JP2007510670A5 - - Google Patents
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- JP2007510670A5 JP2007510670A5 JP2006538530A JP2006538530A JP2007510670A5 JP 2007510670 A5 JP2007510670 A5 JP 2007510670A5 JP 2006538530 A JP2006538530 A JP 2006538530A JP 2006538530 A JP2006538530 A JP 2006538530A JP 2007510670 A5 JP2007510670 A5 JP 2007510670A5
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- Prior art keywords
- cancer
- disease
- thalidomide
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- Prior art date
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 25
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 20
- 229960003433 thalidomide Drugs 0.000 claims 20
- 201000010099 disease Diseases 0.000 claims 19
- 206010028980 Neoplasm Diseases 0.000 claims 15
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- 239000004480 active ingredient Substances 0.000 claims 12
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- 239000008194 pharmaceutical composition Substances 0.000 claims 9
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- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Claims (32)
- サリドマイド、又はその医薬として許容し得る塩、溶媒和物、もしくは立体異性体を含む、特定の癌の治療用、又は予防用の医薬組成物であって、前記癌が、脊髄腫瘍、褐色細胞腫、進行悪性疾患、アミロイド症、神経芽細胞腫、髄膜腫、血管外皮細胞腫、多発性脳転移、多形性膠芽細胞腫、膠芽細胞腫、脳幹神経膠腫、予後不良の悪性脳腫瘍、悪性神経膠腫、未分化星細胞腫、未分化乏突起神経膠腫、神経内分泌腫瘍、直腸腺癌、デュークスC&D結腸直腸癌、切除不能な結腸直腸癌、転移性肝細胞癌、カポジ肉腫、カロタイプ急性骨髄芽球性白血病、ホジキンリンパ腫、非ホジキンリンパ腫、皮膚T細胞リンパ腫、皮膚B細胞リンパ腫、びまん性大細胞型B細胞リンパ腫、低悪性度濾胞性リンパ腫、局在性もしくは転移性黒色腫、腹膜癌、漿液性乳頭癌、婦人科肉腫、軟組織肉腫、セルロデルマ、皮膚血管炎、ランゲルハンス細胞組織球症、平滑筋肉腫、進行性骨化性線維形成異常症、ホルモン抵抗性前立腺癌、切除したハイリスク軟組織肉腫、切除不能な肝細胞癌、ワルデンストレームマクログロブリン血症、くすぶり型骨髄腫、無痛無症候性骨髄腫、輸卵管癌、アンドロゲン非依存性前立腺癌、アンドロゲン依存性IV期非転移性前立腺癌、ホルモン非感受性前立腺癌、化学療法非感受性前立腺癌、乳頭甲状腺癌、濾胞性甲状腺癌、甲状腺髄様癌、又は平滑筋腫である、前記医薬組成物。
- サリドマイド、又はその医薬として許容し得る塩、溶媒和物、もしくは立体異性体と、第2の活性成分を含む、特定の癌の治療用、又は予防用の医薬組成物であって、前記癌が、脊髄腫瘍、褐色細胞腫、進行悪性疾患、アミロイド症、局在進行性膀胱癌、転移性移行細胞膀胱癌、再発性脳腫瘍、進行性脳腫瘍、神経芽細胞腫、髄膜腫、血管外皮細胞腫、多発性脳転移、多形性膠芽細胞腫、膠芽細胞腫、脳幹神経膠腫、予後不良の悪性脳腫瘍、悪性神経膠腫、未分化星細胞腫、未分化乏突起神経膠腫、転移性乳癌、神経内分泌腫瘍、直腸腺癌、デュークスC&D結腸直腸癌、切除不能な結腸直腸癌、転移性肝細胞癌、カポジ肉腫、カロタイプ急性骨髄芽球性白血病、ホジキンリンパ腫、非ホジキンリンパ腫、皮膚T細胞リンパ腫、皮膚B細胞リンパ腫、びまん性大細胞型B細胞リンパ腫、低悪性度濾胞性リンパ腫、局在性もしくは転移性黒色腫、IIIB期非小細胞肺癌、多発性骨髄腫、腹膜癌、漿液性乳頭癌、婦人科肉腫、軟組織肉腫、セルロデルマ、皮膚血管炎、ランゲルハンス細胞組織球症、平滑筋肉腫、進行性骨化性線維形成異常症、ホルモン抵抗性前立腺癌、切除したハイリスク軟組織肉腫、切除不能な肝細胞癌、ワルデンストレームマクログロブリン血症、くすぶり型骨髄腫、無痛無症候性骨髄腫、輸卵管癌、アンドロゲン非依存性前立腺癌、アンドロゲン依存性IV期非転移性前立腺癌、ホルモン非感受性前立腺癌、化学療法非感受性前立腺癌、乳頭甲状腺癌、濾胞性甲状腺癌、甲状腺髄様癌、又は平滑筋腫である、前記医薬組成物。
- サリドマイド、又はその医薬として許容し得る塩、溶媒和物、もしくは立体異性体を含む、望ましくない血管形成を伴う疾患の治療用、又は予防用の医薬組成物であって、前記疾患、又は障害が、糖尿病性網膜症、未熟児網膜症、角膜移植拒絶、血管新生緑内障、水晶体後線維増殖症、増殖性硝子体網膜症、トラコーマ、近視、視窩、流行性角結膜炎、アトピー性角膜炎、上輪部角膜炎、翼状片乾燥性角膜炎、シェーグレン、酒さ性ざ瘡、フィレクテヌローシス、梅毒、脂質変性症、細菌性潰瘍、真菌性潰瘍、単純ヘルペス感染症、帯状疱疹感染症、原虫感染症、カポジ肉腫、モーレン潰瘍、テリエン周辺変性症、マリジナル角質溶解、関節リウマチ、全身性ループス、多発性動脈炎、トラウマ、ウェゲナーサルコイドーシス、強膜炎、スティーブンスジョンソン病、ペリフィゴイド放射状角膜切開、鎌状赤血球貧血、サルコイド、弾性線維性偽黄色腫、パジェット病、静脈閉塞、動脈閉塞、頸動脈閉塞性疾患、慢性ブドウ膜炎、慢性ビトライチス、ライム病、イールズ病、ベーチェット病、網膜炎、脈絡膜炎、推定眼ヒストプラスマ症、ベスト病、スタルガート病、扁平部炎、慢性網膜剥離、過粘稠度症候群、トキソプラズマ症、硬化性胆管炎、ルベオーシス、内毒血症、毒素ショック症候群、骨関節炎、レトロウイルス複製、るいそう、髄膜炎、シリカ誘発性線維症、アスベスト誘発性線維症、獣医学的障害、癌関連高カルシウム血症、脳卒中、循環性ショック、歯周病、歯肉炎、大球性貧血、不応性貧血、又は5q−症候群である、前記医薬組成物。
- サリドマイド、又はその医薬として許容し得る塩、溶媒和物、もしくは立体異性体と、治療上、又は予防上有効な量の第2の活性成分とを含む、望ましくない血管形成を伴う疾患の治療用、又は予防用の医薬組成物であって、前記第2の活性成分が、造血成長因子、サイトカイン、抗癌剤、抗生物質、cox−2阻害剤、免疫調節剤、免疫抑制剤、副腎皮質ステロイド、又はその薬理学的に活性のある突然変異体もしくは誘導体、あるいはその組合せである、前記医薬組成物。
- 前記第2の活性成分が、オブリマーセン、メルファラン、G−CSF、GM−CSF、EPO、トポテカン、ペントキシフィリン、タキソテア、イリノテカン、COX−2阻害剤、シプロフロキサシン、デキサメタゾン、ドキソルビシン、ビンクリスチン、IL2、IFN、ダカルバジン、Ara−C、ビノレルビン、イソトレチノイン、又はその医薬として許容し得る塩、溶媒和物、もしくは立体異性体、又はその薬理学的に活性のある突然変異体もしくは誘導体、あるいはその組合せである、請求項4記載の医薬組成物。
- 対象における特定の癌の治療用又は予防用の薬剤若しくはキットを製造するためのサリドマイド、又はその医薬として許容し得る塩、溶媒和物、もしくは立体異性体の使用であって、前記癌が、脊髄腫瘍、褐色細胞腫、進行悪性疾患、アミロイド症、神経芽細胞腫、髄膜腫、血管外皮細胞腫、多発性脳転移、多形性膠芽細胞腫、膠芽細胞腫、脳幹神経膠腫、予後不良の悪性脳腫瘍、悪性神経膠腫、未分化星細胞腫、未分化乏突起神経膠腫、神経内分泌腫瘍、直腸腺癌、デュークスC&D結腸直腸癌、切除不能な結腸直腸癌、転移性肝細胞癌、カポジ肉腫、カロタイプ急性骨髄芽球性白血病、ホジキンリンパ腫、非ホジキンリンパ腫、皮膚T細胞リンパ腫、皮膚B細胞リンパ腫、びまん性大細胞型B細胞リンパ腫、低悪性度濾胞性リンパ腫、局在性もしくは転移性黒色腫、腹膜癌、漿液性乳頭癌、婦人科肉腫、軟組織肉腫、セルロデルマ、皮膚血管炎、ランゲルハンス細胞組織球症、平滑筋肉腫、進行性骨化性線維形成異常症、ホルモン抵抗性前立腺癌、切除したハイリスク軟組織肉腫、切除不能な肝細胞癌、ワルデンストレームマクログロブリン血症、くすぶり型骨髄腫、無痛無症候性骨髄腫、輸卵管癌、アンドロゲン非依存性前立腺癌、アンドロゲン依存性IV期非転移性前立腺癌、ホルモン非感受性前立腺癌、化学療法非感受性前立腺癌、乳頭甲状腺癌、濾胞性甲状腺癌、甲状腺髄様癌、又は平滑筋腫である、前記使用。
