JP2006523239A5 - - Google Patents
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- Publication number
- JP2006523239A5 JP2006523239A5 JP2006509883A JP2006509883A JP2006523239A5 JP 2006523239 A5 JP2006523239 A5 JP 2006523239A5 JP 2006509883 A JP2006509883 A JP 2006509883A JP 2006509883 A JP2006509883 A JP 2006509883A JP 2006523239 A5 JP2006523239 A5 JP 2006523239A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen
- following formula
- pharmaceutical composition
- protecting group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 20
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 239000001257 hydrogen Substances 0.000 claims 18
- 125000006239 protecting group Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 150000002431 hydrogen Chemical group 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 7
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 7
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000001132 Osteoporosis Diseases 0.000 claims 3
- 230000037118 bone strength Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000030136 Marchiafava-Bignami Disease Diseases 0.000 claims 2
- 208000029725 Metabolic bone disease Diseases 0.000 claims 2
- 229910052805 deuterium Inorganic materials 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039984 Senile osteoporosis Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 125000001118 alkylidene group Chemical group 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 230000008416 bone turnover Effects 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000001054 cortical effect Effects 0.000 claims 1
- 125000005345 deuteroalkyl group Chemical group 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 208000005368 osteomalacia Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000001685 postmenopausal osteoporosis Diseases 0.000 claims 1
- OSFBJERFMQCEQY-UHFFFAOYSA-N propylidene Chemical group [CH]CC OSFBJERFMQCEQY-UHFFFAOYSA-N 0.000 claims 1
- 206010038433 renal dysplasia Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46195803P | 2003-04-10 | 2003-04-10 | |
| US60/461,958 | 2003-04-10 | ||
| PCT/US2004/011059 WO2004092118A2 (en) | 2003-04-10 | 2004-04-09 | 2-propylidene-19-nor-vitamin d compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006523239A JP2006523239A (ja) | 2006-10-12 |
| JP2006523239A5 true JP2006523239A5 (cg-RX-API-DMAC7.html) | 2007-04-19 |
| JP5005340B2 JP5005340B2 (ja) | 2012-08-22 |
Family
ID=33299883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509883A Expired - Fee Related JP5005340B2 (ja) | 2003-04-10 | 2004-04-09 | ２−プロピリデン−１９−ノル−ビタミンｄ化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20060293291A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1613588B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5005340B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20050120787A (cg-RX-API-DMAC7.html) |
| CN (2) | CN100534981C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE556999T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004230948A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0409194A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2516233C (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA05009336A (cg-RX-API-DMAC7.html) |
| MY (1) | MY146504A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ542674A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004092118A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200506204B (cg-RX-API-DMAC7.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060293291A1 (en) * | 2003-04-10 | 2006-12-28 | Deluca Hector F | 2-Propylidene-19-nor-vitamin d compounds |
| US7713951B2 (en) * | 2004-04-09 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin D compounds |
| ES2404061T3 (es) * | 2005-02-11 | 2013-05-23 | Wisconsin Alumni Research Foundation | 2-Metileno-19-nor-(20S-24S)-1-alfa,25-dihidroxivitamina-D2 |
| NZ561076A (en) * | 2005-02-11 | 2010-01-29 | Wisconsin Alumni Res Found | 2-methylene-19-nor-(20S-24EPI)-1alpha,25-dihydroxyvitamin-D2 |
| US8114393B2 (en) | 2005-09-14 | 2012-02-14 | Wisconsin Alumni Research Foundation | Methods and compositions for phosphate binding |
| US20090281340A1 (en) * | 2006-04-05 | 2009-11-12 | Deluca Hector F | 1alpha-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and treatment thereof |
| MX2008012701A (es) | 2006-04-05 | 2009-01-07 | Wisconsin Alumni Res Found | Compuestos de 1-alfa-hidroxi-2-(3'-hidroxipropiliden)-19-nor-vitam ina d y metodos de elaboracion y tratamiento de los mismos. |
| AU2007298651A1 (en) * | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2-methylene-1 alpha-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
| MX2008012114A (es) * | 2006-04-06 | 2009-03-06 | Wisconsin Alumni Res Found | Analogos 19-nor-vitamina d con anillo 1,2, o 3,2 heterociclico. |
| WO2008035207A2 (en) * | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin d3 analogs and uses thereof |
