JP2007520214A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007520214A5 JP2007520214A5 JP2006547195A JP2006547195A JP2007520214A5 JP 2007520214 A5 JP2007520214 A5 JP 2007520214A5 JP 2006547195 A JP2006547195 A JP 2006547195A JP 2006547195 A JP2006547195 A JP 2006547195A JP 2007520214 A5 JP2007520214 A5 JP 2007520214A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- cell
- influenza virus
- plasmids
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 22
- 210000004027 cell Anatomy 0.000 claims description 10
- 241000712461 unidentified influenza virus Species 0.000 claims description 9
- 241000700605 Viruses Species 0.000 claims description 7
- 210000004102 animal cell Anatomy 0.000 claims description 7
- 108091034135 Vault RNA Proteins 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 2
- 102000011931 Nucleoproteins Human genes 0.000 claims description 2
- 108010061100 Nucleoproteins Proteins 0.000 claims description 2
- 102000004389 Ribonucleoproteins Human genes 0.000 claims description 2
- 108010081734 Ribonucleoproteins Proteins 0.000 claims description 2
- 230000001419 dependent effect Effects 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 claims 6
- 210000003501 vero cell Anatomy 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 1
- 241000713196 Influenza B virus Species 0.000 claims 1
- 241000713174 Influenza B virus (B/Ann Arbor/1/1966 [wild- type]) Species 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 230000029812 viral genome replication Effects 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53216403P | 2003-12-23 | 2003-12-23 | |
| US60/532,164 | 2003-12-23 | ||
| PCT/US2004/042669 WO2005062820A2 (en) | 2003-12-23 | 2004-12-22 | Multi plasmid system for the production of influenza virus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011084297A Division JP5264955B2 (ja) | 2003-12-23 | 2011-04-06 | インフルエンザウイルス作製のための多重プラスミド系 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007520214A JP2007520214A (ja) | 2007-07-26 |
| JP2007520214A5 true JP2007520214A5 (https=) | 2007-10-18 |
| JP4771959B2 JP4771959B2 (ja) | 2011-09-14 |
Family
ID=34738759
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006547195A Expired - Lifetime JP4771959B2 (ja) | 2003-12-23 | 2004-12-22 | インフルエンザウイルス作製のための多重プラスミド系 |
| JP2011084297A Expired - Lifetime JP5264955B2 (ja) | 2003-12-23 | 2011-04-06 | インフルエンザウイルス作製のための多重プラスミド系 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011084297A Expired - Lifetime JP5264955B2 (ja) | 2003-12-23 | 2011-04-06 | インフルエンザウイルス作製のための多重プラスミド系 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US20050158342A1 (https=) |
| EP (1) | EP1697521B1 (https=) |
| JP (2) | JP4771959B2 (https=) |
| AT (1) | ATE469972T1 (https=) |
| AU (1) | AU2004308328B2 (https=) |
| CA (1) | CA2551489C (https=) |
| DE (1) | DE602004027537D1 (https=) |
| ES (1) | ES2345492T3 (https=) |
| WO (1) | WO2005062820A2 (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2319864T3 (es) | 2000-04-28 | 2009-05-14 | St. Jude Children's Research Hospital | Sistema de transfeccion de adn para la generacion de virus infecciosos de arn de cadena negativa. |
| US7465456B2 (en) * | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
| DK1499348T3 (en) | 2002-04-26 | 2015-01-05 | Medimmune Llc | PROCEDURE FOR PREPARING INFECTIOUS INFLUENZA B-VIRA IN CELL CULTURE |
| US20060110406A1 (en) * | 2003-02-25 | 2006-05-25 | Medimmune Vaccines, Inc. | Refrigerator-temperature stable influenza vaccine compositions |
| EP2481819A1 (en) | 2003-02-25 | 2012-08-01 | MedImmune Vaccines, Inc. | Cross flow filtration in the production of stabilized influenza vaccine compositions |
