JP2007514763A5 - - Google Patents
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- Publication number
- JP2007514763A5 JP2007514763A5 JP2006545542A JP2006545542A JP2007514763A5 JP 2007514763 A5 JP2007514763 A5 JP 2007514763A5 JP 2006545542 A JP2006545542 A JP 2006545542A JP 2006545542 A JP2006545542 A JP 2006545542A JP 2007514763 A5 JP2007514763 A5 JP 2007514763A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxylesterase
- composition
- combination
- compound
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 35
- 229940122274 Carboxylesterase inhibitor Drugs 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 22
- 102000013392 Carboxylesterase Human genes 0.000 claims 11
- 108010051152 Carboxylesterase Proteins 0.000 claims 11
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 125000004076 pyridyl group Chemical group 0.000 claims 7
- 108010044467 Isoenzymes Proteins 0.000 claims 5
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 5
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical group Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 4
- 230000000840 anti-viral effect Effects 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- -1 trifluoroalkyl ketone compounds Chemical class 0.000 claims 4
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- 125000004772 dichloromethyl group Chemical group [H]C(Cl)(Cl)* 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 230000004060 metabolic process Effects 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Natural products CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 101710128782 Liver carboxylesterase Proteins 0.000 claims 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000005022 aminoacridines Chemical class 0.000 claims 2
- 125000006371 dihalo methyl group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000000968 intestinal effect Effects 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000002467 phosphate group Chemical class [H]OP(=O)(O[H])O[*] 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 229920000178 Acrylic resin Polymers 0.000 claims 1
- 239000004925 Acrylic resin Substances 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 102000004157 Hydrolases Human genes 0.000 claims 1
- 108090000604 Hydrolases Proteins 0.000 claims 1
- 229920001800 Shellac Polymers 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 229940105329 carboxymethylcellulose Drugs 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- VBZWSGALLODQNC-UHFFFAOYSA-N hexafluoroacetone Chemical group FC(F)(F)C(=O)C(F)(F)F VBZWSGALLODQNC-UHFFFAOYSA-N 0.000 claims 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 1
- 229920002401 polyacrylamide Polymers 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 239000004584 polyacrylic acid Substances 0.000 claims 1
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 239000004208 shellac Substances 0.000 claims 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims 1
- 229940113147 shellac Drugs 0.000 claims 1
- 235000013874 shellac Nutrition 0.000 claims 1
- 125000005591 trimellitate group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53154303P | 2003-12-19 | 2003-12-19 | |
| PCT/US2004/042717 WO2005063225A1 (en) | 2003-12-19 | 2004-12-18 | Compositions and methods for treating hepatitis c virus (hcv) infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007514763A JP2007514763A (ja) | 2007-06-07 |
| JP2007514763A5 true JP2007514763A5 (enExample) | 2008-02-14 |
Family
ID=34738664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006545542A Pending JP2007514763A (ja) | 2003-12-19 | 2004-12-18 | Ｃ型肝炎ウイルス（ｈｃｖ）の感染を処置するための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050249805A1 (enExample) |
| EP (1) | EP1699446B1 (enExample) |
| JP (1) | JP2007514763A (enExample) |
| AT (1) | ATE396718T1 (enExample) |
| DE (1) | DE602004014189D1 (enExample) |
| ES (1) | ES2308302T3 (enExample) |
| WO (1) | WO2005063225A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7971730B2 (en) | 2005-08-10 | 2011-07-05 | The Regents Of The University Of California | Collection tubes apparatus, systems and methods |
| JP2010528666A (ja) * | 2007-06-08 | 2010-08-26 | エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント | カルボキシエステラーゼ−１多型およびその使用方法 |
| US20090017108A1 (en) * | 2007-07-11 | 2009-01-15 | Alexander Yuzhakov | Liposome compositions for treatment of hepatitis C |
| US8182826B2 (en) * | 2007-09-11 | 2012-05-22 | Whitmire A Jeffrey | Refreshment towel and applied solution |
| US10966431B2 (en) * | 2007-09-11 | 2021-04-06 | Freedom Towel Holdings, LLC. | Refreshment towel and applied solution |
| US9669405B2 (en) | 2012-10-22 | 2017-06-06 | The Regents Of The University Of California | Sterilizable photopolymer serum separator |
| US10154947B2 (en) | 2016-01-06 | 2018-12-18 | The Procter & Gamble Company | Antiperspirant composition |
| US9730867B2 (en) | 2016-01-06 | 2017-08-15 | The Procter & Gamble Company | Methods of forming a slurry with microcapsules formed from phosphate esters |
| US9732303B2 (en) | 2016-01-06 | 2017-08-15 | The Procter & Gamble Company | Microcapsules formed from phosphate esters and compositions containing same |
| CN110220757B (zh) * | 2019-06-05 | 2021-08-24 | 浙江龙传生物医药科技有限公司 | 用于药物代谢检测的血液保存剂 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4971618A (en) * | 1971-04-16 | 1990-11-20 | Ici Americas Inc. | Herbicide compositions |
| EP1348706B1 (en) * | 2000-12-08 | 2009-08-19 | Takeda Pharmaceutical Company Limited | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof |
| PL374536A1 (en) * | 2002-08-23 | 2005-10-31 | Rigel Pharmaceuticals, Inc. | Pyridyl substituted heterocycles useful for treating or preventing hcv infection |
-
2004
- 2004-12-18 US US11/017,531 patent/US20050249805A1/en not_active Abandoned
- 2004-12-18 WO PCT/US2004/042717 patent/WO2005063225A1/en not_active Ceased
- 2004-12-18 JP JP2006545542A patent/JP2007514763A/ja active Pending
- 2004-12-18 AT AT04814853T patent/ATE396718T1/de not_active IP Right Cessation
- 2004-12-18 EP EP04814853A patent/EP1699446B1/en not_active Expired - Lifetime
- 2004-12-18 ES ES04814853T patent/ES2308302T3/es not_active Expired - Lifetime
- 2004-12-18 DE DE602004014189T patent/DE602004014189D1/de not_active Expired - Fee Related