JP2007519691A5 - - Google Patents
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- Publication number
- JP2007519691A5 JP2007519691A5 JP2006550247A JP2006550247A JP2007519691A5 JP 2007519691 A5 JP2007519691 A5 JP 2007519691A5 JP 2006550247 A JP2006550247 A JP 2006550247A JP 2006550247 A JP2006550247 A JP 2006550247A JP 2007519691 A5 JP2007519691 A5 JP 2007519691A5
- Authority
- JP
- Japan
- Prior art keywords
- atom
- group
- nucleus
- carbon atoms
- radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 alkyl radical Chemical class 0.000 claims description 12
- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 10
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 9
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- 125000000623 heterocyclic group Chemical group 0.000 claims description 6
- 229910052717 sulfur Inorganic materials 0.000 claims description 6
- 125000004434 sulfur atom Chemical group 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 125000001153 fluoro group Chemical group F* 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 3
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 claims description 2
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical group Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims description 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 2
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 2
- 150000005840 aryl radicals Chemical class 0.000 claims description 2
- IANQTJSKSUMEQM-UHFFFAOYSA-N benzofuran Natural products C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 150000003457 sulfones Chemical class 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0400913 | 2004-01-30 | ||
| FR0400913A FR2865732B1 (fr) | 2004-01-30 | 2004-01-30 | Composes de type hydrazide et leur utilisation dans des compositions pharmaceutiques pour le traitement des maladies cardiovasculaires |
| PCT/FR2005/000199 WO2005082882A1 (fr) | 2004-01-30 | 2005-01-31 | Composes de type hydrazide et leur utilisation dans des compositions pharmaceutiques pour le traitement des maladies cardiovasculaires |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007519691A JP2007519691A (ja) | 2007-07-19 |
| JP2007519691A5 true JP2007519691A5 (https=) | 2011-07-07 |
| JP5047629B2 JP5047629B2 (ja) | 2012-10-10 |
Family
ID=34746342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006550247A Expired - Fee Related JP5047629B2 (ja) | 2004-01-30 | 2005-01-31 | ヒドラジドタイプの化合物及び心臓血管系疾患の治療のための製薬組成物の調製における該化合物の使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20070161697A1 (https=) |
| EP (2) | EP2113502B1 (https=) |
| JP (1) | JP5047629B2 (https=) |
| CN (1) | CN100588655C (https=) |
| AT (1) | ATE444961T1 (https=) |
| AU (1) | AU2005217174B2 (https=) |
| BR (1) | BRPI0507248A (https=) |
| CA (1) | CA2554439A1 (https=) |
| DE (1) | DE602005017007D1 (https=) |
| DK (1) | DK2113502T3 (https=) |
| ES (2) | ES2398479T3 (https=) |
| FR (1) | FR2865732B1 (https=) |
| PT (2) | PT1709027E (https=) |
| WO (1) | WO2005082882A1 (https=) |
| ZA (1) | ZA200606909B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006132583A1 (en) * | 2005-06-07 | 2006-12-14 | Innate Pharmaceuticals Ab | Method and means for preventing and inhibiting respiratory disease, atherosclerosis and osteoporosis caused by chlamydia pneumoniae infection |
| EP2338879A1 (en) | 2009-12-15 | 2011-06-29 | Arteria | New phenylhydrazone derivatives and their use as pharmaceuticals |
| WO2012027548A1 (en) * | 2010-08-25 | 2012-03-01 | The Feinstein Institute For Medical Research | Compounds and methods for prevention and treatment of alzheimer's and other diseases |
| CN103044284A (zh) * | 2011-10-13 | 2013-04-17 | 南京大学 | 香草酸酰腙类衍生物及其制备和用途 |
| WO2014028946A2 (en) * | 2012-08-17 | 2014-02-20 | The Broad Institute, Inc. | Modulators of hepatic lipoprotein metabolism |
| CN103613514B (zh) * | 2013-10-30 | 2015-05-13 | 西北师范大学 | 荧光比色识别氰根离子的有机双金属凝胶及其制备和应用 |
| CN104860866B (zh) * | 2015-05-25 | 2018-07-17 | 厦门大学 | 5-(取代碳酰氨基)-1h-吲哚-2-碳酰肼衍生物及其制备方法和应用 |
| CN104829597B (zh) * | 2015-05-25 | 2018-07-17 | 厦门大学 | 1h-吲哚-2-碳酰肼衍生物及其制备方法和用途 |
| CN105348170B (zh) * | 2015-11-06 | 2019-02-05 | 厦门大学 | 1-(2-(碳酰肼取代基团)-1h-吲哚-5-基)-3-取代脲衍生物及制备方法 |
| WO2018107853A2 (en) | 2016-09-26 | 2018-06-21 | Qingdao Primedicine Pharmaceutical Co., Ltd. | N-methyl-d-aspartate receptor allosteric modulators and methods for their use |
| PL233208B1 (pl) * | 2018-09-17 | 2019-09-30 | Politechnika Wroclawska | Iminowe pochodne aldehydów salicylowych i hydrazydu kwasu 4-hydroksybenzoesowego oraz sposób ich wytwarzania |
| WO2023060161A1 (en) * | 2021-10-06 | 2023-04-13 | The Research Foundation For The State University Of New York | Anti-fungals compounds targeting the synthesis of fungal sphingolipids |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB762187A (en) * | 1952-10-09 | 1956-11-28 | Bayer Ag | Metal complexes of hydrazide-hydrazones and process for producing the same |
| JPS4819628B1 (https=) * | 1969-01-07 | 1973-06-14 | ||
| US3859281A (en) * | 1971-07-01 | 1975-01-07 | American Home Prod | 2,6-dichlorobenzylidenehydrazides |
| US3829492A (en) * | 1972-02-04 | 1974-08-13 | Rohm & Haas | Fungicidal salicylaldehyde hydrazones and azines |
| US3963480A (en) * | 1973-04-11 | 1976-06-15 | Sterling Drug Inc. | Herbicidal pyrrole-2-carboxamides |
| JPS62501709A (ja) * | 1985-02-11 | 1987-07-09 | ジ・アップジョン・カンパニ− | 駆虫薬ピリジニル・アシルヒドラゾン、その使用方法および組成物 |
| US5424333A (en) * | 1985-10-21 | 1995-06-13 | Rohm And Haas Company | Anthelmintic N'-substituted-N,N'-disubstitutedhydrazines |
| US6005113A (en) * | 1996-05-15 | 1999-12-21 | Molecular Probes, Inc. | Long wavelength dyes for infrared tracing |
| JPH11106371A (ja) * | 1997-07-04 | 1999-04-20 | Nisshin Flour Milling Co Ltd | アシルヒドラゾン誘導体 |
| JP2001233767A (ja) * | 2000-02-25 | 2001-08-28 | Shionogi & Co Ltd | アポａｉ発現亢進剤 |
| WO2002102301A2 (en) * | 2000-12-07 | 2002-12-27 | Cytovia, Inc. | Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| US20040110963A1 (en) * | 2001-01-22 | 2004-06-10 | Kaspar Burri | Novel hydrazones |
| DE20108608U1 (de) * | 2001-05-23 | 2001-08-09 | Wella Ag, 64295 Darmstadt | 2,5-Diamino-benzaldehyd-Derivate und diese Verbindungen enthaltende Färbemittel |
| EP1462105A1 (en) * | 2003-03-28 | 2004-09-29 | Procorde GmbH | Activation specific inhibitors of NF-kB and method of treating inflammatory processes in cardio-vascular diseases |
| DE10348022A1 (de) * | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
| EP2022495B1 (en) * | 2006-05-31 | 2014-07-23 | Mochida Pharmaceutical Co., Ltd. | Composition for preventing the occurrence of cardiovascular event in multiple risk patient |
-
2004
- 2004-01-30 FR FR0400913A patent/FR2865732B1/fr not_active Expired - Fee Related
-
2005
- 2005-01-31 US US10/587,697 patent/US20070161697A1/en not_active Abandoned
- 2005-01-31 PT PT05717518T patent/PT1709027E/pt unknown
- 2005-01-31 DE DE602005017007T patent/DE602005017007D1/de not_active Expired - Lifetime
- 2005-01-31 ES ES09166657T patent/ES2398479T3/es not_active Expired - Lifetime
- 2005-01-31 EP EP09166657A patent/EP2113502B1/fr not_active Expired - Lifetime
- 2005-01-31 BR BRPI0507248-4A patent/BRPI0507248A/pt not_active IP Right Cessation
- 2005-01-31 AT AT05717518T patent/ATE444961T1/de not_active IP Right Cessation
- 2005-01-31 PT PT91666578T patent/PT2113502E/pt unknown
- 2005-01-31 ZA ZA200606909A patent/ZA200606909B/en unknown
- 2005-01-31 CA CA002554439A patent/CA2554439A1/fr not_active Abandoned
- 2005-01-31 EP EP05717518A patent/EP1709027B1/fr not_active Expired - Lifetime
- 2005-01-31 WO PCT/FR2005/000199 patent/WO2005082882A1/fr not_active Ceased
- 2005-01-31 JP JP2006550247A patent/JP5047629B2/ja not_active Expired - Fee Related
- 2005-01-31 AU AU2005217174A patent/AU2005217174B2/en not_active Ceased
- 2005-01-31 ES ES05717518T patent/ES2334574T3/es not_active Expired - Lifetime
- 2005-01-31 DK DK09166657.8T patent/DK2113502T3/da active
- 2005-01-31 CN CN200580009749A patent/CN100588655C/zh not_active Expired - Fee Related
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