- 前記薬剤又はキットが、第2の活性成分をさらに含む、請求項6記載の使用。
- 前記薬剤又はキットが、放射線療法、ホルモン療法、生物療法、又は免疫療法に使用される、請求項6記載の使用。
- 新たに診断された多発性骨髄腫の治療用又は予防用の薬剤若しくはキットの製造における、サリドマイド、又はその医薬として許容し得る塩、溶媒和物、もしくは立体異性体及びデキサメタゾンの使用。
- 対象における望ましくない血管形成を伴う疾患又は障害の治療用又は予防用の薬剤若しくはキットの製造における、サリドマイド、又はその医薬として許容し得る塩、溶媒和物、もしくは立体異性体の使用であって、前記サリドマイドは30〜2000mgの量であり、前記疾患又は障害が、糖尿病性網膜症、未熟児網膜症、角膜移植拒絶、血管新生緑内障、水晶体後線維増殖症、増殖性硝子体網膜症、トラコーマ、近視、視窩、流行性角結膜炎、アトピー性角膜炎、上輪部角膜炎、翼状片乾燥性角膜炎、シェーグレン、酒さ性ざ瘡、フィレクテヌローシス、梅毒、脂質変性症、細菌性潰瘍、真菌性潰瘍、単純ヘルペス感染症、帯状疱疹感染症、原虫感染症、カポジ肉腫、モーレン潰瘍、テリエン周辺変性症、マリジナル角質溶解、関節リウマチ、全身性ループス、多発性動脈炎、トラウマ、ウェゲナーサルコイドーシス、強膜炎、スティーブンスジョンソン病、ペリフィゴイド放射状角膜切開、鎌状赤血球貧血、サルコイド、弾性線維性偽黄色腫、パジェット病、静脈閉塞、動脈閉塞、頸動脈閉塞性疾患、慢性ブドウ膜炎、慢性ビトライチス、ライム病、イールズ病、ベーチェット病、網膜炎、脈絡膜炎、推定眼ヒストプラスマ症、ベスト病、スタルガート病、扁平部炎、慢性網膜剥離、過粘稠度症候群、トキソプラズマ症、硬化性胆管炎、ルベオーシス、特発性肺線維症、内毒血症、毒素ショック症候群、骨関節炎、レトロウイルス複製、るいそう、髄膜炎、シリカ誘発性線維症、アスベスト誘発性線維症、獣医学的障害、癌関連高カルシウム血症、脳卒中、循環性ショック、歯周病、歯肉炎、大球性貧血、不応性貧血、又は5q−症候群である、前記使用。
- 前記薬剤又はキットが、第2の活性成分をさらに含む、請求項10記載の使用。
- 前記第2の活性成分が、造血成長因子、サイトカイン、抗癌剤、抗生物質、COX−2阻害剤、免疫調節剤、免疫抑制剤、副腎皮質ステロイド、又はその薬理学的に活性のある突然変異体もしくは誘導体、あるいはその組み合わせである、請求項7、又は11記載の使用。
- 前記第2の活性成分が、オブリマーセン、メルファラン、GM−CSF、EPO、トポテカン、ペントキシフィリン、タキソテア、イリノテカン、COX−2阻害剤、シプロフロキサシン、デキサメタゾン、ドキソルビシン、ビンクリスチン、IL2、IFN、ダカルバジン、Ara−C、ビノレルビン、イソトレチノイン、又はその医薬として許容し得る塩、溶媒和物、もしくは立体異性体、又はその薬理学的に活性のある突然変異体もしくは誘導体、あるいはその組合せである、請求項12記載の使用。
- 前記サリドマイドが、50〜2000mgの量である、請求項6、9又は10いずれか一項記載の使用。
- 前記サリドマイドが、50〜1000mgの量である、請求項14記載の使用。
- 前記サリドマイドが、50〜800mgの量である、請求項15記載の使用。
- 前記サリドマイドが、200〜800mgの量である、請求項16記載の使用。
- 前記サリドマイドが、50mg、100mg、200mg、300mg又は400mgの量である、請求項16記載の使用。
- 前記薬剤が、前記対象への経口投与、粘膜投与、非経口投与、局所投与、経真皮投与、又は経皮膚投与に適した剤形である、請求項6、9又は10いずれか一項記載の使用。
- 前記剤形が、錠剤、カプレット、カプセル、カシェ剤、トローチ、ロゼンジ、分散液、坐薬、散剤、エアロゾル、ゲル、液体、点眼薬、及び無菌的固体を含む、請求項19記載の使用。
- 前記第2の活性成分が、1〜1000mgの量である、請求項7又は11いずれか一項記載の使用。
- 前記第2の活性成分が、5〜500mgの量である、請求項21記載の使用。
- 前記第2の活性成分が、10〜350mgの量である、請求項22記載の使用。
- 前記第2の活性成分が、50〜200mgの量である、請求項23記載の使用。
- 前記疾患又は障害が、特発性肺線維症である、請求項10又は11記載の使用。
