JP2007520214A5 - - Google Patents
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- JP2007520214A5 JP2007520214A5 JP2006547195A JP2006547195A JP2007520214A5 JP 2007520214 A5 JP2007520214 A5 JP 2007520214A5 JP 2006547195 A JP2006547195 A JP 2006547195A JP 2006547195 A JP2006547195 A JP 2006547195A JP 2007520214 A5 JP2007520214 A5 JP 2007520214A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- cell
- influenza virus
- plasmids
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 22
- 210000004027 cell Anatomy 0.000 claims description 10
- 241000712461 unidentified influenza virus Species 0.000 claims description 9
- 241000700605 Viruses Species 0.000 claims description 7
- 210000004102 animal cell Anatomy 0.000 claims description 7
- 108091034135 Vault RNA Proteins 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 2
- 102000011931 Nucleoproteins Human genes 0.000 claims description 2
- 108010061100 Nucleoproteins Proteins 0.000 claims description 2
- 102000004389 Ribonucleoproteins Human genes 0.000 claims description 2
- 108010081734 Ribonucleoproteins Proteins 0.000 claims description 2
- 230000001419 dependent effect Effects 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 claims 6
- 210000003501 vero cell Anatomy 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 1
- 241000713196 Influenza B virus Species 0.000 claims 1
- 241000713174 Influenza B virus (B/Ann Arbor/1/1966 [wild- type]) Species 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 230000029812 viral genome replication Effects 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53216403P | 2003-12-23 | 2003-12-23 | |
| US60/532,164 | 2003-12-23 | ||
| PCT/US2004/042669 WO2005062820A2 (en) | 2003-12-23 | 2004-12-22 | Multi plasmid system for the production of influenza virus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011084297A Division JP5264955B2 (ja) | 2003-12-23 | 2011-04-06 | インフルエンザウイルス作製のための多重プラスミド系 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007520214A JP2007520214A (ja) | 2007-07-26 |
| JP2007520214A5 true JP2007520214A5 (https=) | 2007-10-18 |
| JP4771959B2 JP4771959B2 (ja) | 2011-09-14 |
Family
ID=34738759
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006547195A Expired - Lifetime JP4771959B2 (ja) | 2003-12-23 | 2004-12-22 | インフルエンザウイルス作製のための多重プラスミド系 |
| JP2011084297A Expired - Lifetime JP5264955B2 (ja) | 2003-12-23 | 2011-04-06 | インフルエンザウイルス作製のための多重プラスミド系 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011084297A Expired - Lifetime JP5264955B2 (ja) | 2003-12-23 | 2011-04-06 | インフルエンザウイルス作製のための多重プラスミド系 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US20050158342A1 (https=) |
| EP (1) | EP1697521B1 (https=) |
| JP (2) | JP4771959B2 (https=) |
| AT (1) | ATE469972T1 (https=) |
| AU (1) | AU2004308328B2 (https=) |
| CA (1) | CA2551489C (https=) |
| DE (1) | DE602004027537D1 (https=) |
| ES (1) | ES2345492T3 (https=) |
| WO (1) | WO2005062820A2 (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02010642A (es) * | 2000-04-28 | 2004-05-17 | St Jude Children S Res Hospital | Sistema de transfeccion de adn para la generacion de virus de influenza infeccioso. |
| US7465456B2 (en) | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
| ES2526191T3 (es) * | 2002-04-26 | 2015-01-08 | Medimmune, Llc | Método para producir virus influenza B infeccioso en cultivo celular |
| US20060110406A1 (en) | 2003-02-25 | 2006-05-25 | Medimmune Vaccines, Inc. | Refrigerator-temperature stable influenza vaccine compositions |
| US7262045B2 (en) | 2003-02-25 | 2007-08-28 | Medimmune Vaccines, Inc. | Methods of producing influenza vaccine compositions |
| ATE469972T1 (de) | 2003-12-23 | 2010-06-15 | Medimmune Llc | Multiplasmid-system zur erzeugung des grippevirus |
| EP2995678A1 (en) * | 2004-05-24 | 2016-03-16 | MedImmune, LLC | Multi plasmid system for the production of attenuated influenza b virus |
| JP5147405B2 (ja) | 2004-10-06 | 2013-02-20 | メディミューン，エルエルシー | 冷蔵温度安定型インフルエンザワクチン組成物 |
| ES2536745T3 (es) * | 2004-12-08 | 2015-05-28 | Medimmune, Llc | Métodos de producción de composiciones de vacuna contra la gripe |
| ATE547511T1 (de) | 2004-12-23 | 2012-03-15 | Medimmune Llc | Nichttumorbildende mdck-zellinie zur vermehrung von viren |
| US7959929B2 (en) | 2005-04-21 | 2011-06-14 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| US11865172B2 (en) | 2005-04-21 | 2024-01-09 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| RU2008101367A (ru) | 2005-06-21 | 2009-08-10 | Медиммун, Ллк (Us) | Способы и композиции для экспрессии отрицательной смысловой вирусной рнк в собачьих клетках |
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| US8354114B2 (en) | 2005-10-17 | 2013-01-15 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
| ES2496315T3 (es) * | 2005-10-19 | 2014-09-18 | University Of Florida Research Foundation, Incorporated | Materiales para el control de la enfermedad respiratoria en caninos |
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| PT2016194E (pt) | 2006-04-19 | 2015-07-20 | Medimmune Llc | Métodos e composições para expressar arn viral de polaridade negativa em células caninas |
