JP2007520536A5 - - Google Patents
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- Publication number
- JP2007520536A5 JP2007520536A5 JP2006551903A JP2006551903A JP2007520536A5 JP 2007520536 A5 JP2007520536 A5 JP 2007520536A5 JP 2006551903 A JP2006551903 A JP 2006551903A JP 2006551903 A JP2006551903 A JP 2006551903A JP 2007520536 A5 JP2007520536 A5 JP 2007520536A5
- Authority
- JP
- Japan
- Prior art keywords
- imidazol
- pyrimidin
- phenyl
- methyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000004943 pyrimidin-6-yl group Chemical group N1=CN=CC=C1* 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 7
- -1 4-Aminothieno [2,3-d] pyrimidin-6-yl Chemical group 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- CUZHRBBCMHSKCY-UHFFFAOYSA-N 1-[3-[5-(4-aminothieno[2,3-d]pyrimidin-6-yl)-1-methylimidazol-4-yl]phenyl]-3-(2-chlorophenyl)urea Chemical compound C=1C2=C(N)N=CN=C2SC=1C=1N(C)C=NC=1C(C=1)=CC=CC=1NC(=O)NC1=CC=CC=C1Cl CUZHRBBCMHSKCY-UHFFFAOYSA-N 0.000 claims 1
- LKIVFLDYOQCVHX-UHFFFAOYSA-N 1-[3-[5-(4-aminothieno[2,3-d]pyrimidin-6-yl)-1-methylimidazol-4-yl]phenyl]-3-(2-fluorophenyl)urea Chemical compound C=1C2=C(N)N=CN=C2SC=1C=1N(C)C=NC=1C(C=1)=CC=CC=1NC(=O)NC1=CC=CC=C1F LKIVFLDYOQCVHX-UHFFFAOYSA-N 0.000 claims 1
- HRPGZMZTOCXIAO-UHFFFAOYSA-N 1-[3-[5-(4-aminothieno[2,3-d]pyrimidin-6-yl)-1-methylimidazol-4-yl]phenyl]-3-(3-chlorophenyl)urea Chemical compound C=1C2=C(N)N=CN=C2SC=1C=1N(C)C=NC=1C(C=1)=CC=CC=1NC(=O)NC1=CC=CC(Cl)=C1 HRPGZMZTOCXIAO-UHFFFAOYSA-N 0.000 claims 1
- XFXZMJXQNBRRGU-UHFFFAOYSA-N 1-[3-[5-(4-aminothieno[2,3-d]pyrimidin-6-yl)-1-methylimidazol-4-yl]phenyl]-3-(3-fluorophenyl)urea Chemical compound C=1C2=C(N)N=CN=C2SC=1C=1N(C)C=NC=1C(C=1)=CC=CC=1NC(=O)NC1=CC=CC(F)=C1 XFXZMJXQNBRRGU-UHFFFAOYSA-N 0.000 claims 1
- 108010090091 TIE-2 Receptor Proteins 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 230000001772 anti-angiogenic effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000012948 isocyanate Substances 0.000 claims 1
- 150000002513 isocyanates Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229940124617 receptor tyrosine kinase inhibitor Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0402518.5A GB0402518D0 (en) | 2004-02-05 | 2004-02-05 | Therapeutic agents |
| PCT/GB2005/000339 WO2005075483A1 (en) | 2004-02-05 | 2005-02-01 | Substituted thieno - and thiazolo - [2, 3-d] pyridines as inhibitors of tie2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007520536A JP2007520536A (ja) | 2007-07-26 |
| JP2007520536A5 true JP2007520536A5 (enExample) | 2008-03-21 |
Family
ID=31985686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006551903A Pending JP2007520536A (ja) | 2004-02-05 | 2005-02-01 | Ｔｉｅ２の阻害剤としての置換チエノ及びチアゾロ−［２，３−ｄ］ピリミジン及び［２，３−ｃ］ピリジン |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7476677B2 (enExample) |
| EP (1) | EP1716155B1 (enExample) |
| JP (1) | JP2007520536A (enExample) |
| CN (1) | CN1942475A (enExample) |
| AT (1) | ATE387453T1 (enExample) |
| DE (1) | DE602005005024T2 (enExample) |
| ES (1) | ES2300977T3 (enExample) |
| GB (1) | GB0402518D0 (enExample) |
| WO (1) | WO2005075483A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2307456B1 (en) | 2008-06-27 | 2014-10-15 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| US20100093714A1 (en) * | 2008-10-13 | 2010-04-15 | Devraj Chakravarty | AMIDES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS |
| SG182361A1 (en) * | 2010-01-29 | 2012-08-30 | Hanmi Science Co Ltd | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES |
| CN102250112A (zh) * | 2010-05-18 | 2011-11-23 | 上海再启生物技术有限公司 | 7-溴-4-氨基噻吩并嘧啶的制备方法 |
| TWI492949B (zh) * | 2010-06-09 | 2015-07-21 | Abbvie Bahamas Ltd | 結晶型激酶抑制劑 |
| TWI482770B (zh) * | 2010-06-09 | 2015-05-01 | Abbvie Bahamas Ltd | 結晶型激酶抑制劑 |
| CA2802042A1 (en) * | 2010-06-09 | 2011-12-15 | Abbott Laboratories | Crystalline forms of kinase inhibitors |
| JP5797345B2 (ja) * | 2011-12-30 | 2015-10-21 | ハンミ ファーム． シーオー．， エルティーディー． | プロテインキナーゼに対する阻害活性を有するチエノ［３，２−ｄ］ピリミジン誘導体 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2331878A1 (en) | 1998-05-14 | 1999-11-18 | G.D. Searle & Co. | 1,5-diaryl substituted pyrazoles as p38 kinase inhibitors |
| GB0102687D0 (en) * | 2001-02-02 | 2001-03-21 | Pharmacia & Upjohn Spa | Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them |
| JP2005508904A (ja) * | 2001-09-11 | 2005-04-07 | スミスクライン ビーチャム コーポレーション | 血管新生阻害剤としてのフロ−及びチエノピリミジン誘導体 |
| DE60222804T2 (de) | 2001-12-21 | 2008-07-03 | Vernalis (Cambridge) Ltd., Abington | 3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung |
| US7560552B2 (en) * | 2002-03-21 | 2009-07-14 | Abbott Laboratories | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors |
| AU2003246972A1 (en) * | 2002-08-06 | 2004-02-23 | Astrazeneca Ab | Condensed pyridines and pyrimidines with tie2 (tek) activity |
-
2004
- 2004-02-05 GB GBGB0402518.5A patent/GB0402518D0/en not_active Ceased
-
2005
- 2005-02-01 CN CNA2005800119556A patent/CN1942475A/zh active Pending
- 2005-02-01 ES ES05702081T patent/ES2300977T3/es not_active Expired - Lifetime
- 2005-02-01 AT AT05702081T patent/ATE387453T1/de not_active IP Right Cessation
- 2005-02-01 WO PCT/GB2005/000339 patent/WO2005075483A1/en not_active Ceased
- 2005-02-01 US US10/588,621 patent/US7476677B2/en not_active Expired - Fee Related
- 2005-02-01 JP JP2006551903A patent/JP2007520536A/ja active Pending
- 2005-02-01 DE DE602005005024T patent/DE602005005024T2/de not_active Expired - Fee Related
- 2005-02-01 EP EP05702081A patent/EP1716155B1/en not_active Expired - Lifetime