JP2007522206A5 - - Google Patents
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- Publication number
- JP2007522206A5 JP2007522206A5 JP2006553050A JP2006553050A JP2007522206A5 JP 2007522206 A5 JP2007522206 A5 JP 2007522206A5 JP 2006553050 A JP2006553050 A JP 2006553050A JP 2006553050 A JP2006553050 A JP 2006553050A JP 2007522206 A5 JP2007522206 A5 JP 2007522206A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- chemical formula
- compound represented
- following chemical
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 22
- 239000000126 substance Substances 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 6
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 239000003054 catalyst Substances 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- GBRBMTNGQBKBQE-UHFFFAOYSA-L copper;diiodide Chemical compound I[Cu]I GBRBMTNGQBKBQE-UHFFFAOYSA-L 0.000 claims 3
- KVKFRMCSXWQSNT-UHFFFAOYSA-N n,n'-dimethylethane-1,2-diamine Chemical compound CNCCNC KVKFRMCSXWQSNT-UHFFFAOYSA-N 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims 3
- 229910000160 potassium phosphate Inorganic materials 0.000 claims 3
- 235000011009 potassium phosphates Nutrition 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000006649 (C2-C20) alkynyl group Chemical group 0.000 claims 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 239000010949 copper Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- SSJXIUAHEKJCMH-PHDIDXHHSA-N (1r,2r)-cyclohexane-1,2-diamine Chemical compound N[C@@H]1CCCC[C@H]1N SSJXIUAHEKJCMH-PHDIDXHHSA-N 0.000 claims 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 1
- HDUQBBZIBXQSHP-UHFFFAOYSA-N 1-(2-hydroxy-3-iodophenyl)-3-(2h-tetrazol-5-yl)propane-1,3-dione Chemical compound OC1=C(I)C=CC=C1C(=O)CC(=O)C1=NNN=N1 HDUQBBZIBXQSHP-UHFFFAOYSA-N 0.000 claims 1
- WVYJQNAFKSMNIT-UHFFFAOYSA-N 4-(4-phenylbutoxy)benzamide Chemical compound C1=CC(C(=O)N)=CC=C1OCCCCC1=CC=CC=C1 WVYJQNAFKSMNIT-UHFFFAOYSA-N 0.000 claims 1
- -1 C 4-7 carbocycle Chemical group 0.000 claims 1
- 125000003358 C2-C20 alkenyl group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004419 alkynylene group Chemical group 0.000 claims 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 claims 1
- 229910000024 caesium carbonate Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 claims 1
- 150000004985 diamines Chemical class 0.000 claims 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 238000007363 ring formation reaction Methods 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 125000004665 trialkylsilyl group Chemical group 0.000 claims 1
- 229910052727 yttrium Inorganic materials 0.000 claims 1
- 0 CC(*)(C=C1)C=C(*)C(OC(C(CN*)=N*C*)=C2)=C1C2=O Chemical compound CC(*)(C=C1)C=C(*)C(OC(C(CN*)=N*C*)=C2)=C1C2=O 0.000 description 10
- GUGXENROMIJRPN-UHFFFAOYSA-N CC(c1cccc(C)c1O)=O Chemical compound CC(c1cccc(C)c1O)=O GUGXENROMIJRPN-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020040009280A KR100683274B1 (ko) | 2004-02-12 | 2004-02-12 | 치환된 벤조피란 화합물의 제조방법 |
| PCT/KR2005/000365 WO2005077942A1 (en) | 2004-02-12 | 2005-02-07 | Process for preparing substituted benzopyran compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007522206A JP2007522206A (ja) | 2007-08-09 |
| JP2007522206A5 true JP2007522206A5 (enExample) | 2008-03-06 |
| JP4512100B2 JP4512100B2 (ja) | 2010-07-28 |
Family
