JP2007522223A5 - - Google Patents
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- Publication number
- JP2007522223A5 JP2007522223A5 JP2006553213A JP2006553213A JP2007522223A5 JP 2007522223 A5 JP2007522223 A5 JP 2007522223A5 JP 2006553213 A JP2006553213 A JP 2006553213A JP 2006553213 A JP2006553213 A JP 2006553213A JP 2007522223 A5 JP2007522223 A5 JP 2007522223A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antioxidant
- morphine
- active ingredient
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 28
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 14
- 239000003963 antioxidant agent Substances 0.000 claims 10
- 235000006708 antioxidants Nutrition 0.000 claims 10
- 230000003078 antioxidant effect Effects 0.000 claims 8
- 229960005181 morphine Drugs 0.000 claims 7
- 229920000642 polymer Polymers 0.000 claims 7
- 229920001661 Chitosan Polymers 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- 238000013270 controlled release Methods 0.000 claims 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 4
- 239000003242 anti bacterial agent Substances 0.000 claims 3
- 239000004599 antimicrobial Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- 239000011668 ascorbic acid Substances 0.000 claims 2
- 229960005070 ascorbic acid Drugs 0.000 claims 2
- 229940098779 methanesulfonic acid Drugs 0.000 claims 2
- 150000004682 monohydrates Chemical class 0.000 claims 2
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims 2
- 235000010378 sodium ascorbate Nutrition 0.000 claims 2
- 229960005055 sodium ascorbate Drugs 0.000 claims 2
- 239000001509 sodium citrate Substances 0.000 claims 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 2
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229960000686 benzalkonium chloride Drugs 0.000 claims 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960004106 citric acid Drugs 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- 229910001873 dinitrogen Inorganic materials 0.000 claims 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000007922 nasal spray Substances 0.000 claims 1
- 229940097496 nasal spray Drugs 0.000 claims 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims 1
- 235000010234 sodium benzoate Nutrition 0.000 claims 1
- 239000004299 sodium benzoate Substances 0.000 claims 1
- 229960001790 sodium citrate Drugs 0.000 claims 1
- 235000011083 sodium citrates Nutrition 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/776,333 US20050175679A1 (en) | 2004-02-10 | 2004-02-10 | Controlled release formulations |
| PCT/US2005/004163 WO2005077346A1 (en) | 2004-02-10 | 2005-02-09 | Controlled release formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007522223A JP2007522223A (ja) | 2007-08-09 |
| JP2007522223A5 true JP2007522223A5 (https=) | 2008-04-03 |
Family
ID=34827359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006553213A Pending JP2007522223A (ja) | 2004-02-10 | 2005-02-09 | 制御放出配合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20050175679A1 (https=) |
| EP (1) | EP1720532A1 (https=) |
| JP (1) | JP2007522223A (https=) |
| KR (1) | KR20060135769A (https=) |
| AU (1) | AU2005212355B2 (https=) |
| BR (1) | BRPI0506630A (https=) |
| CA (1) | CA2555882A1 (https=) |
| IL (1) | IL177328A0 (https=) |
| MX (1) | MXPA06009094A (https=) |
| WO (1) | WO2005077346A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007083984A1 (en) | 2006-01-23 | 2007-07-26 | Gwangju Institute Of Science And Technology | Conjugate comprising pharmaceutical active compound covalently bound to mucoadhesive polymer and transmucosal delivery method of pharmaceutical active compound using the same |
| KR100766820B1 (ko) | 2006-01-23 | 2007-10-17 | 광주과학기술원 | 단백질 또는 펩타이드의 경점막 운반 시스템 |
| US20080182819A1 (en) * | 2007-01-29 | 2008-07-31 | Act Iii Licensing, Llc | Chitosan compositions and methods for using chitosan compositions in the treatment of health disorders |
| JP5258315B2 (ja) * | 2007-05-25 | 2013-08-07 | ロート製薬株式会社 | フルニソリド含有粘膜適用組成物 |
