WO2005070391A2 - Method of producing microparticles - Google Patents

Method of producing microparticles Download PDF

Info

Publication number
WO2005070391A2
WO2005070391A2 PCT/GB2005/000174 GB2005000174W WO2005070391A2 WO 2005070391 A2 WO2005070391 A2 WO 2005070391A2 GB 2005000174 W GB2005000174 W GB 2005000174W WO 2005070391 A2 WO2005070391 A2 WO 2005070391A2
Authority
WO
WIPO (PCT)
Prior art keywords
microparticles
eudragit
solvent
vehicle
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2005/000174
Other languages
English (en)
French (fr)
Other versions
WO2005070391A3 (en
Inventor
Abdul Waseh Basit
Richard Andrew Kendall
Sudax Shina Murdan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College London
Original Assignee
University College London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0401291A external-priority patent/GB0401291D0/en
Priority claimed from GB0418141A external-priority patent/GB0418141D0/en
Priority to DE602005025606T priority Critical patent/DE602005025606D1/de
Priority to US10/597,328 priority patent/US8343545B2/en
Priority to EP05701939A priority patent/EP1722761B1/en
Priority to AT05701939T priority patent/ATE493116T1/de
Application filed by University College London filed Critical University College London
Priority to JP2006550272A priority patent/JP4961213B2/ja
Priority to DK05701939.0T priority patent/DK1722761T3/da
Publication of WO2005070391A2 publication Critical patent/WO2005070391A2/en
Publication of WO2005070391A3 publication Critical patent/WO2005070391A3/en
Anticipated expiration legal-status Critical
Priority to US13/705,928 priority patent/US20130101646A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Definitions

  • HLB hydophilic-lipophilic balance
  • the mixture of surfactants is preferably an equimolar mixture of only two surfactants, and may comprise sorbitan monoleate and sorbitan dioleate.
  • Other surfactant combinations include Tween 80 and Span 85; Span 80 and Span 85; Span 85 and Span 20; Span 80 and Span 20; or a combination of any two thereof.
  • sorbitan sesquioleate is used as a surfactant to stabilise said emulsion.
  • Sorbitan sesquioleate is available from Uniquema under the trade name Arlacel 83 and is an equimolar mixture of sorbitan monoleate and sorbitan dioleate.
  • composition of microparticles obtainable by means of a method as defined above.
  • a method of medical treatment comprising administering to a patient an effective amount of said microparticles.
  • the proposed method of microencapsulation can also be used for Eudragit LlOO and mixtures of LI 00 and S 100

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Colloid Chemistry (AREA)
PCT/GB2005/000174 2004-01-21 2005-01-19 Method of producing microparticles Ceased WO2005070391A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DK05701939.0T DK1722761T3 (da) 2004-01-21 2005-01-19 Fremgangsmåde til frembringelse af mikropartikler
JP2006550272A JP4961213B2 (ja) 2004-01-21 2005-01-19 マイクロ粒子の製造方法
US10/597,328 US8343545B2 (en) 2004-01-21 2005-01-19 Method of producing microparticles
EP05701939A EP1722761B1 (en) 2004-01-21 2005-01-19 Method of producing microparticles
AT05701939T ATE493116T1 (de) 2004-01-21 2005-01-19 Verfahren zur herstellung von mikroteilchen
DE602005025606T DE602005025606D1 (de) 2004-01-21 2005-01-19 Verfahren zur herstellung von mikroteilchen
US13/705,928 US20130101646A1 (en) 2004-01-21 2012-12-05 Method of Producing Microparticles

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0401291A GB0401291D0 (en) 2004-01-21 2004-01-21 Method of producing microparticles
GB0401291.0 2004-01-21
GB0418141.8 2004-08-13
GB0418141A GB0418141D0 (en) 2004-08-13 2004-08-13 Method of producing microparticles

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/705,928 Continuation US20130101646A1 (en) 2004-01-21 2012-12-05 Method of Producing Microparticles

Publications (2)

Publication Number Publication Date
WO2005070391A2 true WO2005070391A2 (en) 2005-08-04
WO2005070391A3 WO2005070391A3 (en) 2005-09-09

Family

ID=34809878

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/000174 Ceased WO2005070391A2 (en) 2004-01-21 2005-01-19 Method of producing microparticles

