BRPI0417759A - combinação de (a) n-{5-[4-(metil-piperazino-metil)-benzoilamido]-2-metilf enil}-4-(3-piridil)-2-pirimidina-amina e (b) pelo menos um inibidor de hipusinação e o seu uso - Google Patents
combinação de (a) n-{5-[4-(metil-piperazino-metil)-benzoilamido]-2-metilf enil}-4-(3-piridil)-2-pirimidina-amina e (b) pelo menos um inibidor de hipusinação e o seu usoInfo
- Publication number
- BRPI0417759A BRPI0417759A BRPI0417759-2A BRPI0417759A BRPI0417759A BR PI0417759 A BRPI0417759 A BR PI0417759A BR PI0417759 A BRPI0417759 A BR PI0417759A BR PI0417759 A BRPI0417759 A BR PI0417759A
- Authority
- BR
- Brazil
- Prior art keywords
- methyl
- pyrimidine
- pyridyl
- amine
- combination
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"COMBINAçãO DE (A) N-{5-¢4-(4-METIL-PIPERAZINO-METIL)-BENZOILAMIDO!-2-METIL FENIL)-4-(3-PIRIDIL)-2-PIRIMIDINA-AMINA E (B) PELO MENOS UM INIBIDOR DE HIPUSINAçãO E O SEU USO". A presente invenção refere-se a um método de tratamento de um animal de sangue quente, especialmente um ser humano, tendo uma doença prolifertiva compreendendo administra ao animal uma combinação que compreende (a) N-{5-¢4-(4-metil-piperazino-metil)-benzoilamido!-2-metilfenil}-4-(3-piridil )-2-pirimidina-amina e (b) pelo menos um inibidor de hipusinação, a uma combinação compreendendo (a) e (b) como definido acima e opcionalmente pelo menos um veículo farmaceuticamente aceitável para o uso simultâneo, separado ou seqüencial, em particular para o atraso de progressão ou tratamento de uma doença proliferativa e finalmente para o uso de pelo menos um inibidor de hipusinação para a preparação de um medicamento para o atraso de progressão ou tratamento de leucemia, particularmente leucemia resistente a Imatinib.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53156303P | 2003-12-19 | 2003-12-19 | |
PCT/EP2004/014439 WO2005058320A1 (en) | 2003-12-19 | 2004-12-17 | COMBINATION OF (a) N-{5-[4-(4-METHYL-PIPERAZINO-METHYL)-BENZOYLAMIDO]-2METHYLPHENYL}-4-(3-PYRIDYL)-2-PYRIMIDINE-AMINE AND (b) AT LEAST ONE HYPUSINATION INHIBITOR AND THE USE THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0417759A true BRPI0417759A (pt) | 2007-04-10 |
Family
ID=34700180
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0417759-2A BRPI0417759A (pt) | 2003-12-19 | 2004-12-17 | combinação de (a) n-{5-[4-(metil-piperazino-metil)-benzoilamido]-2-metilf enil}-4-(3-piridil)-2-pirimidina-amina e (b) pelo menos um inibidor de hipusinação e o seu uso |
Country Status (17)
Country | Link |
---|---|
US (1) | US20080139480A1 (pt) |
EP (1) | EP1696917A1 (pt) |
JP (1) | JP2007514699A (pt) |
KR (1) | KR20060125810A (pt) |
CN (1) | CN1889952A (pt) |
AU (2) | AU2004298761A1 (pt) |
BR (1) | BRPI0417759A (pt) |
CA (1) | CA2547196A1 (pt) |
EC (1) | ECSP066656A (pt) |
IL (1) | IL176070A0 (pt) |
MA (1) | MA28240A1 (pt) |
MX (1) | MXPA06006925A (pt) |
NO (1) | NO20063326L (pt) |
RU (1) | RU2006125741A (pt) |
TN (1) | TNSN06182A1 (pt) |
WO (1) | WO2005058320A1 (pt) |
ZA (1) | ZA200603904B (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8921403B2 (en) | 2007-08-31 | 2014-12-30 | Janssen Pharmaceutica, Nv | Combinations of imazalil and hydroxypyridones |
WO2009036753A2 (de) * | 2007-09-20 | 2009-03-26 | Schebo Biotech Ag | Neue pharmazeutika, verfahren zu ihrer herstellung und ihre verwendung in der medizinischen therapie |