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| CA2690196A1 (en) | 2007-06-18 | 2008-12-24 | Medimmune, Llc | Influenza b viruses having alterations in the hemaglutinin polypeptide |
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| EP2045323A1 (en) * | 2007-10-05 | 2009-04-08 | Avir Green Hills Biotechnology Research Development Trade Ag | Linear expression constructs for production of influenza virus particles |
| CN102215865B (zh) | 2008-09-24 | 2013-10-30 | 米迪缪尼有限公司 | 病毒纯化方法 |
| JP5686741B2 (ja) | 2008-12-16 | 2015-03-18 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | インフルエンザワクチンの生成 |
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| CN102741399A (zh) | 2009-10-20 | 2012-10-17 | 诺华有限公司 | 用于病毒拯救的改良反向遗传方法 |
| EP2493912B1 (en) | 2009-10-26 | 2020-07-29 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in vero cells |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| EP2694645A1 (en) | 2011-04-08 | 2014-02-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for increasing the replication capacity of an influenza virus in cultured cells |
| EP2710381A2 (en) | 2011-05-16 | 2014-03-26 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods for screening substances capable of modulating the replication of an influenza virus |
| ES2655051T3 (es) | 2011-08-26 | 2018-02-16 | Wisconsin Alumni Research Foundation | Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas |
| US9364530B2 (en) | 2012-03-22 | 2016-06-14 | Fraunhofer Usa, Inc. | Virus-like particles comprising a matrix protein from a plant enveloped virus and uses thereof |
| US9982240B2 (en) | 2012-08-03 | 2018-05-29 | Sanofi Pasteur | Production of infectious influenza viruses |
| US9950057B2 (en) | 2013-07-15 | 2018-04-24 | Wisconsin Alumni Research Foundation (Warf) | High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| WO2016201127A1 (en) | 2015-06-09 | 2016-12-15 | Sanofi Pasteur, Inc. | Methods of optimizing nucleotide sequences encoding engineered influenza proteins |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| CA3014435C (en) | 2016-02-19 | 2023-04-18 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza b virus replication for vaccine development |
| US10844097B2 (en) | 2016-06-02 | 2020-11-24 | Sanofi Pasteur Inc. | Engineered influenza antigenic polypeptides and immunogenic compositions thereof |
| WO2018215937A1 (en) * | 2017-05-24 | 2018-11-29 | Novartis Ag | Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
| JP2021508696A (ja) | 2017-12-22 | 2021-03-11 | コーダ−ジェニックス・インコーポレイテッドＣｏｄａ−Ｇｅｎｉｘ， Ｉｎｃ． | がん処置のためのコドン対脱最適化領域を有する組換え型ウイルス及びその使用法 |
| CN112040977A (zh) | 2018-03-08 | 2020-12-04 | 科达金尼克斯有限公司 | 减毒黄病毒 |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| US11241492B2 (en) | 2019-01-23 | 2022-02-08 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to genes in influenza viruses |
| WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| CN110042084A (zh) * | 2019-04-11 | 2019-07-23 | 浙江森卫生物医药发展有限公司 | 一种活病毒流感疫苗的生产方法以及制剂 |
| US11390649B2 (en) | 2019-05-01 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| WO2021150874A1 (en) | 2020-01-24 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized na |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| WO2025074921A1 (ja) * | 2023-10-06 | 2025-04-10 | 株式会社微生物化学研究所 | ウイルスの生産方法 |
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| ATE469972T1 (de) | 2003-12-23 | 2010-06-15 | Medimmune Llc | Multiplasmid-system zur erzeugung des grippevirus |
| EP2995678A1 (en) | 2004-05-24 | 2016-03-16 | MedImmune, LLC | Multi plasmid system for the production of attenuated influenza b virus |
| JP5147405B2 (ja) | 2004-10-06 | 2013-02-20 | メディミューン，エルエルシー | 冷蔵温度安定型インフルエンザワクチン組成物 |
| ES2382446T3 (es) | 2004-11-01 | 2012-06-08 | Eiken Kagaku Kabushiki Kaisha | Método de detección del virus de la gripe aviar H5 |
| CA2690196A1 (en) | 2007-06-18 | 2008-12-24 | Medimmune, Llc | Influenza b viruses having alterations in the hemaglutinin polypeptide |
| CN102026628A (zh) * | 2008-02-15 | 2011-04-20 | 太阳医药高级研发有限公司 | 具有降低崩裂效果的口服控释片剂 |
-
2004
- 2004-12-22 AT AT04814807T patent/ATE469972T1/de not_active IP Right Cessation
- 2004-12-22 WO PCT/US2004/042669 patent/WO2005062820A2/en not_active Ceased
- 2004-12-22 AU AU2004308328A patent/AU2004308328B2/en not_active Ceased
- 2004-12-22 EP EP04814807A patent/EP1697521B1/en not_active Expired - Lifetime
- 2004-12-22 CA CA2551489A patent/CA2551489C/en not_active Expired - Fee Related
- 2004-12-22 JP JP2006547195A patent/JP4771959B2/ja not_active Expired - Lifetime
- 2004-12-22 ES ES04814807T patent/ES2345492T3/es not_active Expired - Lifetime
- 2004-12-22 US US11/018,624 patent/US20050158342A1/en not_active Abandoned
- 2004-12-22 DE DE602004027537T patent/DE602004027537D1/de not_active Expired - Lifetime
-
2008
- 2008-12-16 US US12/336,158 patent/US8093033B2/en not_active Expired - Lifetime
-
2011
- 2011-04-06 JP JP2011084297A patent/JP5264955B2/ja not_active Expired - Lifetime
- 2011-12-01 US US13/309,498 patent/US8409843B2/en not_active Expired - Fee Related
-
2013
- 2013-02-27 US US13/779,549 patent/US9255253B2/en not_active Expired - Lifetime
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