JP2007513326A5 - - Google Patents

Download PDF

Info

Publication number
JP2007513326A5
JP2007513326A5 JP2006539829A JP2006539829A JP2007513326A5 JP 2007513326 A5 JP2007513326 A5 JP 2007513326A5 JP 2006539829 A JP2006539829 A JP 2006539829A JP 2006539829 A JP2006539829 A JP 2006539829A JP 2007513326 A5 JP2007513326 A5 JP 2007513326A5
Authority
JP
Japan
Prior art keywords
fragment
cell
tissue
molecule
peptide antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2006539829A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007513326A (ja
JP4773361B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2004/037569 external-priority patent/WO2005046449A2/en
Publication of JP2007513326A publication Critical patent/JP2007513326A/ja
Publication of JP2007513326A5 publication Critical patent/JP2007513326A5/ja
Application granted granted Critical
Publication of JP4773361B2 publication Critical patent/JP4773361B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2006539829A 2003-11-10 2004-11-10 可溶性tcr分子とその使用方法 Expired - Lifetime JP4773361B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51879003P 2003-11-10 2003-11-10
US60/518,790 2003-11-10
PCT/US2004/037569 WO2005046449A2 (en) 2003-11-10 2004-11-10 Soluble tcr molecules and methods of use

Publications (3)

Publication Number Publication Date
JP2007513326A JP2007513326A (ja) 2007-05-24
JP2007513326A5 true JP2007513326A5 (https=) 2007-12-27
JP4773361B2 JP4773361B2 (ja) 2011-09-14

Family

ID=34590303

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006539829A Expired - Lifetime JP4773361B2 (ja) 2003-11-10 2004-11-10 可溶性tcr分子とその使用方法

Country Status (8)

Country Link
US (4) US8772451B2 (https=)
EP (1) EP1691661B1 (https=)
JP (1) JP4773361B2 (https=)
KR (1) KR101131297B1 (https=)
CN (2) CN1901839A (https=)
AU (1) AU2004289316B2 (https=)
CA (1) CA2544483C (https=)
WO (1) WO2005046449A2 (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1982176A1 (en) * 2006-01-30 2008-10-22 Dako Denmark A/S High-speed quantification of antigen specific t-cells in whole blood by flow cytometry
JP4748542B2 (ja) * 2006-02-24 2011-08-17 古河電気工業株式会社 フローサイトメトリーによる生体分子の定量システム、及び定量方法
EP2361930A3 (en) 2007-03-26 2011-10-26 Dako Denmark A/S Multimers of MHC-peptide complexes and uses thereof in Borrelia infectious diseases
DK2160401T3 (da) 2007-05-11 2014-10-20 Altor Bioscience Corp Fusionsmolekyler og il-15-varianter
EP3620465B1 (en) * 2007-07-03 2025-02-19 Dako Denmark A/S Improved methods for generation, labeling and use of mhc multimers
US10611818B2 (en) 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
DK2254592T3 (da) 2008-02-28 2019-09-09 Dako Denmark As MHC-multimerer til Borrelia-diagnostik og sygdom
WO2009117117A1 (en) * 2008-03-19 2009-09-24 Altor Bioscience Corporation T cell receptor fusions and conjugates and methods of use there of
US10722562B2 (en) * 2008-07-23 2020-07-28 Immudex Aps Combinatorial analysis and repair
GB0817244D0 (en) * 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
WO2010037402A1 (en) 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
EP2258719A1 (en) * 2009-05-19 2010-12-08 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Multiple target T cell receptor
US11053299B2 (en) 2010-09-21 2021-07-06 Immunity Bio, Inc. Superkine
CN107880136B (zh) 2010-09-21 2021-11-12 阿尔托生物科学有限公司 多聚体il-15可溶性融合分子与其制造与使用方法
WO2012058627A2 (en) * 2010-10-29 2012-05-03 Miqin Zhang Pre-targeted nanoparticle system and method for labeling biological particles
CA2945816A1 (en) 2014-04-15 2015-10-22 University Of Virginia Patent Foundation Isolated t cell receptors and methods of use therefor
CA3151221C (en) 2014-06-30 2026-01-13 Altor Bioscience Corporation Il-15-based molecules and methods of use thereof
AU2017271593B2 (en) 2016-05-27 2021-04-22 Altor Bioscience Corporation Construction and characterization of multimeric IL-15-based molecules with CD3 binding domains
WO2018026018A1 (ja) * 2016-08-05 2018-02-08 国立大学法人東北大学 T細胞受容体の認識機構を用いたがん又は感染症の治療及び診断
CN118562016A (zh) 2016-10-21 2024-08-30 艾尔特生物科技公司 基于多聚体il-15的分子
CN117986384A (zh) 2017-03-06 2024-05-07 艾尔特生物科技公司 与il-12和il-18的基于il-15的融合物
EP3592776A4 (en) * 2017-03-08 2021-01-06 Agency for Science, Technology and Research T-CELL RECEPTOR LIKE ANTIBODIES THAT BIND TO THE P53 MHC CLASS I COMPLEX
US20190048055A1 (en) 2017-03-31 2019-02-14 Altor Bioscience Corporation Alt-803 in combination with anti-cd38 antibody for cancer therapies
EP3676289B1 (en) 2017-08-28 2026-03-04 Altor BioScience, LLC Il-15-based fusions to il-7 and il-21
AU2018345400B2 (en) * 2017-10-05 2024-06-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for selectively expanding cells expressing a TCR with a murine constant region
TW202003011A (zh) 2018-03-26 2020-01-16 美商艾爾特生物科技責任有限公司 抗PDL1、IL-15及TGF-β受體組合分子
US20220275043A1 (en) 2018-07-17 2022-09-01 Massachusetts Institute Of Technology Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof
US12258373B2 (en) 2018-12-17 2025-03-25 Immudex Aps Panel comprising Borrelia MHC multimers

