JP2007523192A5 - - Google Patents
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- Publication number
- JP2007523192A5 JP2007523192A5 JP2006554304A JP2006554304A JP2007523192A5 JP 2007523192 A5 JP2007523192 A5 JP 2007523192A5 JP 2006554304 A JP2006554304 A JP 2006554304A JP 2006554304 A JP2006554304 A JP 2006554304A JP 2007523192 A5 JP2007523192 A5 JP 2007523192A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- use according
- anal
- metastatic
- uterine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 206010028980 Neoplasm Diseases 0.000 claims 80
- 201000011510 cancer Diseases 0.000 claims 72
- 206010061424 Anal cancer Diseases 0.000 claims 38
- QZPQTZZNNJUOLS-UHFFFAOYSA-N beta-lapachone Chemical compound C12=CC=CC=C2C(=O)C(=O)C2=C1OC(C)(C)CC2 QZPQTZZNNJUOLS-UHFFFAOYSA-N 0.000 claims 24
- 206010008342 Cervix carcinoma Diseases 0.000 claims 21
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 21
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 21
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 21
- 206010038389 Renal cancer Diseases 0.000 claims 21
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 21
- 201000010881 cervical cancer Diseases 0.000 claims 21
- 201000004101 esophageal cancer Diseases 0.000 claims 21
- 201000010982 kidney cancer Diseases 0.000 claims 21
- 201000007270 liver cancer Diseases 0.000 claims 21
- 208000014018 liver neoplasm Diseases 0.000 claims 21
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 20
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 20
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 20
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 20
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 20
- 210000000214 mouth Anatomy 0.000 claims 20
- 206010046766 uterine cancer Diseases 0.000 claims 20
- 208000007860 Anus Neoplasms Diseases 0.000 claims 19
- 206010005003 Bladder cancer Diseases 0.000 claims 19
- 206010014733 Endometrial cancer Diseases 0.000 claims 19
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 19
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 19
- 206010025537 Malignant anorectal neoplasms Diseases 0.000 claims 19
- 208000032271 Malignant tumor of penis Diseases 0.000 claims 19
- 208000002471 Penile Neoplasms Diseases 0.000 claims 19
- 206010034299 Penile cancer Diseases 0.000 claims 19
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 claims 19
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 19
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 19
- 206010057644 Testis cancer Diseases 0.000 claims 19
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 19
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 19
- 201000007696 anal canal cancer Diseases 0.000 claims 19
- 201000011165 anus cancer Diseases 0.000 claims 19
- 201000009036 biliary tract cancer Diseases 0.000 claims 19
- 208000020790 biliary tract neoplasm Diseases 0.000 claims 19
- 210000000988 bone and bone Anatomy 0.000 claims 19
- 201000007455 central nervous system cancer Diseases 0.000 claims 19
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 19
- 201000010175 gallbladder cancer Diseases 0.000 claims 19
- 206010017758 gastric cancer Diseases 0.000 claims 19
- 208000014899 intrahepatic bile duct cancer Diseases 0.000 claims 19
- 206010023841 laryngeal neoplasm Diseases 0.000 claims 19
- 201000011682 nervous system cancer Diseases 0.000 claims 19
- 201000008106 ocular cancer Diseases 0.000 claims 19
- 210000004798 organs belonging to the digestive system Anatomy 0.000 claims 19
- 201000002314 small intestine cancer Diseases 0.000 claims 19
- 201000011549 stomach cancer Diseases 0.000 claims 19
- 201000003120 testicular cancer Diseases 0.000 claims 19
- 210000002105 tongue Anatomy 0.000 claims 19
- 201000005112 urinary bladder cancer Diseases 0.000 claims 19
- 230000002485 urinary effect Effects 0.000 claims 19
- 206010046885 vaginal cancer Diseases 0.000 claims 19
- 208000013139 vaginal neoplasm Diseases 0.000 claims 19
- 206010061523 Lip and/or oral cavity cancer Diseases 0.000 claims 18
- 206010062129 Tongue neoplasm Diseases 0.000 claims 18
