JP2007510718A5 - - Google Patents
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- Publication number
- JP2007510718A5 JP2007510718A5 JP2006539449A JP2006539449A JP2007510718A5 JP 2007510718 A5 JP2007510718 A5 JP 2007510718A5 JP 2006539449 A JP2006539449 A JP 2006539449A JP 2006539449 A JP2006539449 A JP 2006539449A JP 2007510718 A5 JP2007510718 A5 JP 2007510718A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- substituted
- nitrogen
- cancer
- leukemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KGHCTQBSAXEKSO-SGIWWJKMSA-N C[C@H]1C=C([C@@H]([C@H](/C=C\C=C(/C)\C(NC(C(C(C[C@@H](C)C2)=C3NCCN4CCC4)=O)=CC3=O)=O)OC)OC(N)=O)[O](C)[C@H]1[C@H]2OC Chemical compound C[C@H]1C=C([C@@H]([C@H](/C=C\C=C(/C)\C(NC(C(C(C[C@@H](C)C2)=C3NCCN4CCC4)=O)=CC3=O)=O)OC)OC(N)=O)[O](C)[C@H]1[C@H]2OC KGHCTQBSAXEKSO-SGIWWJKMSA-N 0.000 description 2
- HVOYZOQVDYHUPF-UHFFFAOYSA-N CNCCN(C)C Chemical compound CNCCN(C)C HVOYZOQVDYHUPF-UHFFFAOYSA-N 0.000 description 1
- NBCUUUHWGYGHNW-UHFFFAOYSA-N CNCCN1CC1 Chemical compound CNCCN1CC1 NBCUUUHWGYGHNW-UHFFFAOYSA-N 0.000 description 1
- GHRFMGAHWCWXEG-UHFFFAOYSA-N CNCCN1CCC1 Chemical compound CNCCN1CCC1 GHRFMGAHWCWXEG-UHFFFAOYSA-N 0.000 description 1
- PHSPJQZRQAJPPF-UHFFFAOYSA-N CNCCc1c[nH]cn1 Chemical compound CNCCc1c[nH]cn1 PHSPJQZRQAJPPF-UHFFFAOYSA-N 0.000 description 1
- OPTVWVTZZUXRTH-NQXVYZFTSA-N C[C@H]1C=C([C@@H]([C@H](/C=C\C=C(/C)\C(NC(C(C(C[C@@H](C)C2)=C3NCCN(C)C)=O)=CC3=O)=O)OC)OC(N)=O)[O](C)[C@H]1[C@H]2OC Chemical compound C[C@H]1C=C([C@@H]([C@H](/C=C\C=C(/C)\C(NC(C(C(C[C@@H](C)C2)=C3NCCN(C)C)=O)=CC3=O)=O)OC)OC(N)=O)[O](C)[C@H]1[C@H]2OC OPTVWVTZZUXRTH-NQXVYZFTSA-N 0.000 description 1
- AHGRLBFPDJETNY-HWQVIYOQSA-N C[C@H]1C=C([C@@H]([C@H](/C=C\C=C(/C)\C(NC(C(C(C[C@@H](C)C2)=C3NCCN4CCCC4)=O)=CC3=O)=O)OC)OC(N)=O)[O](C)[C@H]1[C@H]2OC Chemical compound C[C@H]1C=C([C@@H]([C@H](/C=C\C=C(/C)\C(NC(C(C(C[C@@H](C)C2)=C3NCCN4CCCC4)=O)=CC3=O)=O)OC)OC(N)=O)[O](C)[C@H]1[C@H]2OC AHGRLBFPDJETNY-HWQVIYOQSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51947903P | 2003-11-12 | 2003-11-12 | |
| US60/519,479 | 2003-11-12 | ||
| PCT/US2004/011638 WO2005056531A1 (en) | 2003-11-12 | 2004-04-16 | 11-o-methylgeldanamycin compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007510718A JP2007510718A (ja) | 2007-04-26 |
| JP2007510718A5 true JP2007510718A5 (https=) | 2007-06-14 |
| JP4717003B2 JP4717003B2 (ja) | 2011-07-06 |
Family
ID=34676572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006539449A Expired - Fee Related JP4717003B2 (ja) | 2003-11-12 | 2004-04-16 | １１−ｏ−メチルゲルダナマイシン化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6870049B1 (https=) |
| EP (1) | EP1682514A4 (https=) |
| JP (1) | JP4717003B2 (https=) |
| CA (1) | CA2545457A1 (https=) |
| WO (1) | WO2005056531A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7259156B2 (en) | 2004-05-20 | 2007-08-21 | Kosan Biosciences Incorporated | Geldanamycin compounds and method of use |
| WO2007059116A2 (en) * | 2005-11-14 | 2007-05-24 | Abraxis Bioscience, Inc. | Geldanamycin derivatives and pharmaceutical compositions thereof |
| US20070207992A1 (en) * | 2006-02-21 | 2007-09-06 | Board Of Trustees Of Michigan State University | Geldanamycin derivatives and method of use thereof |
| DE102006044472A1 (de) * | 2006-09-21 | 2008-04-03 | Discovery Partner International Gmbh | Geldanamycin-Derivate |
