 |
-
2005
- 2005-01-24 AU AU2005207026A patent/AU2005207026A1/en not_active Abandoned
- 2005-01-24 WO PCT/US2005/002193 patent/WO2005069994A2/en not_active Ceased
- 2005-01-24 JP JP2006551370A patent/JP2007524412A/ja active Pending
- 2005-01-24 US US11/040,114 patent/US20050261170A1/en not_active Abandoned
- 2005-01-24 CA CA002553221A patent/CA2553221A1/en not_active Abandoned
- 2005-01-24 EP EP05722512A patent/EP1732608A2/en not_active Withdrawn
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