US8575187B2 (en) | 2008-02-06 | 2013-11-05 | Janssen Pharmaceutica, Nv | Combinations of anilinopyrimidines and pyrion compounds |
US8043422B2 (en) | 2008-02-06 | 2011-10-25 | Janssen Pharmaceutica, Nv | Combinations of phenylpyrroles and pyrion compounds |
WO2010048712A1 (en) * | 2008-10-31 | 2010-05-06 | University Health Network | Ciclopirox and cytarabine for the treatment of leukemic disorders |
AU2011261501B2 (en) * | 2010-06-01 | 2016-01-21 | Biotheryx, Inc. | Methods of treating hematologic malignancies using 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone |
JP5844354B2 (ja) | 2010-06-01 | 2016-01-13 | ビオトヘルイク, インコーポレイテッド | ヒドロキシピリドン誘導体、その医薬組成物、及び増殖性疾患治療のためのその治療的使用 |
US8691834B2 (en) | 2010-06-10 | 2014-04-08 | Janssen Pharmaceutica Nv | Combinations of pyrimethanil and monoterpenes |
CN102958366B (zh) | 2010-07-01 | 2015-02-11 | 詹森药业有限公司 | pyrion化合物与聚乙烯亚胺的抗微生物组合 |
CN103191110A (zh) * | 2013-03-28 | 2013-07-10 | 中国科学院昆明植物研究所 | 环吡酮及环吡酮胺在制备防治黑色素瘤的药物中的应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8528983D0 (en) * | 1985-11-25 | 1986-01-02 | Ciba Geigy Ag | Use of chelating agents |
EP0227593A1 (en) * | 1985-11-25 | 1987-07-01 | The Hospital For Sick Children | Use of chelating agents |
TW533205B (en) * | 1996-06-25 | 2003-05-21 | Novartis Ag | Substituted 3,5-diphenyl-l,2,4-triazoles and their pharmaceutical composition |
EP1379257B1 (en) * | 2001-03-23 | 2009-08-12 | Enzon, Inc. | Prodrugs of anticancer agents employing substituted aromatic acids |
WO2004007676A2 (en) * | 2002-07-15 | 2004-01-22 | Combinatorx, Incorporated | Combination therapy for the treatment of neoplasms |
-
2004
- 2004-12-17 CA CA002547196A patent/CA2547196A1/en not_active Abandoned
- 2004-12-17 AU AU2004298761A patent/AU2004298761A1/en not_active Abandoned
- 2004-12-17 RU RU2006125741/14A patent/RU2006125741A/ru not_active Application Discontinuation
- 2004-12-17 MX MXPA06006925A patent/MXPA06006925A/es not_active Application Discontinuation
- 2004-12-17 US US10/583,107 patent/US20080139480A1/en not_active Abandoned
- 2004-12-17 KR KR1020067012061A patent/KR20060125810A/ko not_active Application Discontinuation
- 2004-12-17 JP JP2006544368A patent/JP2007514699A/ja active Pending
- 2004-12-17 WO PCT/EP2004/014439 patent/WO2005058320A1/en active Application Filing
- 2004-12-17 EP EP04804040A patent/EP1696917A1/en not_active Withdrawn
- 2004-12-17 BR BRPI0417759-2A patent/BRPI0417759A/pt not_active IP Right Cessation
- 2004-12-17 CN CNA2004800362740A patent/CN1889952A/zh active Pending
-
2006
- 2006-05-16 ZA ZA200603904A patent/ZA200603904B/en unknown
- 2006-05-31 IL IL176070A patent/IL176070A0/en unknown
- 2006-06-15 TN TNP2006000182A patent/TNSN06182A1/en unknown
- 2006-06-19 EC EC2006006656A patent/ECSP066656A/es unknown
- 2006-06-26 MA MA29141A patent/MA28240A1/fr unknown
- 2006-07-18 NO NO20063326A patent/NO20063326L/no not_active Application Discontinuation
-
2009
- 2009-04-28 AU AU2009201694A patent/AU2009201694A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL176070A0 (en) | 2006-10-05 |
EP1696917A1 (en) | 2006-09-06 |
WO2005058320A1 (en) | 2005-06-30 |
US20080139480A1 (en) | 2008-06-12 |
NO20063326L (no) | 2006-09-19 |
