JP2007523091A5 - - Google Patents
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- JP2007523091A5 JP2007523091A5 JP2006553364A JP2006553364A JP2007523091A5 JP 2007523091 A5 JP2007523091 A5 JP 2007523091A5 JP 2006553364 A JP2006553364 A JP 2006553364A JP 2006553364 A JP2006553364 A JP 2006553364A JP 2007523091 A5 JP2007523091 A5 JP 2007523091A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- bicarbonate
- carbonate
- buffer
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 44
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 17
- 239000007787 solid Substances 0.000 claims 13
- 239000007853 buffer solution Substances 0.000 claims 12
- 239000000872 buffer Substances 0.000 claims 11
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 6
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 claims 5
- 229960001475 zolpidem Drugs 0.000 claims 5
- 210000000214 mouth Anatomy 0.000 claims 4
- 210000004877 mucosa Anatomy 0.000 claims 3
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical group [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- 239000001099 ammonium carbonate Substances 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 2
- 239000007884 disintegrant Substances 0.000 claims 2
- 206010022437 insomnia Diseases 0.000 claims 2
- 239000007937 lozenge Substances 0.000 claims 2
- 210000002200 mouth mucosa Anatomy 0.000 claims 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 claims 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical group [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 1
- 235000012538 ammonium bicarbonate Nutrition 0.000 claims 1
- 235000012501 ammonium carbonate Nutrition 0.000 claims 1
- 210000005178 buccal mucosa Anatomy 0.000 claims 1
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims 1
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims 1
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 1
- 235000010216 calcium carbonate Nutrition 0.000 claims 1
- 239000002274 desiccant Substances 0.000 claims 1
- QWDJLDTYWNBUKE-UHFFFAOYSA-L magnesium bicarbonate Chemical compound [Mg+2].OC([O-])=O.OC([O-])=O QWDJLDTYWNBUKE-UHFFFAOYSA-L 0.000 claims 1
- 239000002370 magnesium bicarbonate Substances 0.000 claims 1
- 229910000022 magnesium bicarbonate Inorganic materials 0.000 claims 1
- 235000014824 magnesium bicarbonate Nutrition 0.000 claims 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims 1
- 239000001095 magnesium carbonate Substances 0.000 claims 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims 1
- 235000014380 magnesium carbonate Nutrition 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims 1
- 235000015497 potassium bicarbonate Nutrition 0.000 claims 1
- 239000011736 potassium bicarbonate Substances 0.000 claims 1
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 1
- 235000011181 potassium carbonates Nutrition 0.000 claims 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 1
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 1
- 235000017550 sodium carbonate Nutrition 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60895704P | 2004-02-17 | 2004-02-17 | |
| US60/608,957 | 2004-02-17 | ||
| US59862904P | 2004-08-03 | 2004-08-03 | |
| US60/598,629 | 2004-08-03 | ||
| PCT/US2005/005021 WO2005079761A1 (en) | 2004-02-17 | 2005-02-16 | Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007523091A JP2007523091A (ja) | 2007-08-16 |
| JP2007523091A5 true JP2007523091A5 (enExample) | 2008-02-28 |
| JP5179757B2 JP5179757B2 (ja) | 2013-04-10 |
Family
