JP2007511581A5 - - Google Patents
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- Publication number
- JP2007511581A5 JP2007511581A5 JP2006540430A JP2006540430A JP2007511581A5 JP 2007511581 A5 JP2007511581 A5 JP 2007511581A5 JP 2006540430 A JP2006540430 A JP 2006540430A JP 2006540430 A JP2006540430 A JP 2006540430A JP 2007511581 A5 JP2007511581 A5 JP 2007511581A5
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- formula
- aprotic solvent
- onium cation
- coy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 8
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 4
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 239000000010 aprotic solvent Substances 0.000 claims 3
- 150000001768 cations Chemical class 0.000 claims 3
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 claims 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 1
- YZUPZGFPHUVJKC-UHFFFAOYSA-N 1-bromo-2-methoxyethane Chemical compound COCCBr YZUPZGFPHUVJKC-UHFFFAOYSA-N 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- -1 alkaline earth metal cation Chemical class 0.000 claims 1
- 150000003927 aminopyridines Chemical class 0.000 claims 1
- 239000012024 dehydrating agents Substances 0.000 claims 1
- FAMRKDQNMBBFBR-BQYQJAHWSA-N diethyl azodicarboxylate Substances CCOC(=O)\N=N\C(=O)OCC FAMRKDQNMBBFBR-BQYQJAHWSA-N 0.000 claims 1
- FAMRKDQNMBBFBR-UHFFFAOYSA-N ethyl n-ethoxycarbonyliminocarbamate Chemical compound CCOC(=O)N=NC(=O)OCC FAMRKDQNMBBFBR-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 125000005207 tetraalkylammonium group Chemical group 0.000 claims 1
- 125000005497 tetraalkylphosphonium group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03292892 | 2003-11-20 | ||
| PCT/EP2004/052806 WO2005054175A2 (en) | 2003-11-20 | 2004-11-04 | New process for the preparation of nitrooxyderivatives of paracetamol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007511581A JP2007511581A (ja) | 2007-05-10 |
| JP2007511581A5 true JP2007511581A5 (enExample) | 2007-12-13 |
Family
ID=34639350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006540430A Pending JP2007511581A (ja) | 2003-11-20 | 2004-11-04 | パラセタモールのニトロオキシ誘導体類の新しい製造方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7442826B2 (enExample) |
| EP (1) | EP1727787B1 (enExample) |
| JP (1) | JP2007511581A (enExample) |
| AT (1) | ATE399757T1 (enExample) |
| CA (1) | CA2546807A1 (enExample) |
| DE (1) | DE602004014822D1 (enExample) |
| ES (1) | ES2309579T3 (enExample) |
| WO (1) | WO2005054175A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7723529B2 (en) * | 2004-07-20 | 2010-05-25 | Nicox S.A. | Process for preparing nitrooxy esters, nitrooxy thioesters nitrooxy carbonates and nitrooxy thiocarbinates, intermediates useful in said process and preparation thereof |
| EP2188245B1 (en) | 2007-08-17 | 2013-11-06 | Council of Scientific & Industrial Research | Nitric oxide releasing derivatives of paracetamol |
| US8062653B2 (en) * | 2009-02-18 | 2011-11-22 | Bezwada Biomedical, Llc | Controlled release of nitric oxide and drugs from functionalized macromers and oligomers |
| WO2010108843A1 (en) * | 2009-03-27 | 2010-09-30 | Nicox S.A. | Use of nitrooxyderivative of paracetamol for the treatment of muscular dystrophies |
| NZ600516A (en) | 2009-12-11 | 2014-01-31 | Dsm Ip Assets Bv | Nitrooxy alkanoic acids and derivatives thereof in feed for reducing methane emission in ruminants, and/or to improve ruminant performance |
| CA2835743C (en) | 2011-05-26 | 2019-07-09 | Dsm Ip Assets B.V. | Use of a feed composition for reducing methane emission in ruminants, and/or to improve ruminant performance |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3443998A1 (de) | 1984-12-01 | 1986-06-05 | Boehringer Mannheim Gmbh, 6800 Mannheim | Amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
| IT1307928B1 (it) * | 1999-01-26 | 2001-11-29 | Nicox Sa | Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina. |
| IT1314184B1 (it) | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
| IT1319202B1 (it) * | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per le malattie a base infiammatoria. |
| JP2005524676A (ja) * | 2002-03-20 | 2005-08-18 | ザ・ユニバーシティ・オブ・クイーンズランド | 一酸化窒素供与体及びオピオイド鎮痛薬を含む方法及び組成物 |
| ITMI20020597A1 (it) * | 2002-03-22 | 2003-09-22 | Nicox Sa | Derivati del probucolo |
-
2004
- 2004-11-04 DE DE602004014822T patent/DE602004014822D1/de not_active Expired - Lifetime
- 2004-11-04 WO PCT/EP2004/052806 patent/WO2005054175A2/en not_active Ceased
- 2004-11-04 JP JP2006540430A patent/JP2007511581A/ja active Pending
- 2004-11-04 ES ES04798162T patent/ES2309579T3/es not_active Expired - Lifetime
- 2004-11-04 CA CA002546807A patent/CA2546807A1/en not_active Abandoned
- 2004-11-04 US US10/579,904 patent/US7442826B2/en not_active Expired - Fee Related
- 2004-11-04 EP EP04798162A patent/EP1727787B1/en not_active Expired - Lifetime
- 2004-11-04 AT AT04798162T patent/ATE399757T1/de not_active IP Right Cessation
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