JP2007513877A5 - - Google Patents
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- Publication number
- JP2007513877A5 JP2007513877A5 JP2006539731A JP2006539731A JP2007513877A5 JP 2007513877 A5 JP2007513877 A5 JP 2007513877A5 JP 2006539731 A JP2006539731 A JP 2006539731A JP 2006539731 A JP2006539731 A JP 2006539731A JP 2007513877 A5 JP2007513877 A5 JP 2007513877A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- sulfinyl
- ethene
- chlorophenyl
- methoxyphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52052303P | 2003-11-14 | 2003-11-14 | |
| US60/520,523 | 2003-11-14 | ||
| PCT/US2004/037293 WO2005046599A2 (en) | 2003-11-14 | 2004-11-08 | Alpha, beta-unsaturated sulfoxides for treating proliferative disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007513877A JP2007513877A (ja) | 2007-05-31 |
| JP2007513877A5 true JP2007513877A5 (https=) | 2007-12-27 |
| JP5196787B2 JP5196787B2 (ja) | 2013-05-15 |
Family
ID=34590471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006539731A Expired - Fee Related JP5196787B2 (ja) | 2003-11-14 | 2004-11-08 | 増殖性疾患を治療するためのα，β−不飽和スルホキシド |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7744889B2 (https=) |
| EP (1) | EP1689706B1 (https=) |
| JP (1) | JP5196787B2 (https=) |
| KR (1) | KR20060109871A (https=) |
| AU (1) | AU2004289281C1 (https=) |
| CA (1) | CA2546495C (https=) |
| DK (1) | DK1689706T3 (https=) |
| ES (1) | ES2621802T3 (https=) |
| HU (1) | HUE032523T2 (https=) |
| IL (1) | IL174426A (https=) |
| NZ (1) | NZ545995A (https=) |
| WO (1) | WO2005046599A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101274524B1 (ko) * | 2004-03-16 | 2013-06-19 | 온코노바 테라퓨틱스, 인코포레이티드 | 증식성 질병 치료용 치환 페녹시- 및 페닐티오- 유도체 |
| US20090306207A1 (en) * | 2005-01-05 | 2009-12-10 | Reddy M V Ramana | Treatment of Drug-Resistant Proliferative Disorders |
| WO2006104668A2 (en) * | 2005-03-11 | 2006-10-05 | Temple University - Of The Commonwealth System Of Higher Education | Composition and methods for the treatment of proliferative diseases |
| WO2007005670A2 (en) * | 2005-06-30 | 2007-01-11 | The Research Foundation Of The State University Of New York | Natural and synthetic sulfoxide, selenone and selenoxide analogs and polymer conjugated forms thereof for the modulation of angiogenesis |
| JP5734869B2 (ja) * | 2008-12-16 | 2015-06-17 | オンコノバ・セラピューティックス・インコーポレーテッド | ヒトにおける細胞毒性物質の有害作用に対する治療レジメンの有効性を決定する方法 |
| GB201010359D0 (en) | 2010-06-21 | 2010-08-04 | Univ Nottingham | Compounds for treating proliferative disorders |
| EP2486923B1 (en) * | 2011-02-11 | 2015-09-09 | Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG | Histone deacetylase (HDAC) inhibiting compounds and method of making same |
| KR101992929B1 (ko) | 2012-09-20 | 2019-06-25 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 치환된 알킬 디아릴 유도체, 제조방법 및 용도 |
| KR20160005356A (ko) * | 2013-05-07 | 2016-01-14 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 방사선완화 약제학적 제형 |
| CN104892471B (zh) * | 2015-05-15 | 2020-03-27 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 具有蛋白酪氨酸激酶抑制活性的物质、其制备方法及用途 |
| US10383831B2 (en) * | 2015-08-03 | 2019-08-20 | Temple University—Of the Commonwealth System of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
| CN106432011B (zh) * | 2016-09-18 | 2018-11-02 | 中国医学科学院放射医学研究所 | 一类具有辐射防护作用的新化合物、其制备方法及其药物应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3865867A (en) | 1967-06-19 | 1975-02-11 | Monsanto Co | Meta-bifunctional benzenes |
| US3975435A (en) | 1974-03-06 | 1976-08-17 | Givaudan Corporation | Substituted cinnamanilides |
| DK586175A (da) * | 1974-12-28 | 1976-06-29 | Asahi Chemical Ind | Cephalosporin-forbindelser |
| JPH05262733A (ja) * | 1992-03-23 | 1993-10-12 | Sapporo Breweries Ltd | 含硫黄化合物，その製造法及びそれを有効成分とする抗潰瘍剤 |
| US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
| CN1275596C (zh) * | 1997-05-14 | 2006-09-20 | 阿特罗吉尼克斯公司 | 普罗布考单酯在制备用于治疗心血管疾病和炎性疾病的药物中的应用 |
| US6548553B2 (en) | 1997-10-03 | 2003-04-15 | Temple University-Of The Commonwealth System Of Higher Education | Styryl sulfone anticancer agents |