ID=38102004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006553364A Expired - Fee Related JP5179757B2 (ja) | 2004-02-17 | 2005-02-16 | 口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (6) | US7658945B2 (enExample) |
| EP (1) | EP1715853A4 (enExample) |
| JP (1) | JP5179757B2 (enExample) |
| KR (5) | KR20070030178A (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070030178A (ko) * | 2004-02-17 | 2007-03-15 | 트랜스오랄 파마슈티칼스, 인코포레이티드 | 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의사용 방법 |
| GB0423800D0 (en) * | 2004-10-27 | 2004-12-01 | Orexo Ab | New pharmaceutical formulations |
| US20070225322A1 (en) * | 2005-05-25 | 2007-09-27 | Transoral Pharmaceuticals, Inc. | Compositions and methods for treating middle-of-the night insomnia |
| US20070287740A1 (en) * | 2005-05-25 | 2007-12-13 | Transcept Pharmaceuticals, Inc. | Compositions and methods of treating middle-of-the night insomnia |
| BRPI0609984A2 (pt) * | 2005-05-25 | 2010-05-18 | Transcept Pharmaceuticals Inc | uso de zolpidem ou um sal do mesmo |
| JP4963846B2 (ja) * | 2006-03-03 | 2012-06-27 | エルメッド エーザイ株式会社 | 口腔内崩壊錠及びその製造方法 |
| CA2687124A1 (en) * | 2006-05-19 | 2007-12-13 | Somaxon Pharmaceuticals, Inc. | Low dose doxepin formulations, including buccal, sublingual and fastmelt formulations, and uses of the same to treat insomnia |
| WO2008067549A2 (en) * | 2006-11-30 | 2008-06-05 | Transcept Pharmaceuticals, Inc. | Stabilized zolpidem pharmaceutical compositions |
| US20080145425A1 (en) * | 2006-12-15 | 2008-06-19 | Pliva Research & Development Limited | Pharmaceutical composition of zolpidem |
| WO2009146104A1 (en) * | 2008-04-02 | 2009-12-03 | Accentia Biopharmaceuticals, Inc. | Formulations, devices and methods for treating and preventing mucositis |
| US20100266682A1 (en) * | 2008-12-10 | 2010-10-21 | Nipun Davar | Polyethylene glycol-coated sodium carbonate as a pharmaceutical excipient and compositions produced from the same |
| US20100143486A1 (en) * | 2008-12-10 | 2010-06-10 | Nipun Davar | Polyethylene glycol-coated sodium carbonate as a pharmaceutical excipient and compositions produced from the same |
| KR101080001B1 (ko) * | 2009-01-19 | 2011-11-04 | 보령제약 주식회사 | 졸피뎀 또는 그의 약제학적으로 허용되는 염을 포함하는 구강 속붕해정 |
| PT2952191T (pt) | 2009-06-12 | 2018-11-30 | Sunovion Pharmaceuticals Inc | Apomorfina sublingual |
| US20120288450A1 (en) * | 2009-08-14 | 2012-11-15 | Eduardo Jose Gonzales | Chewing gum formula for enhancing psycho-spirituality |
| US20110038915A1 (en) * | 2009-08-14 | 2011-02-17 | Eduardo Jose Gonzalez | Chewing Gum Formula for Enhancing Psycho-Spirituality |
| PT2501234T (pt) * | 2009-11-20 | 2017-12-13 | Tonix Pharma Holdings Ltd | Métodos e composições para o tratamento de sintomas associados com distúrbios de stress pós-traumático utilizando ciclobenzaprina |
| US20110319389A1 (en) | 2010-06-24 | 2011-12-29 | Tonix Pharmaceuticals, Inc. | Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine |
| FR2968992B1 (fr) * | 2010-12-16 | 2013-02-08 | Sanofi Aventis | Comprime pharmaceutique orodispersible a base de zolpidem |
| EP2651357B1 (en) | 2010-12-16 | 2020-04-01 | Sunovion Pharmaceuticals Inc. | Sublingual films |
| US11998516B2 (en) | 2011-03-07 | 2024-06-04 | Tonix Pharma Holdings Limited | Methods and compositions for treating depression using cyclobenzaprine |
| US20130143912A1 (en) * | 2011-12-06 | 2013-06-06 | Dr. Reddy's Laboratories Inc. | Sublingual zolpidem formulations |
| FR3000896B1 (fr) * | 2013-01-14 | 2016-08-26 | Philippe Perovitch | Forme galenique pour l'administration de principe(s) actif(s) permettant l'induction acceleree du sommeil et/ou le traitement des troubles du sommeil |
| MY196014A (en) | 2013-03-15 | 2023-03-06 | Tonix Pharmaceuticals Inc | Eutectic Formulations of Cyclobenzaprine Hydrochloride and Amitriptyline Hydrochloride |
| US12274276B2 (en) | 2013-10-03 | 2025-04-15 | Altria Client Services Llc | Dissolvable-chewable tablet |
| US11779045B2 (en) | 2013-10-03 | 2023-10-10 | Altria Client Services Llc | Dissolvable-chewable exhausted-tobacco tablet |
| US10244786B2 (en) | 2013-10-03 | 2019-04-02 | Altria Client Services Llc | Tobacco lozenge |
| US10105320B2 (en) | 2013-10-03 | 2018-10-23 | Altria Client Services | Soluble fiber lozenge |
| US9351936B2 (en) | 2013-10-03 | 2016-05-31 | Altria Client Services Llc | Nicotine lozenge |
| US9999243B2 (en) | 2013-10-03 | 2018-06-19 | Altria Client Services Llc | Exhausted tobacco lozenge |
| CA2888219C (en) * | 2014-02-07 | 2018-07-10 | Scilabs Pharmaceuticals, Inc. | All natural, non-toxic sublingual drug delivery systems |
| SG10201902203VA (en) | 2014-09-18 | 2019-04-29 | Tonix Pharma Holdings Ltd | Eutectic formulations of cyclobenzaprine hydrochloride |
| JP6532153B2 (ja) * | 2015-01-30 | 2019-06-19 | ライオン株式会社 | 内服用錠剤 |
| CA3127926A1 (en) | 2015-04-21 | 2016-10-27 | Sunovion Pharmaceuticals Inc. | Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa |
| EP3324971B1 (en) * | 2015-07-23 | 2024-06-12 | Athena Pharmaceutiques SAS | Zolpidem composition and process for preparing the same |
| US10835499B2 (en) | 2015-12-30 | 2020-11-17 | Corium, Inc. | Systems and methods for long term transdermal administration |
| CN108697637A (zh) * | 2016-01-27 | 2018-10-23 | 因斯塔尔科技股份公司 | 用于治疗性处理的口腔粘膜纳米纤维载体 |
| CN109922796B (zh) | 2016-06-23 | 2023-04-07 | 考里安有限责任公司 | 具有亲水和疏水域的粘合剂基质和治疗剂 |
| JP7071330B2 (ja) | 2016-07-27 | 2022-05-18 | コリウム， インコーポレイテッド | 炭酸水素ナトリウムのｉｎ ｓｉｔｕ変換で促進されたアミン薬物の経皮送達 |
| EP3490544A1 (en) | 2016-07-27 | 2019-06-05 | Corium International, Inc. | Memantine transdermal delivery systems |
| KR102424270B1 (ko) | 2016-07-27 | 2022-07-25 | 코리움, 인크. | 경구 전달과 생물학적으로 동등한 약물동역학을 가진 경피 전달 시스템 |
| SG11201912172YA (en) | 2017-06-20 | 2020-01-30 | Physicians Seal Llc | Orally dissolving melatonin formulation with acidifying agent that renders melatonin soluble in saliva |
| BR112020011345A2 (pt) | 2017-12-11 | 2020-11-17 | Tonix Pharma Holdings Limited | tratamento com ciclobenzaprina para agitação, psicose e declínio cognitivo na demência e condições neurodegenerativas |
| WO2019126531A1 (en) | 2017-12-20 | 2019-06-27 | Corium, Inc. | Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point |
| CN108113969A (zh) * | 2018-02-06 | 2018-06-05 | 江苏长泰药业有限公司 | 一种快速崩解的酒石酸唑吡坦舌下片及其制备方法 |
| GEAP202215600A (en) * | 2018-10-08 | 2022-10-25 | Troikaa Pharmaceuticals Ltd | Oromucosal solutions of zolpidem or pharmaceutically acceptable salts thereof |
Family Cites Families (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2492382A1 (fr) | 1980-10-22 | 1982-04-23 | Synthelabo | Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique |
| US4405647A (en) | 1981-06-15 | 1983-09-20 | Wm. Wrigley Jr. Company | Method of compacting chewing gum base |
| US4863737A (en) | 1985-05-01 | 1989-09-05 | University Of Utah | Compositions and methods of manufacture of compressed powder medicaments |
| US5855908A (en) | 1984-05-01 | 1999-01-05 | University Of Utah Research Foundation | Non-dissolvable drug-containing dosage-forms for use in the transmucosal delivery of a drug to a patient |
| US5288498A (en) | 1985-05-01 | 1994-02-22 | University Of Utah Research Foundation | Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments |
| US5785989A (en) | 1985-05-01 | 1998-07-28 | University Utah Research Foundation | Compositions and methods of manufacturing of oral dissolvable medicaments |
| US5288497A (en) * | 1985-05-01 | 1994-02-22 | The University Of Utah | Compositions of oral dissolvable medicaments |
| US5132114A (en) | 1985-05-01 | 1992-07-21 | University Of Utah Research Foundation | Compositions and methods of manufacture of compressed powder medicaments |
| FR2606410B1 (fr) | 1986-11-07 | 1989-02-24 | Synthelabo | Imidazopyridines, leur preparation et leur application en therapeutique |
| US5719197A (en) | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5223264A (en) | 1989-10-02 | 1993-06-29 | Cima Labs, Inc. | Pediatric effervescent dosage form |
| US5178878A (en) | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
| US5284659A (en) | 1990-03-30 | 1994-02-08 | Cherukuri Subraman R | Encapsulated flavor with bioadhesive character in pressed mints and confections |
| US5686094A (en) | 1991-04-01 | 1997-11-11 | Theratech, Inc. | Controlled release formulations for the treatment of xerostomia |
| DE4112652A1 (de) * | 1991-04-18 | 1992-10-22 | Wolman Gmbh Dr | Holzschutzmittel |
| US5786357A (en) * | 1991-12-02 | 1998-07-28 | Sepracor Inc. | Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone |
| US6005109A (en) | 1997-10-30 | 1999-12-21 | Pflizer Inc. | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
| TW370529B (en) | 1992-12-17 | 1999-09-21 | Pfizer | Pyrazolopyrimidines |
| US5503846A (en) | 1993-03-17 | 1996-04-02 | Cima Labs, Inc. | Base coated acid particles and effervescent formulation incorporating same |
| US5965162A (en) | 1993-09-10 | 1999-10-12 | Fuisz Technologies Ltd. | Process for forming chewable quickly dispersing multi-vitamin preparation and product therefrom |
| US5895664A (en) | 1993-09-10 | 1999-04-20 | Fuisz Technologies Ltd. | Process for forming quickly dispersing comestible unit and product therefrom |
| US5576014A (en) | 1994-01-31 | 1996-11-19 | Yamanouchi Pharmaceutical Co., Ltd | Intrabuccally dissolving compressed moldings and production process thereof |
| GB9401894D0 (en) * | 1994-02-01 | 1994-03-30 | Rhone Poulenc Rorer Ltd | New compositions of matter |
| US5869082A (en) | 1996-04-12 | 1999-02-09 | Flemington Pharmaceutical Corp. | Buccal, non-polar spray for nitroglycerin |
| ES2234010T3 (es) | 1996-04-12 | 2005-06-16 | Novadel Pharma Inc. | Aerosol bucal polar. |
| US5955098A (en) | 1996-04-12 | 1999-09-21 | Flemington Pharmaceutical Corp. | Buccal non polar spray or capsule |
| US5804165A (en) * | 1996-07-24 | 1998-09-08 | Arnold; Michael J. | Antiplaque oral composition |
| US6024981A (en) | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
| DK1001748T3 (da) * | 1997-07-25 | 2006-08-21 | Alpex Pharma Sa | Fremgangsmåde til fremstilling af et granulat, som er egnet til fremstilling af i munden oplöselige tabletter, som kan sönderdeles hurtigt |
| US20030095927A1 (en) | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating muscular and skeletal disorders |
| US20040136914A1 (en) | 1997-10-01 | 2004-07-15 | Dugger Harry A. | Buccal, polar and non-polar spray containing ondansetron |
| WO1999016417A1 (en) | 1997-10-01 | 1999-04-08 | Flemington Pharmaceutical Corporation | Buccal, polar and non-polar spray or capsule |
| US20030095926A1 (en) | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the gastrointestinal tract or urinary tract |
| US20030190286A1 (en) | 1997-10-01 | 2003-10-09 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating allergies or asthma |
| US20040136915A1 (en) | 1997-10-01 | 2004-07-15 | Dugger Harry A. | Buccal, polar and non-polar spray containing atropine |
| US20030077228A1 (en) | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating endocrine disorders |
| US20030077229A1 (en) | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs |
| US20030185761A1 (en) | 1997-10-01 | 2003-10-02 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
| US20030077227A1 (en) | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system |
| US20040136913A1 (en) | 1997-10-01 | 2004-07-15 | Dugger Harry A. | Buccal, polar and non-polar spray containing sumatriptan |
| US20050281752A1 (en) | 1997-10-01 | 2005-12-22 | Dugger Harry A Iii | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system |
| US20050002867A1 (en) | 1997-10-01 | 2005-01-06 | Novadel Pharma Inc. | Buccal, polar and non-polar sprays containing propofol |
| US20030082107A1 (en) | 1997-10-01 | 2003-05-01 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating an infectious disease or cancer |
| US20030095925A1 (en) | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders |
| US7632517B2 (en) | 1997-10-01 | 2009-12-15 | Novadel Pharma Inc. | Buccal, polar and non-polar spray containing zolpidem |
| US20040141923A1 (en) | 1997-10-01 | 2004-07-22 | Dugger Harry A. | Buccal, polar and non-polar spray containing alprazolam |
| US6200604B1 (en) | 1998-03-27 | 2001-03-13 | Cima Labs Inc. | Sublingual buccal effervescent |
| US6350470B1 (en) | 1998-04-29 | 2002-02-26 | Cima Labs Inc. | Effervescent drug delivery system for oral administration |
| US6576250B1 (en) | 1998-03-27 | 2003-06-10 | Cima Labs Inc. | Pharmaceutical compositions for rectal and vaginal administration |
| US20030118645A1 (en) | 1998-04-29 | 2003-06-26 | Pather S. Indiran | Pharmaceutical compositions for rectal and vaginal administration |
| US20030091629A1 (en) | 1998-03-27 | 2003-05-15 | Cima Labs Inc. | Sublingual buccal effervescent |
| US6197334B1 (en) | 1998-04-13 | 2001-03-06 | Donald V. Renda | Lozenge and method of making |
| AUPP294698A0 (en) * | 1998-04-15 | 1998-05-07 | Gray, Bruce | Removable ball joint |
| US6348485B1 (en) | 1998-06-09 | 2002-02-19 | Takeda Chemical Industries, Ltd. | Method for treating or preventing sleep disorders |
| US6368625B1 (en) | 1998-08-12 | 2002-04-09 | Cima Labs Inc. | Orally disintegrable tablet forming a viscous slurry |
| JP4815053B2 (ja) | 1998-08-13 | 2011-11-16 | シーマ・ラブス、インコーポレイテッド | 経口投与の固形投与形態物としてのマイクロエマルション |
| US6358060B2 (en) | 1998-09-03 | 2002-03-19 | Jsr Llc | Two-stage transmucosal medicine delivery system for symptom relief |
| US6344222B1 (en) | 1998-09-03 | 2002-02-05 | Jsr Llc | Medicated chewing gum delivery system for nicotine |
| US20020098264A1 (en) | 1998-11-27 | 2002-07-25 | Cherukuri Subraman R. | Medicated chewing gum delivery system for nicotine |
| SE9803239D0 (sv) | 1998-09-24 | 1998-09-24 | Diabact Ab | Composition for the treatment of acute pain |
| SE9803240D0 (sv) | 1998-09-24 | 1998-09-24 | Diabact Ab | A pharmaceutical composition having a rapid action |
| US7815937B2 (en) | 1998-10-27 | 2010-10-19 | Biovail Laboratories International Srl | Quick dissolve compositions and tablets based thereon |
| EP1005863A1 (en) * | 1998-12-04 | 2000-06-07 | Synthelabo | Controlled-release dosage forms comprising a short acting hypnotic or a salt thereof |
| US7163705B2 (en) | 1998-12-15 | 2007-01-16 | Wm. Wrigley Jr. Company | Coated chewing gum product and method of making |
