JP2007515949A5 - - Google Patents

Info

Publication number

JP2007515949A5

JP2007515949A5 JP2006539632A JP2006539632A JP2007515949A5 JP 2007515949 A5 JP2007515949 A5 JP 2007515949A5 JP 2006539632 A JP2006539632 A JP 2006539632A JP 2006539632 A JP2006539632 A JP 2006539632A JP 2007515949 A5 JP2007515949 A5 JP 2007515949A5

Authority

JP

Japan

Prior art keywords

tgf

antagonist

cancer

tumor

patient

Prior art date

2004-11-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 claims 67
• 206010028980 Neoplasm Diseases 0.000 claims 46
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 44
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 44
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 44
• 206010027476 Metastases Diseases 0.000 claims 27
• 229940127089 cytotoxic agent Drugs 0.000 claims 27
• 238000012360 testing method Methods 0.000 claims 26
• 239000000126 substance Substances 0.000 claims 25
• 239000003814 drug Substances 0.000 claims 23
• 201000011510 cancer Diseases 0.000 claims 22
• 230000009401 metastasis Effects 0.000 claims 20
• 239000002876 beta blocker Substances 0.000 claims 19
• 238000010171 animal model Methods 0.000 claims 16
• 210000004872 soft tissue Anatomy 0.000 claims 16
• 206010006187 Breast cancer Diseases 0.000 claims 15
• 239000002246 antineoplastic agent Substances 0.000 claims 15
• 210000000988 bone and bone Anatomy 0.000 claims 15
• 208000026310 Breast neoplasm Diseases 0.000 claims 14
• 239000005557 antagonist Substances 0.000 claims 13
• 241001465754 Metazoa Species 0.000 claims 12
• 239000002254 cytotoxic agent Substances 0.000 claims 12
• 231100000599 cytotoxic agent Toxicity 0.000 claims 12
• 101150029707 ERBB2 gene Proteins 0.000 claims 9
• 210000004027 cell Anatomy 0.000 claims 9
• 230000000694 effects Effects 0.000 claims 9
• 206010027452 Metastases to bone Diseases 0.000 claims 7
• 239000004037 angiogenesis inhibitor Substances 0.000 claims 7
• 238000001959 radiotherapy Methods 0.000 claims 6
• 230000006378 damage Effects 0.000 claims 5
• 206010065687 Bone loss Diseases 0.000 claims 4
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 4
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 4
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 4
• 239000003795 chemical substances by application Substances 0.000 claims 3
• 210000002919 epithelial cell Anatomy 0.000 claims 3
• 230000014509 gene expression Effects 0.000 claims 3
• 230000012010 growth Effects 0.000 claims 3
• 229960000575 trastuzumab Drugs 0.000 claims 3
• 206010055113 Breast cancer metastatic Diseases 0.000 claims 2
• 206010009944 Colon cancer Diseases 0.000 claims 2
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
• 230000000973 chemotherapeutic effect Effects 0.000 claims 2
• 230000009422 growth inhibiting effect Effects 0.000 claims 2
• 201000001441 melanoma Diseases 0.000 claims 2
• 238000012216 screening Methods 0.000 claims 2
• 210000001519 tissue Anatomy 0.000 claims 2
• 230000004614 tumor growth Effects 0.000 claims 2
• 206010027457 Metastases to liver Diseases 0.000 claims 1
• 206010027458 Metastases to lung Diseases 0.000 claims 1
• 241000283984 Rodentia Species 0.000 claims 1
• 206010068771 Soft tissue neoplasm Diseases 0.000 claims 1
• 238000002591 computed tomography Methods 0.000 claims 1
• 210000005228 liver tissue Anatomy 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 230000036210 malignancy Effects 0.000 claims 1
• 238000012544 monitoring process Methods 0.000 claims 1
• 231100000957 no side effect Toxicity 0.000 claims 1
• 238000011275 oncology therapy Methods 0.000 claims 1
• 230000035945 sensitivity Effects 0.000 claims 1
• 230000002269 spontaneous effect Effects 0.000 claims 1
• 238000001356 surgical procedure Methods 0.000 claims 1
• 210000004881 tumor cell Anatomy 0.000 claims 1