| CA2551489C (en) | 2003-12-23 | 2013-09-03 | Gregory Duke | Multi plasmid system for the production of influenza virus |
| HUE025727T2 (en) * | 2004-05-24 | 2016-04-28 | Medimmune Llc | Multi-plasmid system for producing influenza virus |
| EP2769735B1 (en) | 2004-10-06 | 2017-04-19 | MedImmune, LLC | Refrigerator-temperature stable influenza vaccine compositions |
| US7510719B2 (en) * | 2004-12-08 | 2009-03-31 | Medimmune, Llc | Methods of producing influenza vaccine compositions |
| DK2368975T3 (en) | 2004-12-23 | 2015-01-05 | Medimmune Llc | Non-tumorigenic MDCK cell line for the propagation of viruses |
| US11865172B2 (en) | 2005-04-21 | 2024-01-09 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| US7959929B2 (en) | 2005-04-21 | 2011-06-14 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| EP1917352A4 (en) * | 2005-06-21 | 2009-03-25 | Medimmune Vaccines Inc | METHODS AND COMPOSITIONS FOR EXPRESSING HETEROLOGOUS PROTEASE |
| US7790434B2 (en) * | 2005-06-21 | 2010-09-07 | Medimmune, Llc | Methods and compositions for expressing negative-sense viral RNA in canine cells |
| EP1945778B1 (en) | 2005-10-17 | 2012-12-26 | MedImmune, LLC | Methods of increasing influenza virus replication |
| CN101563361B (zh) * | 2005-10-19 | 2014-01-29 | 佛罗里达大学研究基金公司 | 能够感染犬科动物的流感病毒及其用途 |
| JP2009514844A (ja) * | 2005-11-04 | 2009-04-09 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | スプリットインフルエンザワクチン用のアジュバントとしての遊離水相界面活性剤を含むエマルション |
| EP1984022A2 (en) * | 2006-01-17 | 2008-10-29 | CREATOGEN Laboratories GmbH | Influenza vaccine |
| CA2647985C (en) | 2006-03-31 | 2014-12-30 | Warf-Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| US7682619B2 (en) | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
| DK2016194T3 (en) | 2006-04-19 | 2015-06-15 | Medimmune Llc | METHODS AND COMPOSITIONS FOR EXPRESSION OF VIRAL NEGATIVE SENSE RNA IN DOG CELLS |
| US9072701B2 (en) * | 2006-04-21 | 2015-07-07 | St. Jude Children's Research Hospital | Avian influenza viruses, vaccines, compositions, formulations, and methods |
| WO2008133701A1 (en) * | 2006-07-21 | 2008-11-06 | Medimmune, Llc. | Methods and compositions for increasing replication capacity of an influenza virus |
| EP2615167A1 (en) | 2006-09-15 | 2013-07-17 | MedImmune, LLC | Method for eliminating DNA contaminants from viral preparations |
| WO2008118487A2 (en) * | 2007-03-26 | 2008-10-02 | University Of Massachusetts Medical School | Compositions and methods for incresing immunogenicity of glycoprotein vaccines |
| US20080294361A1 (en) * | 2007-05-24 | 2008-11-27 | Popp Shane M | Intelligent execution system for the monitoring and execution of vaccine manufacturing |
| US9474798B2 (en) | 2007-06-18 | 2016-10-25 | Wisconsin Alumni Research Foundation | Influenza M2 protein mutant viruses as live influenza attenuated vaccines |
| EP2674486A1 (en) * | 2007-06-18 | 2013-12-18 | MedImmune, LLC | Influenza B viruses having alterations in the hemaglutinin polypeptide |
| EP2045323A1 (en) * | 2007-10-05 | 2009-04-08 | Avir Green Hills Biotechnology Research Development Trade Ag | Linear expression constructs for production of influenza virus particles |
| US8785173B2 (en) | 2008-09-24 | 2014-07-22 | Medimmune, Llc | Methods for purification of viruses |
| CN107365751B (zh) | 2008-12-16 | 2021-07-09 | 纳米医疗公司 | 流感疫苗的生产 |
| WO2010144797A2 (en) | 2009-06-12 | 2010-12-16 | Vaccine Technologies, Incorporated | Influenza vaccines with enhanced immunogenicity and uses thereof |
| CA2778332A1 (en) * | 2009-10-20 | 2011-04-28 | Novartis Ag | Improved reverse genetics methods for virus rescue |