- 前記サリドマイドが、50〜2000mgの量である、請求項25記載の使用。
- 前記サリドマイドが、50〜1000mgの量である、請求項26記載の使用。
- 前記サリドマイドが、50〜800mgの量である、請求項27記載の使用。
- 前記サリドマイドが、200〜800mgの量である、請求項28記載の使用。
- 前記サリドマイドが、50mg、100mg、200mg、300mg又は400mgの量である、請求項29記載の使用。
- 多発性骨髄腫の治療用又は予防用の薬剤若しくはキットの製造における、サリドマイド、又はその医薬として許容し得る塩、溶媒和物、もしくは立体異性体及びデキサメタゾンの使用であって、前記サリドマイドが30mg、200〜2000mgの量である、前記使用。
- 前記薬剤又はキットが、幹細胞若しくは骨髄をさらに含む、請求項10又は31記載の使用。
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US20090137631A1 (en) * | 2007-11-22 | 2009-05-28 | National Yang-Ming University | Methods and pharmaceutical compositions for regulation of g- and/or gc-rich nucleic acid expression |
US8445529B2 (en) * | 2008-07-14 | 2013-05-21 | Santen Pharmaceutical Co., Ltd. | Indole derivative having, carbamoyl group, ureido group and substituted oxy group |
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2004
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- 2004-11-04 AU AU2004288714A patent/AU2004288714A1/en not_active Abandoned
- 2004-11-04 BR BRPI0416275-7A patent/BRPI0416275A/pt not_active IP Right Cessation
- 2004-11-04 EP EP09004755A patent/EP2077112A1/en not_active Withdrawn
- 2004-11-04 AP AP2006003637A patent/AP2006003637A0/xx unknown
- 2004-11-04 WO PCT/US2004/037083 patent/WO2005046593A2/en active Application Filing
- 2004-11-04 JP JP2006538530A patent/JP2007510670A/ja not_active Withdrawn
- 2004-11-04 OA OA1200600149A patent/OA13284A/en unknown
- 2004-11-04 KR KR1020067011015A patent/KR20060124607A/ko not_active Application Discontinuation
- 2004-11-04 CA CA002545128A patent/CA2545128C/en not_active Expired - Fee Related
- 2004-11-04 US US10/576,138 patent/US20070208057A1/en not_active Abandoned
- 2004-11-04 CN CNA2004800400013A patent/CN1901911A/zh active Pending
- 2004-11-04 ZA ZA200603718A patent/ZA200603718B/en unknown
- 2004-11-04 EA EA200600921A patent/EA200600921A1/ru unknown
-
2006
- 2006-05-04 IL IL175427A patent/IL175427A0/en unknown
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