AU2004298761A1 (en) | 2005-06-30 |
MA28240A1 (fr) | 2006-10-02 |
ZA200603904B (en) | 2007-09-26 |
AU2009201694A1 (en) | 2009-05-28 |
TNSN06182A1 (en) | 2007-11-15 |
KR20060125810A (ko) | 2006-12-06 |
CA2547196A1 (en) | 2005-06-30 |
ECSP066656A (es) | 2006-10-25 |
CN1889952A (zh) | 2007-01-03 |
RU2006125741A (ru) | 2008-01-27 |
JP2007514699A (ja) | 2007-06-07 |
MXPA06006925A (es) | 2006-08-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0209647A (pt) | Combinação que compreende n-{5-[4-(4-metil-piperazino-metil)-benzoilamido]-2-metil fenil}-4-(3-piridil)-2-pirimidina-amina e um agente quimioterapêutico | |
TNSN06182A1 (en) | COMBINATION OF (a) N-{5-[4-(4-METHYL-PYPERAZINO-METHYL)-BENZOYLAMIDO] -2-METHYLPHENYL} -4-(3-PYRIDIL)-2-PYRIMIDINE-AMINE AND (b) AT LEAST ONE HYPUSINATION INHIBITOR AND USE THEREOF | |
AR053984A1 (es) | Combinacion de un inhibidor de proteina cinasa src y un inhibidor bcr - abl para el tratamiento de enfermedades proliferativas | |
BR0308053A (pt) | Stents revestidos com n-{5-[4-(4-metil-piperazino-metil)-benzoilamido]-2-metil fenil}-4-(3-piridil)-2-pirimidina-amina | |
HU0102039D0 (en) | Use of paclitaxel stabilized with albumin for the preparation of pharmaceutical compositions treating solid tumors and the pharmaceutical compositions obtained thereby | |
FI941222A0 (fi) | Ei-peptidyyli-tyyppisiä integriini-inhibiittoreita, jotka ovat spesifisiä GPIIbIIIa-reseptorin suhteen | |
NO20031833D0 (no) | Behandling av gastrointestinale stromatumorer | |
TR200000060T2 (tr) | Bir N-fenil-2-pirimidinamin türevinin kristal modifikasyonu ve yapım işlemleri ve kullanımı. | |
DE60118547D1 (de) | Pharmazeutische zusammensetzung zur behandlung von kolorektalem krebs welche thalidomid und irinotecan enthält | |
DK1301201T3 (da) | Behandling af glycogenosis type II | |
DK0665749T3 (da) | Sammensætning til behandling af Parkinsons sygdom | |
AU2003259521A8 (en) | Combination of a) n-{5-(4-(4-methyl-piperazino-methyl)-benzoylamido)-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and b) a histone deacetylase inhibitor for the treatment of leukemia | |
AU2003233946A8 (en) | 4-(4-methylpiperazin-1-ylmethyl)-n-(4-methyl-3(4-pyridin-3-yl)pyrimidin-2-yl-amino)phenyl)-benzamide for treating ang ii-mediated diseases | |
NO984950L (no) | Forbindelser med veksthormonfrigj°rende egenskaper | |
EE05124B1 (et) | Toimeainena dotsetakseeli v?i selle hdraati sisaldava kompositsiooni kasutamine | |
BR0307286A (pt) | Tratamento de artrite reumatóide usando imatinib | |
ATE476183T1 (de) | Verfahren zur behandlung von soliden tumoren einschliesslich der verabreichung einer kombination mit imatinib und einem effluxpumpenhemmer | |
DE60235499D1 (de) | ZELLWACHSTUMSHEMMER MIT ANTI-PepT-ANTIKÖRPER | |
EP1704863A3 (en) | Combination comprising N-5-4-(4-Methyl-Piperazino-Methyl-)Benzoyla Mido]-2-Methylphenyl -4-(3-Pyridyl)-2Phyrimidine-amine and a chemotherapeutic agent | |
BRPI0410704A (pt) | uso de inibidor c-abl- tirosina quinase, pdgf-r- tirosina quinase, ou c-kit-tirosina quinase no tratamento da diabete | |
ECSP045161A (es) | Piperidin-2,6-diona sustituida con heterociclo en la posición 3 | |
WO2004103374A3 (en) | Imatinib combinations for head and neck cancers | |
JP2005508846A5 (pt) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |