JP2007514699A5 - - Google Patents
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- Publication number
- JP2007514699A5 JP2007514699A5 JP2006544368A JP2006544368A JP2007514699A5 JP 2007514699 A5 JP2007514699 A5 JP 2007514699A5 JP 2006544368 A JP2006544368 A JP 2006544368A JP 2006544368 A JP2006544368 A JP 2006544368A JP 2007514699 A5 JP2007514699 A5 JP 2007514699A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- hypusinated
- leukemia
- ciclopirox
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003112 inhibitor Substances 0.000 claims 12
- 208000032839 leukemia Diseases 0.000 claims 8
- SCKYRAXSEDYPSA-UHFFFAOYSA-N ciclopirox Chemical compound ON1C(=O)C=C(C)C=C1C1CCCCC1 SCKYRAXSEDYPSA-UHFFFAOYSA-N 0.000 claims 6
- 229960003749 ciclopirox Drugs 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000002062 proliferating effect Effects 0.000 claims 4
- TZXKOCQBRNJULO-UHFFFAOYSA-N Ferriprox Chemical compound CC1=C(O)C(=O)C=CN1C TZXKOCQBRNJULO-UHFFFAOYSA-N 0.000 claims 3
- 239000005517 L01XE01 - Imatinib Substances 0.000 claims 3
- UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical compound CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 claims 3
- BOFQWVMAQOTZIW-UHFFFAOYSA-N deferasirox Chemical group C1=CC(C(=O)O)=CC=C1N1C(C=2C(=CC=CC=2)O)=NC(C=2C(=CC=CC=2)O)=N1 BOFQWVMAQOTZIW-UHFFFAOYSA-N 0.000 claims 3
- 229960003266 deferiprone Drugs 0.000 claims 3
- 229960000958 deferoxamine Drugs 0.000 claims 3
- 229960002706 gusperimus Drugs 0.000 claims 3
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims 3
- 229960002411 imatinib Drugs 0.000 claims 3
- IDINUJSAMVOPCM-INIZCTEOSA-N n-[(1s)-2-[4-(3-aminopropylamino)butylamino]-1-hydroxy-2-oxoethyl]-7-(diaminomethylideneamino)heptanamide Chemical compound NCCCNCCCCNC(=O)[C@H](O)NC(=O)CCCCCCN=C(N)N IDINUJSAMVOPCM-INIZCTEOSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical group 0.000 claims 2
- -1 4-Methyl-piperazino-methyl Chemical group 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53156303P | 2003-12-19 | 2003-12-19 | |
| PCT/EP2004/014439 WO2005058320A1 (en) | 2003-12-19 | 2004-12-17 | COMBINATION OF (a) N-{5-[4-(4-METHYL-PIPERAZINO-METHYL)-BENZOYLAMIDO]-2METHYLPHENYL}-4-(3-PYRIDYL)-2-PYRIMIDINE-AMINE AND (b) AT LEAST ONE HYPUSINATION INHIBITOR AND THE USE THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007514699A JP2007514699A (ja) | 2007-06-07 |
| JP2007514699A5 true JP2007514699A5 (enExample) | 2008-02-07 |
Family
ID=34700180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006544368A Pending JP2007514699A (ja) | 2003-12-19 | 2004-12-17 | （ａ）Ｎ−｛５−［４−（４−メチル−ピペラジノ−メチル）−ベンゾイルアミド］−２−メチルフェニル｝−４−（３−ピリジル）−２−ピリミジン−アミンおよび（ｂ）少なくとも１個のハイプシン化阻害剤を含む組み合わせ物およびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20080139480A1 (enExample) |
| EP (1) | EP1696917A1 (enExample) |
| JP (1) | JP2007514699A (enExample) |
| KR (1) | KR20060125810A (enExample) |
| CN (1) | CN1889952A (enExample) |
| AU (2) | AU2004298761A1 (enExample) |
| BR (1) | BRPI0417759A (enExample) |
| CA (1) | CA2547196A1 (enExample) |
| EC (1) | ECSP066656A (enExample) |
| IL (1) | IL176070A0 (enExample) |
| MA (1) | MA28240A1 (enExample) |
| MX (1) | MXPA06006925A (enExample) |
| NO (1) | NO20063326L (enExample) |
| RU (1) | RU2006125741A (enExample) |
| TN (1) | TNSN06182A1 (enExample) |
| WO (1) | WO2005058320A1 (enExample) |