Country Status (7)

Country Link
US (2) US8343545B2 (enExample)
EP (1) EP1722761B1 (enExample)
JP (1) JP4961213B2 (enExample)
AT (1) ATE493116T1 (enExample)
DE (1) DE602005025606D1 (enExample)
DK (1) DK1722761T3 (enExample)
WO (1) WO2005070391A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010519236A (ja) * 2007-02-22 2010-06-03 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング 胃液抵抗性の作用物質−マトリックスを有しているペレット

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005025606D1 (de) * 2004-01-21 2011-02-10 Univ London Pharmacy Verfahren zur herstellung von mikroteilchen
GB201107629D0 (en) * 2011-05-06 2011-06-22 Proxima Concepts Ltd Hydrophobic preparations
US11654114B2 (en) * 2017-06-07 2023-05-23 Egy-Nano Pharma, Lp Oral prolonged drug delivery platforms

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020076444A1 (en) 1997-10-21 2002-06-20 Francis Di Costanzo Novel method for obtaining microspheres and resulting products

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652641A (en) * 1984-06-26 1987-03-24 S. C. Mitri Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists
FR2618674B1 (fr) * 1987-07-30 1990-06-15 Ire Celltarg Sa Microparticules comportant un polymere biodegradable controlant la liberation d'un principe actif antimalarique, compositions pharmaceutiques en comprenant et procede de preparation
JP2670680B2 (ja) * 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
JPH04190844A (ja) * 1990-11-26 1992-07-09 Nippon Kayaku Co Ltd マイクロカプセルの製法
WO1999000113A1 (en) 1997-06-27 1999-01-07 Vivorx Pharmaceuticals, Inc. Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US5824638A (en) * 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
KR100289471B1 (ko) 1998-01-19 2001-09-17 김충섭 휀타닐계마취제의이식형서방성제제
US6312712B1 (en) * 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6303651B1 (en) * 1999-09-23 2001-10-16 Thione International, Inc. Synergistic antioxidant veterinary compositions
US6623761B2 (en) * 2000-12-22 2003-09-23 Hassan Emadeldin M. Method of making nanoparticles of substantially water insoluble materials
US6692771B2 (en) * 2001-02-23 2004-02-17 Cima Labs Inc. Emulsions as solid dosage forms for oral administration
DE602005025606D1 (de) * 2004-01-21 2011-02-10 Univ London Pharmacy Verfahren zur herstellung von mikroteilchen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020076444A1 (en) 1997-10-21 2002-06-20 Francis Di Costanzo Novel method for obtaining microspheres and resulting products

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ACTA TECHNOLOGIAE ET LEGIS MEDICAMENTI, vol. 14, no. 1, 2003, pages 53 - 66
GOTO, S. ET AL.: "Eudragit E, L and S (acrylic resins) microcapsules as pH sensitive release preparations of ketoprofen", J. MICROENCAPSULATION, vol. 3, no. 4, 1986, pages 305 - 316
JAMEELA ET AL., JOURNAL OF CONTROLLED RELEASE, vol. 52, 1998, pages 17 - 24
MORISHITA, I. ET AL.: "Controlled release microspheres based on Eudragit L100 for the oral administration of erythromycin", DRUG DESIGN AND DELIVERY, vol. 7, 1991, pages 309 - 319
SQUILLANTE, E. ET AL.: "Microencapsulation of B-galactosidase with Eudragit L100", J. MICROENCAPSULATION, vol. 20, no. 2, 2003, pages 153 - 167

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010519236A (ja) * 2007-02-22 2010-06-03 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング 胃液抵抗性の作用物質−マトリックスを有しているペレット

Also Published As

Publication number Publication date
JP4961213B2 (ja) 2012-06-27
US20080241251A1 (en) 2008-10-02
ATE493116T1 (de) 2011-01-15
JP2007518780A (ja) 2007-07-12
US20130101646A1 (en) 2013-04-25
EP1722761B1 (en) 2010-12-29
US8343545B2 (en) 2013-01-01
WO2005070391A3 (en) 2005-09-09
EP1722761A2 (en) 2006-11-22
DE602005025606D1 (de) 2011-02-10
DK1722761T3 (da) 2011-03-28

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