JP2007508393A5 - - Google Patents
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- Publication number
- JP2007508393A5 JP2007508393A5 JP2006535599A JP2006535599A JP2007508393A5 JP 2007508393 A5 JP2007508393 A5 JP 2007508393A5 JP 2006535599 A JP2006535599 A JP 2006535599A JP 2006535599 A JP2006535599 A JP 2006535599A JP 2007508393 A5 JP2007508393 A5 JP 2007508393A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclohexanol
- ylethyl
- piperazin
- naphthyl
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 22
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- -1 methylenedioxy, benzyloxy Chemical group 0.000 claims 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 6
- 125000004423 acyloxy group Chemical group 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 150000001721 carbon Chemical group 0.000 claims 3
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000001041 indolyl group Chemical group 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- RSILIVTXIUSPEG-UHFFFAOYSA-N 1-(2-piperazin-1-yl-1-pyridin-3-ylethyl)cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1C=NC=CC=1)C1(O)CCCCC1 RSILIVTXIUSPEG-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000001589 carboacyl group Chemical group 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 2
- 125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 claims 2
- 125000001977 isobenzofuranyl group Chemical group C=1(OC=C2C=CC=CC12)* 0.000 claims 2
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000005186 naphthyloxy group Chemical group C1(=CC=CC2=CC=CC=C12)O* 0.000 claims 2
- 150000002825 nitriles Chemical class 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 229940124530 sulfonamide Drugs 0.000 claims 2
- 150000003456 sulfonamides Chemical class 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 150000003462 sulfoxides Chemical class 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- JPVRAQXTYGKFHO-UHFFFAOYSA-N 1-(1-naphthalen-1-yl-2-piperazin-1-ylethyl)cyclobutan-1-ol Chemical compound C1CNCCN1CC(C=1C2=CC=CC=C2C=CC=1)C1(O)CCC1 JPVRAQXTYGKFHO-UHFFFAOYSA-N 0.000 claims 1
- HKAACCZKGRMTRU-UHFFFAOYSA-N 1-(1-naphthalen-1-yl-2-piperazin-1-ylethyl)cycloheptan-1-ol Chemical compound C1CNCCN1CC(C=1C2=CC=CC=C2C=CC=1)C1(O)CCCCCC1 HKAACCZKGRMTRU-UHFFFAOYSA-N 0.000 claims 1
- RUYSZTQZJFNBIF-UHFFFAOYSA-N 1-(1-naphthalen-1-yl-2-piperazin-1-ylethyl)cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1C2=CC=CC=C2C=CC=1)C1(O)CCCCC1 RUYSZTQZJFNBIF-UHFFFAOYSA-N 0.000 claims 1
- SBUROEVBOPDOGG-UHFFFAOYSA-N 1-(1-naphthalen-1-yl-2-piperazin-1-ylethyl)cyclooctan-1-ol Chemical compound C1CNCCN1CC(C=1C2=CC=CC=C2C=CC=1)C1(O)CCCCCCC1 SBUROEVBOPDOGG-UHFFFAOYSA-N 0.000 claims 1
- TWUKOCVCTOFCJM-UHFFFAOYSA-N 1-(1-naphthalen-1-yl-2-piperazin-1-ylethyl)cyclopentan-1-ol Chemical compound C1CNCCN1CC(C=1C2=CC=CC=C2C=CC=1)C1(O)CCCC1 TWUKOCVCTOFCJM-UHFFFAOYSA-N 0.000 claims 1
