JP2007518780A5 - - Google Patents
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- Publication number
- JP2007518780A5 JP2007518780A5 JP2006550272A JP2006550272A JP2007518780A5 JP 2007518780 A5 JP2007518780 A5 JP 2007518780A5 JP 2006550272 A JP2006550272 A JP 2006550272A JP 2006550272 A JP2006550272 A JP 2006550272A JP 2007518780 A5 JP2007518780 A5 JP 2007518780A5
- Authority
- JP
- Japan
- Prior art keywords
- medium
- eudragit
- mixture
- polymer
- bioactive substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 7
- 239000002904 solvent Substances 0.000 claims 7
- 230000000975 bioactive effect Effects 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000011859 microparticle Substances 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 claims 1
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 229920003139 Eudragit® L 100 Polymers 0.000 claims 1
- 229920003135 Eudragit® L 100-55 Polymers 0.000 claims 1
- 229920003159 Eudragit® RS 100 Polymers 0.000 claims 1
- 229920003152 Eudragit® RS polymer Polymers 0.000 claims 1
- 229920003141 Eudragit® S 100 Polymers 0.000 claims 1
- 229920003134 Eudragit® polymer Polymers 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- TTZKGYULRVDFJJ-GIVMLJSASA-N [(2r)-2-[(2s,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-[(z)-octadec-9-enoyl]oxyethyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1O TTZKGYULRVDFJJ-GIVMLJSASA-N 0.000 claims 1
- 229960003515 bendroflumethiazide Drugs 0.000 claims 1
- HDWIHXWEUNVBIY-UHFFFAOYSA-N bendroflumethiazidum Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1NC2CC1=CC=CC=C1 HDWIHXWEUNVBIY-UHFFFAOYSA-N 0.000 claims 1
- 229960004436 budesonide Drugs 0.000 claims 1
- 238000004945 emulsification Methods 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 229940057995 liquid paraffin Drugs 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 229960005205 prednisolone Drugs 0.000 claims 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 1
- 235000011069 sorbitan monooleate Nutrition 0.000 claims 1
- 239000001593 sorbitan monooleate Substances 0.000 claims 1
- 229940035049 sorbitan monooleate Drugs 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0401291A GB0401291D0 (en) | 2004-01-21 | 2004-01-21 | Method of producing microparticles |
| GB0401291.0 | 2004-01-21 | ||
| GB0418141.8 | 2004-08-13 | ||
| GB0418141A GB0418141D0 (en) | 2004-08-13 | 2004-08-13 | Method of producing microparticles |
| PCT/GB2005/000174 WO2005070391A2 (en) | 2004-01-21 | 2005-01-19 | Method of producing microparticles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007518780A JP2007518780A (ja) | 2007-07-12 |
| JP2007518780A5 true JP2007518780A5 (enExample) | 2008-02-28 |
| JP4961213B2 JP4961213B2 (ja) | 2012-06-27 |
Family
ID=34809878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006550272A Expired - Fee Related JP4961213B2 (ja) | 2004-01-21 | 2005-01-19 | マイクロ粒子の製造方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8343545B2 (enExample) |
| EP (1) | EP1722761B1 (enExample) |
| JP (1) | JP4961213B2 (enExample) |
| AT (1) | ATE493116T1 (enExample) |
| DE (1) | DE602005025606D1 (enExample) |
| DK (1) | DK1722761T3 (enExample) |
| WO (1) | WO2005070391A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005025606D1 (de) * | 2004-01-21 | 2011-02-10 | Univ London Pharmacy | Verfahren zur herstellung von mikroteilchen |
| DE102007009242A1 (de) * | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit magensaftresistenter Wirkstoff-Matix |
| GB201107629D0 (en) * | 2011-05-06 | 2011-06-22 | Proxima Concepts Ltd | Hydrophobic preparations |
| US11654114B2 (en) * | 2017-06-07 | 2023-05-23 | Egy-Nano Pharma, Lp | Oral prolonged drug delivery platforms |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4652641A (en) * | 1984-06-26 | 1987-03-24 | S. C. Mitri | Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists |
| FR2618674B1 (fr) * | 1987-07-30 | 1990-06-15 | Ire Celltarg Sa | Microparticules comportant un polymere biodegradable controlant la liberation d'un principe actif antimalarique, compositions pharmaceutiques en comprenant et procede de preparation |
| JP2670680B2 (ja) * | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
| JPH04190844A (ja) * | 1990-11-26 | 1992-07-09 | Nippon Kayaku Co Ltd | マイクロカプセルの製法 |
| WO1999000113A1 (en) | 1997-06-27 | 1999-01-07 | Vivorx Pharmaceuticals, Inc. | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| US5824638A (en) * | 1995-05-22 | 1998-10-20 | Shire Laboratories, Inc. | Oral insulin delivery |
| FR2769854B1 (fr) * | 1997-10-21 | 2000-03-31 | Prographarm Lab | Nouveau procede d'obtention de microspheres et les produits ainsi realises |
| KR100289471B1 (ko) | 1998-01-19 | 2001-09-17 | 김충섭 | 휀타닐계마취제의이식형서방성제제 |
| US6312712B1 (en) * | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
| US6303651B1 (en) * | 1999-09-23 | 2001-10-16 | Thione International, Inc. | Synergistic antioxidant veterinary compositions |
| US6623761B2 (en) * | 2000-12-22 | 2003-09-23 | Hassan Emadeldin M. | Method of making nanoparticles of substantially water insoluble materials |
| US6692771B2 (en) * | 2001-02-23 | 2004-02-17 | Cima Labs Inc. | Emulsions as solid dosage forms for oral administration |
| DE602005025606D1 (de) * | 2004-01-21 | 2011-02-10 | Univ London Pharmacy | Verfahren zur herstellung von mikroteilchen |
-
2005
- 2005-01-19 DE DE602005025606T patent/DE602005025606D1/de not_active Expired - Lifetime
- 2005-01-19 DK DK05701939.0T patent/DK1722761T3/da active
- 2005-01-19 US US10/597,328 patent/US8343545B2/en not_active Expired - Fee Related
- 2005-01-19 EP EP05701939A patent/EP1722761B1/en not_active Expired - Lifetime
- 2005-01-19 WO PCT/GB2005/000174 patent/WO2005070391A2/en not_active Ceased
- 2005-01-19 JP JP2006550272A patent/JP4961213B2/ja not_active Expired - Fee Related
- 2005-01-19 AT AT05701939T patent/ATE493116T1/de active
-
2012
- 2012-12-05 US US13/705,928 patent/US20130101646A1/en not_active Abandoned
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