| AU741042B2 (en) * | 1997-10-03 | 2001-11-22 | Temple University - Of The Commonwealth System Of Higher Education | Styryl sulfone anticancer agents |
| US6201154B1 (en) * | 1999-03-31 | 2001-03-13 | Temple University-Of The Commonwealth Of Higher Education | Z-styryl sulfone anticancer agents |
| US6762207B1 (en) | 1999-04-02 | 2004-07-13 | Temple University - Of The Commonwealth System Of Higher Education | (E)-styryl sulfone anticancer agents |
| EP1173160B1 (en) * | 1999-04-02 | 2005-06-22 | Temple University of the Commonwealth System of Higher Education | (e)-styryl sulfone anticancer agents |
| AU3381399A (en) * | 1999-04-02 | 2000-10-23 | Temple University - Of The Commonwealth System Of Higher Education | Styryl sulfone anticancer agents |
| US6117364A (en) | 1999-05-27 | 2000-09-12 | Nalco/Exxon Energy Chemicals, L.P. | Acid corrosion inhibitor |
| AU778825B2 (en) * | 1999-06-16 | 2004-12-23 | Temple University - Of The Commonwealth System Of Higher Education | (Z)-styryl acetoxyphenyl sulfides as cyclooxygenase inhibitors |
| AU780844B2 (en) * | 1999-10-12 | 2005-04-21 | Temple University-Of The Commonwealth System Of Higher Education | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
| US6767926B1 (en) * | 1999-10-12 | 2004-07-27 | Temple University - Of The Commonwealth System Of Higher Education | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
| US6541475B2 (en) * | 2000-04-14 | 2003-04-01 | Temple University - Of The Commonwealth System Of Higher Education | α, β-unsaturated sulfones for treating proliferative disorders |
| US6486210B2 (en) | 2000-04-14 | 2002-11-26 | Temple University—Of the Commonwealth System of Higher Education | Substituted styryl benzylsulfones for treating proliferative disorders |
| WO2002028828A1 (en) | 2000-10-05 | 2002-04-11 | Temple University - Of The Commonwealth System Of Higher Education | Substituted (e)-styryl benzylsulfones for treating proliferative disorders |
| JPWO2002031337A1 (ja) * | 2000-10-12 | 2004-02-19 | ヤマハ発動機株式会社 | ガス燃料用ミキサー |
| JP2004521126A (ja) * | 2001-02-27 | 2004-07-15 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | （ｚ）−スチリルベンジルスルホン及びそれらの医薬としての使用 |
| AU2002305942B2 (en) * | 2001-02-28 | 2006-10-26 | Onconova Therapeutics, Inc. | Method for protecting cells and tissues from ionizing radiation toxicity with Alpha, Beta unsaturated aryl sulfones |
| US6646009B2 (en) | 2001-02-28 | 2003-11-11 | Temple University — Of Commonwealth System of Higher Education | N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof |
| WO2003072062A2 (en) * | 2002-02-28 | 2003-09-04 | Temple University-Of The Commonwealth System Of Higher Education | Amino-substituted (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders |
| KR101274524B1 (ko) | 2004-03-16 | 2013-06-19 | 온코노바 테라퓨틱스, 인코포레이티드 | 증식성 질병 치료용 치환 페녹시- 및 페닐티오- 유도체 |
| WO2006104668A2 (en) | 2005-03-11 | 2006-10-05 | Temple University - Of The Commonwealth System Of Higher Education | Composition and methods for the treatment of proliferative diseases |
-
2004
- 2004-11-08 JP JP2006539731A patent/JP5196787B2/ja not_active Expired - Fee Related
- 2004-11-08 NZ NZ545995A patent/NZ545995A/en not_active IP Right Cessation
- 2004-11-08 DK DK04816944.5T patent/DK1689706T3/da active
- 2004-11-08 US US10/574,993 patent/US7744889B2/en not_active Expired - Lifetime
- 2004-11-08 AU AU2004289281A patent/AU2004289281C1/en not_active Expired
- 2004-11-08 WO PCT/US2004/037293 patent/WO2005046599A2/en not_active Ceased
- 2004-11-08 KR KR1020067007327A patent/KR20060109871A/ko not_active Ceased
- 2004-11-08 ES ES04816944.5T patent/ES2621802T3/es not_active Expired - Lifetime
- 2004-11-08 CA CA2546495A patent/CA2546495C/en not_active Expired - Lifetime
- 2004-11-08 EP EP04816944.5A patent/EP1689706B1/en not_active Expired - Lifetime
- 2004-11-08 HU HUE04816944A patent/HUE032523T2/en unknown
-
2006
- 2006-03-20 IL IL174426A patent/IL174426A/en active IP Right Grant
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