- GTHMYYQEPTVKHM-UHFFFAOYSA-N 1-(1-naphthalen-2-yl-2-piperazin-1-ylethyl)cyclobutan-1-ol Chemical compound C1CNCCN1CC(C=1C=C2C=CC=CC2=CC=1)C1(O)CCC1 GTHMYYQEPTVKHM-UHFFFAOYSA-N 0.000 claims 1
- HTTUNNQBNOUDMP-UHFFFAOYSA-N 1-(1-naphthalen-2-yl-2-piperazin-1-ylethyl)cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1C=C2C=CC=CC2=CC=1)C1(O)CCCCC1 HTTUNNQBNOUDMP-UHFFFAOYSA-N 0.000 claims 1
- MGCWVDDXPPKNQT-UHFFFAOYSA-N 1-(2-piperazin-1-yl-1-quinolin-3-ylethyl)cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1C=C2C=CC=CC2=NC=1)C1(O)CCCCC1 MGCWVDDXPPKNQT-UHFFFAOYSA-N 0.000 claims 1
- KHYNNQYNYMSTIB-HNNXBMFYSA-N 1-[(1r)-1-(5-chlorothiophen-3-yl)-2-(4-methylpiperazin-1-yl)ethyl]cyclohexan-1-ol Chemical compound C1CN(C)CCN1C[C@H](C1(O)CCCCC1)C1=CSC(Cl)=C1 KHYNNQYNYMSTIB-HNNXBMFYSA-N 0.000 claims 1
- KHYNNQYNYMSTIB-OAHLLOKOSA-N 1-[(1s)-1-(5-chlorothiophen-3-yl)-2-(4-methylpiperazin-1-yl)ethyl]cyclohexan-1-ol Chemical compound C1CN(C)CCN1C[C@@H](C1(O)CCCCC1)C1=CSC(Cl)=C1 KHYNNQYNYMSTIB-OAHLLOKOSA-N 0.000 claims 1
- IFCHBQFBWRMERT-UHFFFAOYSA-N 1-[1-(1-benzothiophen-2-yl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1SC2=CC=CC=C2C=1)C1(O)CCCCC1 IFCHBQFBWRMERT-UHFFFAOYSA-N 0.000 claims 1
- DRAQRLXEPIYYIE-UHFFFAOYSA-N 1-[1-(1-benzothiophen-3-yl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1C2=CC=CC=C2SC=1)C1(O)CCCCC1 DRAQRLXEPIYYIE-UHFFFAOYSA-N 0.000 claims 1
- UIOCALWWKYWNPJ-UHFFFAOYSA-N 1-[1-(1-methylindol-3-yl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C12=CC=CC=C2N(C)C=C1C(C1(O)CCCCC1)CN1CCNCC1 UIOCALWWKYWNPJ-UHFFFAOYSA-N 0.000 claims 1
- ATPVGUAENJWZBH-UHFFFAOYSA-N 1-[1-(1h-indol-3-yl)-2-piperazin-1-ylethyl]cyclohexan-1-ol;dihydrochloride Chemical compound Cl.Cl.C1CNCCN1CC(C=1C2=CC=CC=C2NC=1)C1(O)CCCCC1 ATPVGUAENJWZBH-UHFFFAOYSA-N 0.000 claims 1
- TVEJRNDJZBJGNP-UHFFFAOYSA-N 1-[1-(2-chlorothiophen-3-yl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C1=C(SC=C1)Cl)C1(O)CCCCC1 TVEJRNDJZBJGNP-UHFFFAOYSA-N 0.000 claims 1
- FOCUTFWDGVSLBZ-UHFFFAOYSA-N 1-[1-(4-bromothiophen-2-yl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1SC=C(Br)C=1)C1(O)CCCCC1 FOCUTFWDGVSLBZ-UHFFFAOYSA-N 0.000 claims 1
- LFLGWUQIVASPOV-UHFFFAOYSA-N 1-[1-(5-bromothiophen-2-yl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1SC(Br)=CC=1)C1(O)CCCCC1 LFLGWUQIVASPOV-UHFFFAOYSA-N 0.000 claims 1
- HHPPFFZXAIACRT-UHFFFAOYSA-N 1-[1-(5-chloro-1-benzothiophen-3-yl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1C2=CC(Cl)=CC=C2SC=1)C1(O)CCCCC1 HHPPFFZXAIACRT-UHFFFAOYSA-N 0.000 claims 1
- QVVYUPDVPHVIPQ-UHFFFAOYSA-N 1-[1-(5-chlorothiophen-2-yl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1SC(Cl)=CC=1)C1(O)CCCCC1 QVVYUPDVPHVIPQ-UHFFFAOYSA-N 0.000 claims 1
- KHYNNQYNYMSTIB-UHFFFAOYSA-N 1-[1-(5-chlorothiophen-3-yl)-2-(4-methylpiperazin-1-yl)ethyl]cyclohexan-1-ol Chemical compound C1CN(C)CCN1CC(C1(O)CCCCC1)C1=CSC(Cl)=C1 KHYNNQYNYMSTIB-UHFFFAOYSA-N 0.000 claims 1
- SRKHUCZOFIQCSE-UHFFFAOYSA-N 1-[1-(5-chlorothiophen-3-yl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1CNCCN1CC(C=1C=C(Cl)SC=1)C1(O)CCCCC1 SRKHUCZOFIQCSE-UHFFFAOYSA-N 0.000 claims 1
- XSPHHKRJUKVQPK-UHFFFAOYSA-N 1-[1-(5-methoxy-1-benzothiophen-3-yl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C12=CC(OC)=CC=C2SC=C1C(C1(O)CCCCC1)CN1CCNCC1 XSPHHKRJUKVQPK-UHFFFAOYSA-N 0.000 claims 1
- MOVFDALBQXQPCO-UHFFFAOYSA-N 1-[1-(6-methoxynaphthalen-2-yl)-2-(4-methylpiperazin-1-yl)ethyl]cyclohexan-1-ol Chemical compound C1=CC2=CC(OC)=CC=C2C=C1C(C1(O)CCCCC1)CN1CCN(C)CC1 MOVFDALBQXQPCO-UHFFFAOYSA-N 0.000 claims 1
- ZCTXXQHWWSHIAT-UHFFFAOYSA-N 1-[1-(6-methoxynaphthalen-2-yl)-2-piperazin-1-ylethyl]cyclohexan-1-ol Chemical compound C1=CC2=CC(OC)=CC=C2C=C1C(C1(O)CCCCC1)CN1CCNCC1 ZCTXXQHWWSHIAT-UHFFFAOYSA-N 0.000 claims 1
- VQLFVTXUDZOIJR-UHFFFAOYSA-N 1-[2-(4-aminopiperidin-1-yl)-1-(5-chlorothiophen-3-yl)ethyl]cyclohexan-1-ol Chemical compound C1CC(N)CCN1CC(C1(O)CCCCC1)C1=CSC(Cl)=C1 VQLFVTXUDZOIJR-UHFFFAOYSA-N 0.000 claims 1
- VCQQAKXMXUWGRX-UHFFFAOYSA-N 1-[2-(4-methylpiperazin-1-yl)-1-naphthalen-1-ylethyl]cyclobutan-1-ol Chemical compound C1CN(C)CCN1CC(C1(O)CCC1)C1=CC=CC2=CC=CC=C12 VCQQAKXMXUWGRX-UHFFFAOYSA-N 0.000 claims 1
- IIZCNPUTDHQHLU-UHFFFAOYSA-N 1-[2-(4-methylpiperazin-1-yl)-1-naphthalen-1-ylethyl]cycloheptan-1-ol Chemical compound C1CN(C)CCN1CC(C1(O)CCCCCC1)C1=CC=CC2=CC=CC=C12 IIZCNPUTDHQHLU-UHFFFAOYSA-N 0.000 claims 1
- TXPSUDIPBNUSFB-UHFFFAOYSA-N 1-[2-(4-methylpiperazin-1-yl)-1-naphthalen-1-ylethyl]cyclooctan-1-ol Chemical compound C1CN(C)CCN1CC(C1(O)CCCCCCC1)C1=CC=CC2=CC=CC=C12 TXPSUDIPBNUSFB-UHFFFAOYSA-N 0.000 claims 1
- RLFLWGGBHHIWAO-UHFFFAOYSA-N 1-[2-(4-methylpiperazin-1-yl)-1-naphthalen-1-ylethyl]cyclopentan-1-ol Chemical compound C1CN(C)CCN1CC(C1(O)CCCC1)C1=CC=CC2=CC=CC=C12 RLFLWGGBHHIWAO-UHFFFAOYSA-N 0.000 claims 1
- CBJUVETXAUPVLT-UHFFFAOYSA-N 1-[2-(4-methylpiperazin-1-yl)-1-naphthalen-2-ylethyl]cyclohexan-1-ol Chemical compound C1CN(C)CCN1CC(C1(O)CCCCC1)C1=CC=C(C=CC=C2)C2=C1 CBJUVETXAUPVLT-UHFFFAOYSA-N 0.000 claims 1
- JTIUTIFUOYQNPY-UHFFFAOYSA-N 1-methyl-4-(1-naphthalen-2-yl-2-piperazin-1-ylethyl)piperidin-4-ol Chemical compound C1CN(C)CCC1(O)C(C=1C=C2C=CC=CC2=CC=1)CN1CCNCC1 JTIUTIFUOYQNPY-UHFFFAOYSA-N 0.000 claims 1
- YEKKRPAWNGTFDW-UHFFFAOYSA-N 3-ethyl-1-(4-methylpiperazin-1-yl)-2-naphthalen-1-ylpentan-3-ol Chemical compound C=1C=CC2=CC=CC=C2C=1C(C(O)(CC)CC)CN1CCN(C)CC1 YEKKRPAWNGTFDW-UHFFFAOYSA-N 0.000 claims 1
- CIFVSZAKDRBSML-UHFFFAOYSA-N 3-ethyl-2-naphthalen-1-yl-1-piperazin-1-ylpentan-3-ol Chemical compound C=1C=CC2=CC=CC=C2C=1C(C(O)(CC)CC)CN1CCNCC1 CIFVSZAKDRBSML-UHFFFAOYSA-N 0.000 claims 1
- UIHCCWOFJVGABZ-UHFFFAOYSA-N 4-ethyl-1-(1-naphthalen-1-yl-2-piperazin-1-ylethyl)cyclohexan-1-ol Chemical compound C1CC(CC)CCC1(O)C(C=1C2=CC=CC=C2C=CC=1)CN1CCNCC1 UIHCCWOFJVGABZ-UHFFFAOYSA-N 0.000 claims 1
- ZXYZOEXRHXBRRJ-UHFFFAOYSA-N 4-ethyl-1-[2-(4-methylpiperazin-1-yl)-1-naphthalen-1-ylethyl]cyclohexan-1-ol Chemical compound C1CC(CC)CCC1(O)C(C=1C2=CC=CC=C2C=CC=1)CN1CCN(C)CC1 ZXYZOEXRHXBRRJ-UHFFFAOYSA-N 0.000 claims 1
- WTOQYAIYLYXZLA-UHFFFAOYSA-N 4-methyl-1-(1-naphthalen-1-yl-2-piperazin-1-ylethyl)cyclohexan-1-ol Chemical compound C1CC(C)CCC1(O)C(C=1C2=CC=CC=C2C=CC=1)CN1CCNCC1 WTOQYAIYLYXZLA-UHFFFAOYSA-N 0.000 claims 1
- DMPPVLSNDSVJMF-UHFFFAOYSA-N 4-methyl-1-[2-(4-methylpiperazin-1-yl)-1-naphthalen-1-ylethyl]cyclohexan-1-ol Chemical compound C1CC(C)CCC1(O)C(C=1C2=CC=CC=C2C=CC=1)CN1CCN(C)CC1 DMPPVLSNDSVJMF-UHFFFAOYSA-N 0.000 claims 1
- VHNDPYFDLPRWNW-UHFFFAOYSA-N 4-tert-butyl-1-(1-naphthalen-1-yl-2-piperazin-1-ylethyl)cyclohexan-1-ol Chemical compound C1CC(C(C)(C)C)CCC1(O)C(C=1C2=CC=CC=C2C=CC=1)CN1CCNCC1 VHNDPYFDLPRWNW-UHFFFAOYSA-N 0.000 claims 1
- IUMMUJFGGVLQAX-UHFFFAOYSA-N 4-tert-butyl-1-[2-(4-methylpiperazin-1-yl)-1-naphthalen-1-ylethyl]cyclohexan-1-ol Chemical compound C1CN(C)CCN1CC(C1(O)CCC(CC1)C(C)(C)C)C1=CC=CC2=CC=CC=C12 IUMMUJFGGVLQAX-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 230000002152 alkylating effect Effects 0.000 claims 1
- 230000001668 ameliorated effect Effects 0.000 claims 1
- 150000007514 bases Chemical class 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 230000000407 monoamine reuptake Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51081103P | 2003-10-14 | 2003-10-14 | |
| US56144704P | 2004-04-12 | 2004-04-12 | |
| US57005604P | 2004-05-11 | 2004-05-11 | |
| US10/963,064 US7419980B2 (en) | 2003-10-14 | 2004-10-12 | Fused-aryl and heteroaryl derivatives and methods of their use |
| PCT/US2004/033671 WO2005037283A1 (en) | 2003-10-14 | 2004-10-13 | Fused-aryl and heteroaryl derivatives and methods of their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007508393A JP2007508393A (ja) | 2007-04-05 |
| JP2007508393A5 true JP2007508393A5 (enExample) | 2007-12-13 |
Family
ID=34468484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006535599A Pending JP2007508393A (ja) | 2003-10-14 | 2004-10-13 | 縮合アリールおよびヘテロアリール誘導体およびその使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7419980B2 (enExample) |
| EP (1) | EP1673090A1 (enExample) |
| JP (1) | JP2007508393A (enExample) |
| AR (1) | AR046179A1 (enExample) |
| AU (1) | AU2004281734A1 (enExample) |
| BR (1) | BRPI0415276A (enExample) |
| CA (1) | CA2549733A1 (enExample) |
| MX (1) | MXPA06003879A (enExample) |
| PA (1) | PA8615201A1 (enExample) |
| TW (1) | TW200526603A (enExample) |
| WO (1) | WO2005037283A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7517899B2 (en) * | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
| US7414052B2 (en) * | 2004-03-30 | 2008-08-19 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
| US7772232B2 (en) * | 2004-04-15 | 2010-08-10 | Bristol-Myers Squibb Company | Quinazolinyl compounds as inhibitors of potassium channel function |
| WO2007013936A2 (en) * | 2005-07-21 | 2007-02-01 | Wyeth | Method for treating nervous system disorders and conditions |
| AU2006321947A1 (en) * | 2005-12-05 | 2007-06-14 | Wyeth | Process for preparing substituted aryl cycloalkanol derivatives |
| US7994190B2 (en) | 2006-11-01 | 2011-08-09 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| WO2010016554A1 (ja) * | 2008-08-07 | 2010-02-11 | 武田薬品工業株式会社 | 環状アミン化合物 |
| WO2011046800A1 (en) * | 2009-10-13 | 2011-04-21 | Wellstat Therapeutics Corporation | 3-substituted compounds for reducing uric acid |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3454554A (en) * | 1960-10-14 | 1969-07-08 | Colgate Palmolive Co | Aminoalkyliminodibenzyl compounds |
| FR2035785A6 (enExample) * | 1969-03-28 | 1970-12-24 | Delalande Sa | |
| CS175831B1 (enExample) * | 1974-12-17 | 1977-05-31 | ||
| IL56369A (en) * | 1978-01-20 | 1984-05-31 | Erba Farmitalia | Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them |
| US4310524A (en) * | 1980-04-11 | 1982-01-12 | Richardson-Merrell, Inc. | TCA Composition and method for rapid onset antidepressant therapy |
| PH18686A (en) | 1981-05-26 | 1985-08-29 | Merck & Co Inc | 1-(3 halo-2-pyridinyl) piperazine |
| US4535186A (en) * | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
| CA1280421C (en) | 1985-07-02 | 1991-02-19 | Albert A. Carr | 1,4-disubstituted piperidinyl derivatives |
| ZA885824B (en) | 1987-08-14 | 1989-04-26 | Merrell Dow Pharma | Novel antidepressants |
| US4826844A (en) * | 1987-09-30 | 1989-05-02 | American Home Products Corporation | Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols |
| WO1991018602A1 (en) | 1990-06-01 | 1991-12-12 | Merrell Dow Pharmaceuticals Inc. | (+)-α-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL |
| GB9021535D0 (en) | 1990-10-03 | 1990-11-14 | Wyeth John & Brother Ltd | Piperazine derivatives |
| US5502047A (en) * | 1993-03-22 | 1996-03-26 | Kavey; Neil B. | Treatment for insomnia |
| GB9306103D0 (en) | 1993-03-24 | 1993-05-12 | Wyeth John & Brother Ltd | Piperazine derivatives |
| PL187926B1 (pl) | 1996-03-25 | 2004-11-30 | Lilly Co Eli | Kompozycja farmaceutyczna do leczenia bólu |
| EP0914319B1 (en) | 1996-05-20 | 2001-11-21 | Teijin Limited | Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists |
| JPH10218866A (ja) | 1997-02-07 | 1998-08-18 | Pola Chem Ind Inc | ドーパミン再取り込み阻害剤 |
| IL138084A0 (en) | 1998-03-02 | 2001-10-31 | Lilly Co Eli | Fluoxetine hydrochloride for decreasing hot flashes |
| CA2368083A1 (en) | 1999-04-06 | 2000-10-12 | Sepracor Inc. | Derivatives of venlafaxine and methods of preparing and using the same |
| ATE305788T1 (de) * | 1999-07-01 | 2005-10-15 | Pharmacia & Upjohn Co Llc | (s,s)-reboxetin zur behandlung von inkontinenz |
| BR0111976A (pt) * | 2000-06-27 | 2003-12-09 | Taisho Pharmaceutical Co Ltd | Preparação terapêutica para neurose ou depressão por ansiedade, e, derivado de piperazina |
| EA011451B1 (ru) | 2001-02-12 | 2009-04-28 | Уайт | Новая соль сукцинат о-десметилвенлафаксина |
| CA2442410A1 (en) | 2001-03-29 | 2002-10-10 | Owen Brendan Wallace | Duloxetine for treatment of hot flashes |
| EP1266659A1 (en) | 2001-06-11 | 2002-12-18 | Pantarhei Bioscience B.V. | Pyridoxal in combination with serotonin re-uptake inhibitor for the treatment of hot flushes |
| US20040259850A1 (en) | 2001-10-31 | 2004-12-23 | Alves Stephen E. | Method for treating or preventing symptoms of hormonal variation including hot flashes |
| US6602911B2 (en) | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
| KR20040083472A (ko) * | 2001-12-21 | 2004-10-02 | 다이쇼 세이야꾸 가부시끼가이샤 | 피페라진 유도체 |
| PT1485078E (pt) | 2002-03-15 | 2013-01-14 | Cypress Bioscience Inc | Milnacipran para o tratamento do síndrome do intestino irritável |
| TW200402289A (en) * | 2002-05-17 | 2004-02-16 | Wyeth Corp | Methods of treating gastrointestinary and genitourinary pain disorders |
| MXPA05001705A (es) | 2002-08-14 | 2005-04-19 | Pharmacia & Upjohn Co Llc | Uso de reboxetina para el tratamiento de sofocos. |
| US20040180879A1 (en) * | 2002-10-15 | 2004-09-16 | Deecher Darlene Coleman | Novel method of treating vasomotor symptoms |
| US20040152710A1 (en) * | 2002-10-15 | 2004-08-05 | Deecher Darlene Coleman | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms |
| US7345096B2 (en) * | 2002-10-15 | 2008-03-18 | Wyeth | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms |
-
2004
- 2004-10-12 US US10/963,064 patent/US7419980B2/en not_active Expired - Fee Related
- 2004-10-13 BR BRPI0415276-0A patent/BRPI0415276A/pt not_active IP Right Cessation
- 2004-10-13 WO PCT/US2004/033671 patent/WO2005037283A1/en not_active Ceased
- 2004-10-13 AU AU2004281734A patent/AU2004281734A1/en not_active Abandoned
- 2004-10-13 MX MXPA06003879A patent/MXPA06003879A/es unknown
- 2004-10-13 JP JP2006535599A patent/JP2007508393A/ja active Pending
- 2004-10-13 TW TW093131005A patent/TW200526603A/zh unknown
- 2004-10-13 CA CA002549733A patent/CA2549733A1/en not_active Abandoned
- 2004-10-13 EP EP04794905A patent/EP1673090A1/en not_active Withdrawn
- 2004-10-14 AR ARP040103714A patent/AR046179A1/es unknown
- 2004-10-14 PA PA20048615201A patent/PA8615201A1/es unknown
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