| FR2787715B1 (fr) * | 1998-12-23 | 2002-05-10 | Synthelabo | Composition pharmaceutique comprenant un compose hypnotique ou un de ses sels pharmaceutiquement acceptables |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| DK1038875T3 (da) | 1999-03-25 | 2003-09-29 | Synthon Bv | Imidazopyridine- derivativer og fremgangsmåde til fremstilling deraf |
| US6210699B1 (en) | 1999-04-01 | 2001-04-03 | Watson Pharmaceuticals, Inc. | Oral transmucosal delivery of drugs or any other ingredients via the inner buccal cavity |
| US6383471B1 (en) | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| US6395300B1 (en) | 1999-05-27 | 2002-05-28 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
| US20040258750A1 (en) | 1999-06-28 | 2004-12-23 | Gerard Alaux | Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof |
| US6720001B2 (en) | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| US6264981B1 (en) | 1999-10-27 | 2001-07-24 | Anesta Corporation | Oral transmucosal drug dosage using solid solution |
| US6753011B2 (en) * | 2000-01-14 | 2004-06-22 | Osmotica Corp | Combined diffusion/osmotic pumping drug delivery system |
| TWI220430B (en) | 2000-02-02 | 2004-08-21 | Nat Science Council | Method of synthesizing ferrocenyl-1,3-butadiene |
| JP2003523405A (ja) * | 2000-02-22 | 2003-08-05 | セレジー カナダ インコーポレイテッド | 睡眠改善のための方法および組成物 |
| WO2001078725A2 (en) | 2000-04-13 | 2001-10-25 | Synthon B.V. | Modified release formulations containing a hypnotic agent |
| IL152411A0 (en) | 2000-04-24 | 2003-05-29 | Teva Pharma | Zolpidem hemitartrate |
| US6264987B1 (en) | 2000-05-19 | 2001-07-24 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
| AU2001261744A1 (en) | 2000-05-19 | 2001-12-03 | Npd Llc | Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements |
| US7678387B2 (en) * | 2000-06-06 | 2010-03-16 | Capricorn Pharma, Inc. | Drug delivery systems |
| US6656492B2 (en) | 2000-06-30 | 2003-12-02 | Yamanouchi Pharmaceutical Co., Ltd. | Quick disintegrating tablet in buccal cavity and manufacturing method thereof |
| US6375982B1 (en) | 2000-07-05 | 2002-04-23 | Capricorn Pharma, Inc. | Rapid-melt semi-solid compositions, methods of making same and method of using same |
| JP3589167B2 (ja) * | 2000-08-28 | 2004-11-17 | 住友電装株式会社 | コネクタ |
| US6733781B2 (en) | 2000-12-06 | 2004-05-11 | Wyeth | Fast dissolving tablet |
| NZ527585A (en) | 2001-02-15 | 2005-04-29 | Tanabe Seiyaku Co | Tablets quickly disintegrated in oral cavity |
| US6692771B2 (en) | 2001-02-23 | 2004-02-17 | Cima Labs Inc. | Emulsions as solid dosage forms for oral administration |
| US20020160043A1 (en) * | 2001-02-27 | 2002-10-31 | Dennis Coleman | Compositions and method of manufacture for oral dissolvable dosage forms |
| US7143054B2 (en) * | 2001-07-02 | 2006-11-28 | The Procter & Gamble Company | Assessment of communication strengths of individuals from electronic messages |
| US20030068356A1 (en) | 2001-07-10 | 2003-04-10 | Pather S. Indiran | Sequential drug delivery systems |
| US6624162B2 (en) | 2001-10-22 | 2003-09-23 | Pfizer Inc. | Imidazopyridine compounds as 5-HT4 receptor modulators |
| US7118765B2 (en) | 2001-12-17 | 2006-10-10 | Spi Pharma, Inc. | Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms |
| US6573011B1 (en) * | 2001-12-21 | 2003-06-03 | Eastman Kodak Company | Label with curl and moisture resistant protective layer |
| AU2003221326A1 (en) | 2002-03-06 | 2003-09-16 | Kyowa Hakko Kogyo Co., Ltd. | Tablets quickly disintegrating in oral cavity |
| US20030185884A1 (en) | 2002-04-01 | 2003-10-02 | Singh Nikhilesh Nihala | Therapeutic agent delivery compositions for buccal cavity absorption of pilocarpine |