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US82719A (en) * 1868-10-06 Improved mode of preserving fruits, meats, vegetables
US171552A (en) * 1875-12-28 Improvement in wash-boards
US253632A (en) * 1882-02-14 Heney j
US34513A (en) * 1862-02-25 Improvement in machines for stacking hay
US198144A (en) * 1877-12-11 Improvement in devices for decorating vases
US91079A (en) * 1869-06-08 Improvement in device for operating throttle-valves
US144474A (en) * 1873-11-11 Improvement in the means for propelling vessels
US4384193A (en) 1981-06-09 1983-05-17 Immulok, Inc. Incubating device for specimen mounted on glass slides in immunoassays
ATE243754T1 (de) * 1987-05-21 2003-07-15 Micromet Ag Multifunktionelle proteine mit vorbestimmter zielsetzung
FR2698880B1 (fr) * 1992-11-25 1995-02-24 Inst Nat Sante Rech Med Procédé de production de récepteurs T solubles, produits ainsi obtenus et leur utilisation dans des compositions diagnostiques ou thérapeutiques.
US7074904B2 (en) 1994-07-29 2006-07-11 Altor Bioscience Corporation MHC complexes and uses thereof
WO1996018105A1 (en) 1994-12-06 1996-06-13 The President And Fellows Of Harvard College Single chain t-cell receptor
US5869270A (en) 1996-01-31 1999-02-09 Sunol Molecular Corporation Single chain MHC complexes and uses thereof
DE19616997A1 (de) 1996-04-27 1997-10-30 Boehringer Mannheim Gmbh Verfahren zur automatisierten mikroskopunterstützten Untersuchung von Gewebeproben oder Körperflüssigkeitsproben
WO1999018129A1 (en) * 1997-10-02 1999-04-15 Sunol Molecular Corporation Soluble single-chain t-cell receptor proteins
US6232445B1 (en) 1997-10-29 2001-05-15 Sunol Molecular Corporation Soluble MHC complexes and methods of use thereof
WO1999060120A2 (en) * 1998-05-19 1999-11-25 Avidex Limited Soluble t cell receptor
ES2293748T3 (es) 1998-10-21 2008-03-16 Altor Bioscience Corporation Moleculas de fijacion poliespecificas y usos de las mismas.
JP2002543854A (ja) 1999-05-14 2002-12-24 カイロン コーポレイション 癌におけるetsドメインタンパク質の発現
JP4972264B2 (ja) 1999-12-06 2012-07-11 ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ 高親和性tcrタンパク質および方法
US6406840B1 (en) 1999-12-17 2002-06-18 Biomosaic Systems, Inc. Cell arrays and the uses thereof
EP1118661A1 (en) 2000-01-13 2001-07-25 Het Nederlands Kanker Instituut T cell receptor libraries
KR20020097181A (ko) 2000-02-22 2002-12-31 제노스펙트라 인코포레이티드 마이크로어레이 제작 기술 및 장치
US20020058235A1 (en) * 2000-02-29 2002-05-16 Dinnerstein Mitchell Elliot Jack switch talking block
CA2410642A1 (en) * 2000-05-25 2001-11-29 Sunol Molecular Corporation Modulation of t-cell receptor interactions
EP2322228B1 (en) * 2000-06-05 2018-01-10 Altor BioScience Corporation T cell receptor fusion proteins and conjugates and methods of use thereof
US6466690C1 (en) 2000-12-19 2008-11-18 Bacus Res Lab Inc Method and apparatus for processing an image of a tissue sample microarray
AU2002316190B8 (en) * 2001-06-05 2009-01-29 Altor Bioscience Corporation p53 binding T cell receptor molecules and uses thereof
US6642661B2 (en) 2001-08-28 2003-11-04 Tokyo Electron Limited Method to affect spatial distribution of harmonic generation in a capacitive discharge reactor
JP2006523437A (ja) * 2002-12-03 2006-10-19 アヴィデックス リミテッド レセプター複合体
DK1796237T3 (da) * 2005-12-13 2007-10-29 Nexans Sa Elektrisk gennemföring til forbindelse af en supraledende anordning med en anordning ved rumtemperatur
WO2009117117A1 (en) * 2008-03-19 2009-09-24 Altor Bioscience Corporation T cell receptor fusions and conjugates and methods of use there of
TWM523243U (zh) 2015-04-01 2016-06-01 嚴介宏 手機轉接裝置及系統