| EP2493912B1 (en) | 2009-10-26 | 2020-07-29 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in vero cells |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| WO2012136852A1 (en) | 2011-04-08 | 2012-10-11 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Method for increasing the replication capacity of an influenza virus in cultured cells |
| EP2710381A2 (en) | 2011-05-16 | 2014-03-26 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods for screening substances capable of modulating the replication of an influenza virus |
| JP2014527799A (ja) | 2011-08-26 | 2014-10-23 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス |
| ES2657875T3 (es) | 2012-03-22 | 2018-03-07 | Fraunhofer Usa Inc. | Partículas tipo virus que comprenden una proteína de la matriz de un virus encapsulado de plantas y usos de las mismas |
| US9982240B2 (en) | 2012-08-03 | 2018-05-29 | Sanofi Pasteur | Production of infectious influenza viruses |
| WO2015009743A1 (en) | 2013-07-15 | 2015-01-22 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| US10927151B2 (en) | 2015-06-09 | 2021-02-23 | Sanofi Pasteur Inc. | Methods of optimizing nucleotide sequences encoding engineered influenza proteins |
| US9890363B2 (en) | 2015-07-06 | 2018-02-13 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| US11197925B2 (en) | 2016-02-19 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Influenza B virus replication for vaccine development |
| CA3026096A1 (en) | 2016-06-02 | 2017-12-07 | Sanofi Pasteur Inc. | Engineered influenza antigenic polypeptides and immunogenic compositions thereof |
| WO2018215937A1 (en) * | 2017-05-24 | 2018-11-29 | Novartis Ag | Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
| US12178869B2 (en) | 2017-12-22 | 2024-12-31 | Codagenix Inc. | Recombinant virus with codon-pair deoptimized region and uses thereof for the treatment of cancer |
| WO2019172982A1 (en) | 2018-03-08 | 2019-09-12 | Codagenix Inc. | Attenuated flaviviruses |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| EP3914295A2 (en) | 2019-01-23 | 2021-12-01 | Yoshihiro Kawaoka | Mutations that confer genetic stability to additional genes in influenza viruses |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| CN110042084A (zh) * | 2019-04-11 | 2019-07-23 | 浙江森卫生物医药发展有限公司 | 一种活病毒流感疫苗的生产方法以及制剂 |
| CN114929269A (zh) | 2019-05-01 | 2022-08-19 | 威斯康星校友研究基金会(Warf) | 用于疫苗开发的改进的流感病毒复制 |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| JP2023511444A (ja) | 2020-01-24 | 2023-03-17 | ウィスコンシン アルムニ リサーチ ファンデイション | 安定化されたｎａを有する組換えインフルエンザウイルス |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| WO2025074921A1 (ja) * | 2023-10-06 | 2025-04-10 | 株式会社微生物化学研究所 | ウイルスの生産方法 |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US450052A (en) * | 1891-04-07 | Eters co | ||
| US639958A (en) * | 1899-08-14 | 1899-12-26 | John Bartel | Hat-holder for milliners' use. |
| GB660109A (en) | 1946-10-01 | 1951-10-31 | American Cyanamid Co | Improvements in or relating to the treatment of allantoic fluid containing a propagated virus together with non-viral proteins to obtain the virus in purified and viable from for use in a vaccine |
| US3992522A (en) * | 1973-01-24 | 1976-11-16 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Temperature-sensitive recombinant mutant viruses and a process for producing same |
| US3874999A (en) * | 1973-10-31 | 1975-04-01 | American Cyanamid Co | Process for the purification of virus vaccine |
| US4071618A (en) * | 1974-09-03 | 1978-01-31 | Research Foundation For Microbial Diseases Of Osaka University | Process for preparing virus disease live vaccines |
| US4000257A (en) * | 1975-12-22 | 1976-12-28 | American Cyanamid Company | Process for the purification of influenza virus vaccine |
| US4057626A (en) * | 1976-10-08 | 1977-11-08 | Richardson-Merrell Inc. | Process for detoxifying influenza B virus |
