JP2007508298A5 - - Google Patents
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- Publication number
- JP2007508298A5 JP2007508298A5 JP2006533831A JP2006533831A JP2007508298A5 JP 2007508298 A5 JP2007508298 A5 JP 2007508298A5 JP 2006533831 A JP2006533831 A JP 2006533831A JP 2006533831 A JP2006533831 A JP 2006533831A JP 2007508298 A5 JP2007508298 A5 JP 2007508298A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydroxy
- pharmaceutical composition
- hydrogen
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 150000002431 hydrogen Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 229910052805 deuterium Inorganic materials 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 229930003316 Vitamin D Natural products 0.000 claims 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000001118 alkylidene group Chemical group 0.000 claims 2
- 125000005345 deuteroalkyl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 230000017105 transposition Effects 0.000 claims 2
- 239000011710 vitamin D Substances 0.000 claims 2
- 235000019166 vitamin D Nutrition 0.000 claims 2
- -1 vitamin D compound Chemical class 0.000 claims 2
- 229940046008 vitamin d Drugs 0.000 claims 2
- 239000011612 calcitriol Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/680,881 US7704980B2 (en) | 2003-10-08 | 2003-10-08 | Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds |
| PCT/US2004/023586 WO2005039592A1 (en) | 2003-10-08 | 2004-07-23 | Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin d compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007508298A JP2007508298A (ja) | 2007-04-05 |
| JP2007508298A5 true JP2007508298A5 (cg-RX-API-DMAC7.html) | 2007-05-31 |
Family
ID=34422197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533831A Ceased JP2007508298A (ja) | 2003-10-08 | 2004-07-23 | ２−メチレン−１９−ノル−ビタミンｄ化合物を用いた炎症性腸疾患の治療 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7704980B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1673095B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2007508298A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE448788T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004283073B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2541991A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE602004024221D1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2338428T3 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ546440A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005039592A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011017165A1 (en) * | 2009-08-03 | 2011-02-10 | Wisconsin Alumni Research Foundation | Method of preventing renal disease and treating symptoms thereof |
| CA2794006C (en) * | 2010-03-23 | 2017-11-28 | Wisconsin Alumni Research Foundation | (20s)-2-methylene-19-nor-22-dimethyl-1.alpha.,25-dihydroxyvitamin d3 and (20r)-2-methylene-19-nor-22-dimethyl-1.alpha.,25-hydroxyvitamin d3 |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| EP2556054B1 (en) * | 2010-03-23 | 2017-09-27 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1alpha,25-dihydroxyvitamin d3 |
| FR2961401B1 (fr) * | 2010-06-17 | 2013-04-05 | Laetitia Mathez | Composition anti-inflammatoire |
| CN102631354B (zh) * | 2011-02-11 | 2015-01-21 | 广东泰禾医药科技有限公司 | 含维生素d3和二甲双胍的药物组合物 |
| JP6059716B2 (ja) | 2011-06-03 | 2017-01-11 | ウイスコンシン アラムニ リサーチ ファンデーション | （２２Ｅ）−２−メチレン−２６，２７−シクロ−２２−デヒドロ−１α−ヒドロキシ−１９−ノルビタミンＤ３誘導体 |
| US20130295083A1 (en) * | 2012-05-02 | 2013-11-07 | Wisconsin Alumni Research Foundation | 2a-Methyl-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2AMD) or 2 methylene-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2MD) Support Survival and Function of Transplanted Islet Cells In Type 1 Diabetes |
| EP2866811A1 (en) | 2012-06-29 | 2015-05-06 | Wisconsin Alumni Research Foundation | USE OF 2-METHYLENE-19-NOR-(20S)-1 alpha,25-DIHYDROXYVITAMIN D³ TO TREAT SECONDARY HYPERPARATHYROIDISM |
| US9370527B2 (en) | 2012-12-28 | 2016-06-21 | The Regents Of The University Of Michigan | Amelioration of intestinal fibrosis and treatment of Crohn's disease |
| US9539264B2 (en) | 2014-12-30 | 2017-01-10 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism in patients previously treated with calcimimetics |
| US10369161B2 (en) | 2014-12-30 | 2019-08-06 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism |
| WO2017184262A1 (en) * | 2016-04-18 | 2017-10-26 | Wisconsin Alumni Research Foundation | Use of 2amd and 2md to treat fibrosis |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4221961A1 (de) | 1992-06-30 | 1994-01-05 | Schering Ag | 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel |
| IL107185A (en) | 1992-10-06 | 1998-02-22 | Schering Ag | Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same |
| US5981597A (en) * | 1995-02-13 | 1999-11-09 | Trustees Of The University Of Pennsylvania | Differentiating agents for the treatment of inflammatory intestinal diseases |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US6989377B2 (en) * | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| US6358939B1 (en) * | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| PT1286962E (pt) * | 2000-05-31 | 2008-07-30 | Wisconsin Alumni Res Found | Compostos de 2-etil- e 2-etilideno-19-nor-vitamina d |
| AU2001275445B2 (en) * | 2000-09-08 | 2006-07-27 | Wisconsin Alumni Research Foundation | 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications |
| KR100631457B1 (ko) * | 2001-12-13 | 2006-10-11 | 위스콘신 얼럼나이 리서어치 화운데이션 | (20Ｓ)-1α-히드록시-2-메틸렌-19-노르-비스호모프레그나칼시페롤 및 그의 용도 |
| US6566352B1 (en) * | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| US7259143B2 (en) * | 2002-09-05 | 2007-08-21 | Wisconsin Alumni Research Foundation | Method of extending the dose range of vitamin D compounds |
-
2003
- 2003-10-08 US US10/680,881 patent/US7704980B2/en not_active Expired - Fee Related
-
2004
- 2004-07-23 CA CA002541991A patent/CA2541991A1/en not_active Abandoned
- 2004-07-23 WO PCT/US2004/023586 patent/WO2005039592A1/en not_active Ceased
- 2004-07-23 AT AT04778892T patent/ATE448788T1/de not_active IP Right Cessation
- 2004-07-23 JP JP2006533831A patent/JP2007508298A/ja not_active Ceased
- 2004-07-23 NZ NZ546440A patent/NZ546440A/xx not_active IP Right Cessation
- 2004-07-23 ES ES04778892T patent/ES2338428T3/es not_active Expired - Lifetime
- 2004-07-23 AU AU2004283073A patent/AU2004283073B2/en not_active Expired
- 2004-07-23 EP EP04778892A patent/EP1673095B1/en not_active Expired - Lifetime
- 2004-07-23 DE DE602004024221T patent/DE602004024221D1/de not_active Expired - Lifetime
-
2010
- 2010-02-17 US US12/707,358 patent/US20100160267A1/en not_active Abandoned