Similar Documents

Publication Publication Date Title
JP2007513326A5 (https=)
ES2424269T3 (es) Inmuno-PCR sándwich por desplazamiento
Poetz et al. Protein microarrays: catching the proteome
CN104067125B (zh) 用于检测核小体加合物的方法
US8354231B2 (en) Methods and systems for detecting and/or sorting targets
Lee et al. Emerging protein array technologies for proteomics
Templin et al. Protein microarrays: promising tools for proteomic research
Liang et al. Colorimetric detection of protein microarrays based on nanogold probe coupled with silver enhancement
ES2899191T3 (es) Péptidos y procedimientos de detección de alergia alimentaria
US20200217850A1 (en) Heterogeneous single cell profiling using molecular barcoding
CN102703453B (zh) 特异性识别链霉素的dna适配体及其应用
KR102929834B1 (ko) 결합에 의한 공국재화 샌드위치 어세이
US20190064183A1 (en) Method for detecting nucleosomes containing histone modifications and variants
US20230417742A1 (en) Improved assays to detect nucleosome modifications using antibody-targeted enzyme digestion
CN115380218A (zh) 用于多重化的连接-共定位夹心测定
CN116917496A (zh) 循环转录因子分析
Joos et al. Protein microarrays: potentials and limitations
Gong et al. A facile strategy for multiplex protein detection by a fluorescent microsphere-based digital immunoassay
Tyagi et al. Detection of embryonic stem cell lysate biomarkers by surface plasmon resonance with reduced nonspecific adsorption
EP1141392A1 (en) Fluorescent intensity assay for protein or peptide binding to nucleic acids
WO2023159045A1 (en) Engineered recombinant protein-binding domains as detection reagents
Taussig et al. Progress in antibody arrays
Harma et al. Miniature single-particle immunoassay for prostate-specific antigen in serum using recombinant Fab fragments
JP2009517381A5 (https=)
JP2006525351A5 (https=)