| ZA (1) | ZA200603904B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009027473A1 (en) | 2007-08-31 | 2009-03-05 | Janssen Pharmaceutica Nv | Combinations of imazalil and hydroxypyridones |
| WO2009036753A2 (de) * | 2007-09-20 | 2009-03-26 | Schebo Biotech Ag | Neue pharmazeutika, verfahren zu ihrer herstellung und ihre verwendung in der medizinischen therapie |
| EP2252147B1 (en) | 2008-02-06 | 2012-12-05 | Janssen Pharmaceutica NV | Combinations of fludioxonil and pyrion compounds |
| EP2242365B1 (en) * | 2008-02-06 | 2013-01-16 | Janssen Pharmaceutica NV | Combinations of pyrimethanil and pyrion compounds |
| WO2010048712A1 (en) * | 2008-10-31 | 2010-05-06 | University Health Network | Ciclopirox and cytarabine for the treatment of leukemic disorders |
| CN103153309A (zh) * | 2010-06-01 | 2013-06-12 | 拜欧赛里克斯公司 | 使用6-环己基-1-羟基-4-甲基-2(1h)-吡啶酮治疗血液恶性肿瘤的方法 |
| WO2011153197A1 (en) | 2010-06-01 | 2011-12-08 | Biotheryx, Inc. | Hydroxypyridone derivatives, pharmaceutical compositions thereof, and their therapeutic use for treating proliferative diseases |
| US8691834B2 (en) | 2010-06-10 | 2014-04-08 | Janssen Pharmaceutica Nv | Combinations of pyrimethanil and monoterpenes |
| CN102958366B (zh) | 2010-07-01 | 2015-02-11 | 詹森药业有限公司 | pyrion化合物与聚乙烯亚胺的抗微生物组合 |
| CN103191110A (zh) * | 2013-03-28 | 2013-07-10 | 中国科学院昆明植物研究所 | 环吡酮及环吡酮胺在制备防治黑色素瘤的药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8528983D0 (en) * | 1985-11-25 | 1986-01-02 | Ciba Geigy Ag | Use of chelating agents |
| EP0227593A1 (en) * | 1985-11-25 | 1987-07-01 | The Hospital For Sick Children | Use of chelating agents |
| TW533205B (en) * | 1996-06-25 | 2003-05-21 | Novartis Ag | Substituted 3,5-diphenyl-l,2,4-triazoles and their pharmaceutical composition |
| ES2331562T3 (es) * | 2001-03-23 | 2010-01-08 | Enzon, Inc. | Profarmacos de agentes anticancerigenos que emplean acidos aromaticos sustituidos. |
| AU2003251875A1 (en) * | 2002-07-15 | 2004-02-02 | Combinatorx, Incorporated | Combination therapy for the treatment of neoplasms |
-
2004
- 2004-12-17 JP JP2006544368A patent/JP2007514699A/ja active Pending
- 2004-12-17 US US10/583,107 patent/US20080139480A1/en not_active Abandoned
- 2004-12-17 BR BRPI0417759-2A patent/BRPI0417759A/pt not_active IP Right Cessation
- 2004-12-17 CA CA002547196A patent/CA2547196A1/en not_active Abandoned
- 2004-12-17 EP EP04804040A patent/EP1696917A1/en not_active Withdrawn
- 2004-12-17 CN CNA2004800362740A patent/CN1889952A/zh active Pending
- 2004-12-17 KR KR1020067012061A patent/KR20060125810A/ko not_active Withdrawn
- 2004-12-17 AU AU2004298761A patent/AU2004298761A1/en not_active Abandoned
- 2004-12-17 WO PCT/EP2004/014439 patent/WO2005058320A1/en not_active Ceased
- 2004-12-17 MX MXPA06006925A patent/MXPA06006925A/es not_active Application Discontinuation
- 2004-12-17 RU RU2006125741/14A patent/RU2006125741A/ru not_active Application Discontinuation
-
2006
- 2006-05-16 ZA ZA200603904A patent/ZA200603904B/en unknown
- 2006-05-31 IL IL176070A patent/IL176070A0/en unknown
- 2006-06-15 TN TNP2006000182A patent/TNSN06182A1/en unknown
- 2006-06-19 EC EC2006006656A patent/ECSP066656A/es unknown
- 2006-06-26 MA MA29141A patent/MA28240A1/fr unknown
- 2006-07-18 NO NO20063326A patent/NO20063326L/no not_active Application Discontinuation
-
2009
- 2009-04-28 AU AU2009201694A patent/AU2009201694A1/en not_active Abandoned
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