| JP2011501731A (ja) * | 2007-09-10 | 2011-01-13 | ユニバーシティ オブ マサチューセッツ | ミトコンドリア標的化抗腫瘍剤 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3987035A (en) | 1974-04-05 | 1976-10-19 | University Of Illinois Foundation | Biologically active compounds |
| US4261989A (en) | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
| JPS5874651A (ja) | 1981-09-17 | 1983-05-06 | Takeda Chem Ind Ltd | マクベシン誘導体およびその製造法 |
| US4421687A (en) | 1981-09-26 | 1983-12-20 | Takeda Chemical Industries, Limited | Macbecin derivatives |
| JPS59102398A (ja) | 1982-12-03 | 1984-06-13 | Takeda Chem Ind Ltd | 新規抗生物質およびその製造法 |
| JPS63218620A (ja) | 1987-03-09 | 1988-09-12 | Kyowa Hakko Kogyo Co Ltd | 癌化細胞の正常化剤 |
| JPH0446120A (ja) | 1990-06-11 | 1992-02-17 | Kyowa Hakko Kogyo Co Ltd | 血管新生抑制剤 |
| CA2127457A1 (en) | 1992-01-06 | 1993-07-22 | Walter P. Cullen | Process and uses for 4,5-dihydrogeldanamycin and its hydroquinone |
| EP0664702A1 (en) | 1992-10-14 | 1995-08-02 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Tumoricidal activity of benzoquinonoid ansamycins against prostate cancer and primitive neural malignancies |
| US5387584A (en) | 1993-04-07 | 1995-02-07 | Pfizer Inc. | Bicyclic ansamycins |
| JP2794342B2 (ja) | 1993-06-29 | 1998-09-03 | ファイザー・インク． | 抗癌遺伝子剤および抗癌剤としてのアンサマイシン誘導体 |
| US5932566A (en) | 1994-06-16 | 1999-08-03 | Pfizer Inc. | Ansamycin derivatives as antioncogene and anticancer agents |
| US5662883A (en) | 1995-01-10 | 1997-09-02 | Nanosystems L.L.C. | Microprecipitation of micro-nanoparticulate pharmaceutical agents |
| US5534270A (en) | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
| US5510118A (en) | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
| WO1996034525A1 (en) | 1995-05-02 | 1996-11-07 | The Regents Of The University Of California | Inducement of thermotolerance with benzoquinonoid ansamycins |
| WO2000003737A2 (en) | 1998-07-17 | 2000-01-27 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Water-soluble drugs and methods for their production |
| US6682758B1 (en) | 1998-12-22 | 2004-01-27 | The United States Of America As Represented By The Department Of Health And Human Services | Water-insoluble drug delivery system |
| AU2002217866A1 (en) | 2000-11-06 | 2002-05-15 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Geldanamycin derivatives useful for the treatment of cancer |
| DK1373215T3 (da) * | 2001-03-30 | 2006-11-13 | Us Health | Gelanamycinderivater egnet til behandling af cancer |
| US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| AU2002330998A1 (en) | 2001-08-06 | 2003-02-24 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| WO2003066005A2 (en) * | 2002-02-08 | 2003-08-14 | Conforma Therapeutics Corporation | Ansamycins having improved pharmacological and biological properties |
| RU2005133199A (ru) * | 2003-03-28 | 2006-02-10 | Козан Байосайенсиз, Инк. (Us) | Устройства, способы и композиции для предупреждения рестеноза |
-
2004
- 2004-04-16 US US10/826,446 patent/US6870049B1/en not_active Expired - Lifetime
- 2004-04-16 CA CA002545457A patent/CA2545457A1/en not_active Abandoned
- 2004-04-16 EP EP04750158A patent/EP1682514A4/en not_active Withdrawn
- 2004-04-16 JP JP2006539449A patent/JP4717003B2/ja not_active Expired - Fee Related
- 2004-04-16 WO PCT/US2004/011638 patent/WO2005056531A1/en not_active Ceased
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