| US4338296A (en) * | 1979-10-16 | 1982-07-06 | Smithkline-Rit | Influenza virus and process of producing a vaccine therefrom |
| US4337242A (en) * | 1980-02-05 | 1982-06-29 | Merck & Co., Inc. | Vaccine stabilizer containing L-glutamic acid and L-arginine |
| US4512972A (en) * | 1980-06-30 | 1985-04-23 | Kureha Chemical Industry Co., Ltd. | Nasal preparation and processes for their production |
| JPS57136528A (en) * | 1981-02-09 | 1982-08-23 | Hayashibara Biochem Lab Inc | Preparation of viral vaccine |
| FR2505657A1 (fr) | 1981-05-13 | 1982-11-19 | Pasteur Institut | Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation |
| US4512285A (en) * | 1983-12-27 | 1985-04-23 | Gof Manufacturing Company, Inc. | Apparatus and method for egg turning during incubation |
| US4634666A (en) * | 1984-01-06 | 1987-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Human-murine hybridoma fusion partner |
| JPH0647260B2 (ja) * | 1985-07-30 | 1994-06-22 | 三菱油化株式会社 | 複合成形体 |
| GB8914968D0 (en) | 1989-06-29 | 1989-08-23 | Connaught Lab | Production of virus and purification of viral envelope proteins for vaccine use |
| US5840520A (en) | 1989-08-28 | 1998-11-24 | Aviron | Recombinant negative strand RNA virus expression systems |
| US5166057A (en) | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
| US5854037A (en) * | 1989-08-28 | 1998-12-29 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
| US6887699B1 (en) * | 1990-05-22 | 2005-05-03 | Medimmune Vaccines, Inc. | Recombinant negative strand RNA virus expression systems and vaccines |
| EP1473361A3 (en) | 1992-04-14 | 2004-11-17 | The Mount Sinai School Of Medicine, Of The City University Of New York | Genetically engineered attenuated viruses |
| IL105456A (en) * | 1992-04-21 | 1996-12-05 | American Home Prod | Vaccines of attenuated respiratory syncytial virus |
| CA2075521C (en) | 1992-05-05 | 1995-11-28 | Kuniaki Koyama | Stabilized live vaccine |
| ATE257175T1 (de) * | 1994-07-18 | 2004-01-15 | Conzelmann Karl Klaus Prof Dr | Rekombinantes infektiöses nicht-in-segmente- geteiltes, negativ-strange-rns-virus |
| US5824536A (en) * | 1994-08-23 | 1998-10-20 | St. Jude Children's Research Hospital | Influenza virus replicated in mammalian cell culture and vaccine production |
| US5716821A (en) * | 1994-09-30 | 1998-02-10 | Uab Research Foundation | Prevention and treatment of respiratory tract disease |
| AU3760495A (en) | 1994-09-30 | 1996-04-26 | Aviron | Chimeric Influenza Virus And Electroporation Method |
| US5789229A (en) * | 1994-09-30 | 1998-08-04 | Uab Research Foundation | Stranded RNA virus particles |
| US6146873A (en) * | 1994-11-10 | 2000-11-14 | Baxter Aktiengesellschaft | Production of orthomyxoviruses in monkey kidney cells using protein-free media |
| US7153510B1 (en) * | 1995-05-04 | 2006-12-26 | Yale University | Recombinant vesiculoviruses and their uses |
| US5690937A (en) * | 1995-06-05 | 1997-11-25 | Aviron | Temperature sensitive clustered changed-to-alanine mutants of influenza virus PB2 gene |
| ATE181112T1 (de) | 1995-08-09 | 1999-06-15 | Schweiz Serum & Impfinst | Dem genom von minussträngigen rna-viren entsprechende cdna und verfahren zur herstellung von infektiösen minussträngigen rna-viren |
| US6264957B1 (en) | 1995-09-27 | 2001-07-24 | The United States Of America As Represented By The Department Of Health And Human Services | Product of infectious respiratory syncytial virus from cloned nucleotide sequences |
| ATE213646T1 (de) | 1995-10-20 | 2002-03-15 | Yissum Res Dev Co | Grippe-impfstoff |
| DK0864645T3 (da) | 1995-10-31 | 2005-10-24 | Dnavec Research Inc | Negativstrenget RNA-virusvektor med autonom replikeringsaktivitet |
| DK0863202T3 (da) | 1995-11-01 | 2010-09-27 | Dnavec Research Inc | Rekombinant Sendai-virus |
| US6090391A (en) * | 1996-02-23 | 2000-07-18 | Aviron | Recombinant tryptophan mutants of influenza |
| DE19612966B4 (de) * | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| WO1998002530A1 (en) | 1996-07-15 | 1998-01-22 | The Government Of The United States Of America, As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences |
| CA2265554A1 (en) | 1996-09-27 | 1998-04-02 | American Cyanamid Company | 3' genomic promoter region and polymerase gene mutations responsible for attenuation in viruses of the order designated mononegavirales |
| BR9809456B1 (pt) | 1997-05-23 | 2011-06-28 | molécula isolada de polinucleotìdeo, composição de célula ou isenta de célula, partìcula de piv infeciosa, atenuada e imunogênica, e, composição imunogênica. | |
| DE69837764T2 (de) | 1997-07-11 | 2008-01-31 | Yale University, New Haven | Rhabdovirus mit gentechnisch veränderter hülle |
| KR20010030630A (ko) | 1997-09-19 | 2001-04-16 | 윌리암 에이취 캘넌, 에곤 이 버그 | 약독화 호흡 신시티아 바이러스 |
| GB9815040D0 (en) | 1998-07-10 | 1998-09-09 | Medical Res Council | Conditional mutant |
| US6177082B1 (en) * | 1998-08-13 | 2001-01-23 | The University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
| US6146642A (en) * | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
| US6544785B1 (en) * | 1998-09-14 | 2003-04-08 | Mount Sinai School Of Medicine Of New York University | Helper-free rescue of recombinant negative strand RNA viruses |
| CN1163613C (zh) | 1998-11-20 | 2004-08-25 | 中国科学院上海生物化学研究所 | 人白介素6核转录因子表达质粒系列及其在肿瘤治疗中的应用 |
| EP1035209A1 (en) | 1999-03-06 | 2000-09-13 | ARTEMIS Pharmaceuticals GmbH | Stable recombinant influenza viruses free of helper viruses |
| DE122008000035I1 (de) | 1999-04-06 | 2009-05-20 | Wisconsin Alumni Res Found | Rekombinante influenzaviren zur vakzinherstellung und gentherapie |
| US8715940B2 (en) * | 1999-04-06 | 2014-05-06 | Wisconsin Alumni Research Foundation | Method of making recombinant influenza virus |
| GB9923176D0 (en) | 1999-09-30 | 1999-12-01 | Smithkline Beecham Biolog | Novel composition |
| WO2001064860A2 (en) * | 2000-03-02 | 2001-09-07 | Polymun Scientific Immunbiologische Forschung Gmbh | Recombinant influenza a viruses |
| ES2319864T3 (es) * | 2000-04-28 | 2009-05-14 | St. Jude Children's Research Hospital | Sistema de transfeccion de adn para la generacion de virus infecciosos de arn de cadena negativa. |
| JP5063852B2 (ja) * | 2000-09-25 | 2012-10-31 | ポリマン サイエンティフィック イミューンバイオロジッシュ フォーシュング ゲゼルシャフト ミット ベシュレンクテル ファフツング | 生ワクチン及び製造方法 |
| US7195905B2 (en) * | 2001-12-10 | 2007-03-27 | Baxter Healthcare S.A. | Enveloped virus vaccine and method for production |
| DK1499348T3 (en) * | 2002-04-26 | 2015-01-05 | Medimmune Llc | PROCEDURE FOR PREPARING INFECTIOUS INFLUENZA B-VIRA IN CELL CULTURE |
| US7465456B2 (en) * | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
| EP2481819A1 (en) | 2003-02-25 | 2012-08-01 | MedImmune Vaccines, Inc. | Cross flow filtration in the production of stabilized influenza vaccine compositions |
| US20060110406A1 (en) * | 2003-02-25 | 2006-05-25 | Medimmune Vaccines, Inc. | Refrigerator-temperature stable influenza vaccine compositions |
| US7566458B2 (en) * | 2003-06-16 | 2009-07-28 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| US7037707B2 (en) * | 2003-09-04 | 2006-05-02 | St. Jude Children's Research Hospital | Method for generating influenza viruses and vaccines |
| CA2551489C (en) | 2003-12-23 | 2013-09-03 | Gregory Duke | Multi plasmid system for the production of influenza virus |
| HUE025727T2 (en) | 2004-05-24 | 2016-04-28 | Medimmune Llc | Multi-plasmid system for producing influenza virus |