- 210000000056 organ Anatomy 0.000 claims 18
- 210000003800 pharynx Anatomy 0.000 claims 18
- 201000002510 thyroid cancer Diseases 0.000 claims 18
- 201000006134 tongue cancer Diseases 0.000 claims 18
- 206010005949 Bone cancer Diseases 0.000 claims 17
- 208000018084 Bone neoplasm Diseases 0.000 claims 17
- 201000005443 oral cavity cancer Diseases 0.000 claims 17
- 201000008006 pharynx cancer Diseases 0.000 claims 17
- 210000000626 ureter Anatomy 0.000 claims 17
- 208000037819 metastatic cancer Diseases 0.000 claims 16
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 16
- 208000024519 eye neoplasm Diseases 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 13
- 230000030833 cell death Effects 0.000 claims 7
- 230000001394 metastastic effect Effects 0.000 claims 6
- 206010061289 metastatic neoplasm Diseases 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000006907 apoptotic process Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 206010023825 Laryngeal cancer Diseases 0.000 claims 2
- 208000023915 Ureteral Neoplasms Diseases 0.000 claims 2
- 206010047741 Vulval cancer Diseases 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 230000012820 cell cycle checkpoint Effects 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 230000004614 tumor growth Effects 0.000 claims 2
- 201000011294 ureter cancer Diseases 0.000 claims 2
- 201000005102 vulva cancer Diseases 0.000 claims 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- 206010068116 Metastatic uterine cancer Diseases 0.000 claims 1
- 206010034811 Pharyngeal cancer Diseases 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 208000025188 carcinoma of pharynx Diseases 0.000 claims 1
- 208000024558 digestive system cancer Diseases 0.000 claims 1
- 201000010231 gastrointestinal system cancer Diseases 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54591604P | 2004-02-20 | 2004-02-20 | |
| PCT/US2005/005647 WO2005082358A2 (en) | 2004-02-20 | 2005-02-18 | Use of beta-lapachone as a broad spectrum anti-cancer agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007523192A JP2007523192A (ja) | 2007-08-16 |
| JP2007523192A5 true JP2007523192A5 (https=) | 2008-03-27 |
Family
ID=34910740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006554304A Withdrawn JP2007523192A (ja) | 2004-02-20 | 2005-02-18 | 広域スペクトラム抗癌剤としてのβ−ラパコンの使用 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1722776A2 (https=) |
| JP (1) | JP2007523192A (https=) |
| CA (1) | CA2556794A1 (https=) |
| WO (1) | WO2005082358A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050187288A1 (en) * | 2004-02-20 | 2005-08-25 | Chiang Li | Beta-lapachone and methods of treating cancer |
| CN101119726B (zh) * | 2005-02-16 | 2011-02-02 | 麦仁斯有限公司 | 用于治疗或预防涉及肥胖、糖尿病、代谢综合症、神经变性疾病和线粒体功能障碍疾病的疾病的药物组合物 |
| KR20090071829A (ko) * | 2007-12-28 | 2009-07-02 | 주식회사 머젠스 | 신장질환의 치료 및 예방을 위한 약제 조성물 |
| JPWO2013153821A1 (ja) * | 2012-04-12 | 2015-12-17 | 学校法人北里研究所 | Ｐｄｋ４阻害剤及びその利用 |
| JP7411875B2 (ja) * | 2020-10-08 | 2024-01-12 | 株式会社 キュロム・バイオサイエンス | ベータ－ラパコンを有効成分として含む胆汁うっ滞性肝疾患予防又は治療用薬学組成物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5763625A (en) * | 1995-04-25 | 1998-06-09 | Wisconsin Alumni Research Foundation | Synthesis and use of β-lapachone analogs |
| US5883270A (en) * | 1996-02-20 | 1999-03-16 | Wisconsin Alumni Research Foundation | 4-substituted-1, 2-naphthoquinones and their use in the inhibition of neoplastic cell growth |
| AU2003254029A1 (en) * | 2002-07-17 | 2004-02-02 | Arqule, Inc. | Activated checkpoint therapy and methods of use thereof |
| BR0316296A (pt) * | 2002-11-18 | 2005-12-13 | Arqule Inc | Compostos lapacone e seus métodos de uso |
| WO2004050033A2 (en) * | 2002-12-02 | 2004-06-17 | Arqule, Inc. | Method of treating cancers |
-
2005
- 2005-02-18 EP EP05723508A patent/EP1722776A2/en not_active Ceased
- 2005-02-18 CA CA002556794A patent/CA2556794A1/en not_active Abandoned
- 2005-02-18 JP JP2006554304A patent/JP2007523192A/ja not_active Withdrawn
- 2005-02-18 WO PCT/US2005/005647 patent/WO2005082358A2/en not_active Ceased
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