ID=34858705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006553050A Expired - Fee Related JP4512100B2 (ja) | 2004-02-12 | 2005-02-07 | 置換ベンゾピラン化合物の製造方法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1713796A4 (enExample) |
| JP (1) | JP4512100B2 (enExample) |
| KR (1) | KR100683274B1 (enExample) |
| CN (1) | CN1918150B (enExample) |
| WO (1) | WO2005077942A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8637575B2 (en) | 2008-06-05 | 2014-01-28 | Novotyr Therapeutics Ltd. | Modulators of protein kinase signaling |
| EP3021944B1 (en) | 2013-07-14 | 2018-12-19 | Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. | Igf-1r signaling pathway inhibitors useful in the treatment of neurodegenerative diseases |
| CN107250108B (zh) | 2015-02-05 | 2020-11-27 | 特尔诺沃有限公司 | 用于治疗癌症的irs/stat3双重调节剂与抗癌剂的组合 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US389339A (en) * | 1888-09-11 | Friction-clutch | ||
| GB1296469A (enExample) | 1970-02-05 | 1972-11-15 | ||
| CA960223A (en) * | 1970-02-05 | 1974-12-31 | Mervyn E. Peel | Tetrazolyl chromones |
| US4238495A (en) * | 1976-01-30 | 1980-12-09 | Miles Laboratories, Inc. | 1-(4-Cyano-phenoxy)-2-hydroxy-3-[2-(5-1H-tetrazolyl)-chromon-5-yloxy]-propane and salts thereof |
| US4158663A (en) * | 1977-07-15 | 1979-06-19 | Warner-Lambert Company | Process for the production of 2-substituted chromones |
| JPS60246384A (ja) * | 1984-05-21 | 1985-12-06 | Hokuriku Seiyaku Co Ltd | クロモン−８−カルポキサミド誘導体 |
| CA1261835A (en) * | 1984-08-20 | 1989-09-26 | Masaaki Toda | (fused) benz(thio)amides |
| EP0340706B1 (de) * | 1988-05-03 | 1993-10-13 | BASF Aktiengesellschaft | Verfahren zur Herstellung von Carbonsäurechloriden |
| JPH0395144A (ja) * | 1989-08-04 | 1991-04-19 | Ono Pharmaceut Co Ltd | アミノフェノール誘導体の製造方法 |
| JPH051008A (ja) * | 1991-06-19 | 1993-01-08 | Mitsubishi Kasei Corp | １，４−ジシアノブテン類の製造法 |
| GB9224922D0 (en) | 1992-11-27 | 1993-01-13 | Smithkline Beecham Plc | Process |
| ATE259799T1 (de) | 1994-06-23 | 2004-03-15 | Sumitomo Chemical Co | Verfahren zur herstellung von 2-(tetrazol-5-yl)-4-oxo-4h-benzopyranen |
| CH691301A5 (de) * | 1995-06-29 | 2001-06-29 | Sumitomo Chemical Co | Verfahren zur Herstellung von 2-Acetyl-6-(4-(4-phenylbutoxy)benzoyl)aminophenol. |
| AR004029A1 (es) * | 1995-10-20 | 1998-09-30 | Smithkline Beecham Plc | Nuevas formulaciones farmaceuticas |
| JPH09323955A (ja) * | 1996-06-03 | 1997-12-16 | Kao Corp | 安息香酸誘導体及びこれを含有する医薬 |
| EP0912510B1 (en) * | 1996-07-01 | 2003-05-07 | E.I. Du Pont De Nemours And Company | Nickel catalyzed addition of -nh- containing compounds to vinyl and aryl halides |
| GB9700331D0 (en) | 1997-01-09 | 1997-02-26 | Smithkline Beecham Plc | Process |
| SK285221B6 (sk) * | 1997-05-09 | 2006-09-07 | H. Lundbeck A/S | Spôsob výroby sertindolu a medziproduktov |
| CN1863752A (zh) * | 2002-08-02 | 2006-11-15 | 罗迪亚药业公司 | 铜催化的芳基化 |
-
2004
- 2004-02-12 KR KR1020040009280A patent/KR100683274B1/ko not_active Expired - Fee Related
-
2005
- 2005-02-07 CN CN2005800047261A patent/CN1918150B/zh not_active Expired - Fee Related
- 2005-02-07 JP JP2006553050A patent/JP4512100B2/ja not_active Expired - Fee Related
- 2005-02-07 EP EP05726439A patent/EP1713796A4/en not_active Withdrawn
- 2005-02-07 WO PCT/KR2005/000365 patent/WO2005077942A1/en not_active Ceased
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