| EP2769735B1 (en) | 2004-10-06 | 2017-04-19 | MedImmune, LLC | Refrigerator-temperature stable influenza vaccine compositions |
| EP2388340B1 (en) | 2004-11-01 | 2013-04-03 | Eiken Kagaku Kabushiki Kaisha | Method of detecting H7 avian influenza virus |
| EP2674486A1 (en) * | 2007-06-18 | 2013-12-18 | MedImmune, LLC | Influenza B viruses having alterations in the hemaglutinin polypeptide |
| CN102026628A (zh) * | 2008-02-15 | 2011-04-20 | 太阳医药高级研发有限公司 | 具有降低崩裂效果的口服控释片剂 |
-
2004
- 2004-12-22 CA CA2551489A patent/CA2551489C/en not_active Expired - Fee Related
- 2004-12-22 AU AU2004308328A patent/AU2004308328B2/en not_active Ceased
- 2004-12-22 WO PCT/US2004/042669 patent/WO2005062820A2/en not_active Ceased
- 2004-12-22 JP JP2006547195A patent/JP4771959B2/ja not_active Expired - Lifetime
- 2004-12-22 ES ES04814807T patent/ES2345492T3/es not_active Expired - Lifetime
- 2004-12-22 EP EP04814807A patent/EP1697521B1/en not_active Expired - Lifetime
- 2004-12-22 DE DE602004027537T patent/DE602004027537D1/de not_active Expired - Lifetime
- 2004-12-22 AT AT04814807T patent/ATE469972T1/de not_active IP Right Cessation
- 2004-12-22 US US11/018,624 patent/US20050158342A1/en not_active Abandoned
-
2008
- 2008-12-16 US US12/336,158 patent/US8093033B2/en not_active Expired - Lifetime
-
2011
- 2011-04-06 JP JP2011084297A patent/JP5264955B2/ja not_active Expired - Lifetime
- 2011-12-01 US US13/309,498 patent/US8409843B2/en not_active Expired - Fee Related
-
2013
- 2013-02-27 US US13/779,549 patent/US9255253B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007520214A5 (https=) | ||
| Marriott et al. | Defective interfering viruses and their potential as antiviral agents | |
| Hoenen et al. | Minigenomes, transcription and replication competent virus-like particles and beyond: reverse genetics systems for filoviruses and other negative stranded hemorrhagic fever viruses | |
| EP1631663B1 (en) | High titer recombinant influenza viruses for vaccines and gene therapy | |
| Elliott et al. | Emerging phleboviruses | |
| Conzelmann | Nonsegmented negative-strand RNA viruses: genetics and manipulation of viral genomes | |
| Emonet et al. | Arenavirus reverse genetics: new approaches for the investigation of arenavirus biology and development of antiviral strategies | |
| JP2018531023A5 (https=) | ||
| JP2011182797A5 (https=) | ||
| JP2015119730A5 (https=) | ||
| JP2010512779A5 (https=) | ||
| RU2013133734A (ru) | Получение вирусоподобных частиц в растениях | |
| HRP20221474T1 (hr) | Cjepiva protiv virusa hepatitisa b | |
| EP2561081B1 (en) | Reverse genetics of negative-strand rna viruses in yeast | |
| JP2016533172A5 (https=) | ||
| JP2008520248A (ja) | タンデム転写ユニットを有する組換えインフルエンザベクター | |
| CA2848117A1 (en) | Recombinant influenza virus highly expressing ha protein and preparation method and use thereof | |
| WO2008156681A2 (en) | Adenoviral vectors for influenza virus production | |
| Irie et al. | Sendai virus C proteins regulate viral genome and antigenome synthesis to dictate the negative genome polarity | |
| Martín-Benito et al. | Influenza virus transcription and replication | |
| Ren et al. | Recent advances in Bunyavirus reverse genetics research: systems development, applications, and future perspectives | |
| CN104195154B (zh) | 新城疫病毒Mukteswar中等毒力疫苗株反向遗传操作系统及其应用 | |
| Li et al. | Screening of the high yield influenza B virus on MDCK cell and cloning of its whole genome | |
| Theriault et al. | Rescue of Ebola virus from cDNA using heterologous support proteins | |
| Ritchie et al. | Identification and characterisation of the genomic segment 7 of the infectious salmon anaemia virus genome |