| US20130213393A1 (en) | 2009-12-22 | 2013-08-22 | Evoke Pharma, Inc. | Nasal formulations of metoclopramide |
| PL2747561T3 (pl) * | 2011-08-25 | 2018-11-30 | Evoke Pharma, Inc. | Leczenie objawów związanych z gastroparezą u osobników płci żeńskiej |
| WO2018112061A1 (en) | 2016-12-15 | 2018-06-21 | Evoke Pharma, Inc. | Treatment of moderate and severe gastroparesis |
| JP7217071B2 (ja) * | 2019-09-30 | 2023-02-02 | エルジー・ケム・リミテッド | 高吸水性樹脂およびその製造方法 |
| WO2022038403A1 (ru) * | 2020-10-15 | 2022-02-24 | Владимир ТИМКО | Фармацевтическая композиция на основе налбуфина и/или его солей для назального применения |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4963367A (en) * | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
| US5026825A (en) * | 1988-09-08 | 1991-06-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Intranasal calcitonin formulations |
| US5478565A (en) * | 1990-03-27 | 1995-12-26 | Warner-Lambert Company | Treatment of sinus headache |
| IT1250691B (it) * | 1991-07-22 | 1995-04-21 | Giancarlo Santus | Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac. |
| GB9202464D0 (en) * | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
| US5508282C1 (en) * | 1993-05-17 | 2001-01-23 | Tulin Silver Jeffrey | Composition and method for treating acute or chronic rhinosinusitis |
| US5897858A (en) * | 1994-02-03 | 1999-04-27 | Schering-Plough Healthcare Products, Inc. | Nasal spray compositions exhibiting increased retention in the nasal cavity |
| ATE180971T1 (de) * | 1994-03-30 | 1999-06-15 | Gs Dev Ab | Verwendung von fettsäureester als bioklebstoffe |
| GB9416884D0 (en) * | 1994-08-20 | 1994-10-12 | Danbiosyst Uk | Drug delivery compositions |
| GB9605867D0 (en) * | 1996-03-20 | 1996-05-22 | Svedman Paul | Transdermal device |
| GB9700624D0 (en) * | 1997-01-14 | 1997-03-05 | Danbiosyst Uk | Drug delivery composition |
| US6433040B1 (en) * | 1997-09-29 | 2002-08-13 | Inhale Therapeutic Systems, Inc. | Stabilized bioactive preparations and methods of use |
| US6241969B1 (en) * | 1998-06-26 | 2001-06-05 | Elan Corporation Plc | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
| US6261539B1 (en) * | 1998-12-10 | 2001-07-17 | Akwete Adjei | Medicinal aerosol formulation |
| WO2000047203A1 (en) * | 1999-02-12 | 2000-08-17 | Mqs, Inc. | Formulation and system for intra-oral delivery of pharmaceutical agents |
| US6225343B1 (en) * | 1999-06-16 | 2001-05-01 | Nastech Pharmaceutical Company, Inc. | Compositions and methods comprising morphine gluconate |
| TR200103613T2 (tr) * | 1999-06-16 | 2004-08-23 | Nastech Pharmaceutical Co., Inc. | Burun içinden tatbik edilen morfini içeren farmasötik formülasyonlar ve yöntemler. |
| GB9924797D0 (en) * | 1999-10-20 | 1999-12-22 | West Pharm Serv Drug Res Ltd | Compound |
| WO2002011778A1 (en) * | 2000-05-10 | 2002-02-14 | University Of Kentucky Research Foundation | System and method for intranasal administration of opioids |
| ITMI20010571A1 (it) * | 2001-03-19 | 2002-09-19 | Grisotech S A | Vaccini assorbibili per via trans-mucosale |
-
2004
- 2004-02-10 US US10/776,333 patent/US20050175679A1/en not_active Abandoned
-
2005
- 2005-02-09 BR BRPI0506630-1A patent/BRPI0506630A/pt not_active Application Discontinuation
- 2005-02-09 WO PCT/US2005/004163 patent/WO2005077346A1/en not_active Ceased
- 2005-02-09 EP EP05713244A patent/EP1720532A1/en not_active Withdrawn
- 2005-02-09 JP JP2006553213A patent/JP2007522223A/ja active Pending
- 2005-02-09 MX MXPA06009094A patent/MXPA06009094A/es active IP Right Grant
- 2005-02-09 KR KR1020067016923A patent/KR20060135769A/ko not_active Ceased
- 2005-02-09 AU AU2005212355A patent/AU2005212355B2/en not_active Ceased
- 2005-02-09 CA CA002555882A patent/CA2555882A1/en not_active Abandoned
-
2006
- 2006-08-07 IL IL177328A patent/IL177328A0/en unknown
-
2008
- 2008-03-17 US US12/049,893 patent/US20080221144A1/en not_active Abandoned
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