| WO2003092591A2 (en) * | 2002-04-30 | 2003-11-13 | Npd Llc | Multi-phasic delivery via transmucosal absorption of antiemetic medicaments |
| AU2003285012A1 (en) * | 2002-10-24 | 2004-05-13 | Sepracor, Inc. | Compositions comprising zopiclone derivatives and methods of making and using the same |
| US20050038042A1 (en) | 2002-11-15 | 2005-02-17 | Jenet Codd | Modified release composition comprising a short-acting hypnotic for treatment of sleep disorders |
| SI1587514T1 (sl) | 2003-01-31 | 2006-10-31 | Orexo Ab | Hitro ucinkujoc farmacevtski sestavek |
| US20040185097A1 (en) | 2003-01-31 | 2004-09-23 | Glenmark Pharmaceuticals Ltd. | Controlled release modifying complex and pharmaceutical compositions thereof |
| EP1449525A1 (en) * | 2003-02-20 | 2004-08-25 | Cross Chem Llc | chewing gum in the form of multi-layer tablets |
| US20040265375A1 (en) | 2003-04-16 | 2004-12-30 | Platteeuw Johannes J. | Orally disintegrating tablets |
| EP1656102A2 (en) * | 2003-08-21 | 2006-05-17 | Transoral Pharmaceuticals, Inc. | Compositions for delivering 5-ht agonists across the oral mucosa and methods of use thereof |
| US20050042281A1 (en) | 2003-08-21 | 2005-02-24 | Singh Nikhilesh N. | Compositions for delivering therapeutic agents across the oral mucosa |
| EP1696959A2 (en) | 2003-12-24 | 2006-09-06 | Sepracor, Inc. | Melatonin combination therapy for improving sleep quality |
| KR101184138B1 (ko) | 2003-12-31 | 2012-09-19 | 시마 랩스 인크. | 일반적인 선형 발포성 경구 펜타닐 투약 제형 및 투여 방법 |
| WO2005065317A2 (en) | 2003-12-31 | 2005-07-21 | Cima Labs Inc. | Effervescent oral fentanyl dosage form |
| KR20070030178A (ko) | 2004-02-17 | 2007-03-15 | 트랜스오랄 파마슈티칼스, 인코포레이티드 | 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의사용 방법 |
| EP3216445A1 (en) | 2004-05-28 | 2017-09-13 | Imaginot Pty Ltd. | Oral therapeutic compound delivery system |
| US20080262025A1 (en) | 2004-07-16 | 2008-10-23 | Yatendra Kumar | Processes for the Preparation of Zolpidem and its Hemitartrate |
| US20060051413A1 (en) | 2004-09-08 | 2006-03-09 | Chow Sing S M | Method of enhancing absorptions of transmucosal administration formulations |
| GB0423800D0 (en) | 2004-10-27 | 2004-12-01 | Orexo Ab | New pharmaceutical formulations |
| JP4982065B2 (ja) * | 2005-09-26 | 2012-07-25 | 株式会社東芝 | 映像コンテンツ表示システム、映像コンテンツ表示方法及びそのプログラム |
| US20080145425A1 (en) | 2006-12-15 | 2008-06-19 | Pliva Research & Development Limited | Pharmaceutical composition of zolpidem |
-
2005
- 2005-02-16 KR KR1020067018935A patent/KR20070030178A/ko not_active Ceased
- 2005-02-16 US US11/060,641 patent/US7658945B2/en not_active Expired - Fee Related
- 2005-02-16 KR KR1020137025409A patent/KR20130116378A/ko not_active Withdrawn
- 2005-02-16 KR KR1020147018143A patent/KR20140104986A/ko not_active Withdrawn
- 2005-02-16 KR KR1020127031305A patent/KR20130006523A/ko not_active Withdrawn
- 2005-02-16 KR KR1020157007690A patent/KR20150038745A/ko not_active Ceased
- 2005-02-16 JP JP2006553364A patent/JP5179757B2/ja not_active Expired - Fee Related
- 2005-02-16 EP EP05713712A patent/EP1715853A4/en not_active Withdrawn
-
2007
- 2007-08-03 US US11/833,323 patent/US7682628B2/en not_active Expired - Fee Related
-
2010
- 2010-03-11 US US12/722,398 patent/US20100291004A1/en not_active Abandoned
-
2012
- 2012-01-27 US US13/360,533 patent/US20120328533A1/en not_active Abandoned
-
2014
- 2014-04-15 US US14/253,241 patent/US20150290177A1/en not_active Abandoned
-
2016
- 2016-03-10 US US15/066,774 patent/US20170065517A1/en not_active Abandoned
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