| MX2008012912A (es) * | 2006-04-06 | 2008-11-26 | Wisconsin Alumni Res Found | Analogos de 2-metilen-1a,25-dihidroxi-19,21-dinorvitamina d3 y sus usos. |
| NZ571773A (en) * | 2006-04-06 | 2011-11-25 | Wisconsin Alumni Res Found | 2-Methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin D3 and uses thereof |
| EP2021320A2 (en) | 2006-04-06 | 2009-02-11 | Wisconsin Alumni Research Foundation | 2-substituted-1alpha, 25-dihydroxy-19,26,27-trinor vitamin d analogs and uses thereof |
| WO2008023278A2 (en) * | 2006-04-10 | 2008-02-28 | Wisconsin Alumni Research Foundation | 1alpha-hydroxy-2- (3 ' -hydroxypropylidene) -19-n0r- vitamin d compounds with a 1,1-dimethylpropyl side chain |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3276167D1 (en) | 1981-11-02 | 1987-06-04 | Res Inst Medicine Chem | Intermediates in the synthesis of vitamin d derivatives |
| US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| GB8904154D0 (en) | 1989-02-23 | 1989-04-05 | Leo Pharm Prod Ltd | Chemical compounds |
| NZ232734A (en) | 1989-03-09 | 1991-11-26 | Wisconsin Alumni Res Found | 19-nor vitamin d derivatives and pharmaceutical compositions |
| CA1333616C (en) | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| US5246925A (en) | 1989-03-09 | 1993-09-21 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D compounds for use in treating hyperparathyroidism |
| AU649057B2 (en) | 1990-08-24 | 1994-05-12 | Wisconsin Alumni Research Foundation | Methods and compositions containing vitamin D compounds for improvement of skin conditions |
| ES2123505T3 (es) | 1990-09-07 | 1999-01-16 | Wisconsin Alumni Res Found | Nuevo uso de compuestos de 19-nor-vitamina d 1alfa-hidroxilada para tratar la psoriasis. |
| AU650751B2 (en) | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
| US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| JP3213092B2 (ja) * | 1991-11-01 | 2001-09-25 | 中外製薬株式会社 | ２β位に置換基を有するビタミンＤ誘導体 |
| DE69400495T2 (de) * | 1993-04-05 | 1997-04-30 | Wisconsin Alumni Res Found | 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle |
| US5565589A (en) * | 1993-11-03 | 1996-10-15 | Wisconsin Alumni Research Foundation | 17-formyl-5,6-trans-vitamin D compounds |
| US5428029A (en) * | 1993-11-24 | 1995-06-27 | Hoffmann-La Roche Inc. | Vitamin D3 fluorinated analogs |
| WO1996001811A1 (en) * | 1994-07-11 | 1996-01-25 | The Johns-Hopkins University | 2-substituted 1,25-dihydroxyvitamin d3 derivatives |
| ATE176462T1 (de) | 1994-11-21 | 1999-02-15 | Wisconsin Alumni Res Found | 18,19-dinor-vitamin-d-derivate |
| US5877168A (en) * | 1995-02-10 | 1999-03-02 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivative with substituent at the 2β-position |
| IL118156A (en) | 1995-05-09 | 2001-08-26 | Duphar Int Res | Vitamin d compounds, their preparation and pharmaceutical compositions containing them |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| GB9915839D0 (en) * | 1999-07-06 | 1999-09-08 | Textron Automotive U K | Valve assembly for vehicle washing system |
| EP1524264A3 (en) * | 2000-05-31 | 2010-01-20 | Wisconsin Alumni Research Foundation | 2-ethylidene-19-nor-vitamin D compounds |
| PT1286962E (pt) * | 2000-05-31 | 2008-07-30 | Wisconsin Alumni Res Found | Compostos de 2-etil- e 2-etilideno-19-nor-vitamina d |
| US6846811B2 (en) * | 2002-04-22 | 2005-01-25 | Wisconsin Alumni Research Foundation | (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses |
| US20060293291A1 (en) * | 2003-04-10 | 2006-12-28 | Deluca Hector F | 2-Propylidene-19-nor-vitamin d compounds |
| US7053075B2 (en) * | 2003-11-25 | 2006-05-30 | Deluca Hector F | Methods for reducing body fat using vitamin D compounds |
-
2004
- 2004-04-09 US US10/544,163 patent/US20060293291A1/en not_active Abandoned
- 2004-04-09 ZA ZA200506204A patent/ZA200506204B/en unknown
- 2004-04-09 NZ NZ542674A patent/NZ542674A/en not_active IP Right Cessation
- 2004-04-09 CA CA2516233A patent/CA2516233C/en not_active Expired - Fee Related
- 2004-04-09 AU AU2004230948A patent/AU2004230948A1/en not_active Abandoned
- 2004-04-09 JP JP2006509883A patent/JP5005340B2/ja not_active Expired - Fee Related
- 2004-04-09 WO PCT/US2004/011059 patent/WO2004092118A2/en not_active Ceased
- 2004-04-09 US US10/821,479 patent/US7241747B2/en not_active Expired - Lifetime
- 2004-04-09 EP EP04749961A patent/EP1613588B1/en not_active Expired - Lifetime
- 2004-04-09 CN CNB2004800096206A patent/CN100534981C/zh not_active Expired - Fee Related
- 2004-04-09 BR BRPI0409194-9A patent/BRPI0409194A/pt not_active Application Discontinuation
- 2004-04-09 KR KR1020057019087A patent/KR20050120787A/ko not_active Abandoned
- 2004-04-09 AT AT04749961T patent/ATE556999T1/de active
- 2004-04-09 CN CN2008101302056A patent/CN101293894B/zh not_active Expired - Fee Related
- 2004-04-09 MX MXPA05009336A patent/MXPA05009336A/es active IP Right Grant
- 2004-10-14 MY MYPI20044250A patent/MY146504A/en unknown
-
2007
- 2007-05-17 US US11/750,172 patent/US7531527B2/en not_active Expired - Fee Related